KEGG   PATHWAY: mcep04270
Entry
mcep04270                   Pathway                                
Name
Vascular smooth muscle contraction - Mugil cephalus (flathead mullet)
Description
The vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regulate the blood flow and pressure.
The principal mechanisms that regulate the contractile state of VSMCs are changes in cytosolic Ca2+ concentration ([Ca2+]c). In response to vasoconstrictor stimuli, Ca2+ is mobilized from intracellular stores and/or the extracellular space to increase [Ca2+]c in VSMCs. The increase in [Ca2+]c, in turn, activates the Ca2+-CaM-MLCK pathway and stimulates MLC20 phosphorylation, leading to myosin-actin interactions and, hence, the development of contractile force. The sensitivity of contractile myofilaments or MLC20 phosphorylation to Ca2+ can be secondarily modulated by other signaling pathways. During receptor stimulation, the contractile force is greatly enhanced by the inhibition of myosin phosphatase. Rho/Rho kinase, PKC, and arachidonic acid have been proposed to play a pivotal role in this enhancement.
The signaling events that mediate relaxation include the removal of a contractile agonist (passive relaxation) and activation of cyclic nucleotide-dependent signaling pathways in the continued presence of a contractile agonist (active relaxation). Active relaxation occurs through the inhibition of both Ca2+ mobilization and myofilament Ca2+ sensitivity in VSMCs.
Class
Organismal Systems; Circulatory system
Pathway map
mcep04270  Vascular smooth muscle contraction
mcep04270

Other DBs
GO: 0014829
Organism
Mugil cephalus (flathead mullet) [GN:mcep]
Gene
125011748  adra1aa; adrenoceptor alpha 1Aa [KO:K04135]
124996288  alpha-1A adrenergic receptor-like [KO:K04135]
125021496  alpha-1A adrenergic receptor-like [KO:K04136]
125008422  alpha-1A adrenergic receptor-like [KO:K04136]
125000228  adra1d; alpha-1D adrenergic receptor [KO:K04137]
125018573  agt; angiotensinogen [KO:K09821]
124995725  agtr1b; type-1 angiotensin II receptor A [KO:K04166]
125020049  edn1; endothelin-1 [KO:K16366]
124998909  endothelin-1 [KO:K16367]
125019431  edn2; endothelin-2 [KO:K16367]
125016554  endothelin-2 [KO:K16367]
125006907  endothelin-3 isoform X1 [KO:K05227]
124997636  edn3b; endothelin-3b [KO:K05227]
125014738  endothelin receptor type B-like [KO:K04197]
125004390  ednraa; endothelin receptor type Aa [KO:K04197]
125011604  vasopressin-neurophysin 2-copeptin [KO:K05242]
125015548  avpr1aa; arginine vasopressin receptor 1Aa [KO:K04226]
124999736  arg8-vasotocin receptor-like [KO:K04226]
125011983  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
124996503  guanine nucleotide-binding protein G(q) subunit alpha-like isoform X1 [KO:K04634]
125023161  guanine nucleotide-binding protein subunit alpha-11-like isoform X1 [KO:K04635]
125009101  guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04635]
125011850  phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
125011851  pla2g1b; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
125014142  proca1; uncharacterized protein proca1 [KO:K01047] [EC:3.1.1.4]
125012413  group 3 secretory phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
125018320  pla2g12b; group XIIB secretory phospholipase A2-like protein [KO:K01047] [EC:3.1.1.4]
125003772  pla2g12a; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
125003950  group XIIB secretory phospholipase A2-like protein [KO:K01047] [EC:3.1.1.4]
124996716  pla2g3; group 3 secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
124996814  phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
124998044  pla2g10; group 10 secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
125000784  cytosolic phospholipase A2 epsilon-like isoform X1 [KO:K16342] [EC:3.1.1.4]
125000785  cytosolic phospholipase A2 zeta-like isoform X1 [KO:K16342] [EC:3.1.1.4]
125001211  cytosolic phospholipase A2 zeta-like [KO:K16342] [EC:3.1.1.4]
125001212  cytosolic phospholipase A2 beta-like [KO:K16342] [EC:3.1.1.4]
125001218  cytosolic phospholipase A2 beta-like [KO:K16342] [EC:3.1.1.4]
125009703  cytosolic phospholipase A2-like [KO:K16342] [EC:3.1.1.4]
