KEGG   PATHWAY: pmei04144
Entry
pmei04144                   Pathway                                
Name
Endocytosis - Poecilia mexicana (shortfin molly)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
pmei04144  Endocytosis
pmei04144

Other DBs
GO: 0006897
Organism
Poecilia mexicana (shortfin molly) [GN:pmei]
Gene
106917833  arf6; ADP-ribosylation factor 6 [KO:K07941]
106920654  ADP-ribosylation factor 6 [KO:K07941]
106919961  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like isoform X1 [KO:K00889] [EC:2.7.1.68]
106916277  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like isoform X1 [KO:K00889] [EC:2.7.1.68]
106917759  phosphatidylinositol 4-phosphate 5-kinase type-1 gamma-like isoform X1 [KO:K00889] [EC:2.7.1.68]
106911717  phosphatidylinositol 4-phosphate 5-kinase type-1 beta-like isoform X1 [KO:K00889] [EC:2.7.1.68]
106926316  phosphatidylinositol 4-phosphate 5-kinase type-1 gamma-like isoform X1 [KO:K00889] [EC:2.7.1.68]
106921292  phosphatidylinositol 4-phosphate 5-kinase type-1 beta-like [KO:K00889] [EC:2.7.1.68]
106933785  phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform X1 [KO:K13712] [EC:2.7.1.68]
106924602  pip5kl1; phosphatidylinositol 4-phosphate 5-kinase-like protein 1 [KO:K13712] [EC:2.7.1.68]
106904744  pld2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
106907866  phospholipase D1-like isoform X1 [KO:K01115] [EC:3.1.4.4]
106911544  pld1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
106911327  dynamin-1-like [KO:K01528] [EC:3.6.5.5]
106919037  dynamin-3-like [KO:K01528] [EC:3.6.5.5]
106926184  dnm1; dynamin-1 isoform X1 [KO:K01528] [EC:3.6.5.5]
106920983  dnm3; dynamin-3 isoform X1 [KO:K01528] [EC:3.6.5.5]
106932481  dnm2; dynamin-2 isoform X1 [KO:K23484] [EC:3.6.5.5]
106922044  dynamin-2-like isoform X1 [KO:K23484] [EC:3.6.5.5]
106905474  clathrin light chain A-like isoform X1 [KO:K04644]
106911300  cltb; clathrin light chain B isoform X1 [KO:K04645]
106919490  cltc; clathrin heavy chain 1 isoform X1 [KO:K04646]
106915100  clathrin heavy chain 1-like isoform X1 [KO:K04646]
106926606  clathrin heavy chain 1-like isoform X1 [KO:K04646]
106921732  clathrin heavy chain 1-like [KO:K04646]
106909235  AP-2 complex subunit alpha-2-like isoform X1 [KO:K11824]
106925764  AP-2 complex subunit alpha-2 isoform X1 [KO:K11824]
106908947  AP-1 complex subunit beta-1 isoform X1 [KO:K11825]
106934098  ap2m1; AP-2 complex subunit mu isoform X1 [KO:K11826]
106934162  ap2s1; AP-2 complex subunit sigma [KO:K11827]
106916994  ehd2; EH domain-containing protein 2 isoform X1 [KO:K12469]
106922472  EH domain-containing protein 2-like [KO:K12469]
106907484  TGF-beta receptor type-1-like [KO:K04674] [EC:2.7.11.30]
106915864  tgfbr2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
106917549  TGF-beta receptor type-2-like isoform X1 [KO:K04388] [EC:2.7.11.30]
106904266  zinc finger FYVE domain-containing protein 16-like [KO:K04679]
106909809  zfyve9; zinc finger FYVE domain-containing protein 9 [KO:K04679]
106925916  zinc finger FYVE domain-containing protein 9-like isoform X1 [KO:K04679]
106930947  zinc finger FYVE domain-containing protein 9-like [KO:K04679]
106909348  mothers against decapentaplegic homolog 2-like isoform X1 [KO:K04500]
106930500  mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
106924785  mothers against decapentaplegic homolog 3 [KO:K23605]
106914950  transferrin receptor protein 1-like isoform X1 [KO:K06503]
106903610  transferrin receptor protein 1-like [KO:K06503]
106903456  melanoma receptor tyrosine-protein kinase [KO:K04361] [EC:2.7.10.1]
