KEGG   PATHWAY: osa00270
Entry
osa00270                    Pathway                                
Name
Cysteine and methionine metabolism - Oryza sativa japonica (Japanese rice) (RefSeq)
Description
Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:M00021]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:M00338]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:M00034].
Class
Metabolism; Amino acid metabolism
Pathway map
osa00270  Cysteine and methionine metabolism
osa00270

Module
osa_M00021  Cysteine biosynthesis, serine => cysteine [PATH:osa00270]
osa_M00034  Methionine salvage pathway [PATH:osa00270]
osa_M00368  Ethylene biosynthesis, methionine => ethylene [PATH:osa00270]
Other DBs
GO: 0006534 0006555
Organism
Oryza sativa japonica (Japanese rice) (RefSeq) [GN:osa]
Gene
4339425  probable serine acetyltransferase 5 [KO:K00640] [EC:2.3.1.30]
4324655  probable serine acetyltransferase 1 [KO:K00640] [EC:2.3.1.30]
4331528  probable serine acetyltransferase 2 [KO:K00640] [EC:2.3.1.30]
4331861  probable serine acetyltransferase 3 [KO:K00640] [EC:2.3.1.30]
4331941  probable serine acetyltransferase 4 [KO:K00640] [EC:2.3.1.30]
107280167  probable serine acetyltransferase 1 [KO:K00640] [EC:2.3.1.30]
4334101  cysteine synthase [KO:K01738] [EC:2.5.1.47]
4352839  cysteine synthase [KO:K01738] [EC:2.5.1.47]
4327819  cysteine synthase [KO:K01738] [EC:2.5.1.47]
4332062  cysteine synthase [KO:K01738] [EC:2.5.1.47]
4341321  cysteine synthase-like [KO:K01738] [EC:2.5.1.47]
4340142  cysteine synthase-like [KO:K01738] [EC:2.5.1.47]
4341322  cysteine synthase-like [KO:K01738] [EC:2.5.1.47]
4340140  cysteine synthase-like [KO:K01738] [EC:2.5.1.47]
9266140  cysteine synthase-like [KO:K01738] [EC:2.5.1.47]
107276344  cysteine synthase, chloroplastic/chromoplastic-like [KO:K01738] [EC:2.5.1.47]
107277031  cysteine synthase-like [KO:K01738] [EC:2.5.1.47]
4335048  bifunctional L-3-cyanoalanine synthase/cysteine synthase 2, mitochondrial isoform X1 [KO:K13034] [EC:2.5.1.47 4.4.1.9]
4340283  cystathionine beta-lyase, chloroplastic isoform X1 [KO:K01760] [EC:4.4.1.13]
107275791  cystathionine beta-lyase, chloroplastic-like [KO:K01760] [EC:4.4.1.13]
4348656  homocysteine S-methyltransferase 2 [KO:K00547] [EC:2.1.1.10]
4324713  homocysteine S-methyltransferase 4 [KO:K00547] [EC:2.1.1.10]
4332095  homocysteine S-methyltransferase 1 [KO:K00547] [EC:2.1.1.10]
4352747  homocysteine S-methyltransferase 2 [KO:K00547] [EC:2.1.1.10]
4352833  5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 2 [KO:K00549] [EC:2.1.1.14]
4352832  5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 1 [KO:K00549] [EC:2.1.1.14]
4337733  S-adenosylmethionine synthase 1 [KO:K00789] [EC:2.5.1.6]
4325163  S-adenosylmethionine synthase 3 [KO:K00789] [EC:2.5.1.6]
4326996  S-adenosylmethionine synthase 2 [KO:K00789] [EC:2.5.1.6]
4329955  S-adenosylmethionine decarboxylase proenzyme-like [KO:K01611] [EC:4.1.1.50]
4336294  S-adenosylmethionine decarboxylase proenzyme isoform X1 [KO:K01611] [EC:4.1.1.50]
4347103  S-adenosylmethionine decarboxylase proenzyme [KO:K01611] [EC:4.1.1.50]
107275839  S-adenosylmethionine decarboxylase proenzyme 4-like [KO:K01611] [EC:4.1.1.50]
