KEGG   PATHWAY: pret04144
Entry
pret04144                   Pathway                                
Name
Endocytosis - Poecilia reticulata (guppy)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
pret04144  Endocytosis
pret04144

Other DBs
GO: 0006897
Organism
Poecilia reticulata (guppy) [GN:pret]
Gene
103457904  ADP-ribosylation factor 6 [KO:K07941]
103459005  ADP-ribosylation factor 6-like [KO:K07941]
103463717  pip5k1c; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
103470419  phosphatidylinositol 4-phosphate 5-kinase type-1 beta-like [KO:K00889] [EC:2.7.1.68]
103474080  pip5k1b; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
103472720  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like isoform X1 [KO:K00889] [EC:2.7.1.68]
103478143  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like isoform X2 [KO:K00889] [EC:2.7.1.68]
103479280  phosphatidylinositol 4-phosphate 5-kinase type-1 gamma-like [KO:K00889] [EC:2.7.1.68]
103469625  phosphatidylinositol 4-phosphate 5-kinase-like protein 1 [KO:K13712] [EC:2.7.1.68]
103474111  pip5kl1; phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform X1 [KO:K13712] [EC:2.7.1.68]
103457001  phospholipase D1 [KO:K01115] [EC:3.1.4.4]
103458417  phospholipase D1-like [KO:K01115] [EC:3.1.4.4]
103475777  phospholipase D1 [KO:K01115] [EC:3.1.4.4]
103463775  dnm3; dynamin-3 isoform X1 [KO:K01528] [EC:3.6.5.5]
103478984  dynamin-3-like [KO:K01528] [EC:3.6.5.5]
103473827  dnm1; dynamin-1 isoform X7 [KO:K01528] [EC:3.6.5.5]
103460405  dynamin-1-like [KO:K01528] [EC:3.6.5.5]
103462224  dynamin-2-like isoform X1 [KO:K23484] [EC:3.6.5.5]
103468779  dnm2; dynamin-2 isoform X1 [KO:K23484] [EC:3.6.5.5]
103468048  clta; clathrin light chain A isoform X1 [KO:K04644]
103471122  clathrin light chain B isoform X1 [KO:K04645]
103470020  cltcl1; clathrin heavy chain 2 isoform X2 [KO:K04646]
103474743  clathrin heavy chain 1 isoform X1 [KO:K04646]
103476094  cltc; clathrin heavy chain 1 isoform X1 [KO:K04646]
103462258  AP-2 complex subunit alpha-2 isoform X1 [KO:K11824]
103468143  AP-2 complex subunit alpha-2-like isoform X1 [KO:K11824]
103476383  AP-1 complex subunit beta-1 isoform X1 [KO:K11825]
103479321  ap2m1; AP-2 complex subunit mu isoform X1 [KO:K11826]
103474624  ap2s1; AP-2 complex subunit sigma [KO:K11827]
103474429  EH domain-containing protein 2-like [KO:K12469]
103475062  ehd2; EH domain-containing protein 2 isoform X1 [KO:K12469]
103482409  TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
103465886  tgfbr2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
103472661  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
103463594  zinc finger FYVE domain-containing protein 9-like isoform X1 [KO:K04679]
103473219  zinc finger FYVE domain-containing protein 16 [KO:K04679]
103479913  zfyve9; zinc finger FYVE domain-containing protein 9 [KO:K04679]
103469777  mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
103466539  mothers against decapentaplegic homolog 3-like [KO:K23605]
103462102  mothers against decapentaplegic homolog 3 [KO:K23605]
103456751  transferrin receptor protein 1-like [KO:K06503]
103479192  transferrin receptor protein 1-like [KO:K06503]
103456976  melanoma receptor tyrosine-protein kinase [KO:K04361] [EC:2.7.10.1]
103479868  egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
103463840  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
103477293  fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
103458160  fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
103462605  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
103466654  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
103476312  E3 ubiquitin-protein ligase CBL-like [KO:K04707] [EC:2.3.2.27]
103474573  cbl; E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
103477907  E3 ubiquitin-protein ligase CBL isoform X1 [KO:K22518] [EC:2.3.2.27]
103456752  sh3kbp1; SH3 domain-containing kinase-binding protein 1 isoform X1 [KO:K12470]
103463611  sh3gl1; endophilin-A2 [KO:K11247]
103466777  sh3gl3; endophilin-A3 isoform X1 [KO:K11247]
