KEGG   PATHWAY: mgp04820
Entry
mgp04820                    Pathway                                
Name
Cytoskeleton in muscle cells - Meleagris gallopavo (turkey)
Class
Cellular Processes; Cell motility
Pathway map
mgp04820  Cytoskeleton in muscle cells
mgp04820

Organism
Meleagris gallopavo (turkey) [GN:mgp]
Gene
100540436  COL1A2; collagen alpha-2(I) chain [KO:K06236]
100543004  COL3A1; LOW QUALITY PROTEIN: collagen alpha-1(III) chain [KO:K19720]
100548707  collagen alpha-1(XI) chain-like [KO:K19721]
100545544  COL5A1; collagen alpha-1(V) chain [KO:K19721]
100543158  COL5A2; collagen alpha-2(V) chain isoform X1 [KO:K19721]
104912368  collagen alpha-1(XI) chain-like [KO:K19721]
104913712  collagen alpha-2(I) chain-like [KO:K19721]
100549170  COL24A1; collagen alpha-1(XXIV) chain isoform X1 [KO:K19721]
100542760  COL27A1; collagen alpha-1(XXVII) chain isoform X1 [KO:K19721]
100551098  COL9A1; LOW QUALITY PROTEIN: collagen alpha-1(IX) chain [KO:K08131]
100545906  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
100547243  COL9A2; LOW QUALITY PROTEIN: collagen alpha-2(IX) chain [KO:K08131]
100543191  DCN; decorin [KO:K04660]
100550062  VCAN; versican core protein [KO:K06793]
104909322  elastin-like isoform X1 [KO:K14211]
104909318  elastin [KO:K14211]
100544967  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
100546041  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
100549061  COL6A3; collagen alpha-3(VI) chain isoform X6 [KO:K06238]
100551157  COL6A6; collagen alpha-6(VI) chain isoform X1 [KO:K06238]
100542373  THBS1; thrombospondin-1 [KO:K16857]
100545155  THBS2; thrombospondin-2 [KO:K04659]
100548314  COMP; LOW QUALITY PROTEIN: cartilage oligomeric matrix protein [KO:K04659]
100541177  THBS4; thrombospondin-4 [KO:K04659]
723984  FBN1; fibrillin-1 [KO:K06825]
100538712  FBN3; fibrillin-3 [KO:K23342]
100546990  fibrillin-2 [KO:K23342]
100548601  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
100550138  COL4A1; collagen alpha-1(IV) chain isoform X1 [KO:K06237]
100539562  LOW QUALITY PROTEIN: collagen alpha-4(IV) chain [KO:K06237]
100539715  collagen alpha-3(IV) chain [KO:K06237]
100540855  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
100541005  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
100542803  FBLN2; fibulin-2 [KO:K17307]
100542822  fibulin-1 [KO:K17307]
100549236  basement membrane-specific heparan sulfate proteoglycan core protein [KO:K06255]
100549968  NID1; LOW QUALITY PROTEIN: nidogen-1 [KO:K06826]
100543097  NID2; nidogen-2 [KO:K06826]
100551213  FN1; fibronectin [KO:K05717]
100541597  SDC1; syndecan-1 [KO:K06257]
100190902  SDC2; syndecan-2 precursor [KO:K16336]
100303706  SDC3; syndecan-3 precursor [KO:K16337]
100126249  SDC4; syndecan-4 precursor [KO:K16338]
100543025  AGRN; agrin [KO:K06254]
100543299  desmocollin-2 isoform X1 [KO:K07601]
100544546  DSG2; LOW QUALITY PROTEIN: desmoglein-2 [KO:K07597]
100541032  PKP2; plakophilin-2 [KO:K12642]
100543340  JUP; junction plakoglobin [KO:K10056]
100540737  DSP; desmoplakin isoform X1 [KO:K10381]
100545887  VIM; vimentin [KO:K07606]
100538429  DES; desmin [KO:K07610]
100550433  LAMA1; laminin subunit alpha-1 [KO:K05637]
100545053  laminin subunit alpha-2 [KO:K05637]
104914876  integrin alpha-1-like [KO:K06480]
