KEGG   PATHWAY: ncar04142
Entry
ncar04142                   Pathway                                
Name
Lysosome - Sciurus carolinensis (gray squirrel)
Description
Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
Class
Cellular Processes; Transport and catabolism
Pathway map
ncar04142  Lysosome
ncar04142

Other DBs
GO: 0005764
Organism
Sciurus carolinensis (gray squirrel) [GN:ncar]
Gene
124990219  V-type proton ATPase 116 kDa subunit a 2 isoform X1 [KO:K02154]
124990720  V-type proton ATPase 116 kDa subunit a 4 isoform X1 [KO:K02154]
124958896  V-type proton ATPase 116 kDa subunit a 3-like isoform X1 [KO:K02154]
124979733  V-type proton ATPase 116 kDa subunit a 1 isoform X1 [KO:K02154]
124990674  V-type proton ATPase subunit d 2 [KO:K02146]
124967243  V-type proton ATPase subunit d 1 [KO:K02146]
124958379  V-type proton ATPase subunit H isoform X1 [KO:K02144]
124971871  V-type proton ATPase subunit S1 [KO:K03662]
124970409  V-type proton ATPase 16 kDa proteolipid subunit c [KO:K02155]
124970482  V-type proton ATPase 16 kDa proteolipid subunit c-like [KO:K02155]
124990881  V-type proton ATPase 21 kDa proteolipid subunit c'' isoform X1 [KO:K03661]
124986488  dmX-like protein 1 isoform X1 [KO:K24155]
124975936  LOW QUALITY PROTEIN: dmX-like protein 2 [KO:K24155]
124965445  LOW QUALITY PROTEIN: WD repeat-containing protein 7-like [KO:K24738]
124988519  nuclear receptor coactivator 7 isoform X1 [KO:K25442]
124976785  lysosomal protective protein [KO:K13289] [EC:3.4.16.5]
124982517  cathepsin B isoform X1 [KO:K01363] [EC:3.4.22.1]
124958603  dipeptidyl peptidase 1-like isoform X1 [KO:K01275] [EC:3.4.14.1]
124960311  cathepsin D [KO:K01379] [EC:3.4.23.5]
124961986  cathepsin E [KO:K01382] [EC:3.4.23.34]
124958991  cathepsin F-like [KO:K01373] [EC:3.4.22.41]
124977216  cathepsin G-like isoform X1 [KO:K01319] [EC:3.4.21.20]
124977509  pro-cathepsin H [KO:K01366] [EC:3.4.22.16]
124977877  cathepsin K [KO:K01371] [EC:3.4.22.38]
124964589  procathepsin L-like [KO:K01365] [EC:3.4.22.15]
124965590  procathepsin L-like [KO:K01365] [EC:3.4.22.15]
124965742  procathepsin L-like [KO:K01365] [EC:3.4.22.15]
124994033  cathepsin O-like [KO:K01374] [EC:3.4.22.42]
124959416  cathepsin S [KO:K01368] [EC:3.4.22.27]
124959852  cathepsin W-like [KO:K08569] [EC:3.4.22.-]
124976901  cathepsin Z [KO:K08568] [EC:3.4.18.1]
124966604  napsin-A-like isoform X1 [KO:K08565] [EC:3.4.23.-]
124976234  legumain [KO:K01369] [EC:3.4.22.34]
124958585  tripeptidyl-peptidase 1 isoform X1 [KO:K01279] [EC:3.4.14.9]
124972403  alpha-galactosidase A-like [KO:K01189] [EC:3.2.1.22]
124968963  beta-galactosidase-like [KO:K12309] [EC:3.2.1.23]
124979676  lysosomal alpha-glucosidase-like isoform X1 [KO:K12316] [EC:3.2.1.20]
124977815  lysosomal acid glucosylceramidase [KO:K01201] [EC:3.2.1.45]
124994072  alpha-L-iduronidase-like [KO:K01217] [EC:3.2.1.76]
124982310  alpha-N-acetylgalactosaminidase [KO:K01204] [EC:3.2.1.49]
124976777  galactocerebrosidase isoform X1 [KO:K01202] [EC:3.2.1.46]
124969991  beta-glucuronidase isoform X1 [KO:K01195] [EC:3.2.1.31]
124988496  plasma alpha-L-fucosidase isoform X1 [KO:K01206] [EC:3.2.1.51]
124966587  tissue alpha-L-fucosidase-like [KO:K01206] [EC:3.2.1.51]
124986759  beta-hexosaminidase subunit beta-like [KO:K12373] [EC:3.2.1.52]
124977551  beta-hexosaminidase subunit alpha isoform X1 [KO:K12373] [EC:3.2.1.52]
124994614  beta-mannosidase-like [KO:K01192] [EC:3.2.1.25]
124969157  lysosomal alpha-mannosidase-like isoform X1 [KO:K12311] [EC:3.2.1.24]
124988666  sialidase-1 [KO:K01186] [EC:3.2.1.18]
124990205  hyaluronidase-4 [KO:K01197] [EC:3.2.1.35]
124991282  LOW QUALITY PROTEIN: hyaluronidase PH-20-like [KO:K01197] [EC:3.2.1.35]
124991283  hyaluronidase-1-like [KO:K01197] [EC:3.2.1.35]
