KEGG   PATHWAY: oas04145
Entry
oas04145                    Pathway                                
Name
Phagosome - Ovis aries (sheep)
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
Pathway map
oas04145  Phagosome
oas04145

Other DBs
GO: 0045335
Organism
Ovis aries (sheep) [GN:oas]
Gene
101115638  VAMP3; vesicle-associated membrane protein 3 isoform X2 [KO:K13505]
105608393  vesicle-associated membrane protein 3 [KO:K13505]
101112461  STX12; syntaxin-12 isoform X1 [KO:K13813]
101123563  STX7; syntaxin-7 isoform X1 [KO:K08488]
114116170  syntaxin-7-like [KO:K08488]
443340  ACTG1; actin, cytoplasmic 2 [KO:K05692]
443052  ACTB; actin, cytoplasmic 1 [KO:K05692]
101114326  CORO1A; coronin-1A isoform X2 [KO:K13882]
101103647  STX18; syntaxin-18 isoform X8 [KO:K08492]
101112362  SEC22B; vesicle-trafficking protein SEC22b [KO:K08517]
100171394  OVAR; MHC class I antigen precursor [KO:K06751]
101107908  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X4 [KO:K06751]
106990117  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X4 [KO:K06751]
101107641  BOLA class I histocompatibility antigen, alpha chain BL3-7 isoform X1 [KO:K06751]
101119545  BOLA class I histocompatibility antigen, alpha chain BL3-7 [KO:K06751]
101104866  LOW QUALITY PROTEIN: BOLA class I histocompatibility antigen, alpha chain BL3-6 [KO:K06751]
101111694  LOW QUALITY PROTEIN: BOLA class I histocompatibility antigen, alpha chain BL3-7 [KO:K06751]
101112480  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X2 [KO:K06751]
114109630  BOLA class I histocompatibility antigen, alpha chain BL3-7 isoform X6 [KO:K06751]
101105609  LOW QUALITY PROTEIN: BOLA class I histocompatibility antigen, alpha chain BL3-7 [KO:K06751]
132658253  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
100144749  DYA; MHC class II antigen DY alpha precursor [KO:K06752]
101108696  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
101108962  DQA; HLA class II histocompatibility antigen, DQ alpha 2 chain precursor [KO:K06752]
101119342  OVAR-DRB1; DLA class II histocompatibility antigen, DR-1 beta chain-like precursor [KO:K06752]
101109747  mamu class II histocompatibility antigen, DR alpha chain-like precursor [KO:K06752]
101108961  DLA class II histocompatibility antigen, DR-1 beta chain-like isoform X2 [KO:K06752]
101109219  HLA class II histocompatibility antigen, DO beta chain isoform X1 [KO:K06752]
101109746  HLA class II histocompatibility antigen, DM beta chain isoform X2 [KO:K06752]
101110545  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
101116099  HLA class II histocompatibility antigen, DM alpha chain isoform X2 [KO:K06752]
101114758  LOW QUALITY PROTEIN: DLA class II histocompatibility antigen, DR-1 beta chain [KO:K06752]
101118514  boLa class II histocompatibility antigen, DQB*0101 beta chain isoform X2 [KO:K06752]
101120392  boLa class II histocompatibility antigen, DQB*0101 beta chain isoform X2 [KO:K06752]
101115073  rano class II histocompatibility antigen, A beta chain isoform X1 [KO:K06752]
100302084  RAB5A; ras-related protein Rab-5A [KO:K07887]
101112211  RAB5B; ras-related protein Rab-5B [KO:K07888]
101122039  RAB5C; ras-related protein Rab-5C [KO:K07889]
101114003  EEA1; early endosome antigen 1 [KO:K12478]
101105709  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X2 [KO:K00914] [EC:2.7.1.137]