124998015  cytosolic phospholipase A2 zeta-like [KO:K16342] [EC:3.1.1.4]
125003837  pla2g6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
125022175  calcium-activated potassium channel subunit alpha-1-like isoform X1 [KO:K04936]
125018773  kcnma1a; calcium-activated potassium channel subunit alpha-1a isoform X1 [KO:K04936]
125009981  calcium-activated potassium channel subunit beta-2 isoform X1 [KO:K04938]
125010189  kcnmb2; calcium-activated potassium channel subunit beta-2 [KO:K04938]
125011087  kcnmb3; calcium-activated potassium channel subunit beta-3 [KO:K04939]
125000150  calcium-activated potassium channel subunit beta-4-like [KO:K04941]
124999862  cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
124998958  cacna1db; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
125006589  cacna1da; calcium channel, voltage-dependent, L type, alpha 1D subunit, a isoform X1 [KO:K04851]
125000377  cacna1fa; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04853]
125008328  cacna1fb; calcium channel, voltage-dependent, L type, alpha 1F subunit isoform X1 [KO:K04853]
125006895  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like [KO:K04857]
125024233  calmodulin-1 [KO:K02183]
125006593  calglandulin-like [KO:K02183]
125014343  calml4b; calmodulin-like protein 4 [KO:K02183]
125013316  calm3a; calmodulin 3a (phosphorylase kinase, delta) [KO:K02183]
125018763  calm2a; calmodulin 2a (phosphorylase kinase, delta) [KO:K02183]
125005003  calmodulin-like protein 4 [KO:K02183]
124998844  calmodulin-1 [KO:K02183]
125022708  myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
125009757  mylk4b; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
124998363  mylk5; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
125011146  mylk4a; myosin light chain kinase 2, skeletal/cardiac muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
125007083  myl6; myosin light polypeptide 6 [KO:K12751]
125004030  zgc:153867; myosin light polypeptide 6 isoform X1 [KO:K12751]
125006768  myl9b; myosin regulatory light polypeptide 9b [KO:K12755]
125003663  myosin-10-like isoform X1 [KO:K10352]
125003828  myh9a; myosin-9a isoform X1 [KO:K10352]
125004680  myh11a; myosin-11a isoform X1 [KO:K10352]
124997441  myosin-10 isoform X1 [KO:K10352]
124997695  myosin-11-like [KO:K10352]
124998253  myosin-9-like isoform X1 [KO:K10352]
125023608  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
124999051  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
125018743  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
125008027  plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
124998714  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4-like isoform X1 [KO:K05858] [EC:3.1.4.11]
125006285  inositol 1,4,5-trisphosphate receptor type 1-like isoform X1 [KO:K04958]
125007204  inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
125015051  itpr2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
125008315  itpr3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
125004243  prkcaa; protein kinase C, alpha, a isoform X1 [KO:K02677] [EC:2.7.11.13]
124997961  prkcab; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
125003616  protein kinase C beta type-like isoform X1 [KO:K19662] [EC:2.7.11.13]
124997521  prkcbb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
125015974  prkcg; protein kinase C alpha type [KO:K19663] [EC:2.7.11.13]
125006281  prkcda; protein kinase C, delta A [KO:K06068] [EC:2.7.11.13]
125022292  prkcea; protein kinase C epsilon type [KO:K18050] [EC:2.7.11.13]
125018826  protein kinase C epsilon type-like isoform X1 [KO:K18050] [EC:2.7.11.13]
125024011  prkcha; protein kinase C eta type [KO:K18051] [EC:2.7.11.13]
124999967  prkcq; protein kinase C theta type [KO:K18052] [EC:2.7.11.13]
125012267  araF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
125000036  braF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
124999107  raf1a; raf-1 proto-oncogene, serine/threonine kinase A isoform X1 [KO:K04366] [EC:2.7.11.1]
125015166  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
125009454  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
