KEGG   PATHWAY: ptet04910
Entry
ptet04910                   Pathway                                
Name
Insulin signaling pathway - Puntigrus tetrazona (Sumatra barb)
Description
Insulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the regulatory subunit of phosphoinositide 3-kinase (PI3K). PI3K activates 3-phosphoinositide-dependent protein kinase 1 (PDK1), which activates Akt, a serine kinase. Akt in turn deactivates glycogen synthase kinase 3 (GSK-3), leading to activation of glycogen synthase (GYS) and thus glycogen synthesis. Activation of Akt also results in the translocation of GLUT4 vesicles from their intracellular pool to the plasma membrane, where they allow uptake of glucose into the cell. Akt also leads to mTOR-mediated activation of protein synthesis by eIF4 and p70S6K. The translocation of GLUT4 protein is also elicited through the CAP/Cbl/TC10 pathway, once Cbl is phosphorylated by INSR.
Other signal transduction proteins interact with IRS including GRB2. GRB2 is part of the cascade including SOS, RAS, RAF and MEK that leads to activation of mitogen-activated protein kinase (MAPK) and mitogenic responses in the form of gene transcription. SHC is another substrate of INSR. When tyrosine phosphorylated, SHC associates with GRB2 and can thus activate the RAS/MAPK pathway independently of IRS-1.
Class
Organismal Systems; Endocrine system
Pathway map
ptet04910  Insulin signaling pathway
ptet04910

Organism
Puntigrus tetrazona (Sumatra barb) [GN:ptet]
Gene
122342085  insulin [KO:K04526]
122358096  insb; preproinsulin b [KO:K04526]
122344767  ins; insulin [KO:K04526]
122327303  insrb; insulin receptor b [KO:K04527] [EC:2.7.10.1]
122359571  insra; insulin receptor a [KO:K04527] [EC:2.7.10.1]
122359362  irs1; insulin receptor substrate 1-B [KO:K16172]
122326567  irs4a; insulin receptor substrate 2-B [KO:K07187]
122349609  insulin receptor substrate 2-B isoform X1 [KO:K07187]
122349701  irs2a; insulin receptor substrate 2a [KO:K07187]
122351325  irs2b; insulin receptor substrate 2 [KO:K07187]
122347155  LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
122362518  pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
122344708  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
122346452  pik3r3b; LOW QUALITY PROTEIN: phosphoinositide-3-kinase, regulatory subunit 3b (gamma) [KO:K02649]
122328821  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
122334627  zgc:158659; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
122359036  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
122353565  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
122329752  pdpk1b; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
122341500  pdpk1a; 3-phosphoinositide-dependent protein kinase 1a isoform X1 [KO:K06276] [EC:2.7.11.1]
122325188  LOW QUALITY PROTEIN: RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
122334475  akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
122355848  RAC-beta serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
122362868  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
122356955  akt3a; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
122342821  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
122332296  gsk3ba; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
122345555  gsk3bb; glycogen synthase kinase 3 beta, genome duplicate b [KO:K03083] [EC:2.7.11.26]
122335711  gys1; LOW QUALITY PROTEIN: glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
122342934  gys2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
122361931  ppp1cb; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
122355425  ppp1cab; protein phosphatase 1, catalytic subunit, alpha isozyme b [KO:K06269] [EC:3.1.3.16]
122348866  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
122341604  ppp1caa; protein phosphatase 1, catalytic subunit, alpha isozyme a [KO:K06269] [EC:3.1.3.16]
122344697  ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit A [KO:K06269] [EC:3.1.3.16]
122326885  ppp1r3b; protein phosphatase 1 regulatory subunit 3B [KO:K07189]
122328414  ppp1r3da; protein phosphatase 1, regulatory subunit 3Da [KO:K07189]
122362218  ppp1r3ca; protein phosphatase 1, regulatory subunit 3Ca [KO:K07189]
122355637  ppp1r3cb; protein phosphatase 1 regulatory subunit 3C-B isoform X1 [KO:K07189]
122362908  protein phosphatase 1 regulatory subunit 3E [KO:K07189]
122350159  si:ch211-167b20.8; uncharacterized protein si:ch211-167b20.8 isoform X1 [KO:K07189]
122350419  ppp1r3c2b; protein phosphatase 1 regulatory subunit 3C-B-like [KO:K07189]
122353550  ppp1r3db; protein phosphatase 1, regulatory subunit 3Db [KO:K07189]
122326278  phkg1b; phosphorylase kinase, gamma 1b (muscle) isoform X1 [KO:K00871] [EC:2.7.11.19]