106924542  egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
106924185  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
106903797  fibroblast growth factor receptor 2-like isoform X1 [KO:K05093] [EC:2.7.10.1]
106922536  fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
106908872  fibroblast growth factor receptor 4-like isoform X1 [KO:K05095] [EC:2.7.10.1]
106920161  insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
106915580  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
106904204  cbl; E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
106915552  E3 ubiquitin-protein ligase CBL-like [KO:K04707] [EC:2.3.2.27]
106917666  E3 ubiquitin-protein ligase CBL-like isoform X1 [KO:K22518] [EC:2.3.2.27]
106914951  sh3kbp1; SH3 domain-containing kinase-binding protein 1 isoform X1 [KO:K12470]
106906781  sh3gl3; endophilin-A3 isoform X1 [KO:K11247]
106918639  sh3gl1; endophilin-A2 isoform X1 [KO:K11247]
106926060  endophilin-A1-like [KO:K11247]
106927859  endophilin-A1-like isoform X1 [KO:K11247]
106922386  endophilin-A2-like isoform X1 [KO:K11247]
106912980  endophilin-B1-like [KO:K11248]
106927394  endophilin-B1-like [KO:K11248]
106930523  sh3glb2; endophilin-B2 isoform X1 [KO:K21269]
106924611  endophilin-B2-like [KO:K21269]
106904309  bin1; myc box-dependent-interacting protein 1 isoform X1 [KO:K12562]
106919586  myc box-dependent-interacting protein 1-like isoform X1 [KO:K12562]
106933352  amph; amphiphysin isoform X1 [KO:K12562]
106919546  epsin-1-like isoform X1 [KO:K12471]
106914542  epn2; epsin-2 isoform X1 [KO:K12471]
106916548  epsin-1-like isoform X1 [KO:K12471]
106925877  epn3; epsin-3 isoform X1 [KO:K12471]
106931481  epsin-3-like isoform X1 [KO:K12471]
106914775  eps15l1; epidermal growth factor receptor substrate 15-like 1 isoform X1 [KO:K12472]
106910471  uncharacterized protein LOC106910471 isoform X1 [KO:K12472]
106931814  eps15; epidermal growth factor receptor substrate 15 isoform X1 [KO:K12472]
106910512  spartin-like isoform X1 [KO:K19366]
106922229  spg20; spartin isoform X1 [KO:K19366]
106913992  nedd4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
106918654  nedd4l; E3 ubiquitin-protein ligase NEDD4-like [KO:K13305] [EC:2.3.2.26]
106922714  mdm2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
106907132  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
106917025  rnf41; E3 ubiquitin-protein ligase NRDP1 [KO:K11981] [EC:2.3.2.27]
106923330  itch; E3 ubiquitin-protein ligase Itchy homolog [KO:K05632] [EC:2.3.2.26]
106903371  smurf2; E3 ubiquitin-protein ligase SMURF2 isoform X1 [KO:K04678] [EC:2.3.2.26]
106934056  E3 ubiquitin-protein ligase SMURF2-like [KO:K04678] [EC:2.3.2.26]
106927999  smurf1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
106914573  wwp1; NEDD4-like E3 ubiquitin-protein ligase WWP1 [KO:K05633] [EC:2.3.2.26]
106914624  low-density lipoprotein receptor-like [KO:K12473]
106927660  ldlr; low-density lipoprotein receptor [KO:K12473]
106918214  ldlrap1; low density lipoprotein receptor adapter protein 1 isoform X1 [KO:K12474]
106923249  low density lipoprotein receptor adapter protein 1-like isoform X1 [KO:K12474]
106923993  uncharacterized protein LOC106923993 [KO:K12474]
106924443  low density lipoprotein receptor adapter protein 1-B-like isoform X1 [KO:K12474]
106933872  dab2; disabled homolog 2 isoform X1 [KO:K12475]
106926234  C-C chemokine receptor type 5-like isoform X1 [KO:K04180]
106911187  C-X-C chemokine receptor type 2-like [KO:K05050]
106923175  C-X-C chemokine receptor type 1-like [KO:K05050]