100885768  TFRC; transferrin receptor protein 1 isoform X2 [KO:K06503]
101116491  HGS; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
101102025  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
101107683  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
494439  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
101122445  ATP6V1C1; V-type proton ATPase subunit C 1 isoform X1 [KO:K02148]
101103310  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X1 [KO:K02148]
101116777  V-type proton ATPase subunit D [KO:K02149]
101121176  ATP6V1D; V-type proton ATPase subunit D isoform X1 [KO:K02149]
101123606  V-type proton ATPase subunit D-like [KO:K02149]
101110043  ATP6V1E2; V-type proton ATPase subunit E 2 [KO:K02150]
494438  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
101112724  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
101102659  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
101123332  ATP6V1G2; V-type proton ATPase subunit G 2 [KO:K02152]
101103451  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
101122020  ATP6V0E2; V-type proton ATPase subunit e 2 [KO:K02153]
101108422  ATP6V0E1; V-type proton ATPase subunit e 1 [KO:K02153]
101104057  ATP6V0A4; V-type proton ATPase 116 kDa subunit a 4 isoform X1 [KO:K02154]
101121550  ATP6V0A2; V-type proton ATPase 116 kDa subunit a 2 isoform X1 [KO:K02154]
101123476  ATP6V0A1; V-type proton ATPase 116 kDa subunit a 1 isoform X3 [KO:K02154]
101113184  TCIRG1; V-type proton ATPase 116 kDa subunit a 3 [KO:K02154]
101117677  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
101108509  ATP6V0D1; V-type proton ATPase subunit d 1 isoform X2 [KO:K02146]
101113504  ATP6V1H; V-type proton ATPase subunit H isoform X2 [KO:K02144]
443003  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit c [KO:K02155]
101114221  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit c'' isoform X2 [KO:K03661]
101119886  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
100145880  RAB7A; ras-related protein Rab-7a [KO:K07897]
101115978  RAB7B; ras-related protein Rab-7b isoform X2 [KO:K07898]
101103740  RILP; rab-interacting lysosomal protein [KO:K13883]
101102427  DYNC1H1; cytoplasmic dynein 1 heavy chain 1 [KO:K10413]
101118215  DYNC2H1; cytoplasmic dynein 2 heavy chain 1 isoform X1 [KO:K10414]
101115433  DYNC1I2; cytoplasmic dynein 1 intermediate chain 2 isoform X5 [KO:K10415]
101118013  DYNC1I1; cytoplasmic dynein 1 intermediate chain 1 isoform X10 [KO:K10415]
101108246  DYNC1LI2; cytoplasmic dynein 1 light intermediate chain 2 [KO:K10416]
101112428  DYNC1LI1; cytoplasmic dynein 1 light intermediate chain 1 [KO:K10416]
100302357  TUBA4A; tubulin alpha-4A chain [KO:K07374]
101116286  tubulin alpha-1D chain [KO:K07374]
101118307  tubulin alpha-3 chain isoform X1 [KO:K07374]
101108295  LOW QUALITY PROTEIN: tubulin alpha-3 chain [KO:K07374]
101120326  tubulin alpha-1B chain [KO:K07374]
101107301  TUBAL3; tubulin alpha chain-like 3 isoform X1 [KO:K07374]
101118605  TUBA8; tubulin alpha-8 chain [KO:K07374]
114113987  tubulin alpha-1C chain-like isoform X1 [KO:K07374]
105614728  tubulin alpha-1C chain isoform X1 [KO:K07374]
106990101  tubulin alpha-1B chain isoform X1 [KO:K07374]
101119975  tubulin alpha-1A chain isoform X1 [KO:K07374]
101115144  TUBB1; tubulin beta-1 chain [KO:K07375]
101122734  tubulin beta-2A chain [KO:K07375]
