KEGG   PATHWAY: myd04152
Entry
myd04152                    Pathway                                
Name
AMPK signaling pathway - Myotis davidii (David's myotis)
Description
AMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in the cellular AMP:ATP ratio caused by metabolic stresses that either interfere with ATP production (eg, deprivation for glucose or oxygen) or that accelerate ATP consumption (eg, muscle contraction). Several upstream kinases, including liver kinase B1 (LKB1), calcium/calmodulin kinase kinase-beta (CaMKK beta), and TGF-beta-activated kinase-1 (TAK-1), can activate AMPK by phosphorylating a threonine residue on its catalytic alpha-subunit. Once activated, AMPK leads to a concomitant inhibition of energy-consuming biosynthetic pathways, such as protein, fatty acid and glycogen synthesis, and activation of ATP-producing catabolic pathways, such as fatty acid oxidation and glycolysis.
Class
Environmental Information Processing; Signal transduction
Pathway map
myd04152  AMPK signaling pathway
myd04152

Other DBs
GO: 2000479
Organism
Myotis davidii (David's myotis) [GN:myd]
Gene
102763957  MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
102767396  STK11; serine/threonine kinase 11 [KO:K07298] [EC:2.7.11.1]
102765964  CAB39L; calcium binding protein 39 like [KO:K08272]
102761193  CAB39; calcium binding protein 39 [KO:K08272]
102753563  STRADA; STE20-related kinase adaptor alpha [KO:K08271]
102760986  STRADB; STE20-related kinase adaptor beta [KO:K17532]
102759608  LEP; leptin [KO:K05424]
102757565  LEPR; leptin receptor [KO:K05062]
102752773  CAMKK2; calcium/calmodulin dependent protein kinase kinase 2 [KO:K07359] [EC:2.7.11.17]
102767266  ADRA1A; adrenoceptor alpha 1A [KO:K04135]
102753417  ADIPOQ; adiponectin, C1Q and collagen domain containing [KO:K07296]
102773758  ADIPOR2; adiponectin receptor 2 [KO:K07297]
102756180  ADIPOR1; adiponectin receptor 1 [KO:K07297]
102768354  adiponectin receptor protein 1 [KO:K07297]
102774877  PRKAA2; protein kinase AMP-activated catalytic subunit alpha 2 [KO:K07198] [EC:2.7.11.31]
102759339  PRKAA1; protein kinase AMP-activated catalytic subunit alpha 1 [KO:K07198] [EC:2.7.11.31]
102766305  PRKAB2; protein kinase AMP-activated non-catalytic subunit beta 2 [KO:K07199]
102768765  PRKAB1; protein kinase AMP-activated non-catalytic subunit beta 1 [KO:K07199]
102762694  PRKAG1; protein kinase AMP-activated non-catalytic subunit gamma 1 [KO:K07200]
102761682  PRKAG3; protein kinase AMP-activated non-catalytic subunit gamma 3 [KO:K07200]
102759388  PRKAG2; protein kinase AMP-activated non-catalytic subunit gamma 2 [KO:K07200]
102751621  PFKFB1; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 [KO:K19028] [EC:2.7.1.105 3.1.3.46]
102772244  PFKFB2; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 [KO:K19029] [EC:2.7.1.105 3.1.3.46]
102768559  PFKFB3; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 [KO:K01103] [EC:2.7.1.105 3.1.3.46]
102772908  FBP2; fructose-1,6-bisphosphatase isozyme 2 [KO:K03841] [EC:3.1.3.11]
102770609  FBP1; fructose-bisphosphatase 1 [KO:K03841] [EC:3.1.3.11]
102768013  PFKM; phosphofructokinase, muscle [KO:K00850] [EC:2.7.1.11]
102753287  PFKP; phosphofructokinase, platelet [KO:K00850] [EC:2.7.1.11]
102757968  PFKL; phosphofructokinase, liver type [KO:K00850] [EC:2.7.1.11]
102760735  HNF4A; hepatocyte nuclear factor 4 alpha [KO:K07292]
102765471  G6PC3; glucose-6-phosphatase catalytic subunit 3 [KO:K01084] [EC:3.1.3.9]