106930586  C-X-C chemokine receptor type 2-like [KO:K05050]
106924949  C-X-C chemokine receptor type 1-like [KO:K05050]
106932351  C-X-C chemokine receptor type 4-like [KO:K04189]
106930916  cxcr4; C-X-C chemokine receptor type 4 [KO:K04189]
106909264  rhodopsin kinase-like [KO:K00909] [EC:2.7.11.14]
106929962  grk7; G protein-coupled receptor kinase 7 [KO:K00909] [EC:2.7.11.14]
106930421  grk1; rhodopsin kinase [KO:K00909] [EC:2.7.11.14]
106925192  rhodopsin kinase-like [KO:K00909] [EC:2.7.11.14]
106931527  G protein-coupled receptor kinase 7B-like [KO:K00909] [EC:2.7.11.14]
106911922  beta-adrenergic receptor kinase 2-like [KO:K00910] [EC:2.7.11.15]
106923393  adrbk2; beta-adrenergic receptor kinase 2 [KO:K00910] [EC:2.7.11.15]
106904625  G protein-coupled receptor kinase 6-like [KO:K08291] [EC:2.7.11.16]
106906345  grk6; G protein-coupled receptor kinase 6 [KO:K08291] [EC:2.7.11.16]
106933814  G protein-coupled receptor kinase 5-like isoform X1 [KO:K08291] [EC:2.7.11.16]
106931005  G protein-coupled receptor kinase 6-like isoform X1 [KO:K08291] [EC:2.7.11.16]
106918570  arrb2; beta-arrestin-2 isoform X1 [KO:K04439]
106929762  beta-arrestin-1 [KO:K04439]
106919367  wasl; neural Wiskott-Aldrich syndrome protein isoform X1 [KO:K23612]
106908381  LOW QUALITY PROTEIN: neural Wiskott-Aldrich syndrome protein-like [KO:K23612]
106929780  wiskott-Aldrich syndrome protein-like [KO:K23612]
106913536  actr2; actin-related protein 2 isoform X1 [KO:K17260]
106917606  actin-related protein 2-like isoform X1 [KO:K17260]
106914882  actin-related protein 3 [KO:K18584]
106910959  actin-related protein 3 [KO:K18584]
106934166  actr3b; actin-related protein 3B isoform X1 [KO:K18584]
106905504  actin-related protein 2/3 complex subunit 1A [KO:K05757]
106905506  actin-related protein 2/3 complex subunit 1B-like [KO:K05757]
106910999  actin-related protein 2/3 complex subunit 1A-like [KO:K05757]
106924950  arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
106918308  arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
106923226  actin-related protein 2/3 complex subunit 4 [KO:K05755]
106929784  actin-related protein 2/3 complex subunit 4-like [KO:K05755]
106913885  arpc5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
106907904  actin-related protein 2/3 complex subunit 5-like [KO:K05754]
106907615  WAS/WASL-interacting protein family member 2-like isoform X1 [KO:K19475]
106908640  wipf2; WAS/WASL-interacting protein family member 2 [KO:K19475]
106923572  WAS/WASL-interacting protein family member 3-like isoform X1 [KO:K19475]
106920235  wipf1; WAS/WASL-interacting protein family member 1 isoform X1 [KO:K19475]
106904509  hspa8; heat shock cognate 71 kDa protein [KO:K03283]
106912783  heat shock cognate 71 kDa protein-like [KO:K03283]
106912818  heat shock cognate 71 kDa protein-like [KO:K03283]
106906759  heat shock 70 kDa protein 1 [KO:K03283]
106918504  heat shock 70 kDa protein-like [KO:K03283]
106921192  dnajc6; putative tyrosine-protein phosphatase auxilin isoform X1 [KO:K09526]
106908811  kiaa1033; WASH complex subunit 7 [KO:K18465]
106923398  kiaa0196; WASH complex subunit strumpellin [KO:K18464]
106916448  WASH complex subunit FAM21-like isoform X1 [KO:K18462]
106915381  WAS protein family homolog 1-like [KO:K18461]
106914471  ccdc53; WASH complex subunit CCDC53 [KO:K18463]
106911716  F-actin-capping protein subunit alpha-2-like [KO:K10364]
106930117  F-actin-capping protein subunit alpha-1-like [KO:K10364]
106924281  capzb; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
106921125  vps29; vacuolar protein sorting-associated protein 29 isoform X1 [KO:K18467]