104916711  integrin alpha-IIb-like [KO:K06476]
100545328  ITGA4; integrin alpha-4 [KO:K06483]
100538428  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
100550013  LOW QUALITY PROTEIN: integrin alpha-7 [KO:K06583]
100546503  integrin alpha-8 [KO:K06584]
100538631  ITGA9; integrin alpha-9 [KO:K06585]
100547226  ITGA11; LOW QUALITY PROTEIN: integrin alpha-11 [KO:K06587]
100541922  ITGAV; integrin alpha-V [KO:K06487]
100551464  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
100540307  ITGB3; integrin beta-3 [KO:K06493]
100544044  ITGB4; integrin beta-4 isoform X4 [KO:K06525]
104911802  integrin beta-5 [KO:K06588]
100548345  ITGB6; integrin beta-6 [KO:K06589]
100540683  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
100539565  talin-2 isoform X1 [KO:K06271]
100539689  talin-1 [KO:K06271]
100302597  VCL; vinculin [KO:K05700]
100550274  ACTN2; alpha-actinin-2 [KO:K21073]
100542800  actin, cytoplasmic type 5 [KO:K05692]
100303677  ACTB; actin, cytoplasmic 1 [KO:K05692]
100544583  actin, cytoplasmic 2-like [KO:K05692]
100551088  actin, gamma-enteric smooth muscle [KO:K12315]
100547027  DAG1; dystroglycan [KO:K06265]
104916513  epsilon-sarcoglycan-like [KO:K12565]
100540899  SGCE; epsilon-sarcoglycan isoform X1 [KO:K27061]
104910779  SGCB; beta-sarcoglycan [KO:K12566]
100550922  SGCD; delta-sarcoglycan isoform X1 [KO:K12563]
100547511  SGCG; LOW QUALITY PROTEIN: gamma-sarcoglycan [KO:K12564]
100540204  SSPN; sarcospan [KO:K22194]
100546390  DMD; LOW QUALITY PROTEIN: dystrophin [KO:K10366]
104913061  SNTB2; beta-2-syntrophin [KO:K24064]
100543514  SNTB1; beta-1-syntrophin [KO:K24064]
100546087  dystrobrevin alpha-like [KO:K26998]
104915899  sodium/potassium-transporting ATPase subunit alpha-2 [KO:K01539] [EC:7.2.2.13]
100303690  ATP1A1; sodium/potassium-transporting ATPase subunit alpha-1 [KO:K01539] [EC:7.2.2.13]
100540826  ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 isoform X1 [KO:K01540]
100544093  ATP1B4; protein ATP1B4 isoform X1 [KO:K01540]
100542023  ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540]
100547889  ankyrin-3 isoform X1 [KO:K09259]
100545390  SPTAN1; spectrin alpha chain, non-erythrocytic 1 isoform X1 [KO:K06114]
100547880  spectrin beta chain, non-erythrocytic 5 [KO:K06115]
100539592  SPTBN1; LOW QUALITY PROTEIN: spectrin beta chain, non-erythrocytic 1 [KO:K06115]
100550437  CSRP3; cysteine and glycine-rich protein 3 isoform X1 [KO:K09377]
100538352  CSRP2; cysteine and glycine-rich protein 2 [KO:K09377]
100545606  CSRP1; cysteine and glycine-rich protein 1 [KO:K09377]
100542342  myosin-7B isoform X1 [KO:K24220]
104913742  myosin-1B-like [KO:K24220]
100544198  myosin heavy chain, skeletal muscle, adult [KO:K24220]
100548579  myosin-7B-like [KO:K24220]
100549331  myosin-7-like [KO:K17751]
100545344  LOW QUALITY PROTEIN: myosin-7-like [KO:K17751]
100551398  MYH9; myosin-9 [KO:K10352]
100542649  MYH11; myosin-11 isoform X1 [KO:K10352]
100545901  MYH10; myosin-10 isoform X1 [KO:K10352]
100303704  MYL1; myosin light chain 1/3, skeletal muscle isoform [KO:K05738]
104916619  myosin light chain 3, skeletal muscle isoform-like [KO:K05738]
100538682  MYL3; myosin light chain 3 [KO:K12749]
100543339  MYL4; myosin light chain 4 isoform X2 [KO:K12750]
100547128  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
