KEGG   PATHWAY: pmaj00230
Entry
pmaj00230                   Pathway                                
Name
Purine metabolism - Parus major (Great Tit)
Class
Metabolism; Nucleotide metabolism
Pathway map
pmaj00230  Purine metabolism
pmaj00230

Module
pmaj_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:pmaj00230]
pmaj_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:pmaj00230]
pmaj_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:pmaj00230]
pmaj_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:pmaj00230]
pmaj_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:pmaj00230]
pmaj_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:pmaj00230]
Other DBs
GO: 0006163 0042278
Organism
Parus major (Great Tit) [GN:pmaj]
Gene
107203226  NUDT9; ADP-ribose pyrophosphatase, mitochondrial isoform X1 [KO:K13988] [EC:3.6.1.13]
107212591  ADPRM; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
107204378  NUDT5; ADP-sugar pyrophosphatase isoform X3 [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
107208365  PGM1; phosphoglucomutase-1 isoform X2 [KO:K01835] [EC:5.4.2.2]
107203016  PGM2; phosphoglucomutase-2 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
107207782  PRPS2; ribose-phosphate pyrophosphokinase 2 isoform X1 [KO:K00948] [EC:2.7.6.1]
107203774  PRPS1; ribose-phosphate pyrophosphokinase 1 [KO:K00948] [EC:2.7.6.1]
107202738  PPAT; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
107200378  GART; trifunctional purine biosynthetic protein adenosine-3 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
107200385  trifunctional purine biosynthetic protein adenosine-3-like isoform X2 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
107203210  PAICS; multifunctional protein ADE2 isoform X1 [KO:K01587] [EC:4.1.1.21 6.3.2.6]
107202963  trihelix transcription factor PTL isoform X5 [KO:K01587] [EC:4.1.1.21 6.3.2.6]
107204959  ADSL; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
107207708  ATIC; bifunctional purine biosynthesis protein PURH [KO:K00602] [EC:2.1.2.3 3.5.4.10]
107209822  APRT; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
107206831  NT5C2; cytosolic purine 5'-nucleotidase isoform X1 [KO:K01081] [EC:3.1.3.5]
107206435  cytosolic 5'-nucleotidase 1A-like [KO:K01081] [EC:3.1.3.5]
107211407  NT5M; 5'(3')-deoxyribonucleotidase, mitochondrial [KO:K01081] [EC:3.1.3.5]
107212487  NT5C; 5'(3')-deoxyribonucleotidase, cytosolic type [KO:K01081] [EC:3.1.3.5]
107214087  NT5C1A; cytosolic 5'-nucleotidase 1A [KO:K01081] [EC:3.1.3.5]
107202235  cytosolic 5'-nucleotidase 1B-like [KO:K01081] [EC:3.1.3.5]
107213931  cytosolic purine 5'-nucleotidase isoform X1 [KO:K01081] [EC:3.1.3.5]
107201804  NT5E; 5'-nucleotidase [KO:K19970] [EC:3.1.3.5]
107209648  PNP; purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
107210287  LACC1; laccase domain-containing protein 1 isoform X1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
107203956  HPRT1; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
107210230  IMPDH2; inosine-5'-monophosphate dehydrogenase 2 isoform X2 [KO:K00088] [EC:1.1.1.205]
117243849  basic salivary proline-rich protein 1-like [KO:K00088] [EC:1.1.1.205]
107211082  NME3; nucleoside diphosphate kinase 3 [KO:K00940] [EC:2.7.4.6]
107200312  NME7; nucleoside diphosphate kinase 7 isoform X3 [KO:K00940] [EC:2.7.4.6]
107212449  nucleoside diphosphate kinase-like [KO:K00940] [EC:2.7.4.6]
107212451  NME2; nucleoside diphosphate kinase B [KO:K00940] [EC:2.7.4.6]
107198765  NME6; nucleoside diphosphate kinase 6 isoform X1 [KO:K00940] [EC:2.7.4.6]
107201637  AK9; adenylate kinase 9 isoform X1 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
107206906  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 isoform X1 [KO:K01510] [EC:3.6.1.5]
107200959  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