124992311  hyaluronidase-2 [KO:K01197] [EC:3.2.1.35]
124992430  hyaluronidase-1-like isoform X1 [KO:K01197] [EC:3.2.1.35]
124992431  hyaluronidase-3-like isoform X1 [KO:K01197] [EC:3.2.1.35]
124983902  arylsulfatase A isoform X1 [KO:K01134] [EC:3.1.6.8]
124987087  arylsulfatase B [KO:K01135] [EC:3.1.6.12]
124980635  arylsulfatase G [KO:K12381] [EC:3.1.6.-]
124966494  N-acetylgalactosamine-6-sulfatase isoform X1 [KO:K01132] [EC:3.1.6.4]
124983639  N-acetylglucosamine-6-sulfatase [KO:K01137] [EC:3.1.6.14]
124972244  iduronate 2-sulfatase isoform X1 [KO:K01136] [EC:3.1.6.13]
124980423  N-sulphoglucosamine sulphohydrolase isoform X1 [KO:K01565] [EC:3.10.1.1]
124985098  lysosomal acid lipase/cholesteryl ester hydrolase-like [KO:K01052] [EC:3.1.1.13]
124963372  LOW QUALITY PROTEIN: phospholipase A2 group XV-like [KO:K06129] [EC:3.1.1.5]
124966556  phospholipase A2 group XV isoform X1 [KO:K06129] [EC:3.1.1.5]
124969177  deoxyribonuclease-2-alpha-like [KO:K01158] [EC:3.1.22.1]
124976224  deoxyribonuclease-2-beta isoform X1 [KO:K01158] [EC:3.1.22.1]
124960241  lysosomal acid phosphatase isoform X1 [KO:K14410] [EC:3.1.3.2]
124969297  tartrate-resistant acid phosphatase type 5 [KO:K14379] [EC:3.1.3.2]
124958684  sphingomyelin phosphodiesterase [KO:K12350] [EC:3.1.4.12]
124983780  acid ceramidase isoform X1 [KO:K12348] [EC:3.5.1.23]
124981859  N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase [KO:K01444] [EC:3.5.1.26]
124994370  proactivator polypeptide-like 1 [KO:K12382]
124984920  prosaposin-like isoform X1 [KO:K12382]
124987522  ganglioside GM2 activator-like [KO:K12383]
124983199  palmitoyl-protein thioesterase 1 isoform X1 [KO:K01074] [EC:3.1.2.22]
124985137  lysosome-associated membrane glycoprotein 1-like [KO:K06528]
124971354  lysosome-associated membrane glycoprotein 2-like isoform X1 [KO:K06528]
124993294  lysosome-associated membrane glycoprotein 3-like isoform X1 [KO:K06562]
124979748  macrosialin-like [KO:K06501]
124983579  CD63 antigen [KO:K06497]
124994365  lysosome membrane protein 2 [KO:K12384]
124965260  NPC intracellular cholesterol transporter 1 [KO:K12385]
124971558  NPC intracellular cholesterol transporter 2-like [KO:K13443]
124980602  cystinosin isoform X1 [KO:K12386]
124989145  sialin isoform X1 [KO:K12301]
124979909  natural resistance-associated macrophage protein 1 isoform X1 [KO:K12347]
124983377  natural resistance-associated macrophage protein 2 isoform X1 [KO:K21398]
124993107  lysosomal-associated transmembrane protein 5-like [KO:K12387]
124984873  lysosomal-associated transmembrane protein 4B [KO:K12387]
124963447  lysosomal-associated transmembrane protein 4A [KO:K12387]
124964398  ATP-binding cassette sub-family A member 2 isoform X1 [KO:K05642]
124990655  ABC-type oligopeptide transporter ABCB9 isoform X1 [KO:K05656]
124989697  sialomucin core protein 24-like isoform X1 [KO:K06546]
124982278  ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
124977135  sortilin isoform X1 [KO:K12388]
124970280  LOW QUALITY PROTEIN: battenin-like [KO:K12389]
124984580  ceroid-lipofuscinosis neuronal protein 5 [KO:K12390]
124994675  LOW QUALITY PROTEIN: major facilitator superfamily domain-containing protein 8-like [KO:K12307]
124982625  heparan-alpha-glucosaminide N-acetyltransferase isoform X1 [KO:K10532] [EC:2.3.1.78]
124971034  formylglycine-generating enzyme [KO:K13444] [EC:1.8.3.7]
124983165  N-acetylglucosamine-1-phosphotransferase subunits alpha/beta [KO:K08239] [EC:2.7.8.17]
124970737  N-acetylglucosamine-1-phosphotransferase subunit gamma-like isoform X1 [KO:K10087]
124970782  N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase isoform X1 [KO:K01125] [EC:3.1.4.45]
124988139  LOW QUALITY PROTEIN: cation-independent mannose-6-phosphate receptor-like [KO:K06564]