100549745  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
100547046  MYBPC1; myosin-binding protein C, slow-type isoform X1 [KO:K12557]
100551308  myosin-binding protein C, cardiac-type [KO:K12568]
100550669  MYBPH; myosin-binding protein H [KO:K24494]
100542212  ACTA1; actin, alpha skeletal muscle [KO:K10354]
100303693  actin, alpha cardiac muscle 1 [KO:K12314]
100541147  actin, alpha skeletal muscle B-like [KO:K12314]
100546476  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
100549749  TNNI1; troponin I, slow skeletal muscle isoform X2 [KO:K10371]
100544678  TNNC2; troponin C, skeletal muscle [KO:K12042]
100541452  TNNI2; troponin I, fast skeletal muscle [KO:K12043]
100526769  TNNT3; troponin T, fast skeletal muscle [KO:K12046]
100303672  TNNI3; cardiac troponin I [KO:K12044]
100303665  TNNT2; troponin T, cardiac muscle [KO:K12045]
116217087  tropomyosin alpha-1 chain-like [KO:K10373]
100540000  tropomyosin beta chain isoform X1 [KO:K10374]
100539846  tropomyosin alpha-4 chain-like isoform X1 [KO:K10374]
100539084  TPM3; tropomyosin alpha-3 chain isoform X7 [KO:K09290]
100540818  TPM4; tropomyosin alpha-4 chain isoform X1 [KO:K10375]
100546807  TTN; LOW QUALITY PROTEIN: titin [KO:K12567] [EC:2.7.11.1]
100542030  MYOT; myotilin isoform X3 [KO:K19875]
104914607  TCAP; telethonin [KO:K19879]
100125335  SYNPO2; synaptopodin-2 isoform X1 [KO:K24066]
100547940  nebulin [KO:K18267]
116216847  LOW QUALITY PROTEIN: nebulin-like [KO:K18267]
100543368  MYOZ1; myozenin-1 isoform X1 [KO:K26050]
100539396  MYOZ2; myozenin-2 isoform X1 [KO:K26050]
100548815  MYOZ3; myozenin-3 [KO:K26050]
100544138  PDLIM1; PDZ and LIM domain protein 1 isoform X3 [KO:K23353]
100548391  PDLIM3; PDZ and LIM domain protein 3 isoform X2 [KO:K23353]
100549229  PDLIM4; PDZ and LIM domain protein 4 [KO:K23353]
100545818  CAPZA2; F-actin-capping protein subunit alpha-2 [KO:K10364]
100549604  F-actin-capping protein subunit alpha-2 [KO:K10364]
100538448  CAPZA1; F-actin-capping protein subunit alpha-1 [KO:K10364]
100538958  F-actin-capping protein subunit beta isoforms 1 and 2 [KO:K10365]
100541459  XIRP1; LOW QUALITY PROTEIN: xin actin-binding repeat-containing protein 1 [KO:K27381]
100546255  NRAP; nebulin-related-anchoring protein [KO:K24421]
100540545  MYPN; myopalladin [KO:K22028]
100546044  LDB3; LIM domain-binding protein 3 isoform X2 [KO:K19867]
100544390  PDLIM5; PDZ and LIM domain protein 5 isoform X2 [KO:K19867]
100551069  PDLIM7; LOW QUALITY PROTEIN: PDZ and LIM domain protein 7 [KO:K19867]
100548866  tropomodulin-3 [KO:K10370]
100549019  tropomodulin-2 [KO:K10370]
100544315  TMOD1; tropomodulin-1 [KO:K10370]
100542614  TMOD4; tropomodulin-4 isoform X1 [KO:K10370]
100543861  ZYX; zyxin isoform X1 [KO:K06273]
100546357  FHL1; four and a half LIM domains protein 1 isoform X3 [KO:K14365]
100543756  FHL2; four and a half LIM domains protein 2 [KO:K14380]
100539224  FHL3; four and a half LIM domains protein 3 isoform X1 [KO:K24414]
100541029  LMOD2; leiomodin-2 [KO:K22030]
100551280  LMOD1; LOW QUALITY PROTEIN: leiomodin-1 [KO:K22030]
100539214  LMOD3; leiomodin-3 [KO:K22030]
100538633  ANKRD1; ankyrin repeat domain-containing protein 1 [KO:K21433]
100548550  ANKRD2; ankyrin repeat domain-containing protein 2 [KO:K21434]
