KEGG   PATHWAY: oke00600
Entry
oke00600                    Pathway                                
Name
Sphingolipid metabolism - Oncorhynchus keta (chum salmon)
Class
Metabolism; Lipid metabolism
Pathway map
oke00600  Sphingolipid metabolism
oke00600

Module
oke_M00066  Lactosylceramide biosynthesis [PATH:oke00600]
oke_M00067  Sulfoglycolipids biosynthesis, ceramide/1-alkyl-2-acylglycerol => sulfatide/seminolipid [PATH:oke00600]
oke_M00094  Ceramide biosynthesis [PATH:oke00600]
oke_M00099  Sphingosine biosynthesis [PATH:oke00600]
oke_M00100  Sphingosine degradation [PATH:oke00600]
Other DBs
GO: 0006665
Organism
Oncorhynchus keta (chum salmon) [GN:oke]
Gene
118387251  sptlc1; serine palmitoyltransferase 1 [KO:K00654] [EC:2.3.1.50]
118362805  sptlc2a; serine palmitoyltransferase 2 [KO:K00654] [EC:2.3.1.50]
118387153  serine palmitoyltransferase 2-like isoform X1 [KO:K00654] [EC:2.3.1.50]
118378407  sptlc3; serine palmitoyltransferase 3 isoform X1 [KO:K00654] [EC:2.3.1.50]
118398511  serine palmitoyltransferase 2-like [KO:K00654] [EC:2.3.1.50]
118402031  3-ketodihydrosphingosine reductase-like [KO:K04708] [EC:1.1.1.102]
118401419  ceramide synthase 1 isoform X1 [KO:K04710] [EC:2.3.1.299]
118388659  ceramide synthase 1-like isoform X1 [KO:K04710] [EC:2.3.1.299]
118402276  ceramide synthase 2-like [KO:K24621] [EC:2.3.1.297]
118367683  ceramide synthase 2-like [KO:K24621] [EC:2.3.1.297]
118395630  cers4a; ceramide synthase 4a [KO:K24621] [EC:2.3.1.297]
118378878  ceramide synthase 2-like [KO:K24621] [EC:2.3.1.297]
118376858  cers2a; ceramide synthase 2a [KO:K24621] [EC:2.3.1.297]
118399123  ceramide synthase 2-like [KO:K24621] [EC:2.3.1.297]
118375141  ceramide synthase 2-like [KO:K24622] [EC:2.3.1.297 2.3.1.298]
118386015  cers6; ceramide synthase 6 [KO:K23727] [EC:2.3.1.291]
118371421  ceramide synthase 5-like [KO:K23727] [EC:2.3.1.291]
118381854  ceramide synthase 5-like isoform X1 [KO:K23727] [EC:2.3.1.291]
118367098  ceramide synthase 6-like [KO:K23727] [EC:2.3.1.291]
118376336  cers5; ceramide synthase 5 isoform X1 [KO:K23727] [EC:2.3.1.291]
118362952  acid ceramidase-like [KO:K12348] [EC:3.5.1.23]
118395418  acid ceramidase-like [KO:K12348] [EC:3.5.1.23]
118357465  asah2; neutral ceramidase [KO:K12349] [EC:3.5.1.23]
118395304  alkaline ceramidase 2-like isoform X1 [KO:K01441] [EC:3.5.1.23]
118390449  acer1; alkaline ceramidase 1 isoform X2 [KO:K01441] [EC:3.5.1.23]
118391968  alkaline ceramidase 2-like [KO:K01441] [EC:3.5.1.23]
118390119  alkaline ceramidase 3 [KO:K04711] [EC:3.5.1.-]
118391683  alkaline ceramidase 3-like [KO:K04711] [EC:3.5.1.-]
118369672  sphingolipid delta(4)-desaturase DES1-like isoform X1 [KO:K04712] [EC:1.14.19.17 1.14.18.5]
118370608  degs2; sphingolipid delta(4)-desaturase/C4-monooxygenase DES2 [KO:K04712] [EC:1.14.19.17 1.14.18.5]
118384167  sphingolipid delta(4)-desaturase DES1-like [KO:K04712] [EC:1.14.19.17 1.14.18.5]
118389846  sphingolipid delta(4)-desaturase/C4-monooxygenase DES2-like [KO:K04712] [EC:1.14.19.17 1.14.18.5]