103472977  sh3gl2; endophilin-A1 isoform X2 [KO:K11247]
103479275  endophilin-A2-like isoform X1 [KO:K11247]
103480908  endophilin-A1-like [KO:K11247]
103482296  endophilin-B1-like [KO:K11248]
103458427  endophilin-B1-like [KO:K21269]
103461072  endophilin-B2-like [KO:K21269]
103474097  sh3glb2; endophilin-B2 [KO:K21269]
103460773  amph; amphiphysin isoform X1 [KO:K12562]
103461634  bin1; myc box-dependent-interacting protein 1 isoform X1 [KO:K12562]
103457123  myc box-dependent-interacting protein 1-like [KO:K12562]
103467039  epsin-3 isoform X1 [KO:K12471]
103469151  epn2; epsin-2 [KO:K12471]
103468803  epsin-3-like isoform X1 [KO:K12471]
103478045  epn1; epsin-1 isoform X1 [KO:K12471]
103464071  eps15; epidermal growth factor receptor substrate 15 isoform X1 [KO:K12472]
103464192  epidermal growth factor receptor substrate 15-like 1 isoform X1 [KO:K12472]
103479878  epidermal growth factor receptor substrate 15-like 1 [KO:K12472]
103479233  uncharacterized protein LOC103479233 isoform X1 [KO:K12472]
103475563  spg20; spartin isoform X1 [KO:K19366]
103474976  spartin-like isoform X1 [KO:K19366]
103462529  nedd4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
103473874  nedd4l; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
103459095  mdm2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
103462724  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
103467781  rnf41; E3 ubiquitin-protein ligase NRDP1 [KO:K11981] [EC:2.3.2.27]
103464828  E3 ubiquitin-protein ligase Itchy-like [KO:K05632] [EC:2.3.2.26]
103467052  itch; E3 ubiquitin-protein ligase Itchy homolog isoform X2 [KO:K05632] [EC:2.3.2.26]
103468478  smurf1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
103471952  smurf2; E3 ubiquitin-protein ligase SMURF2 isoform X1 [KO:K04678] [EC:2.3.2.26]
103468522  E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
103482265  wwp1; NEDD4-like E3 ubiquitin-protein ligase WWP1 [KO:K05633] [EC:2.3.2.26]
103468275  low-density lipoprotein receptor-like [KO:K12473]
103468516  ldlr; low-density lipoprotein receptor [KO:K12473]
103457621  low density lipoprotein receptor adapter protein 1-like [KO:K12474]
103458647  ldlrap1; low density lipoprotein receptor adapter protein 1 isoform X1 [KO:K12474]
103472050  low density lipoprotein receptor adapter protein 1-A-like isoform X1 [KO:K12474]
103480522  uncharacterized protein LOC103480522 [KO:K12474]
103473347  dab2; disabled homolog 2 isoform X1 [KO:K12475]
103478363  C-C chemokine receptor type 5-like [KO:K04180]
103478366  C-C chemokine receptor type 5-like isoform X1 [KO:K04180]
103461891  LOW QUALITY PROTEIN: C-X-C chemokine receptor type 2-like [KO:K05050]
103461814  C-X-C chemokine receptor type 1-like [KO:K05050]
103474633  C-X-C chemokine receptor type 1-like [KO:K05050]
103460829  cxcr4; C-X-C chemokine receptor type 4 [KO:K04189]
103478845  C-X-C chemokine receptor type 4-like [KO:K04189]
103461969  grk1; rhodopsin kinase [KO:K00909] [EC:2.7.11.14]
103475792  rhodopsin kinase-like [KO:K00909] [EC:2.7.11.14]
103474448  rhodopsin kinase 2-like [KO:K00909] [EC:2.7.11.14]
103479099  grk7; rhodopsin kinase [KO:K00909] [EC:2.7.11.14]
103480054  rhodopsin kinase-like [KO:K00909] [EC:2.7.11.14]
103473184  beta-adrenergic receptor kinase 2 isoform X1 [KO:K00910] [EC:2.7.11.15]
103464439  grk4; G protein-coupled receptor kinase 4 isoform X1 [KO:K08291] [EC:2.7.11.16]
103473195  G protein-coupled receptor kinase 6-like [KO:K08291] [EC:2.7.11.16]
103476239  grk6; G protein-coupled receptor kinase 6 [KO:K08291] [EC:2.7.11.16]
103470661  G protein-coupled receptor kinase 5-like [KO:K08291] [EC:2.7.11.16]
103459883  arrb2; beta-arrestin-2 isoform X1 [KO:K04439]
103475316  beta-arrestin-1-like [KO:K04439]
103465991  neural Wiskott-Aldrich syndrome protein-like [KO:K23612]
103465239  wiskott-Aldrich syndrome protein-like [KO:K23612]
103459422  wasl; neural Wiskott-Aldrich syndrome protein [KO:K23612]
103476483  actr2; actin-related protein 2 isoform X1 [KO:K17260]
103475930  actin-related protein 2-like isoform X1 [KO:K17260]
