KEGG   PATHWAY: myd04150
Entry
myd04150                    Pathway                                
Name
mTOR signaling pathway - Myotis davidii (David's myotis)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
myd04150  mTOR signaling pathway
myd04150

Organism
Myotis davidii (David's myotis) [GN:myd]
Gene
102751353  RHOA; ras homolog family member A [KO:K04513]
102751460  DVL3; dishevelled segment polarity protein 3 [KO:K02353]
102751662  GSK3B; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
102752580  IGF1; insulin like growth factor 1 [KO:K05459]
102752666  IRS1; insulin receptor substrate 1 [KO:K16172]
102752713  TSC1; tuberous sclerosis 1 [KO:K07206]
102752942  SLC38A9; solute carrier family 38 member 9 [KO:K14995]
102752943  LPIN2; lipin 2 [KO:K15728] [EC:3.1.3.4]
102752980  WNT2; Wnt family member 2 [KO:K00182]
102753036  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
102753170  ATP6V1G1; ATPase H+ transporting V1 subunit G1 [KO:K02152]
102753273  WDR59; WD repeat domain 59 [KO:K20409]
102753563  STRADA; STE20-related kinase adaptor alpha [KO:K08271]
102753598  INS; insulin [KO:K04526]
102753994  TBC1D7; TBC1 domain family member 7 [KO:K20396]
102754411  ATP6V1E2; ATPase H+ transporting V1 subunit E2 [KO:K02150]
102754512  MIOS; meiosis regulator for oocyte development [KO:K20407]
102754570  SLC3A2; solute carrier family 3 member 2 [KO:K06519]
102754661  RPTOR; regulatory associated protein of MTOR complex 1 [KO:K07204]
102754991  GRB2; growth factor receptor bound protein 2 [KO:K04364]
102755181  WNT11; Wnt family member 11 [KO:K01384]
102755323  PTEN; phosphatase and tensin homolog [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
102755646  DEPDC5; DEP domain containing 5 [KO:K20404]
102755652  SEH1L; SEH1 like nucleoporin [KO:K14299]
102755665  NPRL3; NPR3 like, GATOR1 complex subunit [KO:K20406]
102755683  GATSL2; GATS protein like 2 [KO:K23081]
102755774  WNT5B; protein Wnt-5b [KO:K00444]
102755960  NPRL2; NPR2-like, GATOR1 complex subunit [KO:K20405]
102756007  WNT4; Wnt family member 4 [KO:K00408]
102756030  PRKCG; protein kinase C gamma [KO:K19663] [EC:2.7.11.13]
102756150  ATP6V1F; ATPase H+ transporting V1 subunit F [KO:K02151]
102756476  MLST8; MTOR associated protein, LST8 homolog [KO:K08266]
102756714  GRB10; growth factor receptor bound protein 10 [KO:K20064]
102756732  EIF4B; eukaryotic translation initiation factor 4B [KO:K03258]
102756818  PDPK1; 3-phosphoinositide dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
102756961  LPIN3; lipin 3 [KO:K15728] [EC:3.1.3.4]
102757004  PRKCB; protein kinase C beta [KO:K19662] [EC:2.7.11.13]
102757282  MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102757588  RRAGC; Ras related GTP binding C [KO:K16186]
102757803  WNT6; Wnt family member 6 [KO:K00445]
102757838  ATP6V1G3; ATPase H+ transporting V1 subunit G3 [KO:K02152]
102757884  RPS6KA1; ribosomal protein S6 kinase A1 [KO:K04373] [EC:2.7.11.1]
102758002  [KO:K00572]
102758035  ATP6V1A; ATPase H+ transporting V1 subunit A [KO:K02145] [EC:7.1.2.2]
102758131  ATP6V1G2; ATPase H+ transporting V1 subunit G2 [KO:K02152]
102758221  FZD8; frizzled class receptor 8 [KO:K02375]
102758435  WNT8B; Wnt family member 8B [KO:K00714]
102758475  RHEB; Ras homolog enriched in brain [KO:K07208]
102758571  ATP6V1H; ATPase H+ transporting V1 subunit H [KO:K02144]
102758589  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
102758662  EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1 [KO:K07205]