118400470  sphingolipid delta(4)-desaturase DES1-like [KO:K04712] [EC:1.14.19.17 1.14.18.5]
118369716  phosphatidylcholine:ceramide cholinephosphotransferase 1-like [KO:K04714] [EC:2.7.8.27]
118383296  sgms2a; phosphatidylcholine:ceramide cholinephosphotransferase 2 isoform X1 [KO:K04714] [EC:2.7.8.27]
118377356  phosphatidylcholine:ceramide cholinephosphotransferase 2 [KO:K04714] [EC:2.7.8.27]
118368448  phosphatidylcholine:ceramide cholinephosphotransferase 1-like [KO:K04714] [EC:2.7.8.27]
118379206  smpd1; LOW QUALITY PROTEIN: sphingomyelin phosphodiesterase [KO:K12350] [EC:3.1.4.12]
127920654  LOW QUALITY PROTEIN: sphingomyelin phosphodiesterase-like [KO:K12350] [EC:3.1.4.12]
118399956  smpd2b; sphingomyelin phosphodiesterase 2 isoform X1 [KO:K12351] [EC:3.1.4.12]
118401346  sphingomyelin phosphodiesterase 3-like [KO:K12352] [EC:3.1.4.12]
127924544  sphingomyelin phosphodiesterase 5-like [KO:K12352] [EC:3.1.4.12]
118374614  LOW QUALITY PROTEIN: sphingomyelin phosphodiesterase 5 [KO:K12352] [EC:3.1.4.12]
118396570  smpd3; sphingomyelin phosphodiesterase 3 [KO:K12352] [EC:3.1.4.12]
118385354  sphingomyelin phosphodiesterase 4 isoform X1 [KO:K12353] [EC:3.1.4.12]
118394221  sphingomyelin phosphodiesterase 4-like [KO:K12353] [EC:3.1.4.12]
118388090  sphingomyelin phosphodiesterase 4-like isoform X1 [KO:K12353] [EC:3.1.4.12]
118397654  ectonucleotide pyrophosphatase/phosphodiesterase family member 7-like [KO:K12354] [EC:3.1.4.12]
118378989  ectonucleotide pyrophosphatase/phosphodiesterase family member 7-like [KO:K12354] [EC:3.1.4.12]
118372779  ectonucleotide pyrophosphatase/phosphodiesterase family member 7 [KO:K12354] [EC:3.1.4.12]
118360138  zgc:158263; ceramide kinase family protein isoform X1 [KO:K04715] [EC:2.7.1.138]
118360660  ceramide kinase-like isoform X1 [KO:K04715] [EC:2.7.1.138]
118396456  ceramide kinase-like isoform X1 [KO:K04715] [EC:2.7.1.138]
118365870  cerk; ceramide kinase isoform X1 [KO:K04715] [EC:2.7.1.138]
118359323  ceramide kinase-like isoform X1 [KO:K04715] [EC:2.7.1.138]
118371595  phospholipid phosphatase 2-like isoform X1 [KO:K01080] [EC:3.1.3.4]
118393466  phospholipid phosphatase 1-like [KO:K01080] [EC:3.1.3.4]
118394847  phospholipid phosphatase 3-like [KO:K01080] [EC:3.1.3.4]
118371675  plpp3; phospholipid phosphatase 3 isoform X2 [KO:K01080] [EC:3.1.3.4]
118392086  phospholipid phosphatase 3-like isoform X1 [KO:K01080] [EC:3.1.3.4]
118387890  phospholipid phosphatase 1-like isoform X1 [KO:K01080] [EC:3.1.3.4]
127914549  ppap2d; phosphatidic acid phosphatase type 2D [KO:K01080] [EC:3.1.3.4]
127930094  phospholipid phosphatase 3-like [KO:K01080] [EC:3.1.3.4]
118363866  phospholipid phosphatase 2-like [KO:K01080] [EC:3.1.3.4]
118374487  phospholipid phosphatase 3-like isoform X1 [KO:K01080] [EC:3.1.3.4]
118389979  phospholipid phosphatase 2-like isoform X1 [KO:K01080] [EC:3.1.3.4]
127916700  phospholipid phosphatase 2-like [KO:K01080] [EC:3.1.3.4]
127932542  phospholipid phosphatase 3-like [KO:K01080] [EC:3.1.3.4]