124982567  LOW QUALITY PROTEIN: cation-dependent mannose-6-phosphate receptor-like [KO:K10089]
124964536  LOW QUALITY PROTEIN: clathrin light chain A-like [KO:K04644]
124987433  clathrin light chain B isoform X1 [KO:K04645]
124990299  clathrin heavy chain 2 isoform X1 [KO:K04646]
124979220  LOW QUALITY PROTEIN: clathrin heavy chain 1-like [KO:K04646]
124976655  AP-1 complex subunit gamma-like 2 isoform X1 [KO:K12391]
124966646  AP-1 complex subunit gamma-1 isoform X1 [KO:K12391]
124990930  AP-1 complex subunit beta-1 isoform X1 [KO:K12392]
124969327  AP-1 complex subunit mu-1 isoform X1 [KO:K12393]
124969361  AP-1 complex subunit mu-2 isoform X1 [KO:K12393]
124970716  AP-1 complex subunit sigma-1A isoform X1 [KO:K12394]
124971724  AP-1 complex subunit sigma-2 isoform X1 [KO:K12394]
124978853  AP-1 complex subunit sigma-3 isoform X1 [KO:K12395]
124967821  AP-3 complex subunit delta-1 [KO:K12396]
124986829  AP-3 complex subunit beta-1 isoform X1 [KO:K12397]
124970696  AP-3 complex subunit beta-2 [KO:K12397]
124984054  AP-3 complex subunit mu-2 isoform X1 [KO:K12398]
124985203  AP-3 complex subunit mu-1 [KO:K12398]
124986712  AP-3 complex subunit sigma-1 isoform X1 [KO:K12399]
124964177  AP-3 complex subunit sigma-1-like [KO:K12399]
124976040  AP-3 complex subunit sigma-2 isoform X1 [KO:K12399]
124977498  LOW QUALITY PROTEIN: AP-4 complex subunit epsilon-1-like [KO:K12400]
124993852  AP-4 complex subunit beta-1 isoform X1 [KO:K12401]
124970191  AP-4 complex subunit mu-1 [KO:K12402]
124977890  AP-4 complex subunit sigma-1 isoform X1 [KO:K12403]
124979590  AP-4 complex subunit sigma-1-like [KO:K12403]
124970359  ADP-ribosylation factor-binding protein GGA2 isoform X1 [KO:K12404]
124980319  ADP-ribosylation factor-binding protein GGA3 isoform X1 [KO:K12404]
124983095  ADP-ribosylation factor-binding protein GGA1 isoform X1 [KO:K12404]
124968670  mucolipin-1 [KO:K04992]
124970439  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363]
Compound
C00002  ATP
C00008  ADP
C00159  D-Mannose
C00275  D-Mannose 6-phosphate
Reference
PMID:12628346
  Authors
Eskelinen EL, Tanaka Y, Saftig P
  Title
At the acidic edge: emerging functions for lysosomal membrane proteins.
  Journal
Trends Cell Biol 13:137-45 (2003)
DOI:10.1016/S0962-8924(03)00005-9
Reference
PMID:1883197
  Authors
Neufeld EF
  Title
Lysosomal storage diseases.
  Journal
Annu Rev Biochem 60:257-80 (1991)
DOI:10.1146/annurev.bi.60.070191.001353
Reference
PMID:2943218
  Authors
von Figura K, Hasilik A
  Title
Lysosomal enzymes and their receptors.
  Journal
Annu Rev Biochem 55:167-93 (1986)
DOI:10.1146/annurev.bi.55.070186.001123
Reference
PMID:15987739
  Authors
Janvier K, Bonifacino JS
  Title
Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.
  Journal
Mol Biol Cell 16:4231-42 (2005)
DOI:10.1091/mbc.E05-03-0213
Reference
PMID:18635948
  Authors
Vergarajauregui S, Puertollano R
  Title
Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagy.
  Journal
Autophagy 4:832-4 (2008)
DOI:10.4161/auto.6567
Reference
PMID:34249946
  Authors
Jaskolka MC, Winkley SR, Kane PM
  Title
RAVE and Rabconnectin-3 Complexes as Signal Dependent Regulators of Organelle Acidification.
  Journal
Front Cell Dev Biol 9:698190 (2021)
DOI:10.3389/fcell.2021.698190
Reference
PMID:34646033
  Authors
Majdoul S, Compton AA
  Title
Lessons in self-defence: inhibition of virus entry by intrinsic immunity.
  Journal
Nat Rev Immunol 10.1038/s41577-021-00626-8 (2021)
DOI:10.1038/s41577-021-00626-8
Related
pathway
ncar00511  Other glycan degradation
ncar00531  Glycosaminoglycan degradation
ncar04130  SNARE interactions in vesicular transport
ncar04140  Autophagy - animal
ncar04144  Endocytosis
KO pathway
ko04142   
LinkDB

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