KEGG   PATHWAY: myd04140
Entry
myd04140                    Pathway                                
Name
Autophagy - animal - Myotis davidii (David's myotis)
Description
Autophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily conserved among eukaryotes and exquisitely regulated. This progress initiates with production of the autophagosome, a double-membrane intracellular structure of reticular origin that engulfs cytoplasmic contents and ultimately fuses with lysosomes for cargo degradation. Autophagy is regulated in response to extra- or intracellular stress and signals such as starvation, growth factor deprivation and ER stress. Constitutive level of autophagy plays an important role in cellular homeostasis and maintains quality control of essential cellular components.
Class
Cellular Processes; Transport and catabolism
Pathway map
myd04140  Autophagy - animal
myd04140

Other DBs
GO: 0006914
Organism
Myotis davidii (David's myotis) [GN:myd]
Gene
102753598  INS; insulin [KO:K04526]
102770795  IGF1R; insulin like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
102752666  IRS1; insulin receptor substrate 1 [KO:K16172]
102753060  IRS2; insulin receptor substrate 2 [KO:K07187]
102753243  IRS4; insulin receptor substrate 4 [KO:K17446]
102764343  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
102766356  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
102758951  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
102763670  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
102753036  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
102760468  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
102756818  PDPK1; 3-phosphoinositide dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
102772266  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
102773065  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
102755323  PTEN; phosphatase and tensin homolog [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
102762537  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
102762284  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
102761492  NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
102757500  MRAS; muscle RAS oncogene homolog [KO:K07831]
102770869  RRAS; related RAS viral (r-ras) oncogene homolog [KO:K07829]
102765159  RRAS2; related RAS viral (r-ras) oncogene homolog 2 [KO:K07830]
102772748  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
102763997  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
102757282  MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102769037  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102775211  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102751343  HIF1A; hypoxia inducible factor 1 alpha subunit [KO:K08268]
102768434  DDIT4; DNA damage inducible transcript 4 [KO:K08270]
102770093  TSC2; tuberous sclerosis 2 [KO:K07207]
102752713  TSC1; tuberous sclerosis 1 [KO:K07206]
102764592  BNIP3; BCL2 interacting protein 3 [KO:K15464]
102758475  RHEB; Ras homolog enriched in brain [KO:K07208]
102754661  RPTOR; regulatory associated protein of MTOR complex 1 [KO:K07204]
102761701  DEPTOR; DEP domain containing MTOR interacting protein [KO:K20402]
102766933  MTOR; mechanistic target of rapamycin [KO:K07203] [EC:2.7.11.1]
102758931  AKT1S1; AKT1 substrate 1 [KO:K16184]
102756476  MLST8; MTOR associated protein, LST8 homolog [KO:K08266]
102763828  RPS6KB2; ribosomal protein S6 kinase B2 [KO:K04688] [EC:2.7.11.1]
102775361  RPS6KB1; ribosomal protein S6 kinase B1 [KO:K04688] [EC:2.7.11.1]
102773474  IGBP1; immunoglobulin binding protein 1 [KO:K17606]
102774023  immunoglobulin-binding protein 1 [KO:K17606]
102762679  PPP2CA; protein phosphatase 2 catalytic subunit alpha [KO:K04382] [EC:3.1.3.16]
102771922  PPP2CB; protein phosphatase 2 catalytic subunit beta [KO:K04382] [EC:3.1.3.16]
102767979  ULK1; unc-51 like autophagy activating kinase 1 [KO:K21357] [EC:2.7.11.1]
102774469  ULK2; unc-51 like autophagy activating kinase 2 [KO:K08269] [EC:2.7.11.1]
102774319  ATG13; autophagy related 13 [KO:K08331]
102764222  ATG101; autophagy related 101 [KO:K19730]
102754439  RB1CC1; RB1 inducible coiled-coil 1 [KO:K17589]