125010654  map2k2b; LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
125012106  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
124997478  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
125014430  lsp1a; non-muscle caldesmon [KO:K12327]
124999856  cald1a; caldesmon 1a isoform X1 [KO:K12327]
125022221  acta2; actin, aortic smooth muscle [KO:K12313]
125021198  ppp1r14aa; protein phosphatase 1, regulatory (inhibitor) subunit 14Aa [KO:K12328]
125023722  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
125012477  ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit A [KO:K06269] [EC:3.1.3.16]
125015714  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
124997688  ppp1caa; protein phosphatase 1, catalytic subunit, alpha isozyme A [KO:K06269] [EC:3.1.3.16]
124998754  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
124999912  ppp1r12a; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
125011494  protein phosphatase 1 regulatory subunit 12A-like isoform X1 [KO:K12329]
125014678  zmp:0000001167; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K17457]
125004646  ppp1r12c; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
125004095  gna12a; guanine nucleotide-binding protein subunit alpha-12a [KO:K04346]
124998048  gna13b; guanine nucleotide-binding protein subunit alpha-13b [KO:K04639]
125013368  arhgef12a; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
125016198  arhgef1b; rho guanine nucleotide exchange factor 1b isoform X1 [KO:K12330]
125013811  arhgef11; rho guanine nucleotide exchange factor 11 isoform X1 [KO:K12331]
125011903  rho-related GTP-binding protein RhoA-D [KO:K04513]
125011912  rho-related GTP-binding protein RhoA-C-like [KO:K04513]
125006645  transforming protein RhoA [KO:K04513]
125007385  rhoca; ras homolog family member Ca isoform X1 [KO:K04513]
125005026  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
125010798  rock1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
125023444  rock2a; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
124999124  rho-associated protein kinase 1-like isoform X1 [KO:K17388] [EC:2.7.11.1]
125011613  adora2aa; adenosine A2a receptor A [KO:K04266]
124996265  adora2ab; adenosine A2a receptor B [KO:K04266]
125020931  adora2b; adenosine receptor A2b [KO:K04267]
125014150  ptgir; prostacyclin receptor isoform X1 [KO:K04263]
125014358  calcitonin-1-like isoform X1 [KO:K12332]
125005548  calca; calcitonin/calcitonin-related polypeptide, alpha [KO:K12332]
125005359  admA; adrenomedullin A [KO:K12333]
125015043  adm2b; protein ADM2 [KO:K25343]
125000334  adm2a; protein ADM2a [KO:K25343]
125017958  calcrl2; calcitonin gene-related peptide type 1 receptor [KO:K04577]
125017498  calcitonin gene-related peptide type 1 receptor [KO:K04577]
125017172  ramp1; receptor activity-modifying protein 1 isoform X1 [KO:K08447]
125022073  receptor activity-modifying protein 1-like [KO:K08447]
125000599  receptor activity-modifying protein 1-like [KO:K08447]
124998235  ramp2; receptor activity-modifying protein 2 isoform X1 [KO:K08448]
124995965  receptor activity-modifying protein 3-like [KO:K08449]
125013268  gnaS; guanine nucleotide-binding protein G(s) subunit alpha [KO:K04632]
125006078  guanine nucleotide-binding protein G(s) subunit alpha-like isoform X1 [KO:K04632]
125008823  adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
125011216  adenylate cyclase type 1-like isoform X1 [KO:K08041] [EC:4.6.1.1]
125016395  adcy2a; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
125020520  adcy2b; adenylate cyclase type 2b isoform X1 [KO:K08042] [EC:4.6.1.1]
125017029  adcy3a; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
125017693  adcy5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
125019197  adenylate cyclase type 6-like [KO:K08046] [EC:4.6.1.1]
125015099  adenylate cyclase type 6-like [KO:K08046] [EC:4.6.1.1]
125005160  adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
124999026  adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
125000626  adenylate cyclase type 8-like isoform X1 [KO:K08048] [EC:4.6.1.1]
125010885  adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