4342996  spermidine synthase 1 [KO:K00797] [EC:2.5.1.16]
4341195  spermine synthase [KO:K00797] [EC:2.5.1.16]
4328910  spermine synthase [KO:K00797] [EC:2.5.1.16]
4344361  nicotianamine synthase 3 [KO:K05953] [EC:2.5.1.43]
4332608  nicotianamine synthase 1 [KO:K05953] [EC:2.5.1.43]
4332607  nicotianamine synthase 2 [KO:K05953] [EC:2.5.1.43]
4339898  5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 2 [KO:K01244] [EC:3.2.2.16]
4337347  methylthioribose kinase 1 [KO:K00899] [EC:2.7.1.100]
107276080  methylthioribose kinase 2 [KO:K00899] [EC:2.7.1.100]
4350083  methylthioribose-1-phosphate isomerase [KO:K08963] [EC:5.3.1.23]
4350524  probable bifunctional methylthioribulose-1-phosphate dehydratase/enolase-phosphatase E1 [KO:K16054] [EC:4.2.1.109 3.1.3.77]
4326460  probable bifunctional methylthioribulose-1-phosphate dehydratase/enolase-phosphatase E1 [KO:K09880] [EC:3.1.3.77]
4331707  uncharacterized protein LOC4331707 [KO:K08967] [EC:1.13.11.53 1.13.11.54]
4348646  heat stress transcription factor A-2c [KO:K08967] [EC:1.13.11.53 1.13.11.54]
4348647  1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 4 [KO:K08967] [EC:1.13.11.53 1.13.11.54]
107276095  1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 3 isoform X1 [KO:K08967] [EC:1.13.11.53 1.13.11.54]
4347242  probable N-succinyldiaminopimelate aminotransferase DapC [KO:K23977] [EC:2.6.1.117]
4329098  tyrosine aminotransferase isoform X1 [KO:K00815] [EC:2.6.1.5]
4329101  probable aminotransferase TAT2 [KO:K00815] [EC:2.6.1.5]
4350712  probable aminotransferase TAT2 [KO:K00815] [EC:2.6.1.5]
4351017  probable aminotransferase TAT2 [KO:K00815] [EC:2.6.1.5]
4340970  nicotianamine aminotransferase A isoform X1 [KO:K00815] [EC:2.6.1.5]
4323866  aspartate aminotransferase [KO:K00837] [EC:2.6.1.-]
4349123  methionine gamma-lyase [KO:K01761] [EC:4.4.1.11]
4342575  DNA (cytosine-5)-methyltransferase 1B [KO:K00558] [EC:2.1.1.37]
4334435  DNA (cytosine-5)-methyltransferase 1A [KO:K00558] [EC:2.1.1.37]
4347954  DNA (cytosine-5)-methyltransferase 1 [KO:K00558] [EC:2.1.1.37]
4338140  DNA (cytosine-5)-methyltransferase 1 isoform X1 [KO:K00558] [EC:2.1.1.37]
4332128  DNA (cytosine-5)-methyltransferase 1 [KO:K00558] [EC:2.1.1.37]
4337816  proline-rich protein 36 isoform X1 [KO:K17398] [EC:2.1.1.37]
4350455  LOW QUALITY PROTEIN: adenosylhomocysteinase [KO:K01251] [EC:3.13.2.1]
4336750  1-aminocyclopropane-1-carboxylate synthase [KO:K20772] [EC:4.4.1.14]
4333976  1-aminocyclopropane-1-carboxylate synthase 1 [KO:K01762] [EC:4.4.1.14]
4327307  1-aminocyclopropane-1-carboxylate synthase 7 [KO:K01762] [EC:4.4.1.14]
107275635  1-aminocyclopropane-1-carboxylate synthase 7-like [KO:K01762] [EC:4.4.1.14]
107275928  1-aminocyclopropane-1-carboxylate synthase 7-like [KO:K01762] [EC:4.4.1.14]
4347225  1-aminocyclopropane-1-carboxylate oxidase 1 [KO:K05933] [EC:1.14.17.4]
4337818  1-aminocyclopropane-1-carboxylate oxidase [KO:K05933] [EC:1.14.17.4]
4347224  1-aminocyclopropane-1-carboxylate oxidase 1 [KO:K05933] [EC:1.14.17.4]
4324194  1-aminocyclopropane-1-carboxylate oxidase 1 [KO:K05933] [EC:1.14.17.4]