106906520  vacuolar protein sorting-associated protein 26B-like [KO:K18466]
106922785  vps26a; vacuolar protein sorting-associated protein 26A [KO:K18466]
106929715  vps26b; vacuolar protein sorting-associated protein 26B [KO:K18466]
106924554  vps35; vacuolar protein sorting-associated protein 35 [KO:K18468]
106917144  sorting nexin-12 isoform X1 [KO:K17918]
106921912  snx3; sorting nexin-3 [KO:K17918]
106919695  usp8; ubiquitin carboxyl-terminal hydrolase 8 isoform X1 [KO:K11839] [EC:3.4.19.12]
106919527  STAM-binding protein-like A [KO:K11866] [EC:3.4.19.12]
106905591  ras-related protein Rab-7a-like [KO:K07897]
106933604  rab7a; ras-related protein Rab-7a [KO:K07897]
106929788  ras-related protein Rab-7a [KO:K07897]
106925871  hgs; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
106925851  stam2; signal transducing adapter molecule 2 [KO:K04705]
106924795  stam; signal transducing adapter molecule 1 [KO:K04705]
106917340  tsg101; tumor susceptibility gene 101 protein [KO:K12183]
106904543  multivesicular body subunit 12B-like isoform X1 [KO:K12186]
106908480  mvb12b; multivesicular body subunit 12B [KO:K12186]
106917650  multivesicular body subunit 12B-like [KO:K12186]
106922030  multivesicular body subunit 12A-like [KO:K12186]
106918603  vps28; vacuolar protein sorting-associated protein 28 homolog [KO:K12184]
106907832  vacuolar protein sorting-associated protein 37C-like [KO:K12185]
106916412  vps37a; vacuolar protein sorting-associated protein 37A [KO:K12185]
106909059  vacuolar protein sorting-associated protein 37B-like [KO:K12185]
106932220  vps37b; vacuolar protein sorting-associated protein 37B [KO:K12185]
106915972  snf8; vacuolar-sorting protein SNF8 [KO:K12188]
106914119  vps36; vacuolar protein-sorting-associated protein 36 [KO:K12190]
106919515  vps25; vacuolar protein-sorting-associated protein 25 [KO:K12189]
106915349  chmp6; charged multivesicular body protein 6 [KO:K12195]
106918230  charged multivesicular body protein 6-like [KO:K12195]
106912623  putative charged multivesicular body protein 4B-like protein CHMP4BP1 [KO:K12194]
106920197  chmp4b; charged multivesicular body protein 4b [KO:K12194]
106928447  charged multivesicular body protein 4b-like [KO:K12194]
106915364  charged multivesicular body protein 4c-like [KO:K24782]
106928498  chmp3; charged multivesicular body protein 3 isoform X1 [KO:K12193]
106915976  chmp2a; charged multivesicular body protein 2a [KO:K12191]
106932593  chmp2b; charged multivesicular body protein 2b [KO:K12192]
106927874  chmp7; charged multivesicular body protein 7 isoform X1 [KO:K15053]
106919795  vps4b; vacuolar protein sorting-associated protein 4B isoform X1 [KO:K12196]
106906387  vacuolar protein sorting-associated protein 4B-like [KO:K12196]
106908261  vacuolar protein sorting-associated protein 4A [KO:K12196]
106928455  vacuolar protein sorting-associated protein 4A [KO:K12196]
106903983  vta1; vacuolar protein sorting-associated protein VTA1 homolog [KO:K12199]
106912647  charged multivesicular body protein 1b-like [KO:K12197]
106913055  charged multivesicular body protein 1b-1-like [KO:K12197]
106903685  chmp1a; charged multivesicular body protein 1a [KO:K12197]
106923638  chmp1b; charged multivesicular body protein 1b [KO:K12197]
106916085  charged multivesicular body protein 5 [KO:K12198]
106923679  chmp5; charged multivesicular body protein 5 [KO:K12198]
106924902  ist1; IST1 homolog isoform X1 [KO:K19476]
106918147  pdcd6ip; programmed cell death 6-interacting protein isoform X1 [KO:K12200]