118358529  phospholipid phosphatase 1-like [KO:K01080] [EC:3.1.3.4]
118391525  phospholipid phosphatase 1-like [KO:K01080] [EC:3.1.3.4]
118362585  sphingosine-1-phosphate phosphatase 1-like [KO:K04716] [EC:3.1.3.-]
118398552  sgpp1a; sphingosine-1-phosphate phosphatase 1 isoform X1 [KO:K04716] [EC:3.1.3.-]
118374414  sphingosine-1-phosphate phosphatase 2-like [KO:K04717] [EC:3.1.3.-]
127925035  sphingosine kinase 2-like [KO:K04718] [EC:2.7.1.91]
118365717  sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
118364761  sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
118384195  sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
118377576  sphk2; LOW QUALITY PROTEIN: sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
118389218  sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
118369507  sphingosine-1-phosphate lyase 1-like [KO:K01634] [EC:4.1.2.27]
118402054  sphingosine-1-phosphate lyase 1-like isoform X1 [KO:K01634] [EC:4.1.2.27]
127906493  ugcg; ceramide glucosyltransferase isoform X1 [KO:K00720] [EC:2.4.1.80]
118379804  ceramide glucosyltransferase-B [KO:K00720] [EC:2.4.1.80]
118378935  gba; lysosomal acid glucosylceramidase [KO:K01201] [EC:3.2.1.45]
118368888  gba2; non-lysosomal glucosylceramidase [KO:K17108] [EC:3.2.1.45]
118384324  b4galt6; beta-1,4-galactosyltransferase 6 isoform X1 [KO:K07553] [EC:2.4.1.274]
118358814  beta-1,4-galactosyltransferase 6-like isoform X1 [KO:K07553] [EC:2.4.1.274]
118359586  b4galt5; beta-1,4-galactosyltransferase 5 [KO:K09905] [EC:2.4.1.274 2.4.1.-]
118395411  glb1; beta-galactosidase [KO:K12309] [EC:3.2.1.23]
127926863  2-hydroxyacylsphingosine 1-beta-galactosyltransferase-like [KO:K04628] [EC:2.4.1.47]
127927878  ugt8; 2-hydroxyacylsphingosine 1-beta-galactosyltransferase [KO:K04628] [EC:2.4.1.47]
118362775  galcb; galactocerebrosidase isoform X1 [KO:K01202] [EC:3.2.1.46]
118392924  galactosylceramide sulfotransferase-like [KO:K01019] [EC:2.8.2.11]
118365560  galactose-3-O-sulfotransferase 2-like [KO:K01019] [EC:2.8.2.11]
118358055  galactosylceramide sulfotransferase-like [KO:K01019] [EC:2.8.2.11]
118391417  galactosylceramide sulfotransferase-like [KO:K01019] [EC:2.8.2.11]
118384656  galactose-3-O-sulfotransferase 3-like [KO:K01019] [EC:2.8.2.11]
118395715  arsa; arylsulfatase A [KO:K01134] [EC:3.1.6.8]
118398300  sialidase-1-like [KO:K01186] [EC:3.2.1.18]
118399201  sialidase-1-like [KO:K01186] [EC:3.2.1.18]
118374883  sialidase-3-like [KO:K12357] [EC:3.2.1.18]
118374803  neu4; LOW QUALITY PROTEIN: sialidase-4 [KO:K12357] [EC:3.2.1.18]
118390414  sialidase-3-like isoform X1 [KO:K12357] [EC:3.2.1.18]
118380517  gla; alpha-galactosidase A [KO:K01189] [EC:3.2.1.22]
118388567  beta-1,4 N-acetylgalactosaminyltransferase 1-like isoform X1 [KO:K00725] [EC:2.4.1.92]
118376214  beta-1,4 N-acetylgalactosaminyltransferase 1-like isoform X1 [KO:K00725] [EC:2.4.1.92]
118400293  b4galnt1b; beta-1,4 N-acetylgalactosaminyltransferase 1 isoform X2 [KO:K00725] [EC:2.4.1.92]
118385380  beta-hexosaminidase subunit beta-like isoform X1 [KO:K12373] [EC:3.2.1.52]