4330873  1-aminocyclopropane-1-carboxylate oxidase 1-like isoform X1 [KO:K05933] [EC:1.14.17.4]
4349970  1-aminocyclopropane-1-carboxylate oxidase [KO:K05933] [EC:1.14.17.4]
107278688  1-aminocyclopropane-1-carboxylate oxidase 1-like [KO:K05933] [EC:1.14.17.4]
4326958  aspartokinase 2, chloroplastic isoform X1 [KO:K00928] [EC:2.7.2.4]
4334794  aspartokinase 1, chloroplastic [KO:K00928] [EC:2.7.2.4]
4342980  aspartokinase 2, chloroplastic isoform X1 [KO:K00928] [EC:2.7.2.4]
4346642  bifunctional aspartokinase/homoserine dehydrogenase 2, chloroplastic [KO:K12524] [EC:2.7.2.4 1.1.1.3]
4345328  bifunctional aspartokinase/homoserine dehydrogenase 1, chloroplastic isoform X1 [KO:K12524] [EC:2.7.2.4 1.1.1.3]
4334188  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
4332956  cystathionine gamma-synthase 1, chloroplastic [KO:K01739] [EC:2.5.1.48]
4348560  probable cystathionine gamma-synthase 2 [KO:K01739] [EC:2.5.1.48]
4348561  probable cystathionine gamma-synthase 2 [KO:K01739] [EC:2.5.1.48]
107276273  cystathionine gamma-synthase 1, chloroplastic-like [KO:K01739] [EC:2.5.1.48]
4339583  branched-chain-amino-acid aminotransferase 5, chloroplastic isoform X1 [KO:K00826] [EC:2.6.1.42]
4331322  branched-chain-amino-acid aminotransferase 5, chloroplastic isoform X1 [KO:K00826] [EC:2.6.1.42]
4332151  branched-chain-amino-acid aminotransferase 2, chloroplastic [KO:K00826] [EC:2.6.1.42]
4336645  branched-chain-amino-acid aminotransferase 3, chloroplastic isoform X1 [KO:K00826] [EC:2.6.1.42]
4331779  alanine--glyoxylate aminotransferase 2 homolog 1, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
4332775  alanine--glyoxylate aminotransferase 2 homolog 3, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
4339095  alanine--glyoxylate aminotransferase 2 homolog 2, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
4337696  glutamate--cysteine ligase A, chloroplastic [KO:K01919] [EC:6.3.2.2]
4343165  glutamate--cysteine ligase B, chloroplastic [KO:K01919] [EC:6.3.2.2]
9272324  glutathione synthetase, chloroplastic isoform X1 [KO:K21456] [EC:6.3.2.3]
4351008  glutathione synthetase, chloroplastic isoform X1 [KO:K21456] [EC:6.3.2.3]
4325621  aspartate aminotransferase, cytoplasmic [KO:K14454] [EC:2.6.1.1]
4341252  aspartate aminotransferase, mitochondrial [KO:K14455] [EC:2.6.1.1]
4328828  aspartate aminotransferase, mitochondrial isoform X1 [KO:K14455] [EC:2.6.1.1]
4331017  aspartate aminotransferase, chloroplastic [KO:K00811] [EC:2.6.1.1]
4328418  thiosulfate/3-mercaptopyruvate sulfurtransferase 1, mitochondrial [KO:K01011] [EC:2.8.1.1 2.8.1.2]
4352752  thiosulfate/3-mercaptopyruvate sulfurtransferase 2 isoform X1 [KO:K01011] [EC:2.8.1.1 2.8.1.2]
4328012  L-lactate dehydrogenase A [KO:K00016] [EC:1.1.1.27]
4339856  L-lactate dehydrogenase B [KO:K00016] [EC:1.1.1.27]
4330881  putative D-cysteine desulfhydrase 1, mitochondrial [KO:K05396] [EC:4.4.1.15]
9270375  putative D-cysteine desulfhydrase 2, mitochondrial isoform X2 [KO:K05396] [EC:4.4.1.15]
4325155  putative L-cysteine desulfhydrase 1 isoform X1 [KO:K22207] [EC:4.4.1.28]
4325157  putative L-cysteine desulfhydrase 2 [KO:K22207] [EC:4.4.1.28]