125004196  adcy9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
124997289  adenylate cyclase type 9-like isoform X1 [KO:K08049] [EC:4.6.1.1]
125003436  cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
125008931  protein kinase, cAMP-dependent, catalytic, beta a isoform X1 [KO:K04345] [EC:2.7.11.11]
124997569  protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a isoform X1 [KO:K04345] [EC:2.7.11.11]
125010535  protein kinase, cAMP-dependent, catalytic, beta b isoform X1 [KO:K04345] [EC:2.7.11.11]
125016709  atrial natriuretic peptide receptor 1-like isoform X1 [KO:K12323] [EC:4.6.1.2]
125019399  atrial natriuretic peptide receptor 1-like [KO:K12323] [EC:4.6.1.2]
125016238  wu:fj39g12; C-type natriuretic peptide-like [KO:K12336]
125018739  nppal; natriuretic peptide A-like [KO:K12336]
125008922  nppC; C-type natriuretic peptide [KO:K12336]
125010237  si:ch73-265d7.2; C-type natriuretic peptide 2 [KO:K12336]
125022294  LOW QUALITY PROTEIN: uncharacterized protein LOC125022294 [KO:K12324] [EC:4.6.1.2]
125022640  atrial natriuretic peptide receptor 1-like [KO:K12324] [EC:4.6.1.2]
124996591  npr2; atrial natriuretic peptide receptor 2 [KO:K12324] [EC:4.6.1.2]
125009554  atrial natriuretic peptide receptor 2-like [KO:K12324] [EC:4.6.1.2]
125019106  cGMP-dependent protein kinase 1 isoform X1 [KO:K07376] [EC:2.7.11.12]
125005284  mrvi1; inositol 1,4,5-triphosphate receptor associated 1 isoform X1 [KO:K12337]
125013944  gucy1a2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
125003959  gucy1a1; guanylate cyclase soluble subunit alpha-1 [KO:K12318] [EC:4.6.1.2]
125013845  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
125000763  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
125003960  gucy1b1; guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00212  Adenosine
C00219  Arachidonate
C00238  Potassium cation
C00533  Nitric oxide
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00942  3',5'-Cyclic GMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01312  Prostaglandin I2
C14748  20-HETE
C14768  5,6-EET
C14769  8,9-EET
C14770  11,12-EET
C14771  14,15-EET
Reference
PMID:17458653
  Authors
Akata T
  Title
Cellular and molecular mechanisms regulating vascular tone. Part 2: regulatory mechanisms modulating Ca2+ mobilization and/or myofilament Ca2+ sensitivity in vascular smooth muscle cells.
  Journal
J Anesth 21:232-42 (2007)
DOI:10.1007/s00540-006-0488-4
Reference
PMID:12689814
  Authors
Ogut O, Brozovich FV
  Title
Regulation of force in vascular smooth muscle.
  Journal
J Mol Cell Cardiol 35:347-55 (2003)
DOI:10.1016/S0022-2828(03)00045-2
Reference
PMID:16339747
  Authors
Hilgers RH, Webb RC
  Title
Molecular aspects of arterial smooth muscle contraction: focus on Rho.
  Journal
Exp Biol Med (Maywood) 230:829-35 (2005)
DOI:10.1177/153537020523001107
Reference
PMID:12693609
  Authors
Schlossmann J, Feil R, Hofmann F
  Title
Signaling through NO and cGMP-dependent protein kinases.
  Journal
Ann Med 35:21-7 (2003)
DOI:10.1080/07853890310004093
Reference
PMID:16870827
  Authors
Mehta PK, Griendling KK
  Title
Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system.
  Journal
Am J Physiol Cell Physiol 292:C82-97 (2007)
DOI:10.1152/ajpcell.00287.2006
Reference
PMID:19120701
  Authors
Kim HR, Appel S, Vetterkind S, Gangopadhyay SS, Morgan KG
  Title
Smooth muscle signalling pathways in health and disease.
  Journal
J Cell Mol Med 12:2165-80 (2008)
DOI:10.1111/j.1582-4934.2008.00552.x
Reference
PMID:11165670
  Authors
Fukata Y, Amano M, Kaibuchi K
  Title
Rho-Rho-kinase pathway in smooth muscle contraction and cytoskeletal reorganization of non-muscle cells.
  Journal
Trends Pharmacol Sci 22:32-9 (2001)
DOI:10.1016/S0165-6147(00)01596-0
Reference
PMID:17158339
  Authors
Dimopoulos GJ, Semba S, Kitazawa K, Eto M, Kitazawa T
  Title
Ca2+-dependent rapid Ca2+ sensitization of contraction in arterial smooth muscle.
  Journal
Circ Res 100:121-9 (2007)
DOI:10.1161/01.RES.0000253902.90489.df
Reference
PMID:17200683
  Authors
Hynynen MM, Khalil RA
  Title
The vascular endothelin system in hypertension--recent patents and discoveries.