107212208  ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8 [KO:K01510] [EC:3.6.1.5]
107212235  LOW QUALITY PROTEIN: ectonucleoside triphosphate diphosphohydrolase 8-like [KO:K01510] [EC:3.6.1.5]
107212434  CANT1; soluble calcium-activated nucleotidase 1 isoform X2 [KO:K12304] [EC:3.6.1.6]
107213958  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X2 [KO:K12305] [EC:3.6.1.6]
107205897  ENTPD5; ectonucleoside triphosphate diphosphohydrolase 5 [KO:K01511] [EC:3.6.1.6]
107202034  ENTPD6; ectonucleoside triphosphate diphosphohydrolase 6 [KO:K01511] [EC:3.6.1.6]
107208413  ITPA; inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
107201507  XDH; xanthine dehydrogenase/oxidase isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
107216319  NUDT2; bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] [KO:K01518] [EC:3.6.1.17]
107208945  GMPS; GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
107198892  GMPR; GMP reductase 1 isoform X1 [KO:K00364] [EC:1.7.1.7]
107198210  GDA; guanine deaminase [KO:K01487] [EC:3.5.4.3]
107201064  GUK1; guanylate kinase isoform X1 [KO:K00942] [EC:2.7.4.8]
107207454  RRM1; ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
107199938  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B isoform X1 [KO:K10808] [EC:1.17.4.1]
107202615  RRM2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
107202573  HDDC2; HD domain-containing protein 2 [KO:K07023] [EC:3.1.3.89]
107213895  deoxyguanosine kinase, mitochondrial-like [KO:K00904] [EC:2.7.1.113]
107203117  DCK; deoxycytidine kinase [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
107210687  deoxycytidine kinase-like isoform X1 [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
107209306  HDDC3; guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 [KO:K21138] [EC:3.1.7.2]
107214657  PRUNE1; exopolyphosphatase PRUNE1 [KO:K01514] [EC:3.6.1.11]
107201036  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
107199935  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
107207500  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
107198603  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
107209841  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
107200813  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
107211136  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
107210410  GUCY1A2; LOW QUALITY PROTEIN: guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
107203218  GUCY1A1; guanylate cyclase soluble subunit alpha-1 isoform X1 [KO:K12318] [EC:4.6.1.2]
107208956  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
107203428  GUCY1B1; guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
107204266  GUCY2C; heat-stable enterotoxin receptor [KO:K12320] [EC:4.6.1.2]
107210870  GUCY2F; LOW QUALITY PROTEIN: retinal guanylyl cyclase 2 [KO:K12322] [EC:4.6.1.2]
107214622  NPR1; atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
107198475  NPR2; atrial natriuretic peptide receptor 2 [KO:K12324] [EC:4.6.1.2]
107215797  atrial natriuretic peptide receptor 1-like [KO:K12324] [EC:4.6.1.2]
107200594  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
107207558  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
107199586  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B-like [KO:K13755] [EC:3.1.4.17]
107207002  PDE2A; cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X1 [KO:K18283] [EC:3.1.4.17]
107204826  PDE3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A isoform X1 [KO:K19021] [EC:3.1.4.17]
107205883  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B isoform X1 [KO:K13296] [EC:3.1.4.17]
107203048  PDE5A; cGMP-specific 3',5'-cyclic phosphodiesterase isoform X1 [KO:K13762] [EC:3.1.4.35]
107216334  rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta isoform X1 [KO:K13756] [EC:3.1.4.35]
107206990  PDE6C; cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' [KO:K13757] [EC:3.1.4.35]