102760054  ATG2B; autophagy related 2B [KO:K17906]
102752017  ATG2A; autophagy related 2A [KO:K17906]
102762786  WIPI1; WD repeat domain, phosphoinositide interacting 1 [KO:K17908]
102772683  WIPI2; WD repeat domain, phosphoinositide interacting 2 [KO:K17908]
102772430  WDR45B; WD repeat domain 45B [KO:K22991]
102769486  WDR45; WD repeat domain 45 [KO:K22991]
102765120  ATG9A; autophagy related 9A [KO:K17907]
102764653  ATG9B; autophagy related 9B [KO:K17907]
102774356  SUPT20H; SPT20 homolog, SAGA complex component [KO:K21245]
102770227  SMCR8; Smith-Magenis syndrome chromosome region, candidate 8 [KO:K23611]
102771881  WDR41; WD repeat domain 41 [KO:K23610]
102753546  chromosome unknown open reading frame, human C9orf72 [KO:K23609]
102754443  RAB8A; RAB8A, member RAS oncogene family [KO:K07901]
102762935  ras-related protein Rab-8A [KO:K07901]
102767912  RAB39B; RAB39B, member RAS oncogene family [KO:K07925]
102770732  SQSTM1; sequestosome 1 [KO:K14381]
102769631  TBK1; TANK binding kinase 1 [KO:K05410] [EC:2.7.11.10]
102762174  TANK; TRAF family member associated NFKB activator [KO:K12650]
102771330  RAB1A; RAB1A, member RAS oncogene family [KO:K07874]
102761016  RRAGB; Ras related GTP binding B [KO:K16185]
102759027  RRAGA; Ras related GTP binding A [KO:K16185]
102757588  RRAGC; Ras related GTP binding C [KO:K16186]
102774368  RRAGD; Ras related GTP binding D [KO:K16186]
102767396  STK11; serine/threonine kinase 11 [KO:K07298] [EC:2.7.11.1]
102774877  PRKAA2; protein kinase AMP-activated catalytic subunit alpha 2 [KO:K07198] [EC:2.7.11.31]
102759339  PRKAA1; protein kinase AMP-activated catalytic subunit alpha 1 [KO:K07198] [EC:2.7.11.31]
102759840  cGMP-dependent protein kinase 1 [KO:K04345] [EC:2.7.11.11]
102772218  PRKACA; protein kinase cAMP-activated catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
102773780  PRKACB; protein kinase cAMP-activated catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
102760591  PRKCD; protein kinase C delta [KO:K06068] [EC:2.7.11.13]
102772062  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
102764416  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
102775351  mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
102769473  BCL2; BCL2, apoptosis regulator [KO:K02161]
102753986  BCL2L1; BCL2 like 1 [KO:K04570]
102771665  BAD; BCL2 associated agonist of cell death [KO:K02158]
102767074  beclin-2-like [KO:K08334]
102757009  BECN1; beclin 1 [KO:K08334]
102771698  beclin-2-like [KO:K08334]
102756370  beclin-2-like [KO:K08334]
102764429  NRBF2; nuclear receptor binding factor 2 [KO:K21246]
102769127  PIK3R4; phosphoinositide-3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
102773363  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
102755855  ATG14; autophagy related 14 [KO:K17889]
102768382  AMBRA1; autophagy and beclin 1 regulator 1 [KO:K17985]
102765934  TRAF6; TNF receptor associated factor 6 [KO:K03175] [EC:2.3.2.27]
102752584  VMP1; vacuole membrane protein 1 [KO:K21248]
102768125  STX17; syntaxin 17 [KO:K08491]
102769384  UVRAG; UV radiation resistance-associated gene protein [KO:K21249]
102759667  UV radiation resistance-associated gene protein [KO:K21249]
102752075  SH3GLB1; SH3 domain containing GRB2 like endophilin B1 [KO:K11248]
102755423  RUBCN; RUN and cysteine rich domain containing beclin 1 interacting protein [KO:K19330]
102752773  CAMKK2; calcium/calmodulin dependent protein kinase kinase 2 [KO:K07359] [EC:2.7.11.17]
102763957  MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
102773882  ERN1; endoplasmic reticulum to nucleus signaling 1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
102755292  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
102766010  DAPK3; death associated protein kinase 3 [KO:K08803] [EC:2.7.11.1]
102755828  DAPK1; death associated protein kinase 1 [KO:K08803] [EC:2.7.11.1]
102755770  DAPK2; death associated protein kinase 2 [KO:K08803] [EC:2.7.11.1]
102773633  HMGB1; high mobility group box 1 [KO:K10802]
102757612  high mobility group protein B1 [KO:K10802]
102761664  EIF2AK4; eukaryotic translation initiation factor 2 alpha kinase 4 [KO:K16196] [EC:2.7.11.1]
102767480  EIF2S1; eukaryotic translation initiation factor 2 subunit alpha [KO:K03237]