100538603  FMNL1; formin-like protein 1 [KO:K23957]
100543936  FMNL2; formin-like protein 2 isoform X1 [KO:K23957]
104911253  inverted formin-2-like isoform X2 [KO:K23958]
100539970  INF2; inverted formin-2 isoform X2 [KO:K23958]
100548077  DAAM2; disheveled-associated activator of morphogenesis 2 isoform X1 [KO:K04512]
100546650  DAAM1; LOW QUALITY PROTEIN: disheveled-associated activator of morphogenesis 1 [KO:K04512]
100539769  DIAPH2; protein diaphanous homolog 2 isoform X2 [KO:K05741]
100551247  DIAPH3; protein diaphanous homolog 3 isoform X1 [KO:K05745]
100549046  LOW QUALITY PROTEIN: formin-2-like [KO:K02184]
104909659  formin-2-like [KO:K02184]
100549049  myomesin-2 [KO:K24495]
100541533  MYOM3; myomesin-3 [KO:K24495]
100543180  ENO1; alpha-enolase isoform X1 [KO:K01689] [EC:4.2.1.11]
100540825  ENO2; gamma-enolase isoform X1 [KO:K01689] [EC:4.2.1.11]
100541509  ANK2; LOW QUALITY PROTEIN: ankyrin-2 [KO:K09255]
100539848  TRIM54; LOW QUALITY PROTEIN: tripartite motif-containing protein 54 [KO:K10653]
100541812  TRIM55; tripartite motif-containing protein 55 isoform X4 [KO:K10654]
100551180  TRIM63; E3 ubiquitin-protein ligase TRIM63 isoform X1 [KO:K10655] [EC:2.3.2.27]
100540618  AMPD1; AMP deaminase 1 isoform X1 [KO:K01490] [EC:3.5.4.6]
100546778  AMP deaminase 2 [KO:K01490] [EC:3.5.4.6]
100543671  AMPD3; AMP deaminase 3 [KO:K01490] [EC:3.5.4.6]
100548956  OBSCN; LOW QUALITY PROTEIN: obscurin [KO:K17531] [EC:2.7.11.1]
100546035  CAPN3; calpain-3 isoform X1 [KO:K08573] [EC:3.4.22.54]
104917012  LOW QUALITY PROTEIN: plectin-like [KO:K10388]
100545168  SYNE3; nesprin-3 [KO:K21761]
100542938  SYNE1; nesprin-1 isoform X1 [KO:K19326]
100543155  SYNE2; nesprin-2 isoform X1 [KO:K19346]
100546266  SUN1; SUN domain-containing protein 1 isoform X1 [KO:K19347]
100542154  SUN2; SUN domain-containing protein 2 [KO:K19347]
100541524  TMEM43; transmembrane protein 43 isoform X1 [KO:K27488]
100547254  LBR; LOW QUALITY PROTEIN: delta(14)-sterol reductase LBR [KO:K19532] [EC:1.3.1.70]
100551283  LMNB2; lamin-B2 [KO:K07611]
100550044  lamin-L(III)-like [KO:K07611]
Reference
PMID:12142273
  Authors
Clark KA, McElhinny AS, Beckerle MC, Gregorio CC
  Title
Striated muscle cytoarchitecture: an intricate web of form and function.
  Journal
Annu Rev Cell Dev Biol 18:637-706 (2002)
DOI:10.1146/annurev.cellbio.18.012502.105840
Reference
PMID:31407867
  Authors
Mukund K, Subramaniam S
  Title
Skeletal muscle: A review of molecular structure and function, in health and disease.
  Journal
Wiley Interdiscip Rev Syst Biol Med 12:e1462 (2020)
DOI:10.1002/wsbm.1462
Reference
PMID:24481844
  Authors
Stroud MJ, Banerjee I, Veevers J, Chen J
  Title
Linker of nucleoskeleton and cytoskeleton complex proteins in cardiac structure, function, and disease.
  Journal
Circ Res 114:538-48 (2014)
DOI:10.1161/CIRCRESAHA.114.301236
Reference
PMID:28640448
  Authors
Henderson CA, Gomez CG, Novak SM, Mi-Mi L, Gregorio CC
  Title
Overview of the Muscle Cytoskeleton.
  Journal
Compr Physiol 7:891-944 (2017)
DOI:10.1002/cphy.c160033
Reference
PMID:32265741
  Authors
Csapo R, Gumpenberger M, Wessner B
  Title
Skeletal Muscle Extracellular Matrix - What Do We Know About Its Composition, Regulation, and Physiological Roles? A Narrative Review.