102759248  G6PC; glucose-6-phosphatase catalytic subunit [KO:K01084] [EC:3.1.3.9]
102774116  G6PC2; glucose-6-phosphatase catalytic subunit 2 [KO:K01084] [EC:3.1.3.9]
102754608  PCK1; phosphoenolpyruvate carboxykinase 1 [KO:K01596] [EC:4.1.1.32]
102771630  PCK2; phosphoenolpyruvate carboxykinase 2, mitochondrial [KO:K01596] [EC:4.1.1.32]
102770919  CRTC2; CREB regulated transcription coactivator 2 [KO:K16333]
102754892  CREB1; cAMP responsive element binding protein 1 [KO:K05870]
102764297  CREB3L3; cAMP responsive element binding protein 3 like 3 [KO:K09048]
102768092  CREB3L1; cAMP responsive element binding protein 3 like 1 [KO:K09048]
102772259  CREB3L4; cAMP responsive element binding protein 3 like 4 [KO:K09048]
102773515  CREB3L2; cAMP responsive element binding protein 3 like 2 [KO:K09048]
102762431  CREB3; cAMP responsive element binding protein 3 [KO:K09048]
102769297  CREB5; cAMP responsive element binding protein 5 [KO:K09047]
102770595  PPARGC1A; PPARG coactivator 1 alpha [KO:K07202]
102762479  ELAVL1; ELAV like RNA binding protein 1 [KO:K13088]
102759793  CCND1; cyclin D1 [KO:K04503]
102758841  CCNA2; cyclin A2 [KO:K06627]
102752341  CCNA1; cyclin A1 [KO:K06627]
102761531  EEF2K; eukaryotic elongation factor 2 kinase [KO:K08292] [EC:2.7.11.20]
102765734  EEF2; eukaryotic translation elongation factor 2 [KO:K03234]
102766094  FOXO1; forkhead box O1 [KO:K07201]
102751393  FOXO3; forkhead box O3 [KO:K09408]
102756748  SIRT1; sirtuin 1 [KO:K11411] [EC:2.3.1.286]
102751885  SLC2A4; solute carrier family 2 member 4 [KO:K07191]
102771674  GYS2; glycogen synthase 2 [KO:K00693] [EC:2.4.1.11]
102775147  GYS1; glycogen synthase 1 [KO:K00693] [EC:2.4.1.11]
102764534  LIPE; lipase E, hormone sensitive type [KO:K07188] [EC:3.1.1.79]
102767367  HMGCR; 3-hydroxy-3-methylglutaryl-CoA reductase [KO:K00021] [EC:1.1.1.34]
102767914  SREBF1; sterol regulatory element binding transcription factor 1 [KO:K07197]
102761714  FASN; fatty acid synthase [KO:K00665] [EC:2.3.1.85]
102766302  ACACA; acetyl-CoA carboxylase alpha [KO:K11262] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
102759722  SCD; stearoyl-CoA desaturase [KO:K00507] [EC:1.14.19.1]
102758244  SCD5; stearoyl-CoA desaturase 5 [KO:K00507] [EC:1.14.19.1]
102759463  ACACB; acetyl-CoA carboxylase beta [KO:K01946] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
102759504  CPT1A; carnitine palmitoyltransferase 1A [KO:K08765] [EC:2.3.1.21]
102764960  CPT1B; carnitine palmitoyltransferase 1B [KO:K19523] [EC:2.3.1.21]
102770000  CPT1C; carnitine palmitoyltransferase 1C [KO:K19524] [EC:2.3.1.21]
102758921  CIDEA; cell death-inducing DFFA-like effector a [KO:K25893]
102762679  PPP2CA; protein phosphatase 2 catalytic subunit alpha [KO:K04382] [EC:3.1.3.16]
102771922  PPP2CB; protein phosphatase 2 catalytic subunit beta [KO:K04382] [EC:3.1.3.16]
102762854  PPP2R1A; protein phosphatase 2 scaffold subunit Aalpha [KO:K03456]
102758648  PPP2R1B; protein phosphatase 2 scaffold subunit Abeta [KO:K03456]
102773953  PPP2R2D; protein phosphatase 2 regulatory subunit Bdelta [KO:K04354]
102772844  PPP2R2B; protein phosphatase 2 regulatory subunit Bbeta [KO:K04354]
102756870  PPP2R2A; protein phosphatase 2 regulatory subunit Balpha [KO:K04354]
102774976  PPP2R2C; protein phosphatase 2 regulatory subunit Bgamma [KO:K04354]
102765775  PPP2R3C; protein phosphatase 2 regulatory subunit B''gamma [KO:K11583]