103460840  actin-related protein 3-like [KO:K18584]
103460163  actin-related protein 3B-like isoform X2 [KO:K18584]
103473589  actr3; actin-related protein 3 [KO:K18584]
103460841  actin-related protein 3-like [KO:K18584]
103462249  actin-related protein 2/3 complex subunit 1A [KO:K05757]
103462254  actin-related protein 2/3 complex subunit 1B [KO:K05757]
103468132  actin-related protein 2/3 complex subunit 1A-like isoform X1 [KO:K05757]
103476891  arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
103473592  arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
103465077  arpc4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
103465240  actin-related protein 2/3 complex subunit 4-like [KO:K05755]
103468246  actin-related protein 2/3 complex subunit 5-like [KO:K05754]
103479201  actin-related protein 2/3 complex subunit 5-like [KO:K05754]
103472210  WAS/WASL-interacting protein family member 3-like isoform X1 [KO:K19475]
103476649  wipf1; WAS/WASL-interacting protein family member 1 isoform X1 [KO:K19475]
103470340  wipf2; WAS/WASL-interacting protein family member 2 [KO:K19475]
103460283  hspa8; heat shock cognate 71 kDa protein [KO:K03283]
103467171  heat shock 70 kDa protein-like [KO:K03283]
103469482  heat shock 70 kDa protein 1 [KO:K03283]
103469489  heat shock 70 kDa protein 1-like [KO:K03283]
103474213  heat shock cognate 71 kDa protein-like [KO:K03283]
103478507  heat shock cognate 71 kDa protein-like isoform X1 [KO:K03283]
103468265  dnajc6; putative tyrosine-protein phosphatase auxilin isoform X1 [KO:K09526]
103466189  kiaa1033; WASH complex subunit 7 [KO:K18465]
103478345  kiaa0196; WASH complex subunit strumpellin [KO:K18464]
103476888  fam21c; WASH complex subunit FAM21C isoform X1 [KO:K18462]
103466672  wash1; WAS protein family homolog 1 [KO:K18461]
103459181  ccdc53; WASH complex subunit CCDC53 [KO:K18463]
103465634  capza2; F-actin-capping protein subunit alpha-2 [KO:K10364]
103467451  capza1; F-actin-capping protein subunit alpha-1 [KO:K10364]
103465173  capzb; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
103458147  vps29; vacuolar protein sorting-associated protein 29 isoform X1 [KO:K18467]
103462847  vps26a; vacuolar protein sorting-associated protein 26A [KO:K18466]
103474205  vps26b; vacuolar protein sorting-associated protein 26B [KO:K18466]
103476205  vacuolar protein sorting-associated protein 26B-like [KO:K18466]
103462348  vps35; vacuolar protein sorting-associated protein 35 [KO:K18468]
103457490  snx3; sorting nexin-3 [KO:K17918]
103475387  snx12; sorting nexin-12 isoform X1 [KO:K17918]
103462055  usp8; ubiquitin carboxyl-terminal hydrolase 8 isoform X1 [KO:K11839] [EC:3.4.19.12]
103469790  STAM-binding protein-like A [KO:K11866] [EC:3.4.19.12]
103470718  STAM-binding protein-like A [KO:K11866] [EC:3.4.19.12]
103465062  ras-related protein Rab-7a-like [KO:K07897]
103465551  ras-related protein Rab-7a-like [KO:K07897]
103465242  ras-related protein Rab-7a [KO:K07897]
103468795  hgs; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
103478464  stam2; signal transducing adapter molecule 2 [KO:K04705]
103479819  stam; signal transducing adapter molecule 1 [KO:K04705]
103466146  tsg101; tumor susceptibility gene 101 protein [KO:K12183]
103463724  mvb12a; multivesicular body subunit 12A [KO:K12186]
103470619  multivesicular body subunit 12B-like isoform X3 [KO:K12186]
103473113  mvb12b; multivesicular body subunit 12B isoform X1 [KO:K12186]
103472381  vps28; vacuolar protein sorting-associated protein 28 homolog [KO:K12184]
103467096  vps37a; vacuolar protein sorting-associated protein 37A isoform X1 [KO:K12185]
103469548  vps37b; vacuolar protein sorting-associated protein 37B isoform X1 [KO:K12185]
103470412  vacuolar protein sorting-associated protein 37C-like [KO:K12185]
103476297  vacuolar protein sorting-associated protein 37D [KO:K12185]
103481729  snf8; vacuolar-sorting protein SNF8 [KO:K12188]
103475511  vps36; vacuolar protein-sorting-associated protein 36 [KO:K12190]
103481668  vps25; vacuolar protein-sorting-associated protein 25 [KO:K12189]