102772830  MTMR4; myotubularin related protein 4 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
102773236  MTMR3; myotubularin related protein 3 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
102767087  MTMR14; myotubularin related protein 14 [KO:K18086] [EC:3.1.3.64 3.1.3.95]
102774769  ZFYVE1; zinc finger FYVE-type containing 1 [KO:K17603]
102772152  ATG12; autophagy related 12 [KO:K08336]
102766143  ATG5; autophagy related 5 [KO:K08339]
102769786  ATG16L1; autophagy related 16 like 1 [KO:K17890]
102772564  ATG16L2; autophagy related 16 like 2 [KO:K20868]
102769286  ATG7; autophagy related 7 [KO:K08337]
102759066  ATG10; autophagy related 10 [KO:K17888]
102757643  ATG3; autophagy related 3 [KO:K08343]
102763362  CFLAR; CASP8 and FADD like apoptosis regulator [KO:K04724]
102759876  RAB33B; RAB33B, member RAS oncogene family [KO:K07920]
102767625  PRKCQ; protein kinase C theta [KO:K18052] [EC:2.7.11.13]
102768297  GABARAPL2; GABA type A receptor associated protein like 2 [KO:K08341]
102755892  GABARAPL1; GABA type A receptor associated protein like 1 [KO:K08341]
102775333  GABARAP; GABA type A receptor-associated protein [KO:K08341]
102764249  MAP1LC3B; microtubule associated protein 1 light chain 3 beta [KO:K10435]
102758467  MAP1LC3A; microtubule associated protein 1 light chain 3 alpha [KO:K10435]
102752504  ATG4C; autophagy related 4C cysteine peptidase [KO:K08342] [EC:3.4.22.-]
102773706  ATG4A; autophagy related 4A cysteine peptidase [KO:K08342] [EC:3.4.22.-]
102768232  ATG4B; autophagy related 4B cysteine peptidase [KO:K08342] [EC:3.4.22.-]
102768455  ATG4D; autophagy related 4D cysteine peptidase [KO:K08342] [EC:3.4.22.-]
102766206  NBR1; NBR1, autophagy cargo receptor [KO:K17987]
102751578  OPTN; optineurin [KO:K19946]
102756337  CALCOCO2; calcium binding and coiled-coil domain 2 [KO:K21348]
102770081  TAX1BP1; Tax1 binding protein 1 [KO:K21347]
102770298  WDFY3; WD repeat and FYVE domain containing 3 [KO:K22262]
102773513  UBA52; ubiquitin A-52 residue ribosomal protein fusion product 1 [KO:K02927]
102771342  polyubiquitin-D-like [KO:K02927]
102771027  ubiquitin-like [KO:K02927]
102771802  RPS27A; ribosomal protein S27a [KO:K02977]
102764816  UBB; ubiquitin B [KO:K04551]
102762089  SNAP29; synaptosome associated protein 29 [KO:K08509]
102761399  VAMP8; vesicle associated membrane protein 8 [KO:K08512]
102767508  synaptobrevin homolog YKT6 [KO:K08516]
102753526  YKT6; YKT6 v-SNARE homolog (S. cerevisiae) [KO:K08516]
102759087  STX7; syntaxin 7 [KO:K08488]
102751720  ectopic P granules protein 5 homolog [KO:K23883]
102759287  EPG5; ectopic P-granules autophagy protein 5 homolog [KO:K23883]
102763471  PLEKHM1; pleckstrin homology and RUN domain containing M1 [KO:K23282]
102756185  VPS11; VPS11, CORVET/HOPS core subunit [KO:K20179]
102762992  VPS16; VPS16, CORVET/HOPS core subunit [KO:K20180]
102752639  VPS18; VPS18, CORVET/HOPS core subunit [KO:K20181]
102772023  VPS33A; VPS33A, CORVET/HOPS core subunit [KO:K20182]
102754051  VPS39; VPS39, HOPS complex subunit [KO:K20183]
102751845  VPS41; VPS41, HOPS complex subunit [KO:K20184]
102754641  BIRC6; baculoviral IAP repeat containing 6 [KO:K10586] [EC:2.3.2.23]
102756132  GORASP2; golgi reassembly stacking protein 2 [KO:K26797]
102755488  GORASP1; golgi reassembly stacking protein 1 [KO:K26797]
102768624  RAB7A; RAB7A, member RAS oncogene family [KO:K07897]
102754016  RAB7B; RAB7B, member RAS oncogene family [KO:K07898]
102760555  LAMP2; lysosomal associated membrane protein 2 [KO:K06528]
102759397  LAMP1; lysosomal associated membrane protein 1 [KO:K06528]
102752567  CTSD; cathepsin D [KO:K01379] [EC:3.4.23.5]
102771181  cathepsin L1 [KO:K01365] [EC:3.4.22.15]
102757220  cathepsin L1 [KO:K01365] [EC:3.4.22.15]
102752061  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
102764101  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
102771390  CTSB; cathepsin B [KO:K01363] [EC:3.4.22.1]
102761828  cathepsin B-like [KO:K01363] [EC:3.4.22.1]
Compound
C00035  GDP
C00044  GTP
C00350  Phosphatidylethanolamine
C01194  1-Phosphatidyl-D-myo-inositol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:15325584
  Authors
Meijer AJ, Codogno P.