102753112  PPP2R3A; protein phosphatase 2 regulatory subunit B''alpha [KO:K11583]
102767336  PPP2R5B; protein phosphatase 2 regulatory subunit B'beta [KO:K11584]
102761846  PPP2R5D; protein phosphatase 2 regulatory subunit B'delta [KO:K11584]
102767522  PPP2R5A; protein phosphatase 2 regulatory subunit B'alpha [KO:K11584]
102758104  PPP2R5C; protein phosphatase 2 regulatory subunit B'gamma [KO:K11584]
102773081  PPP2R5E; protein phosphatase 2 regulatory subunit B'epsilon [KO:K11584]
102771902  TBC1D1; TBC1 domain family member 1 [KO:K18341]
102773842  RAB2A; RAB2A, member RAS oncogene family [KO:K07877]
102754443  RAB8A; RAB8A, member RAS oncogene family [KO:K07901]
102762935  ras-related protein Rab-8A [KO:K07901]
102752687  RAB10; RAB10, member RAS oncogene family [KO:K07903]
102766733  RAB11B; RAB11B, member RAS oncogene family [KO:K07905]
102775092  RAB14; RAB14, member RAS oncogene family [KO:K07881]
102773631  CFTR; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
102766978  CD36; CD36 molecule [KO:K06259]
102752580  IGF1; insulin like growth factor 1 [KO:K05459]
102770795  IGF1R; insulin like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
102753598  INS; insulin [KO:K04526]
102766590  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
102752666  IRS1; insulin receptor substrate 1 [KO:K16172]
102753060  IRS2; insulin receptor substrate 2 [KO:K07187]
102753243  IRS4; insulin receptor substrate 4 [KO:K17446]
102764343  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
102766356  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
102758951  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
102763670  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
102753036  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
102760468  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
102756818  PDPK1; 3-phosphoinositide dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
102772266  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
102773065  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
102770093  TSC2; tuberous sclerosis 2 [KO:K07207]
102752713  TSC1; tuberous sclerosis 1 [KO:K07206]
102758475  RHEB; Ras homolog enriched in brain [KO:K07208]
102766933  MTOR; mechanistic target of rapamycin [KO:K07203] [EC:2.7.11.1]
102754661  RPTOR; regulatory associated protein of MTOR complex 1 [KO:K07204]
102758931  AKT1S1; AKT1 substrate 1 [KO:K16184]
102763828  RPS6KB2; ribosomal protein S6 kinase B2 [KO:K04688] [EC:2.7.11.1]
102775361  RPS6KB1; ribosomal protein S6 kinase B1 [KO:K04688] [EC:2.7.11.1]
102758662  EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1 [KO:K07205]
102771129  PPARG; peroxisome proliferator activated receptor gamma [KO:K08530]
102767979  ULK1; unc-51 like autophagy activating kinase 1 [KO:K21357] [EC:2.7.11.1]
Compound
C00003  NAD+
C00008  ADP
C00020  AMP
C00022  Pyruvate
C00024  Acetyl-CoA
C00031  D-Glucose
C00040  Acyl-CoA
C00076  Calcium cation
C00083  Malonyl-CoA
C00085  D-Fructose 6-phosphate
C00162  Fatty acid
C00354  D-Fructose 1,6-bisphosphate
C00389  Quercetin
C00665  beta-D-Fructose 2,6-bisphosphate
C00668  alpha-D-Glucose 6-phosphate
C00698  Cl-
C00757  Berberine
C01172  beta-D-Glucose 6-phosphate
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C07151  Metformin
C09731  Epigallocatechin gallate
D08351  Phenformin (BAN)
Reference
PMID:19584320
  Authors
Steinberg GR, Kemp BE
  Title
AMPK in Health and Disease.
