KEGG   PATHWAY: pteh04115
Entry
pteh04115                   Pathway                                
Name
p53 signaling pathway - Piliocolobus tephrosceles (Ugandan red Colobus)
Description
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
Class
Cellular Processes; Cell growth and death
Pathway map
pteh04115  p53 signaling pathway
pteh04115

Organism
Piliocolobus tephrosceles (Ugandan red Colobus) [GN:pteh]
Gene
111540104  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
111525354  CHEK2; serine/threonine-protein kinase Chk2 isoform X1 [KO:K06641] [EC:2.7.11.1]
111544697  ATR; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
111540298  CHEK1; serine/threonine-protein kinase Chk1 isoform X1 [KO:K02216] [EC:2.7.11.1]
111539327  GORAB; RAB6-interacting golgin isoform X1 [KO:K19748]
111528609  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
111522707  MDM4; protein Mdm4 isoform X1 [KO:K10127]
111527100  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
111534857  relA-associated inhibitor-like [KO:K27356]
111519972  PPP1R13L; relA-associated inhibitor [KO:K27356]
111542983  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
111522272  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
111535839  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
111543039  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
111541790  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
111552475  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
111553938  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
111549709  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
111541872  CDK2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
111547640  SFN; 14-3-3 protein sigma [KO:K06644]
111546193  RPRM; protein reprimo [KO:K10128]
111539895  CCNB1; G2/mitotic-specific cyclin-B1 [KO:K05868]
111553698  CCNB2; G2/mitotic-specific cyclin-B2 [KO:K21770]
111547435  LOW QUALITY PROTEIN: G2/mitotic-specific cyclin-B2-like [KO:K21770]
111521941  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
111541101  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
111528537  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
111520681  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
111548898  GTSE1; G2 and S phase-expressed protein 1 [KO:K10129]
111541903  ZNF385A; zinc finger protein 385A isoform X1 [KO:K26543]
111551313  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
111520555  PIDD1; p53-induced death domain-containing protein 1 isoform X3 [KO:K10130]
111545697  TNFRSF10B; tumor necrosis factor receptor superfamily member 10B isoform X1 [KO:K04722]
111545701  TNFRSF10A; tumor necrosis factor receptor superfamily member 10A [KO:K04722]
111547169  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
111527587  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
111520083  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
111546851  PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1 [KO:K10131]
111520160  bcl-2-binding component 3, isoforms 1/2 [KO:K10132]
111540025  TP53AIP1; p53-regulated apoptosis-inducing protein 1 isoform X1 [KO:K13773]
111538339  SIVA1; apoptosis regulatory protein Siva isoform X1 [KO:K22744]
111548123  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
111528437  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
111554440  quinone oxidoreductase PIG3 isoform X1 [KO:K10133] [EC:1.-.-.-]
111540296  EI24; etoposide-induced protein 2.4 homolog [KO:K10134]
111533919  SHISA5; protein shisa-5 [KO:K10135]
111554034  LOW QUALITY PROTEIN: protein shisa-5 [KO:K10135]
111525529  PERP; p53 apoptosis effector related to PMP-22 [KO:K10136]
111521410  ZMAT3; zinc finger matrin-type protein 3 isoform X1 [KO:K10137]
111536575  E3 ubiquitin-protein ligase SIAH1-like [KO:K04506] [EC:2.3.2.27]
111524432  SIAH1; E3 ubiquitin-protein ligase SIAH1 isoform X2 [KO:K04506] [EC:2.3.2.27]
111528103  cytochrome c-like [KO:K08738]
111541425  cytochrome c [KO:K08738]
111551227  cytochrome c-like [KO:K08738]
111551298  cytochrome c-like [KO:K08738]
111551797  cytochrome c [KO:K08738]
111551867  cytochrome c [KO:K08738]
111543337  cytochrome c-like [KO:K08738]
111543628  cytochrome c-like [KO:K08738]
111534452  cytochrome c-like [KO:K08738]
111545049  cytochrome c-like [KO:K08738]
111555014  cytochrome c-like [KO:K08738]
111524229  cytochrome c [KO:K08738]
111525268  cytochrome c-like [KO:K08738]
111539464  cytochrome c-like [KO:K08738]
111526887  cytochrome c-like [KO:K08738]
111540111  cytochrome c-like [KO:K08738]
111520510  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
111527287  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
111551382  caspase-3-like isoform X1 [KO:K02187] [EC:3.4.22.56]
111548479  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
111537902  AIFM2; apoptosis-inducing factor 2 [KO:K22745]
111552313  IGFBP3; insulin-like growth factor-binding protein 3 isoform X1 [KO:K10138]
111523785  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
111527919  SERPINE1; plasminogen activator inhibitor 1 [KO:K03982]
111553376  adhesion G protein-coupled receptor B1 [KO:K04596]
111544932  CD82; CD82 antigen isoform X1 [KO:K06509]
111524230  THBS1; thrombospondin-1 [KO:K16857]
111528454  SERPINB5; serpin B5 [KO:K10139]
111544893  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
111551597  RRM2B; LOW QUALITY PROTEIN: ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
111531878  RRM2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
111551636  SESN3; sestrin-3 [KO:K10141]
111538549  SESN1; sestrin-1 isoform X1 [KO:K10141]
111547605  SESN2; sestrin-2 [KO:K20394]
111551321  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
111524144  TSC2; tuberin isoform X1 [KO:K07207]
111521635  STEAP3; metalloreductase STEAP3 isoform X1 [KO:K10142] [EC:1.16.1.-]
111539371  COP1; E3 ubiquitin-protein ligase COP1 isoform X1 [KO:K10143] [EC:2.3.2.27]
111524565  RCHY1; RING finger and CHY zinc finger domain-containing protein 1 isoform X1 [KO:K10144] [EC:2.3.2.27]
111547192  CCNG1; cyclin-G1 [KO:K10145]
111549349  CCNG2; cyclin-G2 [KO:K10146]
111537669  PPM1D; protein phosphatase 1D [KO:K10147] [EC:3.1.3.16]
111544596  TP73; tumor protein p73 isoform X1 [KO:K10148]
Reference
PMID:16557269
  Authors
Levine AJ, Hu W, Feng Z.