103468818  charged multivesicular body protein 6-like [KO:K12195]
103481849  chmp6; charged multivesicular body protein 6 [KO:K12195]
103464227  charged multivesicular body protein 4b-like [KO:K12194]
103468028  charged multivesicular body protein 4b [KO:K12194]
103466310  charged multivesicular body protein 4b-like [KO:K24782]
103456882  chmp4c; charged multivesicular body protein 4c [KO:K24782]
103458925  chmp3; charged multivesicular body protein 3 isoform X1 [KO:K12193]
103481732  chmp2a; charged multivesicular body protein 2a [KO:K12191]
103461393  chmp2b; charged multivesicular body protein 2b [KO:K12192]
103469669  chmp7; charged multivesicular body protein 7 isoform X1 [KO:K15053]
103466308  vps4a; vacuolar protein sorting-associated protein 4A [KO:K12196]
103463808  vacuolar protein sorting-associated protein 4B-like [KO:K12196]
103479576  vps4b; vacuolar protein sorting-associated protein 4B isoform X1 [KO:K12196]
103457175  vta1; vacuolar protein sorting-associated protein VTA1 homolog [KO:K12199]
103466847  chmp1a; charged multivesicular body protein 1a [KO:K12197]
103475717  chmp1b; charged multivesicular body protein 1b [KO:K12197]
103470937  charged multivesicular body protein 1b-like [KO:K12197]
103456856  charged multivesicular body protein 5 [KO:K12198]
103479829  chmp5; charged multivesicular body protein 5 [KO:K12198]
103462389  ist1; IST1 homolog isoform X1 [KO:K19476]
103472325  pdcd6ip; programmed cell death 6-interacting protein isoform X1 [KO:K12200]
103462277  spg21; maspardin [KO:K19367]
103457232  igf2r; cation-independent mannose-6-phosphate receptor [KO:K06564]
103465960  sorting nexin-1-like [KO:K17917]
103470819  snx2; sorting nexin-2 isoform X1 [KO:K17917]
103462143  snx1; sorting nexin-1 [KO:K17917]
103458253  snx6; sorting nexin-6 [KO:K17920]
103465350  sorting nexin-6-like [KO:K17920]
103477217  snx5; sorting nexin-5 [KO:K17920]
103464669  proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
103467856  proto-oncogene tyrosine-protein kinase Src-like isoform X1 [KO:K05704] [EC:2.7.10.2]
103466143  hras; GTPase HRas [KO:K02833]
103468486  interleukin-2 receptor subunit beta-like [KO:K05069]
103478275  uncharacterized protein LOC103478275 [KO:K05069]
103475386  cytokine receptor common subunit gamma-like isoform X1 [KO:K05070]
103465141  transforming protein RhoA [KO:K04513]
103467398  rho-related GTP-binding protein RhoA-D isoform X1 [KO:K04513]
103467436  rho-related GTP-binding protein RhoA-C-like [KO:K04513]
103466989  rho-related GTP-binding protein RhoA-C [KO:K04513]
103467136  rho-related GTP-binding protein RhoA-B-like [KO:K04513]
103472866  major histocompatibility complex class I-related gene protein-like [KO:K06751]
103472932  major histocompatibility complex class I-related gene protein-like [KO:K06751]
103472949  major histocompatibility complex class I-related gene protein-like [KO:K06751]
103460910  H-2 class I histocompatibility antigen, K-K alpha chain-like [KO:K06751]
103460912  H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
103472788  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
103472869  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
103472924  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
103472938  H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
103472940  LOW QUALITY PROTEIN: major histocompatibility complex class I-related gene protein-like [KO:K06751]
103472944  H-2 class I histocompatibility antigen, K-K alpha chain-like [KO:K06751]
103472943  major histocompatibility complex class I-related gene protein-like [KO:K06751]
103472789  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
103461177  major histocompatibility complex class I-related gene protein-like [KO:K06751]
103461488  major histocompatibility complex class I-related gene protein-like [KO:K06751]
103472950  major histocompatibility complex class I-related gene protein-like [KO:K06751]
103472945  major histocompatibility complex class I-related gene protein-like [KO:K06751]