  Journal
Physiol Rev 89:1025-78 (2009)
DOI:10.1152/physrev.00011.2008
Reference
PMID:15509864
  Authors
Hardie DG.
  Title
The AMP-activated protein kinase pathway--new players upstream and downstream.
  Journal
J Cell Sci 117:5479-87 (2004)
DOI:10.1242/jcs.01540
Reference
PMID:23747347
  Authors
Russo GL, Russo M, Ungaro P
  Title
AMP-activated protein kinase: a target for old drugs against diabetes and cancer.
  Journal
Biochem Pharmacol 86:339-50 (2013)
DOI:10.1016/j.bcp.2013.05.023
Reference
PMID:19393004
  Authors
Ronnett GV, Ramamurthy S, Kleman AM, Landree LE, Aja S
  Title
AMPK in the brain: its roles in energy balance and neuroprotection.
  Journal
J Neurochem 109 Suppl 1:17-23 (2009)
DOI:10.1111/j.1471-4159.2009.05916.x
Reference
PMID:20010958
  Authors
Li J, McCullough LD
  Title
Effects of AMP-activated protein kinase in cerebral ischemia.
  Journal
J Cereb Blood Flow Metab 30:480-92 (2010)
DOI:10.1038/jcbfm.2009.255
Reference
PMID:22700795
  Authors
Sanchez AM, Candau RB, Csibi A, Pagano AF, Raibon A, Bernardi H
  Title
The role of AMP-activated protein kinase in the coordination of skeletal muscle turnover and energy homeostasis.
  Journal
Am J Physiol Cell Physiol 303:C475-85 (2012)
DOI:10.1152/ajpcell.00125.2012
Reference
PMID:16644802
  Authors
Viollet B, Foretz M, Guigas B, Horman S, Dentin R, Bertrand L, Hue L, Andreelli F
  Title
Activation of AMP-activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders.
  Journal
J Physiol 574:41-53 (2006)
DOI:10.1113/jphysiol.2006.108506
Reference
PMID:19629071
  Authors
Shackelford DB, Shaw RJ
  Title
The LKB1-AMPK pathway: metabolism and growth control in tumour suppression.
  Journal
Nat Rev Cancer 9:563-75 (2009)
DOI:10.1038/nrc2676
Reference
PMID:22885100
  Authors
Chung JH, Manganiello V, Dyck JR
  Title
Resveratrol as a calorie restriction mimetic: therapeutic implications.
  Journal
Trends Cell Biol 22:546-54 (2012)
DOI:10.1016/j.tcb.2012.07.004
Reference
PMID:20357764
  Authors
Iwabu M, Yamauchi T, Okada-Iwabu M, Sato K, Nakagawa T, Funata M, Yamaguchi M, Namiki S, Nakayama R, Tabata M, Ogata H, Kubota N, Takamoto I, Hayashi YK, Yamauchi N, Waki H, Fukayama M, Nishino I, Tokuyama K, Ueki K, Oike Y, Ishii S, Hirose K, Shimizu T, Touhara K, Kadowaki T
  Title
Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca(2+) and AMPK/SIRT1.