  Title
The P53 pathway: what questions remain to be explored?
  Journal
Cell Death Differ 13:1027-36 (2006)
DOI:10.1038/sj.cdd.4401910
Reference
PMID:15838523
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
PMID:11747320
  Authors
Balint E E, Vousden KH.
  Title
Activation and activities of the p53 tumour suppressor protein.
  Journal
Br J Cancer 85:1813-23 (2001)
DOI:10.1054/bjoc.2001.2128
Reference
PMID:11313928
  Authors
Taylor WR, Stark GR.
  Title
Regulation of the G2/M transition by p53.
  Journal
Oncogene 20:1803-15 (2001)
DOI:10.1038/sj.onc.1204252
Reference
PMID:15116721
  Authors
Hofseth LJ, Hussain SP, Harris CC.
  Title
p53: 25 years after its discovery.
  Journal
Trends Pharmacol Sci 25:177-81 (2004)
DOI:10.1016/j.tips.2004.02.009
Reference
PMID:12505356
  Authors
Pietenpol JA, Stewart ZA.
  Title
Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.
  Journal
Toxicology 181-182:475-81 (2002)
DOI:10.1016/S0300-483X(02)00460-2
Reference
PMID:10714958
  Authors
Tokino T, Nakamura Y.
  Title
The role of p53-target genes in human cancer.
  Journal
Crit Rev Oncol Hematol 33:1-6 (2000)
DOI:10.1016/S1040-8428(99)00051-7
Reference
PMID:16697662
  Authors
Hermeking H, Benzinger A.
  Title
14-3-3 proteins in cell cycle regulation.
  Journal
Semin Cancer Biol 16:183-92 (2006)
DOI:10.1016/j.semcancer.2006.03.002
Reference
PMID:16915296
  Authors
Sherr CJ.
  Title
Divorcing ARF and p53: an unsettled case.
  Journal
Nat Rev Cancer 6:663-73 (2006)
DOI:10.1038/nrc1954
Reference
PMID:17409411
  Authors
Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ.
  Title
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
  Journal
Cancer Res 67:3043-53 (2007)
DOI:10.1158/0008-5472.CAN-06-4149
Reference
PMID:26037915
  Authors
Resnick-Silverman L, Manfredi JJ
  Title
Two Faces of SIVA.
  Journal
Cancer Discov 5:581-3 (2015)
DOI:10.1158/2159-8290.CD-15-0484
Reference
PMID:19584092
  Authors
Resch U, Schichl YM, Winsauer G, Gudi R, Prasad K, de Martin R
  Title
Siva1 is a XIAP-interacting protein that balances NFkappaB and JNK signalling to promote apoptosis.
  Journal
J Cell Sci 122:2651-61 (2009)
DOI:10.1242/jcs.049940
Reference
PMID:19240372
  Authors
Barkinge JL, Gudi R, Sarah H, Chu F, Borthakur A, Prabhakar BS, Prasad KV
  Title
The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis.
  Journal
J Carcinog 8:2 (2009)
DOI:10.4103/1477-3163.45389
Reference
PMID:12135761
  Authors
Ohiro Y, Garkavtsev I, Kobayashi S, Sreekumar KR, Nantz R, Higashikubo BT, Duffy SL, Higashikubo R, Usheva A, Gius D, Kley N, Horikoshi N
  Title
A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF).
  Journal
FEBS Lett 524:163-71 (2002)
DOI:10.1016/S0014-5793(02)03049-1
Reference
PMID:26646590
  Authors
Hu Y, Ge W, Wang X, Sutendra G, Zhao K, Dedeic Z, Slee EA, Baer C, Lu X
  Title
Caspase cleavage of iASPP potentiates its ability to inhibit p53 and NF-kappaB.
  Journal
Oncotarget 6:42478-90 (2015)
DOI:10.18632/oncotarget.6478
Related
pathway
pteh04110  Cell cycle
pteh04210  Apoptosis
pteh04218  Cellular senescence
KO pathway
ko04115   
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