106930659  spg21; maspardin [KO:K19367]
106917223  igf2r; cation-independent mannose-6-phosphate receptor [KO:K06564]
106918985  snx2; sorting nexin-2 isoform X1 [KO:K17917]
106933548  sorting nexin-1-like [KO:K17917]
106922998  sorting nexin-1-like [KO:K17917]
106932296  sorting nexin-6-like [KO:K17920]
106927421  snx6; sorting nexin-6 isoform X1 [KO:K17920]
106929427  snx5; sorting nexin-5 [KO:K17920]
106927666  proto-oncogene tyrosine-protein kinase Src-like isoform X1 [KO:K05704] [EC:2.7.10.2]
106929012  src; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
106917342  hras; GTPase HRas [KO:K02833]
106919790  interleukin-2 receptor subunit beta-like [KO:K05069]
106919791  uncharacterized protein LOC106919791 [KO:K05069]
106906897  interleukin-2 receptor subunit beta-like isoform X1 [KO:K05069]
106912956  cytokine receptor common subunit gamma-like [KO:K05070]
106931257  cytokine receptor common subunit gamma-like isoform X1 [KO:K05070]
106905410  rho-related GTP-binding protein RhoA-B-like [KO:K04513]
106918068  transforming protein RhoA [KO:K04513]
106903887  rho-related GTP-binding protein RhoA-B-like [KO:K04513]
106926573  rho-related GTP-binding protein RhoA-C isoform X1 [KO:K04513]
106925151  rho-related GTP-binding protein RhoA-D isoform X1 [KO:K04513]
106931696  rho-related GTP-binding protein RhoA-A-like [KO:K04513]
106931768  rho-related GTP-binding protein RhoC-like [KO:K04513]
106912044  major histocompatibility complex class I-related gene protein-like [KO:K06751]
106912079  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
106912684  IgG receptor FcRn large subunit p51-like isoform X1 [KO:K06751]
106919504  major histocompatibility complex class I-related gene protein-like [KO:K06751]
106913258  zinc-alpha-2-glycoprotein-like [KO:K06751]
106913259  patr class I histocompatibility antigen, B-1 alpha chain-like [KO:K06751]
106909533  major histocompatibility complex class I-related gene protein-like [KO:K06751]
106911450  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
106911451  major histocompatibility complex class I-related gene protein-like [KO:K06751]
106911452  major histocompatibility complex class I-related gene protein-like [KO:K06751]
106934274  major histocompatibility complex class I-related gene protein-like [KO:K06751]
106929973  H-2 class I histocompatibility antigen, L-D alpha chain-like [KO:K06751]
106929982  H-2 class I histocompatibility antigen, L-D alpha chain-like [KO:K06751]
106927653  riboflavin-binding protein-like [KO:K13649]
106927835  folr2; folate receptor beta [KO:K13649]
106930676  caveolin-1 [KO:K06278]
106919601  caveolin-2-like [KO:K12958]
106910273  caveolin-2-like isoform X1 [KO:K12958]
106918478  caveolin-2-like [KO:K12958]
106923748  caveolin-2-like [KO:K12958]
106918476  cav3; caveolin-3 [KO:K12959]
106917077  EH domain-containing protein 3 [KO:K12476]
106910136  EH domain-containing protein 4-like isoform X1 [KO:K12477]
106916048  eea1; early endosome antigen 1 isoform X1 [KO:K12478]
106927543  ras-related protein Rab-5A [KO:K07887]
106929564  ras-related protein Rab-5A-like [KO:K07887]
106906665  ras-related protein Rab-5B-like [KO:K07888]
106932477  ras-related protein Rab-5B-like [KO:K07888]
106926197  ras-related protein Rab-5C-like [KO:K07889]
106921571  rab5c; ras-related protein Rab-5C [KO:K07889]
106904054  rabep1; rab GTPase-binding effector protein 1 isoform X1 [KO:K12480]
106905579  rbsn; rabenosyn-5 isoform X1 [KO:K12481]
106924152  rab4a; ras-related protein Rab-4A [KO:K07879]
106906326  RUN and FYVE domain-containing protein 1-like [KO:K12482]