  Journal
Nature 464:1313-9 (2010)
DOI:10.1038/nature08991
Reference
PMID:17307971
  Authors
Towler MC, Hardie DG
  Title
AMP-activated protein kinase in metabolic control and insulin signaling.
  Journal
Circ Res 100:328-41 (2007)
DOI:10.1161/01.RES.0000256090.42690.05
Reference
PMID:23899560
  Authors
Richter EA, Hargreaves M
  Title
Exercise, GLUT4, and skeletal muscle glucose uptake.
  Journal
Physiol Rev 93:993-1017 (2013)
DOI:10.1152/physrev.00038.2012
Reference
PMID:16054041
  Authors
Kahn BB, Alquier T, Carling D, Hardie DG
  Title
AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism.
  Journal
Cell Metab 1:15-25 (2005)
DOI:10.1016/j.cmet.2004.12.003
Reference
PMID:23565491
  Authors
Minokoshi Y, Toda C, Okamoto S
  Title
Regulatory role of leptin in glucose and lipid metabolism in skeletal muscle.
  Journal
Indian J Endocrinol Metab 16:S562-8 (2012)
DOI:10.4103/2230-8210.105573
Reference
PMID:16723978
  Authors
Guggino WB, Stanton BA
  Title
New insights into cystic fibrosis: molecular switches that regulate CFTR.
  Journal
Nat Rev Mol Cell Biol 7:426-36 (2006)
DOI:10.1038/nrm1949
Reference
PMID:16479585
  Authors
Cheng A, Saltiel AR
  Title
More TORC for the gluconeogenic engine.
  Journal
Bioessays 28:231-4 (2006)
DOI:10.1002/bies.20375
Reference
PMID:19197243
  Authors
Herrero-Martin G, Hoyer-Hansen M, Garcia-Garcia C, Fumarola C, Farkas T, Lopez-Rivas A, Jaattela M
  Title
TAK1 activates AMPK-dependent cytoprotective autophagy in TRAIL-treated epithelial cells.
  Journal
EMBO J 28:677-85 (2009)
DOI:10.1038/emboj.2009.8
Reference
PMID:19724019
  Authors
Morris DL, Rui L
  Title
Recent advances in understanding leptin signaling and leptin resistance.
  Journal
Am J Physiol Endocrinol Metab 297:E1247-59 (2009)
DOI:10.1152/ajpendo.00274.2009
Reference
PMID:18725075
  Authors
Minokoshi Y, Shiuchi T, Lee S, Suzuki A, Okamoto S
  Title
Role of hypothalamic AMP-kinase in food intake regulation.
  Journal
Nutrition 24:786-90 (2008)
DOI:10.1016/j.nut.2008.06.002
Reference
PMID:23024365
  Authors
Miyamoto L, Ebihara K, Kusakabe T, Aotani D, Yamamoto-Kataoka S, Sakai T, Aizawa-Abe M, Yamamoto Y, Fujikura J, Hayashi T, Hosoda K, Nakao K
  Title
Leptin activates hepatic 5'-AMP-activated protein kinase through sympathetic nervous system and alpha1-adrenergic receptor: a potential mechanism for improvement of fatty liver in lipodystrophy by leptin.
  Journal
J Biol Chem 287:40441-7 (2012)
DOI:10.1074/jbc.M112.384545
Related
pathway
myd00010  Glycolysis / Gluconeogenesis
myd00061  Fatty acid biosynthesis
myd00500  Starch and sucrose metabolism
myd01040  Biosynthesis of unsaturated fatty acids
myd04110  Cell cycle
myd04140  Autophagy - animal
myd04150  mTOR signaling pathway
myd04151  PI3K-Akt signaling pathway
myd04910  Insulin signaling pathway
myd04920  Adipocytokine signaling pathway
KO pathway
ko04152   
LinkDB

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