KEGG   PATHWAY: npr00230
Entry
npr00230                    Pathway                                
Name
Purine metabolism - Nanorana parkeri (Xizang Plateau frog)
Class
Metabolism; Nucleotide metabolism
Pathway map
npr00230  Purine metabolism
npr00230

Module
npr_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:npr00230]
npr_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:npr00230]
npr_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:npr00230]
npr_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:npr00230]
npr_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:npr00230]
npr_M00546  Purine degradation, xanthine => urea [PATH:npr00230]
npr_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:npr00230]
npr_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:npr00230]
Other DBs
GO: 0006163 0042278
Organism
Nanorana parkeri (Xizang Plateau frog) [GN:npr]
Gene
108789165  NUDT9; ADP-ribose pyrophosphatase, mitochondrial [KO:K13988] [EC:3.6.1.13]
108800850  manganese-dependent ADP-ribose/CDP-alcohol diphosphatase-like [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
108801529  ADPRM; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
108784813  NUDT5; ADP-sugar pyrophosphatase [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
108784916  PGM1; phosphoglucomutase-1 isoform X1 [KO:K01835] [EC:5.4.2.2]
108795904  PGM2; phosphoglucomutase-2 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
108805047  PRPS1; ribose-phosphate pyrophosphokinase 1 isoform X1 [KO:K00948] [EC:2.7.6.1]
108794928  PRPS2; ribose-phosphate pyrophosphokinase 2 isoform X1 [KO:K00948] [EC:2.7.6.1]
108794754  PPAT; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
108787812  GART; trifunctional purine biosynthetic protein adenosine-3 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
108786215  PFAS; phosphoribosylformylglycinamidine synthase [KO:K01952] [EC:6.3.5.3]
108794756  PAICS; multifunctional protein ADE2 [KO:K01587] [EC:4.1.1.21 6.3.2.6]
108794682  ADSL; adenylosuccinate lyase isoform X1 [KO:K01756] [EC:4.3.2.2]
108793614  ATIC; bifunctional purine biosynthesis protein PURH [KO:K00602] [EC:2.1.2.3 3.5.4.10]
108787729  APRT; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
108796251  NT5C1A; cytosolic 5'-nucleotidase 1A [KO:K01081] [EC:3.1.3.5]
108789789  cytosolic 5'-nucleotidase 1A-like [KO:K01081] [EC:3.1.3.5]
108800641  5'(3')-deoxyribonucleotidase, mitochondrial-like [KO:K01081] [EC:3.1.3.5]
108788735  5'(3')-deoxyribonucleotidase, mitochondrial-like [KO:K01081] [EC:3.1.3.5]
108784577  NT5C2; cytosolic purine 5'-nucleotidase [KO:K01081] [EC:3.1.3.5]
108785585  cytosolic purine 5'-nucleotidase-like [KO:K01081] [EC:3.1.3.5]
108795827  NT5E; 5'-nucleotidase isoform X1 [KO:K19970] [EC:3.1.3.5]
108788444  PNP; purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
108787008  purine nucleoside phosphorylase-like [KO:K03783] [EC:2.4.2.1]
108787139  LACC1; laccase domain-containing protein 1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
108794368  HPRT1; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
108804408  IMPDH2; inosine-5'-monophosphate dehydrogenase 2 isoform X1 [KO:K00088] [EC:1.1.1.205]
108790473  inosine-5'-monophosphate dehydrogenase 1 isoform X1 [KO:K00088] [EC:1.1.1.205]
108791060  NME4; nucleoside diphosphate kinase, mitochondrial isoform X1 [KO:K00940] [EC:2.7.4.6]
108789170  nucleoside diphosphate kinase A1 [KO:K00940] [EC:2.7.4.6]
108790472  NME6; nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
108787689  NME7; nucleoside diphosphate kinase 7 [KO:K00940] [EC:2.7.4.6]
108783719  NME3; nucleoside diphosphate kinase 3 [KO:K00940] [EC:2.7.4.6]
108802107  AK9; adenylate kinase 9 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
108792068  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
108788349  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 [KO:K01510] [EC:3.6.1.5]
108787246  ectonucleoside triphosphate diphosphohydrolase 8-like [KO:K01510] [EC:3.6.1.5]
108787250  ectonucleoside triphosphate diphosphohydrolase 8-like [KO:K01510] [EC:3.6.1.5]