106909222  rufy2; RUN and FYVE domain-containing protein 2 isoform X1 [KO:K12482]
106930329  EH domain-containing protein 1-like [KO:K12483]
106928523  vps45; vacuolar protein sorting-associated protein 45 isoform X1 [KO:K12479]
106910775  sorting nexin-4-like [KO:K17919]
106911220  sorting nexin-4-like isoform X1 [KO:K17919]
106921613  rab31; ras-related protein Rab-31 [KO:K07891]
106929008  rab22a; ras-related protein Rab-22A [KO:K07891]
106926996  rab10; ras-related protein Rab-10 [KO:K07903]
106914769  ras-related protein Rab-8A [KO:K07901]
106929578  ras-related protein Rab-8A [KO:K07901]
106903396  rab35; ras-related protein Rab-35 isoform X1 [KO:K07876]
106923665  ras-related protein Rab-35-like [KO:K07876]
106904672  ras-related protein Rab-11A-like [KO:K07904]
106909692  ras-related protein Rab-11A [KO:K07904]
106920194  ras-related protein Rab-11B-like [KO:K07905]
106917762  ras-related protein Rab-11B [KO:K07905]
106917763  ras-related protein Rab-11B-like [KO:K07905]
106919378  rab11 family-interacting protein 1-like isoform X1 [KO:K12484]
106915002  rab11 family-interacting protein 1-like isoform X1 [KO:K12484]
106925811  rab11 family-interacting protein 1-like isoform X1 [KO:K12484]
106924210  rab11fip2; rab11 family-interacting protein 2 [KO:K12484]
106925511  rab11fip1; rab11 family-interacting protein 1 [KO:K12484]
106903638  zfyve27; protrudin isoform X1 [KO:K19368]
106905706  kif5c; kinesin heavy chain isoform 5C [KO:K10396]
106915189  kinesin-1 heavy chain-like isoform X1 [KO:K10396]
106906931  kinesin-1 heavy chain [KO:K10396]
106915585  kinesin heavy chain isoform 5A-like [KO:K10396]
106908438  kinesin heavy chain isoform 5C-like [KO:K10396]
106928430  kif5a; kinesin heavy chain isoform 5A isoform X1 [KO:K10396]
106914954  rab11fip4; rab11 family-interacting protein 4 isoform X1 [KO:K12485]
106929869  rab11fip3; rab11 family-interacting protein 3 isoform X1 [KO:K12485]
106930216  rab11 family-interacting protein 4A-like [KO:K12485]
106929164  partitioning defective 3 homolog isoform X1 [KO:K04237]
106931385  partitioning defective 3 homolog [KO:K04237]
106905206  partitioning defective 6 homolog alpha-like [KO:K06093]
106914450  partitioning defective 6 homolog gamma-like [KO:K06093]
106933639  pard6b; partitioning defective 6 homolog beta [KO:K06093]
106932765  prkcz; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
106916189  prkci; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
106919891  cell division control protein 42 homolog [KO:K04393]
106905228  cell division control protein 42 homolog [KO:K04393]
106933042  cell division control protein 42 homolog [KO:K04393]
106927935  cell division control protein 42 homolog isoform X1 [KO:K04393]
106922247  cell division control protein 42 homolog isoform X1 [KO:K04393]
106912397  stromal membrane-associated protein 1-like [KO:K12486]
106915386  stromal membrane-associated protein 2-like [KO:K12486]
106930920  stromal membrane-associated protein 1-like isoform X1 [KO:K12486]
106925158  git1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
106904865  ARF GTPase-activating protein GIT2-like isoform X1 [KO:K12487]
106918313  git2; ARF GTPase-activating protein GIT2 isoform X1 [KO:K12487]
106928436  asap3; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12488]
106928628  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2-like isoform X1 [KO:K12488]
106929902  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1-like [KO:K12488]
106929947  LOW QUALITY PROTEIN: arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1-like [KO:K12488]
