KEGG   PATHWAY: pruf00230
Entry
pruf00230                   Pathway                                
Name
Purine metabolism - Pyrgilauda ruficollis (rufous-necked snowfinch)
Class
Metabolism; Nucleotide metabolism
Pathway map
pruf00230  Purine metabolism
pruf00230

Module
pruf_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:pruf00230]
pruf_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:pruf00230]
pruf_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:pruf00230]
pruf_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:pruf00230]
pruf_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:pruf00230]
pruf_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:pruf00230]
Other DBs
GO: 0006163 0042278
Organism
Pyrgilauda ruficollis (rufous-necked snowfinch) [GN:pruf]
Gene
121360244  NUDT9; ADP-ribose pyrophosphatase, mitochondrial isoform X1 [KO:K13988] [EC:3.6.1.13]
121352717  ADPRM; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
121362338  NUDT5; ADP-sugar pyrophosphatase isoform X1 [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
121362143  PGM1; phosphoglucomutase-1 isoform X1 [KO:K01835] [EC:5.4.2.2]
121348769  PGM2; phosphoglucomutase-2 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
121356186  PRPS2; ribose-phosphate pyrophosphokinase 2 isoform X1 [KO:K00948] [EC:2.7.6.1]
121363025  PRPS1; ribose-phosphate pyrophosphokinase 1 [KO:K00948] [EC:2.7.6.1]
121358846  PPAT; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
121356332  GART; trifunctional purine biosynthetic protein adenosine-3 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
121356339  trifunctional purine biosynthetic protein adenosine-3-like [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
121361156  ADSL; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
121349611  ATIC; bifunctional purine biosynthesis protein ATIC [KO:K00602] [EC:2.1.2.3 3.5.4.10]
121362148  APRT; adenine phosphoribosyltransferase isoform X1 [KO:K00759] [EC:2.4.2.7]
121363914  NT5C; 5'(3')-deoxyribonucleotidase, cytosolic type [KO:K01081] [EC:3.1.3.5]
121360795  cytosolic 5'-nucleotidase 1B-like [KO:K01081] [EC:3.1.3.5]
121361015  cytosolic 5'-nucleotidase 1A-like [KO:K01081] [EC:3.1.3.5]
121349956  NT5C1A; cytosolic 5'-nucleotidase 1A [KO:K01081] [EC:3.1.3.5]
121350152  NT5C2; cytosolic purine 5'-nucleotidase isoform X1 [KO:K01081] [EC:3.1.3.5]
121350756  NT5M; 5'(3')-deoxyribonucleotidase, mitochondrial [KO:K01081] [EC:3.1.3.5]
121359277  cytosolic purine 5'-nucleotidase-like isoform X1 [KO:K01081] [EC:3.1.3.5]
121360484  NT5E; 5'-nucleotidase [KO:K19970] [EC:3.1.3.5]
121348957  purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
121353321  LACC1; purine nucleoside phosphorylase LACC1 isoform X1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
121354217  hypoxanthine-guanine phosphoribosyltransferase-like isoform X1 [KO:K00760] [EC:2.4.2.8]
121363149  HPRT1; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
121355078  IMPDH1; inosine-5'-monophosphate dehydrogenase 1 [KO:K00088] [EC:1.1.1.205]
121350234  IMPDH2; inosine-5'-monophosphate dehydrogenase 2 isoform X1 [KO:K00088] [EC:1.1.1.205]
121363890  nucleoside diphosphate kinase-like isoform X1 [KO:K00940] [EC:2.7.4.6]
121355072  nucleoside diphosphate kinase 6-like [KO:K00940] [EC:2.7.4.6]
121350665  nucleoside diphosphate kinase, mitochondrial-like isoform X1 [KO:K00940] [EC:2.7.4.6]
121350667  NME3; nucleoside diphosphate kinase 3 [KO:K00940] [EC:2.7.4.6]
121351550  NME7; nucleoside diphosphate kinase 7 isoform X1 [KO:K00940] [EC:2.7.4.6]
121363814  nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
121359296  AK9; adenylate kinase 9 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
121352991  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
121350169  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 isoform X1 [KO:K01510] [EC:3.6.1.5]