103472922  LOW QUALITY PROTEIN: major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
103472933  major histocompatibility complex class I-related gene protein-like [KO:K06751]
103468372  rtbdn; retbindin isoform X2 [KO:K13649]
103474473  folr2; folate receptor beta [KO:K13649]
103465631  cav2; caveolin-2 isoform X1 [KO:K12958]
103465217  caveolin-2-like [KO:K12958]
103464552  caveolin-2-like [KO:K12958]
103466888  caveolin-2-like [KO:K12958]
103465216  cav3; caveolin-3 [KO:K12959]
103457740  EH domain-containing protein 3 [KO:K12476]
103458107  EH domain-containing protein 4-like isoform X2 [KO:K12477]
103466097  eea1; early endosome antigen 1 [KO:K12478]
103472355  rab5a; ras-related protein Rab-5A [KO:K07887]
103477863  ras-related protein Rab-5A-like [KO:K07887]
103481860  ras-related protein Rab-5B-like [KO:K07888]
103469407  rab5c; ras-related protein Rab-5C [KO:K07889]
103481258  ras-related protein Rab-5C [KO:K07889]
103476292  rabep1; rab GTPase-binding effector protein 1 isoform X1 [KO:K12480]
103467523  rbsn; rabenosyn-5 [KO:K12481]
103462809  rab4a; ras-related protein Rab-4A [KO:K07879]
103471126  RUN and FYVE domain-containing protein 1-like [KO:K12482]
103462821  rufy2; RUN and FYVE domain-containing protein 2 isoform X1 [KO:K12482]
103471421  EH domain-containing protein 1-like isoform X1 [KO:K12483]
103472556  vps45; vacuolar protein sorting-associated protein 45 isoform X1 [KO:K12479]
103461636  sorting nexin-4-like [KO:K17919]
103459747  sorting nexin-4-like [KO:K17919]
103464666  rab22a; ras-related protein Rab-22A [KO:K07891]
103479733  rab31; ras-related protein Rab-31 [KO:K07891]
103457277  rab10; ras-related protein Rab-10 [KO:K07903]
103463528  rab8a; ras-related protein Rab-8A [KO:K07901]
103479775  ras-related protein Rab-8A isoform X1 [KO:K07901]
103460653  ras-related protein Rab-35-like [KO:K07876]
103469534  rab35; ras-related protein Rab-35 isoform X1 [KO:K07876]
103460107  ras-related protein Rab-11A [KO:K07904]
103477555  ras-related protein Rab-11A-like [KO:K07904]
103463719  ras-related protein Rab-11B-like [KO:K07905]
103463721  ras-related protein Rab-11B-like [KO:K07905]
103479314  ras-related protein Rab-11B [KO:K07905]
103458179  uncharacterized protein LOC103458179 isoform X1 [KO:K12484]
103471510  rab11 family-interacting protein 1-like isoform X1 [KO:K12484]
103470525  rab11 family-interacting protein 1-like isoform X1 [KO:K12484]
103477129  rab11fip2; rab11 family-interacting protein 2 [KO:K12484]
103473715  rab11fip1; rab11 family-interacting protein 1 [KO:K12484]
103465788  zfyve27; protrudin isoform X2 [KO:K19368]
103457469  kif5c; kinesin heavy chain [KO:K10396]
103464406  kinesin heavy chain isoform X1 [KO:K10396]
103460122  kinesin heavy chain-like [KO:K10396]
103467251  kinesin heavy chain-like [KO:K10396]
103479480  kinesin-1 heavy chain [KO:K10396]
103482337  kif5b; kinesin-1 heavy chain isoform X1 [KO:K10396]
103468194  rab11 family-interacting protein 4A-like [KO:K12485]
103468621  rab11fip4; rab11 family-interacting protein 4 isoform X2 [KO:K12485]
103481088  rab11fip3; rab11 family-interacting protein 3 isoform X1 [KO:K12485]
103479466  pard3; partitioning defective 3 homolog isoform X1 [KO:K04237]
103482325  partitioning defective 3 homolog isoform X1 [KO:K04237]
103465768  partitioning defective 6 homolog alpha-like isoform X1 [KO:K06093]
103466907  pard6b; partitioning defective 6 homolog beta [KO:K06093]
103472428  pard6g; partitioning defective 6 homolog gamma [KO:K06093]
103466966  prkcz; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
103479885  prkci; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
103465423  cell division control protein 42 homolog isoform X1 [KO:K04393]
103467678  cell division control protein 42 homolog isoform X1 [KO:K04393]
103472837  cell division control protein 42 homolog [KO:K04393]
103477991  cell division control protein 42 homolog isoform X1 [KO:K04393]
103477993  cell division control protein 42 homolog [KO:K04393]
103465175  stromal membrane-associated protein 1-like [KO:K12486]
103472177  stromal membrane-associated protein 2-like [KO:K12486]