122355171  phkg2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform [KO:K00871] [EC:2.7.11.19]
122359232  phkg1a; phosphorylase kinase, gamma 1a (muscle) [KO:K00871] [EC:2.7.11.19]
122348723  phka1a; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
122348849  phkb; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
122354172  phka2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
122326238  calm3b; calmodulin 3b (phosphorylase kinase, delta) [KO:K02183]
122331026  calml4b; calmodulin-like protein 4 [KO:K02183]
122361733  calm1a; calmodulin-1a [KO:K02183]
122348030  calml4a; calmodulin-like protein 4a [KO:K02183]
122355676  calm2b; calmodulin 2b, (phosphorylase kinase, delta) [KO:K02183]
122356669  calm2a; calmodulin 2a (phosphorylase kinase, delta) [KO:K02183]
122359219  calm3a; calmodulin 3a (phosphorylase kinase, delta) [KO:K02183]
122326087  pygma; glycogen phosphorylase, muscle form [KO:K00688] [EC:2.4.1.1]
122362229  pygb; glycogen phosphorylase, brain form isoform X1 [KO:K00688] [EC:2.4.1.1]
122349242  pygmb; phosphorylase, glycogen, muscle b [KO:K00688] [EC:2.4.1.1]
122357141  pygl; glycogen phosphorylase, liver form [KO:K00688] [EC:2.4.1.1]
122348325  pde3b; cGMP-inhibited 3',5'-cyclic phosphodiesterase B isoform X1 [KO:K13296] [EC:3.1.4.17]
122333172  cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
122341761  prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a isoform X1 [KO:K04345] [EC:2.7.11.11]
122344253  prkacab; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
122360276  prkacbb; protein kinase, cAMP-dependent, catalytic, beta b isoform X1 [KO:K04345] [EC:2.7.11.11]
122353933  prkacba; protein kinase, cAMP-dependent, catalytic, beta a [KO:K04345] [EC:2.7.11.11]
122327967  prkar2ab; protein kinase, cAMP-dependent, regulatory, type II, alpha, B [KO:K04739]
122330668  cAMP-dependent protein kinase type II-beta regulatory subunit [KO:K04739]
122333403  prkar1ab; protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) b isoform X1 [KO:K04739]
122340397  prkar1aa; protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) a [KO:K04739]
122341447  prkar1b; cAMP-dependent protein kinase type I-beta regulatory subunit isoform X1 [KO:K04739]
122350398  prkar2aa; protein kinase, cAMP-dependent, regulatory, type II, alpha A [KO:K04739]
122323687  lipea; lipase, hormone-sensitive a [KO:K07188] [EC:3.1.1.79]
122360111  lipeb; hormone-sensitive lipase isoform X1 [KO:K07188] [EC:3.1.1.79]
122350343  prkcz; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
122323185  prkci; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
122348704  solute carrier family 2, facilitated glucose transporter member 4-like [KO:K07191]
122343534  flot1a; flotillin-1a [KO:K07192]
122345077  flot2a; flotillin-2a isoform X1 [KO:K07192]
122359221  flot2b; flotillin-2b [KO:K07192]
122359934  flot1b; flotillin-1b [KO:K07192]
122358353  SH2B adapter protein 2 isoform X1 [KO:K07193]
122356333  LOW QUALITY PROTEIN: sorbin and SH3 domain-containing protein 1 [KO:K06086]
122359556  cbl; E3 ubiquitin-protein ligase CBL isoform X1 [KO:K04707] [EC:2.3.2.27]
122353180  cblb; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase CBL-B [KO:K22517] [EC:2.3.2.27]
122326476  crkl; crk-like protein [KO:K04438]
122326541  crk; adapter molecule crk [KO:K04438]
122332573  rapgef1b; LOW QUALITY PROTEIN: rap guanine nucleotide exchange factor 1b [KO:K06277]
122350575  rapgef1a; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
122332150  rho-related GTP-binding protein RhoQ-like isoform X1 [KO:K07194]
122355433  rhoq; rho-related GTP-binding protein RhoQ [KO:K07194]
122333517  exoc7; exocyst complex component 7 isoform X1 [KO:K07195]
122341880  trip10a; LOW QUALITY PROTEIN: cdc42-interacting protein 4 homolog [KO:K07196]
122337923  srebf1; sterol regulatory element-binding protein 1 isoform X1 [KO:K07197]
122345305  acaca; acetyl-CoA carboxylase 1 isoform X1 [KO:K11262] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
122344977  acacb; acetyl-CoA carboxylase isoform X1 [KO:K01946] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
122355207  fasn; fatty acid synthase [KO:K00665] [EC:2.3.1.85]
122356180  hkdc1; hexokinase HKDC1 [KO:K00844] [EC:2.7.1.1]
122356181  hk1; hexokinase-1 [KO:K00844] [EC:2.7.1.1]
122345156  hk2; hexokinase-2 isoform X1 [KO:K00844] [EC:2.7.1.1]
122350055  gck; hexokinase-4 isoform X1 [KO:K12407] [EC:2.7.1.2]
122324774  prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
122345475  prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
122362094  prkab2; 5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
122350296  prkab1b; 5'-AMP-activated protein kinase subunit beta-1b [KO:K07199]