108796391  CANT1; LOW QUALITY PROTEIN: soluble calcium-activated nucleotidase 1 [KO:K12304] [EC:3.6.1.6]
108792480  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
108802467  ENTPD5; ectonucleoside triphosphate diphosphohydrolase 5 [KO:K01511] [EC:3.6.1.6]
108801077  ENTPD6; ectonucleoside triphosphate diphosphohydrolase 6 [KO:K01511] [EC:3.6.1.6]
108784477  U8 snoRNA-decapping enzyme-like [KO:K16855] [EC:3.6.1.62 3.6.1.64]
108795561  ITPA; inosine triphosphate pyrophosphatase isoform X1 [KO:K01519] [EC:3.6.1.66]
108796807  XDH; xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
108797456  NUDT2; bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] isoform X1 [KO:K01518] [EC:3.6.1.17]
108787468  GMPS; GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
108802680  GMP reductase 1-like [KO:K00364] [EC:1.7.1.7]
108787184  GMPR2; GMP reductase 2 [KO:K00364] [EC:1.7.1.7]
108791709  GDA; guanine deaminase [KO:K01487] [EC:3.5.4.3]
108788791  GUK1; LOW QUALITY PROTEIN: guanylate kinase [KO:K00942] [EC:2.7.4.8]
108803090  RRM1; ribonucleoside-diphosphate reductase large subunit isoform X1 [KO:K10807] [EC:1.17.4.1]
108789865  RRM2; ribonucleoside-diphosphate reductase subunit M2 isoform X1 [KO:K10808] [EC:1.17.4.1]
108789065  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
108792921  HDDC2; HD domain-containing protein 2 [KO:K07023] [EC:3.1.3.89]
108789617  deoxyguanosine kinase, mitochondrial-like [KO:K00904] [EC:2.7.1.113]
108797251  deoxycytidine kinase-like isoform X1 [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
108784695  DCK; deoxycytidine kinase [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
108799817  HDDC3; guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 [KO:K21138] [EC:3.1.7.2]
108797266  PRUNE1; protein prune homolog [KO:K01514] [EC:3.6.1.11]
108796974  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
108795542  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
108788450  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
108801019  adenylate cyclase type 5-like [KO:K08045] [EC:4.6.1.1]
108802250  adenylate cyclase type 6-like [KO:K08046] [EC:4.6.1.1]
108794932  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
108788952  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
108790811  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
108789645  GUCY1A3; guanylate cyclase soluble subunit alpha-3 [KO:K12318] [EC:4.6.1.2]
108798037  guanylate cyclase soluble subunit alpha-2-like [KO:K12318] [EC:4.6.1.2]
108789639  GUCY1B3; guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
108786354  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
108787012  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
108793773  GUCY2D; retinal guanylyl cyclase 1 [KO:K12321] [EC:4.6.1.2]
108799503  GUCY2F; retinal guanylyl cyclase 2 [KO:K12322] [EC:4.6.1.2]
108798208  LOW QUALITY PROTEIN: retinal guanylyl cyclase 2-like [KO:K12322] [EC:4.6.1.2]
108798364  guanylate cyclase 2G-like [KO:K22600] [EC:4.6.1.2]
108795208  NPR1; atrial natriuretic peptide receptor 1 isoform X1 [KO:K12323] [EC:4.6.1.2]
108803575  atrial natriuretic peptide receptor 2-like [KO:K12324] [EC:4.6.1.2]
108791371  atrial natriuretic peptide receptor 1-like [KO:K12324] [EC:4.6.1.2]
108794254  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C [KO:K13755] [EC:3.1.4.17]
108797370  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
108789484  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A [KO:K13755] [EC:3.1.4.17]
108794906  cGMP-dependent 3',5'-cyclic phosphodiesterase-like [KO:K18283] [EC:3.1.4.17]
108798566  PDE3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A isoform X1 [KO:K19021] [EC:3.1.4.17]
108790039  PDE5A; cGMP-specific 3',5'-cyclic phosphodiesterase isoform X1 [KO:K13762] [EC:3.1.4.35]
108784296  PDE6A; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha [KO:K08718] [EC:3.1.4.35]
108788172  rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta-like [KO:K13756] [EC:3.1.4.35]
108788822  PDE6C; cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' [KO:K13757] [EC:3.1.4.35]
108792491  PDE6D; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta [KO:K13758]
