Entry Name Cellular senescence - Piliocolobus tephrosceles (Ugandan red Colobus)
Description Cellular senescence is a state of irreversible cellular arrest and can be triggered by a number of factors, such as telomere shortening, oncogene activation, irradiation, DNA damage and oxidative stress. It is characterized by enlarged flattened morphology, senescence-associated beta-galactosidase (SA-b-gal) activity, secretion of inflammatory cytokines, growth factors and matrix metalloproteinases, as part of the senescence-associated secretory phenotype (SASP). Cellular senescence is functionally associated with many biological processes including aging, tumor suppression, placental biology, embryonic development, and wound healing.
Class Cellular Processes; Cell growth and deathBRITE hierarchy
Pathway map Other DBs Organism Piliocolobus tephrosceles (Ugandan red Colobus) [GN:
pteh ]
Gene 111520681 GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402 ]
111521034 NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332 ]
111521403 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
111523340 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
111524370 CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851 ]
111528537 GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402 ]
111529272 VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862 ]
111529467 RAD50; DNA repair protein RAD50 isoform X1 [KO:K10866 ] [EC:3.6.-.-]
111536234 RAD9B; cell cycle checkpoint control protein RAD9B isoform X1 [KO:K10995 ]
111537117 TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376 ]
111537825 VDAC2; voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15040 ]
111537850 PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
111538928 BTRC; F-box/WD repeat-containing protein 1A isoform X1 [KO:K03362 ]
111539679 SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500 ]
111539891 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
111540617 ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959 ]
111541101 GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402 ]
111541171 TRPV4; transient receptor potential cation channel subfamily V member 4 [KO:K04973 ]
111541379 NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333 ]
111544092 VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041 ]
111544131 EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 isoform X1 [KO:K07205 ]
111544647 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
111545684 PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
111546970 ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958 ]
111547216 FBXW11; F-box/WD repeat-containing protein 11 isoform X1 [KO:K03362 ]
111547968 PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
111547971 NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580 ]
111548339 CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183 ]
111548349 SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605 ]
111548774 PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
111551042 NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446 ]
111551618 MRE11; double-strand break repair protein MRE11 isoform X1 [KO:K10865 ]
111552313 IGFBP3; insulin-like growth factor-binding protein 3 isoform X1 [KO:K10138 ]
111552800 TRPM7; transient receptor potential cation channel subfamily M member 7 isoform X1 [KO:K04982 ] [EC:2.7.11.1 ]
111552902 NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334 ]
111554142 TGFB1; transforming growth factor beta-1 proprotein isoform X2 [KO:K13375 ]
111554247 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
Compound C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Munoz-Espin D, Serrano M
Title Cellular senescence: from physiology to pathology.
Journal Reference Authors Childs BG, Durik M, Baker DJ, van Deursen JM
Title Cellular senescence in aging and age-related disease: from mechanisms to therapy.
Journal Reference Authors Sharpless NE, Sherr CJ
Title Forging a signature of in vivo senescence.
Journal Reference Authors Fridlyanskaya I, Alekseenko L, Nikolsky N
Title Senescence as a general cellular response to stress: A mini-review.
Journal Reference Authors Lujambio A
Title To clear, or not to clear (senescent cells)? That is the question.
Journal Reference Authors Di Mitri D, Alimonti A
Title Non-Cell-Autonomous Regulation of Cellular Senescence in Cancer.
Journal Reference Authors Francica P, Aebersold DM, Medova M
Title Senescence as biologic endpoint following pharmacological targeting of receptor tyrosine kinases in cancer.
Journal Reference Authors Bartling B
Title Cellular senescence in normal and premature lung aging.
Journal Reference Authors Munoz-Espin D, Canamero M, Maraver A, Gomez-Lopez G, Contreras J, Murillo-Cuesta S, Rodriguez-Baeza A, Varela-Nieto I, Ruberte J, Collado M, Serrano M
Title Programmed cell senescence during mammalian embryonic development.
Journal Reference Authors Herranz N, Gallage S, Gil J
Title TORn about SASP regulation.
Journal Reference Authors Martin N, Bernard D
Title Calcium signaling and cellular senescence.
Journal Reference Authors Farfariello V, Iamshanova O, Germain E, Fliniaux I, Prevarskaya N
Title Calcium homeostasis in cancer: A focus on senescence.
Journal Reference Authors McCarthy DA, Clark RR, Bartling TR, Trebak M, Melendez JA
Title Redox control of the senescence regulator interleukin-1alpha and the secretory phenotype.
Journal Reference Authors Donninger H, Schmidt ML, Mezzanotte J, Barnoud T, Clark GJ
Title Ras signaling through RASSF proteins.
Journal Reference Authors Barnoud T, Schmidt ML, Donninger H, Clark GJ
Title The role of the NORE1A tumor suppressor in Oncogene-Induced Senescence.
Journal Reference Authors Kang C, Xu Q, Martin TD, Li MZ, Demaria M, Aron L, Lu T, Yankner BA, Campisi J, Elledge SJ
Title The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4.
Journal Reference Authors Cao X, Li M
Title A New Pathway for Senescence Regulation.
Journal Reference Authors Gire V, Dulic V
Title Senescence from G2 arrest, revisited.
Journal Reference Authors Mowla SN, Lam EW, Jat PS
Title Cellular senescence and aging: the role of B-MYB.
Journal Reference Authors Yao H, Chung S, Hwang JW, Rajendrasozhan S, Sundar IK, Dean DA, McBurney MW, Guarente L, Gu W, Ronty M, Kinnula VL, Rahman I
Title SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice.
Journal Reference Authors Hwang JW, Yao H, Caito S, Sundar IK, Rahman I
Title Redox regulation of SIRT1 in inflammation and cellular senescence.
Journal Related KO pathway
