Entry
Name
Gastric acid secretion - Oryctolagus cuniculus (rabbit)
Description
Gastric acid is a key factor in normal upper gastrointestinal functions, including protein digestion and calcium and iron absorption, as well as providing some protection against bacterial infections. The principal stimulants of acid secretion at the level of the parietal cell are histamine (paracrine), gastrin (hormonal), and acetycholine (ACh; neurocrine). Stimulation of acid secretion typically involves an initial elevation of intracellular calcium and cAMP, followed by activation of protein kinase cascades, which trigger the translocation of the proton pump, H+,K+-ATPase, from cytoplasmic tubulovesicles to the apical plasma membrane and thereby H+ secretion into the stomach lumen.
Class
Organismal Systems; Digestive system
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Pathway map
Ortholog table
Other DBs
Organism
Oryctolagus cuniculus (rabbit) [GN:
ocu ]
Gene
100340719 guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634 ]
100356806 inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959 ]
100008939 inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960 ]
100008904 guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632 ]
100338391 guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630 ]
100359147 guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630 ]
100339066 guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630 ]
100008804 KCNE2; potassium voltage-gated channel subfamily E member 2 [KO:K04896 ]
100009443 potassium voltage-gated channel subfamily KQT member 1 [KO:K04926 ]
100338120 ATP-sensitive inward rectifier potassium channel 1 isoform X1 [KO:K04995 ]
100008597 KCNJ10; ATP-sensitive inward rectifier potassium channel 10 [KO:K05003 ]
100347016 ATP-sensitive inward rectifier potassium channel 15 isoform X2 [KO:K05008 ]
100009577 ATP1B2; sodium/potassium-transporting ATPase subunit beta-2 [KO:K01540 ]
100008749 ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540 ]
100008788 ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540 ]
Compound
C01245 D-myo-Inositol 1,4,5-trisphosphate
Reference
Authors
Schubert ML, Peura DA
Title
Control of gastric acid secretion in health and disease.
Journal
Reference
Authors
Urushidani T, Forte JG
Title
Signal transduction and activation of acid secretion in the parietal cell.
Journal
Reference
Authors
Yao X, Forte JG
Title
Cell biology of acid secretion by the parietal cell.
Journal
Reference
Authors
Heitzmann D, Warth R
Title
No potassium, no acid: K+ channels and gastric acid secretion.
Journal
Reference
Authors
Kopic S, Murek M, Geibel JP
Title
Revisiting the parietal cell.
Journal
Reference
Authors
Schubert ML
Title
Gastric secretion.
Journal
Reference
Authors
Konturek SJ, Konturek PC, Brzozowski T, Konturek JW, Pawlik WW
Title
From nerves and hormones to bacteria in the stomach; Nobel prize for achievements in gastrology during last century.
Journal
J Physiol Pharmacol 56:507-30 (2005)
Reference
Authors
Forte JG, Zhu L
Title
Apical recycling of the gastric parietal cell H,K-ATPase.
Journal
Reference
Authors
Szaszak M, Christian F, Rosenthal W, Klussmann E
Title
Compartmentalized cAMP signalling in regulated exocytic processes in non-neuronal cells.
Journal
Reference
Authors
Heitzmann D, Warth R
Title
Physiology and pathophysiology of potassium channels in gastrointestinal epithelia.
Journal
Reference
Authors
Heitzmann D, Grahammer F, von Hahn T, Schmitt-Graff A, Romeo E, Nitschke R, Gerlach U, Lang HJ, Verrey F, Barhanin J, Warth R
Title
Heteromeric KCNE2/KCNQ1 potassium channels in the luminal membrane of gastric parietal cells.
Journal
Reference
Authors
Seidler U, Song P, Xiao F, Riederer B, Bachmann O, Chen M
Title
Recent advances in the molecular and functional characterization of acid/base and electrolyte transporters in the basolateral membranes of gastric and duodenal epithelial cells.
Journal
Related pathway
ocu04974 Protein digestion and absorption
KO pathway
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