108796721  PDE6G; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13759]
108796260  retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma-like [KO:K13759]
108793451  PDE6H; retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13760]
108804917  PDE9A; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A [KO:K13761] [EC:3.1.4.35]
108799607  PDE10A; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [KO:K18438] [EC:3.1.4.17 3.1.4.35]
108791208  dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A-like [KO:K13298] [EC:3.1.4.17 3.1.4.35]
108788320  PDE11A; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A [KO:K13298] [EC:3.1.4.17 3.1.4.35]
108786797  ADSSL1; adenylosuccinate synthetase isozyme 1 [KO:K01939] [EC:6.3.4.4]
108799546  AMPD1; AMP deaminase 1 [KO:K01490] [EC:3.5.4.6]
108795707  AMPD2; AMP deaminase 2 [KO:K01490] [EC:3.5.4.6]
108786202  AMPD3; AMP deaminase 3 isoform X1 [KO:K01490] [EC:3.5.4.6]
108797657  ADK; adenosine kinase isoform X1 [KO:K00856] [EC:2.7.1.20]
108802936  ADA; adenosine deaminase [KO:K01488] [EC:3.5.4.4]
108791582  CECR1; adenosine deaminase CECR1 [KO:K19572] [EC:3.5.4.4]
108789782  AK5; adenylate kinase isoenzyme 5 isoform X1 [KO:K00939] [EC:2.7.4.3]
108792333  AK4; adenylate kinase 4, mitochondrial [KO:K00939] [EC:2.7.4.3]
108793535  AK2; adenylate kinase 2, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
108794674  AK8; adenylate kinase 8 [KO:K00939] [EC:2.7.4.3]
108799339  adenylate kinase isoenzyme 5-like [KO:K00939] [EC:2.7.4.3]
108799346  AK1; adenylate kinase isoenzyme 1 isoform X1 [KO:K00939] [EC:2.7.4.3]
108786867  AK7; adenylate kinase 7 isoform X1 [KO:K00939] [EC:2.7.4.3]
108794211  AK6; adenylate kinase isoenzyme 6 [KO:K18532] [EC:2.7.4.3]
108791539  AK3; GTP:AMP phosphotransferase AK3, mitochondrial isoform X1 [KO:K00944] [EC:2.7.4.10]
108797124  ENTPD2; ectonucleoside triphosphate diphosphohydrolase 2 [KO:K01509] [EC:3.6.1.-]
108801483  NTPCR; cancer-related nucleoside-triphosphatase [KO:K06928] [EC:3.6.1.15]
108796226  ENPP1; ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
108796231  ENPP3; ectonucleotide pyrophosphatase/phosphodiesterase family member 3 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
108790310  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1 [KO:K13293] [EC:3.1.4.53]
108792338  PDE4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
108797380  cAMP-specific 3',5'-cyclic phosphodiesterase 4D-like [KO:K13293] [EC:3.1.4.53]
108787405  PDE7B; cAMP-specific 3',5'-cyclic phosphodiesterase 7B isoform X1 [KO:K18436] [EC:3.1.4.53]
108796811  PDE7A; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X1 [KO:K18436] [EC:3.1.4.53]
108787663  PDE8B; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B [KO:K18437] [EC:3.1.4.53]
108804816  PDE8A; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1 [KO:K18437] [EC:3.1.4.53]
108793024  FHIT; bis(5'-adenosyl)-triphosphatase [KO:K01522] [EC:3.6.1.29]
108795529  ENPP4; bis(5'-adenosyl)-triphosphatase ENPP4 [KO:K18424] [EC:3.6.1.29]
108794025  PAPSS2; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform X1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
108785431  PAPSS1; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
108791380  uricase-like [KO:K00365] [EC:1.7.3.3]
108795273  5-hydroxyisourate hydrolase-like isoform X1 [KO:K07127] [EC:3.5.2.17]
108796339  URAD; putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase [KO:K13485] [EC:4.1.1.97]
108796426  allantoinase, mitochondrial-like [KO:K01466] [EC:3.5.2.5]
108790286  ALLC; LOW QUALITY PROTEIN: probable allantoicase [KO:K01477] [EC:3.5.3.4]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
npr00030  Pentose phosphate pathway
npr00220  Arginine biosynthesis
npr00250  Alanine, aspartate and glutamate metabolism
npr00260  Glycine, serine and threonine metabolism
npr00340  Histidine metabolism
npr00630  Glyoxylate and dicarboxylate metabolism
npr00730  Thiamine metabolism
npr00740  Riboflavin metabolism
npr00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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