122353162  prkab1a; 5'-AMP-activated protein kinase subunit beta-1a [KO:K07199]
122329951  prkag2a; 5'-AMP-activated protein kinase subunit gamma-2a isoform X1 [KO:K07200]
122361782  prkag2b; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
122351583  prkag3b; 5'-AMP-activated protein kinase subunit gamma-3b isoform X1 [KO:K07200]
122346022  prkag3a; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
122346665  prkag1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
122358542  forkhead box protein O1-A isoform X1 [KO:K07201]
122352722  foxo1b; forkhead box protein O1-B [KO:K07201]
122361052  forkhead box protein O1-B-like [KO:K07201]
122348454  ppargc1a; LOW QUALITY PROTEIN: peroxisome proliferator-activated receptor gamma coactivator 1-alpha [KO:K07202]
122333390  g6pc3; glucose-6-phosphatase 3 [KO:K01084] [EC:3.1.3.9]
122341418  g6pc1b; glucose-6-phosphatase b [KO:K01084] [EC:3.1.3.9]
122355590  g6pc1a.2; glucose-6-phosphatase catalytic subunit 1 [KO:K01084] [EC:3.1.3.9]
122355593  g6pc1a.1; glucose-6-phosphatase a, catalytic subunit, tandem duplicate 1 [KO:K01084] [EC:3.1.3.9]
122349147  fbp2; fructose-1,6-bisphosphatase isozyme 2 isoform X1 [KO:K03841] [EC:3.1.3.11]
122349148  fbp1a; fructose-1,6-bisphosphatase 1a [KO:K03841] [EC:3.1.3.11]
122345498  fbp1b; fructose-1,6-bisphosphatase 1b [KO:K03841] [EC:3.1.3.11]
122329830  pck2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
122334339  pck1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
122350309  mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
122346819  LOW QUALITY PROTEIN: regulatory-associated protein of mTOR-like [KO:K07204]
122359346  rps6kb1b; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
122352511  rps6kb1a; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
122351206  rps6; 40S ribosomal protein S6 [KO:K02991]
122326256  eif4ebp1; eukaryotic translation initiation factor 4E-binding protein 1 isoform X1 [KO:K07205]
122324438  eif4e1b; eukaryotic translation initiation factor 4E-1B [KO:K03259]
122328135  eif4e2; eukaryotic translation initiation factor 4E type 2 [KO:K03259]
122332170  eukaryotic translation initiation factor 4E-1A-like isoform X1 [KO:K03259]
122334610  eif4e2rs1; eukaryotic translation initiation factor 4E family member 2 related sequence 1 [KO:K03259]
122356545  eif4e1c; eukaryotic translation initiation factor 4E family member 1c isoform X1 [KO:K03259]
122357575  eif4ea; eukaryotic translation initiation factor 4E-1A [KO:K03259]
122326532  tsc1b; TSC complex subunit 1b [KO:K07206]
122345163  tsc1a; TSC complex subunit 1a isoform X1 [KO:K07206]
122346357  tsc2; tuberin isoform X1 [KO:K07207]
122329808  rheb; GTP-binding protein Rheb [KO:K07208]
122347127  rhebl1; ras homolog, mTORC1 binding like 1 [KO:K07208]
122326411  bada; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
122326478  bcl2-associated agonist of cell death-like isoform X1 [KO:K02158]
122348429  badb; BCL2 associated agonist of cell death b [KO:K02158]
122361104  shc1; SHC-transforming protein 1 isoform X1 [KO:K06279]
122327715  shc2; SHC-transforming protein 2 isoform X1 [KO:K17447]
122332578  shc3; SHC-transforming protein 3 [KO:K17448]
122347088  grb2a; growth factor receptor-bound protein 2a isoform X1 [KO:K04364]
122341812  grb2b; growth factor receptor-bound protein 2b [KO:K04364]
122354393  son of sevenless homolog 2-like [KO:K03099]
122354677  sos1; son of sevenless homolog 1 isoform X1 [KO:K03099]
122356517  sos2; son of sevenless homolog 2 [KO:K03099]
122331115  hrasa; HRas proto-oncogene, GTPase a [KO:K02833]
122349499  hrasb; HRas proto-oncogene, GTPase b [KO:K02833]
122330578  kras; GTPase KRas isoform X1 [KO:K07827]
122330765  GTPase KRas-like [KO:K07827]
122341555  zgc:55558 [KO:K07827]
122350810  nras; GTPase NRas [KO:K07828]
122345507  araf; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
122342715  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
122328991  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
122354079  raf1b; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
122323040  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
122324621  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
122327733  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
122338606  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
122345817  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
122324688  mknk2a; MAP kinase-interacting serine/threonine-protein kinase 2a isoform X1 [KO:K04372] [EC:2.7.11.1]
122349974  mknk2b; MAP kinase-interacting serine/threonine-protein kinase 2b [KO:K04372] [EC:2.7.11.1]
122354139  mknk1; MAP kinase-interacting serine/threonine-protein kinase 1 [KO:K04372] [EC:2.7.11.1]