  Title
Regulation and role of autophagy in mammalian cells.
  Journal
Int J Biochem Cell Biol 36:2445-62 (2004)
DOI:10.1016/j.biocel.2004.02.002
Reference
PMID:16099218
  Authors
Deretic V.
  Title
Autophagy in innate and adaptive immunity.
  Journal
Trends Immunol 26:523-8 (2005)
DOI:10.1016/j.it.2005.08.003
Reference
PMID:16200202
  Authors
Levine B, Yuan J.
  Title
Autophagy in cell death: an innocent convict?
  Journal
J Clin Invest 115:2679-88 (2005)
DOI:10.1172/JCI26390
Reference
PMID:15325588
  Authors
Tanida I, Ueno T, Kominami E.
  Title
LC3 conjugation system in mammalian autophagy.
  Journal
Int J Biochem Cell Biol 36:2503-18 (2004)
DOI:10.1016/j.biocel.2004.05.009
Reference
PMID:15928708
  Authors
Lum JJ, DeBerardinis RJ, Thompson CB.
  Title
Autophagy in metazoans: cell survival in the land of plenty.
  Journal
Nat Rev Mol Cell Biol 6:439-48 (2005)
DOI:10.1038/nrm1660
Reference
PMID:15978794
  Authors
Reggiori F, Klionsky DJ.
  Title
Autophagosomes: biogenesis from scratch?
  Journal
Curr Opin Cell Biol 17:415-22 (2005)
DOI:10.1016/j.ceb.2005.06.007
Reference
PMID:11099404
  Authors
Klionsky DJ, Emr SD.
  Title
Autophagy as a regulated pathway of cellular degradation.
  Journal
Science 290:1717-21 (2000)
DOI:10.1126/science.290.5497.1717
Reference
PMID:16125113
  Authors
Bechet D, Tassa A, Taillandier D, Combaret L, Attaix D.
  Title
Lysosomal proteolysis in skeletal muscle.
  Journal
Int J Biochem Cell Biol 37:2098-114 (2005)
DOI:10.1016/j.biocel.2005.02.029
Reference
PMID:19653858
  Authors
He C, Klionsky DJ
  Title
Regulation mechanisms and signaling pathways of autophagy.
  Journal
Annu Rev Genet 43:67-93 (2009)
DOI:10.1146/annurev-genet-102808-114910
Reference
PMID:19802558
  Authors
Yang Z, Klionsky DJ
  Title
An overview of the molecular mechanism of autophagy.
  Journal
Curr Top Microbiol Immunol 335:1-32 (2009)
DOI:10.1007/978-3-642-00302-8_1
Reference
PMID:20034776
  Authors
Yang Z, Klionsky DJ
  Title
Mammalian autophagy: core molecular machinery and signaling regulation.
  Journal
Curr Opin Cell Biol 22:124-31 (2010)
DOI:10.1016/j.ceb.2009.11.014
Reference
PMID:21187343
  Authors
Chen Y, Klionsky DJ
  Title
The regulation of autophagy - unanswered questions.
  Journal
J Cell Sci 124:161-70 (2011)
DOI:10.1242/jcs.064576
Reference
PMID:21801009
  Authors
Mizushima N, Yoshimori T, Ohsumi Y
  Title
The role of Atg proteins in autophagosome formation.
  Journal
Annu Rev Cell Dev Biol 27:107-32 (2011)
DOI:10.1146/annurev-cellbio-092910-154005
Reference
PMID:24343578
  Authors
Russell RC, Yuan HX, Guan KL
  Title
Autophagy regulation by nutrient signaling.
  Journal
Cell Res 24:42-57 (2014)
DOI:10.1038/cr.2013.166
Reference
PMID:25948417
  Authors
Noda NN, Fujioka Y
  Title
Atg1 family kinases in autophagy initiation.
  Journal
Cell Mol Life Sci 72:3083-96 (2015)
DOI:10.1007/s00018-015-1917-z
Related
pathway
myd04010  MAPK signaling pathway
myd04141  Protein processing in endoplasmic reticulum
myd04142  Lysosome
myd04150  mTOR signaling pathway
myd04152  AMPK signaling pathway
myd04910  Insulin signaling pathway
KO pathway
ko04140   
LinkDB

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