4348905  malate dehydrogenase, cytoplasmic [KO:K00025] [EC:1.1.1.37]
4336595  malate dehydrogenase, cytoplasmic-like [KO:K00025] [EC:1.1.1.37]
4352871  malate dehydrogenase, glyoxysomal [KO:K00026] [EC:1.1.1.37]
4334274  malate dehydrogenase, glyoxysomal-like [KO:K00026] [EC:1.1.1.37]
4326249  malate dehydrogenase, mitochondrial [KO:K00026] [EC:1.1.1.37]
4327423  malate dehydrogenase, chloroplastic [KO:K00026] [EC:1.1.1.37]
4345657  malate dehydrogenase, chloroplastic [KO:K00026] [EC:1.1.1.37]
4339682  malate dehydrogenase, mitochondrial [KO:K00026] [EC:1.1.1.37]
4343993  malate dehydrogenase, chloroplastic [KO:K00026] [EC:1.1.1.37]
4327479  cysteine synthase-like [KO:K22846] [EC:2.5.1.144]
4337230  D-3-phosphoglycerate dehydrogenase 3, chloroplastic [KO:K00058] [EC:1.1.1.95 1.1.1.399]
4341713  D-3-phosphoglycerate dehydrogenase 3, chloroplastic [KO:K00058] [EC:1.1.1.95 1.1.1.399]
4345710  D-3-phosphoglycerate dehydrogenase 1, chloroplastic [KO:K00058] [EC:1.1.1.95 1.1.1.399]
9270715  phosphoserine aminotransferase 1, chloroplastic [KO:K00831] [EC:2.6.1.52]
Compound
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00022  Pyruvate
C00041  L-Alanine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00065  L-Serine
C00073  L-Methionine
C00094  Sulfite
C00097  L-Cysteine
C00109  2-Oxobutanoate
C00155  L-Homocysteine
C00170  5'-Methylthioadenosine
C00197  3-Phospho-D-glycerate
C00263  L-Homoserine
C00283  Hydrogen sulfide
C00409  Methanethiol
C00441  L-Aspartate 4-semialdehyde
C00491  L-Cystine
C00506  L-Cysteate
C00606  3-Sulfino-L-alanine
C00793  D-Cysteine
C00957  Mercaptopyruvate
C00979  O-Acetyl-L-serine
C01005  O-Phospho-L-serine
C01077  O-Acetyl-L-homoserine
C01118  O-Succinyl-L-homoserine
C01137  S-Adenosylmethioninamine
C01180  4-Methylthio-2-oxobutanoic acid
C01234  1-Aminocyclopropane-1-carboxylate
C01817  L-Homocystine
C01962  Thiocysteine
C02218  Dehydroalanine
C02291  L-Cystathionine
C02356  (S)-2-Aminobutanoate
C02989  L-Methionine S-oxide
C03082  4-Phospho-L-aspartate
C03089  5-Methylthio-D-ribose
C03145  N-Formylmethionine
C03232  3-Phosphonooxypyruvate
C03539  S-Ribosyl-L-homocysteine
C04188  S-Methyl-5-thio-D-ribose 1-phosphate
C04582  S-Methyl-5-thio-D-ribulose 1-phosphate
C05324  Nicotianamine
C05524  Aminoacyl-L-methionine
C05526  S-Glutathionyl-L-cysteine
C05527  3-Sulfinylpyruvate
C05528  3-Sulfopyruvate
C05823  3-Mercaptolactate
C05824  S-Sulfo-L-cysteine
C06547  Ethylene
C08276  3-(Methylthio)propanoate
C09306  Sulfur dioxide
C11437  1-Deoxy-D-xylulose 5-phosphate
C11481  HSO3-
C11499  (S)-3-Sulfolactate
C11537  (2R)-3-Sulfolactate
C15606  1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one
C15650  2,3-Diketo-5-methylthiopentyl-1-phosphate
C15651  2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate
C18049  N-Acyl-L-homoserine lactone
C19787  5'-S-Methyl-5'-thioinosine
C21015  gamma-L-Glutamyl-L-2-aminobutyrate
C21016  Ophthalmate
C22359  S-Methyl-1-thio-D-xylulose 5-phosphate
Reference
  Authors
Sekowska A, Denervaud V, Ashida H, Michoud K, Haas D, Yokota A, Danchin A
  Title
Bacterial variations on the methionine salvage pathway.