122350582  elk1; ETS domain-containing protein Elk-1 [KO:K04375]
122347170  socs1b; suppressor of cytokine signaling 1b [KO:K04694]
122342157  socs1a; suppressor of cytokine signaling 1a [KO:K04694]
122343447  socs2; suppressor of cytokine signaling 2 isoform X1 [KO:K04695]
122335421  socs3a; suppressor of cytokine signaling 3a [KO:K04696]
122355606  socs3b; suppressor of cytokine signaling 3b [KO:K04696]
122362354  socs4; suppressor of cytokine signaling 4 [KO:K04697]
122350563  ptpn1; tyrosine-protein phosphatase non-receptor type 1 [KO:K05696] [EC:3.1.3.48]
122360031  ptprfb; receptor-type tyrosine-protein phosphatase F isoform X1 [KO:K05695] [EC:3.1.3.48]
122346473  ptprfa; protein tyrosine phosphatase receptor type Fa isoform X1 [KO:K05695] [EC:3.1.3.48]
122326583  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
122326296  mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
122333386  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
122356615  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
122350917  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
122332943  inppl1a; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2A [KO:K15909] [EC:3.1.3.86]
122358278  inppl1b; inositol polyphosphate phosphatase-like 1b isoform X1 [KO:K15909] [EC:3.1.3.86]
Compound
C00031  D-Glucose
C00369  Starch
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
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Reference
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Reference
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Reference
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Reference
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Reference
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Reference
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Nat Genet 37:19-24 (2005)
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Reference
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Oncogene 24:7426-34 (2005)
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Reference
PMID:10567225
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Reference
PMID:9445476
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Science 279:707-10 (1998)
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Reference
PMID:9609110
  Authors
Ogawa W, Matozaki T, Kasuga M.
  Title
Role of binding proteins to IRS-1 in insulin signalling.
  Journal
Mol Cell Biochem 182:13-22 (1998)
Reference
PMID:9609111
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Ceresa BP, Pessin JE.
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Insulin regulation of the Ras activation/inactivation cycle.
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Mol Cell Biochem 182:23-9 (1998)
Reference
PMID:15229476
  Authors
Pollak MN, Schernhammer ES, Hankinson SE.
  Title
Insulin-like growth factors and neoplasia.
  Journal
Nat Rev Cancer 4:505-18 (2004)
DOI:10.1038/nrc1387
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PMID:9346240
  Authors
Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y, Greenberg ME.
  Title
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery.
  Journal
Cell 91:231-41 (1997)
DOI:10.1016/S0092-8674(00)80405-5
Reference
PMID:17344645
  Authors
Ferre P, Foufelle F
  Title
SREBP-1c transcription factor and lipid homeostasis: clinical perspective.
  Journal
Horm Res 68:72-82 (2007)
DOI:10.1159/000100426
Reference
PMID:18291668
  Authors
Raghow R, Yellaturu C, Deng X, Park EA, Elam MB
  Title
SREBPs: the crossroads of physiological and pathological lipid homeostasis.
  Journal
Trends Endocrinol Metab 19:65-73 (2008)
DOI:10.1016/j.tem.2007.10.009
Reference
PMID:11343120
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Clement S, Krause U, Desmedt F, Tanti JF, Behrends J, Pesesse X, Sasaki T, Penninger J, Doherty M, Malaisse W, Dumont JE, Le Marchand-Brustel Y, Erneux C, Hue L, Schurmans S
  Title
The lipid phosphatase SHIP2 controls insulin sensitivity.
  Journal
Nature 409:92-7 (2001)
DOI:10.1038/35051094
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PMID:12791379
  Authors
Backers K, Blero D, Paternotte N, Zhang J, Erneux C
  Title
The termination of PI3K signalling by SHIP1 and SHIP2 inositol 5-phosphatases.
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Adv Enzyme Regul 43:15-28 (2003)
DOI:10.1016/S0065-2571(02)00043-2
Related
pathway
ptet00010  Glycolysis / Gluconeogenesis
ptet00061  Fatty acid biosynthesis
ptet00500  Starch and sucrose metabolism
ptet04010  MAPK signaling pathway
ptet04070  Phosphatidylinositol signaling system
ptet04210  Apoptosis
KO pathway
ko04910   
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