103477312  smap1; stromal membrane-associated protein 1 [KO:K12486]
103474807  git1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
103473760  ARF GTPase-activating protein GIT2-like isoform X1 [KO:K12487]
103470331  git2; ARF GTPase-activating protein GIT2 isoform X1 [KO:K12487]
103457155  asap2; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 [KO:K12488]
103456836  asap1; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12488]
103459941  asap3; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12488]
103464795  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2-like isoform X1 [KO:K12488]
103458854  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 [KO:K12488]
103460059  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3-like isoform X1 [KO:K12489]
103461083  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3-like isoform X1 [KO:K12489]
103463472  acap2; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12489]
103464920  acap3; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12489]
103480479  acap1; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 [KO:K12489]
103459901  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1-like [KO:K18439]
103474463  arap1; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K18439]
103480503  arap2; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 [KO:K18440]
103471782  arap3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
103456779  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1-like isoform X1 [KO:K12491]
103479692  agap3; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12491]
103465330  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1-like [KO:K17848]
103467903  agap2; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K17848]
103465278  arfgap1; ADP-ribosylation factor GTPase-activating protein 1 isoform X1 [KO:K12492]
103459189  arfgap3; ADP-ribosylation factor GTPase-activating protein 3 [KO:K12493]
103460819  arfgap2; ADP-ribosylation factor GTPase-activating protein 2 [KO:K12493]
103473807  PH and SEC7 domain-containing protein 2-like [KO:K12494]
103471049  psd2; PH and SEC7 domain-containing protein 2 [KO:K12494]
103477395  PH and SEC7 domain-containing protein 1-like [KO:K12494]
103481754  PH and SEC7 domain-containing protein 1-like isoform X1 [KO:K12494]
103465482  IQ motif and SEC7 domain-containing protein 1-like isoform X7 [KO:K12495]
103459247  iqsec3; IQ motif and SEC7 domain-containing protein 3 isoform X1 [KO:K12495]
103467579  IQ motif and SEC7 domain-containing protein 1 isoform X1 [KO:K12495]
103467712  LOW QUALITY PROTEIN: IQ motif and SEC7 domain-containing protein 2-like [KO:K12495]
103466704  IQ motif and SEC7 domain-containing protein 3 [KO:K12495]
103469219  cytohesin-3-like [KO:K18441]
103468843  cyth1; cytohesin-1 isoform X3 [KO:K18441]
103478093  cyth2; cytohesin-2 [KO:K18441]
103479743  cytohesin-1-like [KO:K18441]
103481821  cytohesin-1-like [KO:K18441]
103481978  cytohesin-3 [KO:K18441]
103456590  arfgef1; brefeldin A-inhibited guanine nucleotide-exchange protein 1 isoform X1 [KO:K18442]
103466908  arfgef2; brefeldin A-inhibited guanine nucleotide-exchange protein 2 [KO:K18442]
103476528  gbf1; Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X1 [KO:K18443]
103468656  ADP-ribosylation factor 1-like [KO:K07937]
103479702  arf1; ADP-ribosylation factor 1 [KO:K07937]
103481611  ADP-ribosylation factor 1 [KO:K07937]
103465261  ADP-ribosylation factor 3 [KO:K07938]
103467363  arf3; ADP-ribosylation factor 3 [KO:K07938]
103466027  ADP-ribosylation factor 4-like [KO:K07939]
103459372  ADP-ribosylation factor 4 [KO:K07939]
103464348  arf4; ADP-ribosylation factor 4 isoform X1 [KO:K07939]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
pret04060  Cytokine-cytokine receptor interaction
pret04070  Phosphatidylinositol signaling system
pret04130  SNARE interactions in vesicular transport
pret04142  Lysosome
pret04350  TGF-beta signaling pathway
KO pathway
ko04144   
LinkDB

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