121357544  ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8 [KO:K01510] [EC:3.6.1.5]
121357545  ectonucleoside triphosphate diphosphohydrolase 8-like [KO:K01510] [EC:3.6.1.5]
121363444  CANT1; soluble calcium-activated nucleotidase 1 isoform X1 [KO:K12304] [EC:3.6.1.6]
121365990  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
121353926  ENTPD6; ectonucleoside triphosphate diphosphohydrolase 6 [KO:K01511] [EC:3.6.1.6]
121356044  ENTPD5; ectonucleoside triphosphate diphosphohydrolase 5 [KO:K01511] [EC:3.6.1.6]
121359844  ITPA; inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
121357042  XDH; xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
121350460  NUDT2; bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] [KO:K01518] [EC:3.6.1.17]
121353775  GMPS; GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
121357846  GMPR; GMP reductase 1 isoform X1 [KO:K00364] [EC:1.7.1.7]
121348656  GDA; guanine deaminase isoform X1 [KO:K01487] [EC:3.5.4.3]
121365303  GUK1; guanylate kinase isoform X1 [KO:K00942] [EC:2.7.4.8]
121355131  RRM1; ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
121359151  RRM2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
121355453  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B isoform X1 [KO:K10808] [EC:1.17.4.1]
121354868  HDDC2; 5'-deoxynucleotidase HDDC2 [KO:K07023] [EC:3.1.3.89]
121355616  DGUOK; deoxyguanosine kinase, mitochondrial [KO:K00904] [EC:2.7.1.113]
121349346  DCK; deoxycytidine kinase [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
121361421  deoxycytidine kinase 2 isoform X1 [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
121352241  HDDC3; guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 [KO:K21138] [EC:3.1.7.2]
121353489  PRUNE1; exopolyphosphatase PRUNE1 isoform X1 [KO:K01514] [EC:3.6.1.11]
121356124  adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
121358032  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
121356628  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
121356310  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
121348916  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
121364662  ADCY8; LOW QUALITY PROTEIN: adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
121350906  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
121364166  GUCY1A2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
121360240  GUCY1A1; guanylate cyclase soluble subunit alpha-1 [KO:K12318] [EC:4.6.1.2]
121360211  GUCY1B1; guanylate cyclase soluble subunit beta-1 isoform X1 [KO:K12319] [EC:4.6.1.2]
121357919  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
121361116  GUCY2C; heat-stable enterotoxin receptor [KO:K12320] [EC:4.6.1.2]
121362549  LOW QUALITY PROTEIN: retinal guanylyl cyclase 1-like [KO:K12321] [EC:4.6.1.2]
121350534  GUCY2F; LOW QUALITY PROTEIN: retinal guanylyl cyclase 2 [KO:K12322] [EC:4.6.1.2]
121353556  NPR1; atrial natriuretic peptide receptor 1 isoform X1 [KO:K12323] [EC:4.6.1.2]
121355518  NPR2; atrial natriuretic peptide receptor 2 [KO:K12324] [EC:4.6.1.2]
121363723  atrial natriuretic peptide receptor 2-like [KO:K12324] [EC:4.6.1.2]
121353977  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B [KO:K13755] [EC:3.1.4.17]
121356443  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A [KO:K13755] [EC:3.1.4.17]
121354733  PDE2A; cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X1 [KO:K18283] [EC:3.1.4.17]
121362682  PDE3A; LOW QUALITY PROTEIN: cGMP-inhibited 3',5'-cyclic phosphodiesterase A [KO:K19021] [EC:3.1.4.17]
121361029  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B isoform X1 [KO:K13296] [EC:3.1.4.17]
121361509  PDE5A; cGMP-specific 3',5'-cyclic phosphodiesterase isoform X1 [KO:K13762] [EC:3.1.4.35]
121355531  PDE6B; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta [KO:K13756] [EC:3.1.4.35]
121350229  PDE6C; cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' isoform X1 [KO:K13757] [EC:3.1.4.35]