107208808  PDE6D; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta [KO:K13758]
107204262  PDE6H; retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13760]
107213119  PDE9A; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1 [KO:K13761] [EC:3.1.4.35]
107201632  PDE10A; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X1 [KO:K18438] [EC:3.1.4.17 3.1.4.35]
107207701  PDE11A; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A isoform X1 [KO:K13298] [EC:3.1.4.17 3.1.4.35]
107201933  ADSS2; adenylosuccinate synthetase isozyme 2 isoform X1 [KO:K01939] [EC:6.3.4.4]
107205722  ADSS1; adenylosuccinate synthetase isozyme 1 [KO:K01939] [EC:6.3.4.4]
107205644  AMPD3; AMP deaminase 3 isoform X1 [KO:K01490] [EC:3.5.4.6]
107214901  AMPD2; AMP deaminase 2 [KO:K01490] [EC:3.5.4.6]
107214946  AMPD1; AMP deaminase 1 isoform X1 [KO:K01490] [EC:3.5.4.6]
107206681  ADK; adenosine kinase isoform X1 [KO:K00856] [EC:2.7.1.20]
107213054  ADA; adenosine deaminase [KO:K01488] [EC:3.5.4.4]
107205081  ADA2; adenosine deaminase 2 isoform X1 [KO:K19572] [EC:3.5.4.4]
107206364  AK7; adenylate kinase 7 isoform X1 [KO:K00939] [EC:2.7.4.3]
107212098  AK8; adenylate kinase 8 isoform X1 [KO:K00939] [EC:2.7.4.3]
107214091  AK2; adenylate kinase 2, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
107212211  AK1; adenylate kinase isoenzyme 1 isoform X1 [KO:K00939] [EC:2.7.4.3]
107207997  AK5; adenylate kinase isoenzyme 5 [KO:K00939] [EC:2.7.4.3]
107208417  AK4; adenylate kinase 4, mitochondrial [KO:K00939] [EC:2.7.4.3]
107215785  AK6; adenylate kinase isoenzyme 6 [KO:K18532] [EC:2.7.4.3]
107198317  AK3; GTP:AMP phosphotransferase AK3, mitochondrial isoform X1 [KO:K00944] [EC:2.7.4.10]
107212045  ENTPD2; ectonucleoside triphosphate diphosphohydrolase 2 isoform X1 [KO:K01509] [EC:3.6.1.-]
107201783  NTPCR; cancer-related nucleoside-triphosphatase isoform X1 [KO:K06928] [EC:3.6.1.15]
107201745  ENPP1; ectonucleotide pyrophosphatase/phosphodiesterase family member 1 isoform X1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
107201746  ENPP3; ectonucleotide pyrophosphatase/phosphodiesterase family member 3 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
107208132  PDE4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
107215443  PDE4C; cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform X1 [KO:K13293] [EC:3.1.4.53]
107216174  PDE4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1 [KO:K13293] [EC:3.1.4.53]
107201725  PDE7B; cAMP-specific 3',5'-cyclic phosphodiesterase 7B isoform X1 [KO:K18436] [EC:3.1.4.53]
107200018  PDE7A; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X1 [KO:K18436] [EC:3.1.4.53]
107209337  PDE8A; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1 [KO:K18437] [EC:3.1.4.53]
107216218  PDE8B; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B [KO:K18437] [EC:3.1.4.53]
107210320  FHIT; bis(5'-adenosyl)-triphosphatase [KO:K01522] [EC:3.6.1.29]
107201655  ENPP4; bis(5'-adenosyl)-triphosphatase ENPP4 [KO:K18424] [EC:3.6.1.29]
107203349  PAPSS1; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
107207094  PAPSS2; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform X1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
107208239  uricase-like [KO:K00365] [EC:1.7.3.3]
107210065  cadherin-1-like isoform X1 [KO:K13484] [EC:3.5.2.17 4.1.1.97]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
pmaj00030  Pentose phosphate pathway
pmaj00220  Arginine biosynthesis
pmaj00250  Alanine, aspartate and glutamate metabolism
pmaj00260  Glycine, serine and threonine metabolism
pmaj00340  Histidine metabolism
pmaj00630  Glyoxylate and dicarboxylate metabolism
pmaj00730  Thiamine metabolism
pmaj00740  Riboflavin metabolism
pmaj00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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