  Journal
BMC Microbiol 4:9 (2004)
DOI:10.1186/1471-2180-4-9
Reference
  Authors
Ashida H, Saito Y, Kojima C, Kobayashi K, Ogasawara N, Yokota A.
  Title
A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO.
  Journal
Science 302:286-90 (2003)
DOI:10.1126/science.1086997
Reference
  Authors
Sekowska A, Danchin A.
  Title
The methionine salvage pathway in Bacillus subtilis.
  Journal
BMC Microbiol 2:8 (2002)
DOI:10.1186/1471-2180-2-8
Reference
  Authors
Berger BJ, English S, Chan G, Knodel MH.
  Title
Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis.
  Journal
J Bacteriol 185:2418-31 (2003)
DOI:10.1128/JB.185.8.2418-2431.2003
Reference
  Authors
Goyer A, Collakova E, Shachar-Hill Y, Hanson AD
  Title
Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway.
  Journal
Plant Cell Physiol 48:232-42 (2007)
DOI:10.1093/pcp/pcl055
Reference
  Authors
Rebeille F, Jabrin S, Bligny R, Loizeau K, Gambonnet B, Van Wilder V, Douce R, Ravanel S
  Title
Methionine catabolism in Arabidopsis cells is initiated by a gamma-cleavage process and leads to S-methylcysteine and isoleucine syntheses.
  Journal
Proc Natl Acad Sci U S A 103:15687-92 (2006)
DOI:10.1073/pnas.0606195103
Reference
  Authors
Pirkov I, Norbeck J, Gustafsson L, Albers E
  Title
A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.
  Journal
FEBS J 275:4111-20 (2008)
DOI:10.1111/j.1742-4658.2008.06552.x
Reference
  Authors
Ashida H, Saito Y, Kojima C, Yokota A
  Title
Enzymatic characterization of 5-methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway in Bacillus subtilis.
  Journal
Biosci Biotechnol Biochem 72:959-67 (2008)
DOI:10.1271/bbb.70651
Reference
  Authors
Kitabatake M, So MW, Tumbula DL, Soll D
  Title
Cysteine biosynthesis pathway in the archaeon Methanosarcina barkeri encoded by acquired bacterial genes?
  Journal
J Bacteriol 182:143-5 (2000)
DOI:10.1128/JB.182.1.143-145.2000
Reference
  Authors
Mino K, Ishikawa K
  Title
Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.
  Journal
J Bacteriol 185:2277-84 (2003)
DOI:10.1128/JB.185.7.2277-2284.2003
Reference
  Authors
Tanabe S
  Title
Development of assay methods for endogenous inorganic sulfur compounds and sulfurtransferases and evaluation of the physiological functions of bound sulfur.
  Journal
Yakugaku Zasshi 128:881-900 (2008)
DOI:10.1248/yakushi.128.881
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Gutierrez JA, Crowder T, Rinaldo-Matthis A, Ho MC, Almo SC, Schramm VL
  Title
Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing.
  Journal
Nat Chem Biol 5:251-7 (2009)
DOI:10.1038/nchembio.153
Related
pathway
osa00010  Glycolysis / Gluconeogenesis
osa00250  Alanine, aspartate and glutamate metabolism
osa00260  Glycine, serine and threonine metabolism
osa00290  Valine, leucine and isoleucine biosynthesis
osa00430  Taurine and hypotaurine metabolism
osa00480  Glutathione metabolism
osa00620  Pyruvate metabolism
osa00640  Propanoate metabolism
osa00770  Pantothenate and CoA biosynthesis
osa00900  Terpenoid backbone biosynthesis
osa00920  Sulfur metabolism
KO pathway
ko00270   
LinkDB

DBGET integrated database retrieval system