101106224  TUBB6; tubulin beta-6 chain [KO:K07375]
101109608  TUBB4B; tubulin beta-4B chain [KO:K07375]
105609865  TUBB4A; tubulin beta-4A chain [KO:K07375]
100303606  TUBB; tubulin beta chain [KO:K07375]
101122475  TUBB2B; tubulin beta-2B chain [KO:K07375]
101119403  LAMP1; lysosome-associated membrane glycoprotein 1 [KO:K06528]
101113307  LAMP2; lysosome-associated membrane glycoprotein 2 isoform X3 [KO:K06528]
101120727  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X6 [KO:K00921] [EC:2.7.1.150]
101102802  M6PR; cation-dependent mannose-6-phosphate receptor isoform X1 [KO:K10089]
443533  NOS1; nitric oxide synthase 1 isoform X1 [KO:K13240] [EC:1.14.13.39]
101123053  MPO; myeloperoxidase [KO:K10789] [EC:1.11.2.2]
780510  procathepsin L [KO:K01365] [EC:3.4.22.15]
101113725  CTSL; procathepsin L [KO:K01365] [EC:3.4.22.15]
780472  CTSS; cathepsin S isoform X1 [KO:K01368] [EC:3.4.22.27]
101108676  SEC61A2; protein transport protein Sec61 subunit alpha isoform X1 [KO:K10956]
101114060  SEC61A1; protein transport protein Sec61 subunit alpha [KO:K10956]
101102793  SEC61B; protein transport protein Sec61 subunit beta [KO:K09481]
114113665  protein transport protein Sec61 subunit beta-like [KO:K09481]
114117822  protein transport protein Sec61 subunit gamma-like [KO:K07342]
101115580  TAP1; antigen peptide transporter 1 isoform X2 [KO:K05653] [EC:7.4.2.14]
101109491  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
105609515  calreticulin-like [KO:K08057]
101104396  CALR; calreticulin [KO:K08057]
114114906  LOW QUALITY PROTEIN: calreticulin [KO:K08057]
101122273  CANX; calnexin isoform X2 [KO:K08054]
101123401  FCAR; immunoglobulin alpha Fc receptor isoform X1 [KO:K06513]
100192431  FCGR1A; high affinity immunoglobulin gamma Fc receptor I precursor [KO:K06498]
101106730  low affinity immunoglobulin gamma Fc region receptor II-like isoform X3 [KO:K06472]
100192432  FCGR2B; low affinity immunoglobulin gamma Fc region receptor II-b precursor [KO:K12560]
100192433  FCGR3A; low affinity immunoglobulin gamma Fc region receptor III-A precursor [KO:K06463]
101113211  Ig mu chain C region membrane-bound form [KO:K06856]
101107430  C1R; complement C1r subcomponent isoform X1 [KO:K01330] [EC:3.4.21.41]
443217  ITGAM; integrin alpha-M precursor [KO:K06461]
494433  ITGB2; integrin beta-2 precursor [KO:K06464]
101108131  C3; complement C3 [KO:K03990]
114114921  complement C3-like isoform X1 [KO:K03990]
101120299  COLEC11; collectin-11 isoform X1 [KO:K10066]
101102949  COLEC12; collectin-12 [KO:K10062]
101107498  MBLA; LOW QUALITY PROTEIN: mannose-binding protein A [KO:K03991]
101116362  MBL2; mannose-binding protein C [KO:K03991]
443033  SFTPA1; pulmonary surfactant-associated protein A precursor [KO:K10067]
114110794  collectin-46-like isoform X1 [KO:K10068]
105605755  collectin-46 [KO:K10068]
101106651  pulmonary surfactant-associated protein D [KO:K10068]
101108297  collectin-46 [KO:K10068]
101113398  collectin-43 isoform X1 [KO:K10068]
443143  ITGAV; integrin alpha-V precursor [KO:K06487]
101119848  ITGA2; integrin alpha-2 [KO:K06481]
443140  ITGA5; integrin alpha-5 isoform X2 [KO:K06484]
443141  ITGB1; integrin beta-1 precursor [KO:K05719]
100423047  ITGB3; integrin beta-3 isoform X2 [KO:K06493]
101120887  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