102758774  TNF; tumor necrosis factor [KO:K03156]
102758820  FZD1; frizzled class receptor 1 [KO:K02432]
102758931  AKT1S1; AKT1 substrate 1 [KO:K16184]
102758951  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
102759027  RRAGA; Ras related GTP binding A [KO:K16185]
102759282  ATP6V1B2; ATPase H+ transporting V1 subunit B2 [KO:K02147]
102759339  PRKAA1; protein kinase AMP-activated catalytic subunit alpha 1 [KO:K07198] [EC:2.7.11.31]
102759586  ATP6V1E1; ATPase H+ transporting V1 subunit E1 [KO:K02150]
102760161  RPS6; ribosomal protein S6 [KO:K02991]
102760294  FLCN; folliculin [KO:K09594]
102760376  LRP5L; LDL receptor related protein 5 like [KO:K03068]
102760422  BRAF; B-Raf proto-oncogene, serine/threonine kinase [KO:K04365] [EC:2.7.11.1]
102760468  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
102760704  RNF152; ring finger protein 152 [KO:K15705] [EC:2.3.2.27]
102760888  CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
102760913  FZD6; frizzled class receptor 6 [KO:K02376]
102760986  STRADB; STE20-related kinase adaptor beta [KO:K17532]
102761016  RRAGB; Ras related GTP binding B [KO:K16185]
102761192  ATP6V1C1; ATPase H+ transporting V1 subunit C1 [KO:K02148]
102761193  CAB39; calcium binding protein 39 [KO:K08272]
102761492  NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
102761590  SLC7A5; solute carrier family 7 member 5 [KO:K13780]
102761701  DEPTOR; DEP domain containing MTOR interacting protein [KO:K20402]
102761920  FZD9; frizzled class receptor 9 [KO:K02842]
102762164  WNT10A; Wnt family member 10A [KO:K01357]
102762284  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
102762494  RPS6KA2; ribosomal protein S6 kinase A2 [KO:K04373] [EC:2.7.11.1]
102762537  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
102762550  ATP6V1C2; ATPase H+ transporting V1 subunit C2 [KO:K02148]
102762695  FZD4; frizzled class receptor 4 [KO:K02354]
102762947  FNIP2; folliculin interacting protein 2 [KO:K20401]
102763119  MAPKAP1; mitogen-activated protein kinase associated protein 1 [KO:K20410]
102763262  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
102763548  WNT8A; Wnt family member 8A [KO:K00714]
102763646  FZD3; frizzled class receptor 3 [KO:K02329]
102763670  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
102763828  RPS6KB2; ribosomal protein S6 kinase B2 [KO:K04688] [EC:2.7.11.1]
102763997  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
102764080  RPS6KA3; ribosomal protein S6 kinase A3 [KO:K04373] [EC:2.7.11.1]
102764343  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
102764739  LPIN1; lipin 1 [KO:K15728] [EC:3.1.3.4]
102764831  TELO2; telomere maintenance 2 [KO:K11137]
102764877  WNT1; Wnt family member 1 [KO:K03209]
102765024  WNT2B; Wnt family member 2B [KO:K00182]
102765167  WNT10B; Wnt family member 10B [KO:K01357]
102765396  EIF4E1B; eukaryotic translation initiation factor 4E family member 1B [KO:K03259]
102765562  WNT9A; Wnt family member 9A [KO:K01064]
102765570  PRR5; proline rich 5 [KO:K20411]
102765585  FZD5; frizzled class receptor 5 [KO:K02375]
102765661  PRKCA; protein kinase C alpha [KO:K02677] [EC:2.7.11.13]
102765964  CAB39L; calcium binding protein 39 like [KO:K08272]
102766031  SGK1; serine/threonine-protein kinase Sgk1 [KO:K13302] [EC:2.7.11.1]
102766228  SEC13; SEC13 homolog, nuclear pore and COPII coat complex component [KO:K14004]
102766352  WDR24; WD repeat domain 24 [KO:K20408]
102766356  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