  Journal
Front Physiol 11:253 (2020)
DOI:10.3389/fphys.2020.00253
Reference
PMID:27114860
  Authors
Pinch M, Guth R, Samanta MP, Chaidez A, Unguez GA
  Title
The myogenic electric organ of Sternopygus macrurus: a non-contractile tissue with a skeletal muscle transcriptome.
  Journal
PeerJ 4:e1828 (2016)
DOI:10.7717/peerj.1828
Reference
PMID:23860255
  Authors
Sequeira V, Nijenkamp LL, Regan JA, van der Velden J
  Title
The physiological role of cardiac cytoskeleton and its alterations in heart failure.
  Journal
Biochim Biophys Acta 1838:700-22 (2014)
DOI:10.1016/j.bbamem.2013.07.011
Reference
PMID:36960155
  Authors
Zhang B, Powers JD, McCulloch AD, Chi NC
  Title
Nuclear mechanosignaling in striated muscle diseases.
  Journal
Front Physiol 14:1126111 (2023)
DOI:10.3389/fphys.2023.1126111
Reference
PMID:21464301
  Authors
Al-Amoudi A, Castano-Diez D, Devos DP, Russell RB, Johnson GT, Frangakis AS
  Title
The three-dimensional molecular structure of the desmosomal plaque.
  Journal
Proc Natl Acad Sci U S A 108:6480-5 (2011)
DOI:10.1073/pnas.1019469108
Reference
PMID:33067392
  Authors
Sikora M, Ermel UH, Seybold A, Kunz M, Calloni G, Reitz J, Vabulas RM, Hummer G, Frangakis AS
  Title
Desmosome architecture derived from molecular dynamics simulations and cryo-electron tomography.
  Journal
Proc Natl Acad Sci U S A 117:27132-27140 (2020)
DOI:10.1073/pnas.2004563117
Reference
PMID:26910421
  Authors
Xu XP, Kim E, Swift M, Smith JW, Volkmann N, Hanein D
  Title
Three-Dimensional Structures of Full-Length, Membrane-Embedded Human alpha(IIb)beta(3) Integrin Complexes.
  Journal
Biophys J 110:798-809 (2016)
DOI:10.1016/j.bpj.2016.01.016
Reference
PMID:22945352
  Authors
Wang W, Shi Z, Jiao S, Chen C, Wang H, Liu G, Wang Q, Zhao Y, Greene MI, Zhou Z
  Title
Structural insights into SUN-KASH complexes across the nuclear envelope.
  Journal
Cell Res 22:1440-52 (2012)
DOI:10.1038/cr.2012.126
Reference
PMID:23597672
  Authors
Sosa BA, Kutay U, Schwartz TU
  Title
Structural insights into LINC complexes.
  Journal
Curr Opin Struct Biol 23:285-91 (2013)
DOI:10.1016/j.sbi.2013.03.005
Reference
PMID:33058875
  Authors
Cruz VE, Esra Demircioglu F, Schwartz TU
  Title
Structural Analysis of Different LINC Complexes Reveals Distinct Binding Modes.
  Journal
J Mol Biol 432:6028-6041 (2020)
DOI:10.1016/j.jmb.2020.09.019
Reference
PMID:36523505
  Authors
Schuler SC, Liu Y, Dumontier S, Grandbois M, Le Moal E, Cornelison D, Bentzinger CF
  Title
Extracellular matrix: Brick and mortar in the skeletal muscle stem cell niche.
  Journal
Front Cell Dev Biol 10:1056523 (2022)
DOI:10.3389/fcell.2022.1056523
Reference
PMID:30425656
  Authors
Brull A, Morales Rodriguez B, Bonne G, Muchir A, Bertrand AT
  Title
The Pathogenesis and Therapies of Striated Muscle Laminopathies.
  Journal
Front Physiol 9:1533 (2018)
DOI:10.3389/fphys.2018.01533
Reference
PMID:36552829
  Authors
Storey EC, Fuller HR
  Title
Genotype-Phenotype Correlations in Human Diseases Caused by Mutations of LINC Complex-Associated Genes: A Systematic Review and Meta-Summary.
  Journal
Cells 11:cells11244065 (2022)
DOI:10.3390/cells11244065
Related
pathway
mgp04512  ECM-receptor interaction
mgp04814  Motor proteins
KO pathway
ko04820   
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