101106433  THBS1; thrombospondin-1 isoform X6 [KO:K16857]
101116784  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
101116840  THBS2; thrombospondin-2 isoform X2 [KO:K04659]
101115211  THBS4; thrombospondin-4 [KO:K04659]
101107864  COMP; cartilage oligomeric matrix protein [KO:K04659]
554262  TLR2; toll-like receptor 2 precursor [KO:K10159]
554257  TLR6; toll-like receptor 6 [KO:K10169]
554263  TLR4; toll-like receptor 4 precursor [KO:K10160]
443216  CD14; monocyte differentiation antigen CD14 precursor [KO:K04391]
100505388  MRC1; macrophage mannose receptor 1 precursor [KO:K06560]
101111081  PLA2R1; secretory phospholipase A2 receptor isoform X1 [KO:K06560]
101122041  MRC2; C-type mannose receptor 2 [KO:K06560]
101102057  CD209 antigen-like protein E isoform X1 [KO:K06563]
678685  CLEC7A; C-type lectin domain family 7 member A isoform X1 [KO:K10074]
101121746  MSR1; macrophage scavenger receptor types I and II isoform X2 [KO:K06558]
101111074  MARCO; macrophage receptor MARCO isoform X1 [KO:K13884]
101117918  OLR1; oxidized low-density lipoprotein receptor 1 isoform X2 [KO:K08763]
101115654  SCARB1; scavenger receptor class B member 1 isoform X5 [KO:K13885]
101102230  platelet glycoprotein 4-like isoform X1 [KO:K06259]
101114861  platelet glycoprotein 4-like isoform X4 [KO:K06259]
101115115  platelet glycoprotein 4 isoform X1 [KO:K06259]
101106452  cytochrome b-245 light chain [KO:K08009]
100036757  CYBB; cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
100101233  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
780489  NCF1; neutrophil cytosol factor 1 isoform X1 [KO:K08011]
101106094  NCF2; neutrophil cytosol factor 2 isoform X2 [KO:K08010]
101122939  NCF4; neutrophil cytosol factor 4 isoform X1 [KO:K08012]
Compound
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
PMID:15894272
  Authors
Stuart LM, Ezekowitz RA
  Title
Phagocytosis: elegant complexity.
  Journal
Immunity 22:539-50 (2005)
DOI:10.1016/j.immuni.2005.05.002
Reference
PMID:10684585
  Authors
Tjelle TE, Lovdal T, Berg T
  Title
Phagosome dynamics and function.
  Journal
Bioessays 22:255-63 (2000)
DOI:10.1002/(SICI)1521-1878(200003)22:3<255::AID-BIES7>3.0.CO;2-R
Reference
PMID:18492791
  Authors
Dupuy AG, Caron E
  Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  Journal
J Cell Sci 121:1773-83 (2008)
DOI:10.1242/jcs.018036
Reference
PMID:15036145
  Authors
Brumell JH, Grinstein S
  Title
Salmonella redirects phagosomal maturation.
  Journal
Curr Opin Microbiol 7:78-84 (2004)
DOI:10.1016/j.mib.2003.12.005
Reference
PMID:17245426
  Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
  Journal
EMBO J 26:313-24 (2007)
DOI:10.1038/sj.emboj.7601511
Reference
PMID:17637737
  Authors
Luzio JP, Pryor PR, Bright NA
  Title
Lysosomes: fusion and function.
  Journal
Nat Rev Mol Cell Biol 8:622-32 (2007)
DOI:10.1038/nrm2217
Reference
PMID:18513324
  Authors
Sumimoto H
  Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  Journal
FEBS J 275:3249-77 (2008)
DOI:10.1111/j.1742-4658.2008.06488.x
Related
pathway
oas04142  Lysosome
oas04144  Endocytosis
oas04610  Complement and coagulation cascades
oas04612  Antigen processing and presentation
oas04620  Toll-like receptor signaling pathway
oas04666  Fc gamma R-mediated phagocytosis
KO pathway
ko04145   
LinkDB

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