102766511  EIF4E2; eukaryotic translation initiation factor 4E family member 2 [KO:K03259]
102766520  RICTOR; RPTOR independent companion of MTOR complex 2 [KO:K08267]
102766590  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
102766933  MTOR; mechanistic target of rapamycin [KO:K07203] [EC:2.7.11.1]
102767329  WNT9B; Wnt family member 9B [KO:K01064]
102767347  RPS6KA6; ribosomal protein S6 kinase A6 [KO:K04373] [EC:2.7.11.1]
102767396  STK11; serine/threonine kinase 11 [KO:K07298] [EC:2.7.11.1]
102767458  FZD2; frizzled class receptor 2 [KO:K02235]
102767487  GATSL3; GATS protein like 3 [KO:K23080]
102767612  WNT3; Wnt family member 3 [KO:K00312]
102767647  ATP6V1B1; ATPase H+ transporting V1 subunit B1 [KO:K02147]
102767875  TTI1; TELO2 interacting protein 1 [KO:K20403]
102767979  ULK1; unc-51 like autophagy activating kinase 1 [KO:K21357] [EC:2.7.11.1]
102768105  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]
102768434  DDIT4; DNA damage inducible transcript 4 [KO:K08270]
102768521  ATP6V1D; ATPase H+ transporting V1 subunit D [KO:K02149]
102768884  TNFRSF1A; TNF receptor superfamily member 1A [KO:K03158]
102769019  LAMTOR5; late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 [KO:K16344]
102769037  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102769471  LAMTOR2; late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 [KO:K20398]
102770093  TSC2; tuberous sclerosis 2 [KO:K07207]
102770215  DVL1; dishevelled segment polarity protein 1 [KO:K02353]
102770529  FZD7; frizzled class receptor 7 [KO:K02432]
102770564  SKP2; S-phase kinase associated protein 2 [KO:K03875]
102770795  IGF1R; insulin like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
102771010  WNT5A; Wnt family member 5A [KO:K00444]
102771718  DVL2; dishevelled segment polarity protein 2 [KO:K02353]
102771880  PRR5L; proline rich 5 like [KO:K20411]
102772266  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
102772477  LRP6; LDL receptor related protein 6 [KO:K03068]
102772748  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
102773065  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
102773418  SESN2; sestrin 2 [KO:K20394]
102773494  WNT16; Wnt family member 16 [KO:K01558]
102773651  CLIP1; CAP-Gly domain containing linker protein 1 [KO:K10421]
102773824  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
102773859  LAMTOR3; late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 [KO:K04370]
102774271  WNT3A; Wnt family member 3A [KO:K00312]
102774368  RRAGD; Ras related GTP binding D [KO:K16186]
102774469  ULK2; unc-51 like autophagy activating kinase 2 [KO:K08269] [EC:2.7.11.1]
102774573  LAMTOR4; late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 [KO:K20399]
102774877  PRKAA2; protein kinase AMP-activated catalytic subunit alpha 2 [KO:K07198] [EC:2.7.11.31]
102775211  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102775236  LAMTOR1; late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 [KO:K20397]
102775361  RPS6KB1; ribosomal protein S6 kinase B1 [KO:K04688] [EC:2.7.11.1]
102775415  FNIP1; folliculin interacting protein 1 [KO:K20400]
107181364  LRP5; LDL receptor related protein 5 [KO:K03068]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
myd00561  Glycerolipid metabolism
myd04010  MAPK signaling pathway
myd04140  Autophagy - animal
myd04151  PI3K-Akt signaling pathway
myd04152  AMPK signaling pathway
myd04810  Regulation of actin cytoskeleton
myd04910  Insulin signaling pathway
KO pathway
ko04150   

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