  Journal
Recent Pat Cardiovasc Drug Discov 1:95-108 (2006)
DOI:10.2174/157489006775244263
Reference
PMID:15269340
  Authors
Brain SD, Grant AD
  Title
Vascular actions of calcitonin gene-related peptide and adrenomedullin.
  Journal
Physiol Rev 84:903-34 (2004)
DOI:10.1152/physrev.00037.2003
Reference
PMID:11773611
  Authors
Roman RJ
  Title
P-450 metabolites of arachidonic acid in the control of cardiovascular function.
  Journal
Physiol Rev 82:131-85 (2002)
DOI:10.1152/physrev.00021.2001
Reference
PMID:18040024
  Authors
Surks HK
  Title
cGMP-dependent protein kinase I and smooth muscle relaxation: a tale of two isoforms.
  Journal
Circ Res 101:1078-80 (2007)
DOI:10.1161/CIRCRESAHA.107.165779
Reference
PMID:15026027
  Authors
Vanhoutte PM
  Title
Endothelium-dependent hyperpolarizations: the history.
  Journal
Pharmacol Res 49:503-8 (2004)
DOI:10.1016/j.phrs.2003.11.015
Reference
PMID:10221985
  Authors
Davis MJ, Hill MA
  Title
Signaling mechanisms underlying the vascular myogenic response.
  Journal
Physiol Rev 79:387-423 (1999)
DOI:10.1152/physrev.1999.79.2.387
Reference
PMID:11679404
  Authors
Fleming I.
  Title
Cytochrome p450 and vascular homeostasis.
  Journal
Circ Res 89:753-62 (2001)
DOI:10.1161/hh2101.099268
Reference
PMID:10911373
  Authors
Carvajal JA, Germain AM, Huidobro-Toro JP, Weiner CP
  Title
Molecular mechanism of cGMP-mediated smooth muscle relaxation.
  Journal
J Cell Physiol 184:409-20 (2000)
DOI:10.1002/1097-4652(200009)184:3<409::AID-JCP16>3.0.CO;2-K
Reference
PMID:18552454
  Authors
Ko EA, Han J, Jung ID, Park WS
  Title
Physiological roles of K+ channels in vascular smooth muscle cells.
  Journal
J Smooth Muscle Res 44:65-81 (2008)
DOI:10.1540/jsmr.44.65
Reference
PMID:18703404
  Authors
Woodard GE, Rosado JA
  Title
Natriuretic peptides in vascular physiology and pathology.
  Journal
Int Rev Cell Mol Biol 268:59-93 (2008)
DOI:10.1016/S1937-6448(08)00803-4
Reference
PMID:11709400
  Authors
Berry C, Touyz R, Dominiczak AF, Webb RC, Johns DG
  Title
Angiotensin receptors: signaling, vascular pathophysiology, and interactions with ceramide.
  Journal
Am J Physiol Heart Circ Physiol 281:H2337-65 (2001)
DOI:10.1152/ajpheart.2001.281.6.H2337
Reference
PMID:15725705
  Authors
Hirano K, Hirano M, Kanaide H
  Title
Regulation of myosin phosphorylation and myofilament Ca2+ sensitivity in vascular smooth muscle.
  Journal
J Smooth Muscle Res 40:219-36 (2004)
DOI:10.1540/jsmr.40.219
Reference
PMID:9458738
  Authors
Freeman EJ, Ruehr ML, Dorman RV
  Title
ANG II-induced translocation of cytosolic PLA2 to the nucleus in vascular smooth muscle cells.
  Journal
Am J Physiol 274:C282-8 (1998)
DOI:10.1152/ajpcell.1998.274.1.C282
Reference
PMID:12060106
  Authors
Murphy TV, Spurrell BE, Hill MA
  Title
Cellular signalling in arteriolar myogenic constriction: involvement of tyrosine phosphorylation pathways.
  Journal
Clin Exp Pharmacol Physiol 29:612-9 (2002)
DOI:10.1046/j.1440-1681.2002.03698.x
Related
pathway
mcep00590  Arachidonic acid metabolism
mcep04020  Calcium signaling pathway
KO pathway
ko04270   
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