121353803  PDE6D; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta [KO:K13758]
121363462  PDE6G; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma isoform X1 [KO:K13759]
121357222  PDE6H; retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13760]
121364569  PDE9A; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1 [KO:K13761] [EC:3.1.4.35]
121349813  PDE10A; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [KO:K18438] [EC:3.1.4.17 3.1.4.35]
121356610  PDE11A; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A [KO:K13298] [EC:3.1.4.17 3.1.4.35]
121358560  ADSS2; adenylosuccinate synthetase isozyme 2 [KO:K01939] [EC:6.3.4.4]
121358190  ADSS1; adenylosuccinate synthetase isozyme 1 [KO:K01939] [EC:6.3.4.4]
121365454  AMPD2; AMP deaminase 2 [KO:K01490] [EC:3.5.4.6]
121349789  AMPD1; AMP deaminase 1 isoform X1 [KO:K01490] [EC:3.5.4.6]
121352061  AMPD3; AMP deaminase 3 isoform X1 [KO:K01490] [EC:3.5.4.6]
121356758  ADK; adenosine kinase isoform X1 [KO:K00856] [EC:2.7.1.20]
121359667  ADA; adenosine deaminase [KO:K01488] [EC:3.5.4.4]
121362693  ADA2; adenosine deaminase 2 [KO:K19572] [EC:3.5.4.4]
121349949  AK2; adenylate kinase 2, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
121361920  AK5; adenylate kinase isoenzyme 5 [KO:K00939] [EC:2.7.4.3]
121361963  AK4; adenylate kinase 4, mitochondrial [KO:K00939] [EC:2.7.4.3]
121357583  AK8; adenylate kinase 8 isoform X1 [KO:K00939] [EC:2.7.4.3]
121357605  AK1; adenylate kinase isoenzyme 1 [KO:K00939] [EC:2.7.4.3]
121358194  AK7; adenylate kinase 7 [KO:K00939] [EC:2.7.4.3]
121351314  AK6; adenylate kinase isoenzyme 6 [KO:K18532] [EC:2.7.4.3]
121363658  AK3; GTP:AMP phosphotransferase AK3, mitochondrial isoform X1 [KO:K00944] [EC:2.7.4.10]
121357551  ENTPD2; ectonucleoside triphosphate diphosphohydrolase 2 [KO:K01509] [EC:3.6.1.-]
121363288  NTPCR; cancer-related nucleoside-triphosphatase [KO:K06928] [EC:3.6.1.15]
121354860  ENPP3; ectonucleotide pyrophosphatase/phosphodiesterase family member 3 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
121354988  ENPP1; ectonucleotide pyrophosphatase/phosphodiesterase family member 1 isoform X1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
121352673  PDE4C; cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform X1 [KO:K13293] [EC:3.1.4.53]
121355455  PDE4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1 [KO:K13293] [EC:3.1.4.53]
121361906  PDE4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
121354858  PDE7B; cAMP-specific 3',5'-cyclic phosphodiesterase 7B isoform X1 [KO:K18436] [EC:3.1.4.53]
121356822  PDE7A; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X1 [KO:K18436] [EC:3.1.4.53]
121354285  PDE8A; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1 [KO:K18437] [EC:3.1.4.53]
121363634  PDE8B; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X1 [KO:K18437] [EC:3.1.4.53]
121351327  FHIT; bis(5'-adenosyl)-triphosphatase isoform X1 [KO:K01522] [EC:3.6.1.29]
121360803  ENPP4; bis(5'-adenosyl)-triphosphatase ENPP4 [KO:K18424] [EC:3.6.1.29]
121360307  PAPSS1; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 isoform X1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
121356670  PAPSS2; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform X1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
121362003  uricase-like [KO:K00365] [EC:1.7.3.3]
121362407  5-hydroxyisourate hydrolase-like [KO:K07127] [EC:3.5.2.17]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
pruf00030  Pentose phosphate pathway
pruf00220  Arginine biosynthesis
pruf00250  Alanine, aspartate and glutamate metabolism
pruf00260  Glycine, serine and threonine metabolism
pruf00340  Histidine metabolism
pruf00630  Glyoxylate and dicarboxylate metabolism
pruf00730  Thiamine metabolism
pruf00740  Riboflavin metabolism
pruf00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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