118387383  beta-hexosaminidase subunit beta-like [KO:K12373] [EC:3.2.1.52]
118382395  ganglioside GM2 activator-like isoform X1 [KO:K12383]
118385195  prosaposin-like [KO:K12382]
118393250  prosaposin isoform X1 [KO:K12382]
118387633  sftpba; prosaposin isoform X1 [KO:K12382]
118380370  psap; prosaposin isoform X1 [KO:K12382]
118375425  prosaposin-like isoform X1 [KO:K12382]
Compound
C00065  L-Serine
C00154  Palmitoyl-CoA
C00195  N-Acylsphingosine
C00319  Sphingosine
C00346  Ethanolamine phosphate
C00550  Sphingomyelin
C00836  Sphinganine
C01120  Sphinganine 1-phosphate
C01190  Glucosylceramide
C01290  Lactosylceramide
C01747  Psychosine
C02686  Galactosylceramide
C02934  3-Dehydrosphinganine
C02960  Ceramide 1-phosphate
C03108  D-Glucosylsphingosine
C03272  Globoside
C03405  Lactosylceramide sulfate
C03640  Sphingosyl-phosphocholine
C04730  GM3
C04737  alpha-D-Galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
C04884  N-Acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C04911  D-Galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C05681  Ceramide 2-aminoethylphosphonate
C06062  Ceramide phosphoethanolamine
C06124  Sphingosine 1-phosphate
C06125  Sulfatide
C06126  Digalactosylceramide
C06127  Digalactosylceramide sulfate
C06128  GM4
C06135  GA2
C06136  GA1
C12126  Dihydroceramide
C12144  Phytosphingosine
C12145  Phytoceramide
C22467  Gangliotriaosylceramide-II3 sulfate
Reference
PMID:12011104
  Authors
Merrill AH Jr.
  Title
De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway.
  Journal
J Biol Chem 277:25843-6 (2002)
DOI:10.1074/jbc.R200009200
Reference
PMID:10652340
  Authors
Tani M, Okino N, Mitsutake S, Tanigawa T, Izu H, Ito M.
  Title
Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized.
  Journal
J Biol Chem 275:3462-8 (2000)
DOI:10.1074/jbc.275.5.3462
Reference
PMID:11305904
  Authors
Hannun YA, Luberto C, Argraves KM.
  Title
Enzymes of sphingolipid metabolism: from modular to integrative signaling.
  Journal
Biochemistry 40:4893-903 (2001)
DOI:10.1021/bi002836k
Reference
PMID:1495423
  Authors
Merrill AH Jr, Wang E.
  Title
Enzymes of ceramide biosynthesis.
  Journal
Methods Enzymol 209:427-37 (1992)
DOI:10.1016/0076-6879(92)09053-6
Reference
PMID:8457204
  Authors
Hirschberg K, Rodger J, Futerman AH.
  Title
The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver.
  Journal
Biochem J 290 ( Pt 3):751-7 (1993)
DOI:10.1042/bj2900751
Reference
PMID:10366774
  Authors
Dickson RC, Lester RL.
  Title
Metabolism and selected functions of sphingolipids in the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1438:305-21 (1999)
DOI:10.1016/S1388-1981(99)00068-2
Related
pathway
oke00260  Glycine, serine and threonine metabolism
oke00601  Glycosphingolipid biosynthesis - lacto and neolacto series
oke00603  Glycosphingolipid biosynthesis - globo and isoglobo series
oke00604  Glycosphingolipid biosynthesis - ganglio series
KO pathway
ko00600   
LinkDB

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