106925342  asap2; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12488]
106909718  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3-like isoform X1 [KO:K12489]
106932585  acap2; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12489]
106933692  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3-like [KO:K12489]
106934131  acap1; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 [KO:K12489]
106928403  acap3; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12489]
106931322  arap1; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K18439]
106918552  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1-like [KO:K18440]
106923613  arap2; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 [KO:K18440]
106922903  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3-like isoform X1 [KO:K12490]
106930559  agap3; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12491]
106924461  agap1; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12491]
106920721  agap2; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K17848]
106923267  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1-like [KO:K17848]
106906823  arfgap1; ADP-ribosylation factor GTPase-activating protein 1 isoform X1 [KO:K12492]
106914480  arfgap3; ADP-ribosylation factor GTPase-activating protein 3 [KO:K12493]
106910584  arfgap2; ADP-ribosylation factor GTPase-activating protein 2 isoform X1 [KO:K12493]
106915994  PH and SEC7 domain-containing protein 1-like isoform X1 [KO:K12494]
106917421  PH and SEC7 domain-containing protein 2-like [KO:K12494]
106903847  uncharacterized protein LOC106903847 isoform X1 [KO:K12494]
106921454  PH and SEC7 domain-containing protein 2-like [KO:K12494]
106915396  IQ motif and SEC7 domain-containing protein 3-like [KO:K12495]
106915887  IQ motif and SEC7 domain-containing protein 2-like isoform X1 [KO:K12495]
106903673  IQ motif and SEC7 domain-containing protein 1-like isoform X1 [KO:K12495]
106911202  iqsec1; IQ motif and SEC7 domain-containing protein 1 isoform X1 [KO:K12495]
106932526  IQ motif and SEC7 domain-containing protein 1-like isoform X1 [KO:K12495]
106931840  IQ motif and SEC7 domain-containing protein 3-like isoform X1 [KO:K12495]
106920077  cytohesin-1 isoform X1 [KO:K18441]
106909539  cytohesin-2 isoform X1 [KO:K18441]
106909698  cytohesin-3-like [KO:K18441]
106925840  cytohesin-3 [KO:K18441]
106927466  cyth1; cytohesin-1 isoform X1 [KO:K18441]
106934044  cytohesin-2-like isoform X1 [KO:K18441]
106928257  cytohesin-3-like [KO:K18441]
106923891  cytohesin-3-like [KO:K18441]
106933637  arfgef2; brefeldin A-inhibited guanine nucleotide-exchange protein 2 isoform X1 [KO:K18442]
106934308  arfgef1; brefeldin A-inhibited guanine nucleotide-exchange protein 1 isoform X1 [KO:K18442]
106916519  gbf1; Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X1 [KO:K18443]
106905864  ADP-ribosylation factor 1-like [KO:K07937]
106917290  ADP-ribosylation factor 1 [KO:K07937]
106925137  ADP-ribosylation factor 1-like [KO:K07937]
106906313  ADP-ribosylation factor 3 [KO:K07938]
106921537  ADP-ribosylation factor 3 isoform X1 [KO:K07938]
106906158  ADP-ribosylation factor 4-like [KO:K07939]
106926908  ADP-ribosylation factor 4 [KO:K07939]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
pmei04060  Cytokine-cytokine receptor interaction
pmei04070  Phosphatidylinositol signaling system
pmei04130  SNARE interactions in vesicular transport
pmei04142  Lysosome
pmei04350  TGF-beta signaling pathway
KO pathway
ko04144   
LinkDB

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