KEGG   PATHWAY: rtem00230
Entry
rtem00230                   Pathway                                
Name
Purine metabolism - Rana temporaria (common frog)
Class
Metabolism; Nucleotide metabolism
Pathway map
rtem00230  Purine metabolism
rtem00230

Module
rtem_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:rtem00230]
rtem_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:rtem00230]
rtem_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:rtem00230]
rtem_M00546  Purine degradation, xanthine => urea [PATH:rtem00230]
rtem_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:rtem00230]
rtem_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:rtem00230]
Other DBs
GO: 0006163 0042278
Organism
Rana temporaria (common frog) [GN:rtem]
Gene
120943072  NUDT9; ADP-ribose pyrophosphatase, mitochondrial isoform X1 [KO:K13988] [EC:3.6.1.13]
120918990  manganese-dependent ADP-ribose/CDP-alcohol diphosphatase-like [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
120919145  ADPRM; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase isoform X1 [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
120931702  NUDT5; ADP-sugar pyrophosphatase isoform X1 [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
120946068  PGM1; phosphoglucomutase-1 isoform X1 [KO:K01835] [EC:5.4.2.2]
120924280  PGM2; phosphoglucomutase-2 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
120913082  PRPS1; ribose-phosphate pyrophosphokinase 1 [KO:K00948] [EC:2.7.6.1]
120926524  PRPS2; ribose-phosphate pyrophosphokinase 2 isoform X1 [KO:K00948] [EC:2.7.6.1]
120922536  PPAT; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
120927909  trifunctional purine biosynthetic protein adenosine-3-like [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
120942933  PFAS; phosphoribosylformylglycinamidine synthase isoform X1 [KO:K01952] [EC:6.3.5.3]
120945417  ADSL; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
120943919  ATIC; bifunctional purine biosynthesis protein ATIC [KO:K00602] [EC:2.1.2.3 3.5.4.10]
120922006  adenine phosphoribosyltransferase-like [KO:K00759] [EC:2.4.2.7]
120946986  NT5C2; cytosolic purine 5'-nucleotidase isoform X1 [KO:K01081] [EC:3.1.3.5]
120943191  NT5M; 5'(3')-deoxyribonucleotidase, mitochondrial [KO:K01081] [EC:3.1.3.5]
120933045  cytosolic purine 5'-nucleotidase-like isoform X1 [KO:K01081] [EC:3.1.3.5]
120936309  cytosolic 5'-nucleotidase 1A-like [KO:K01081] [EC:3.1.3.5]
120926773  NT5C1A; cytosolic 5'-nucleotidase 1A [KO:K01081] [EC:3.1.3.5]
120937088  NT5E; 5'-nucleotidase [KO:K19970] [EC:3.1.3.5]
120917772  purine nucleoside phosphorylase-like [KO:K03783] [EC:2.4.2.1]
120918681  purine nucleoside phosphorylase-like [KO:K03783] [EC:2.4.2.1]
120940516  purine nucleoside phosphorylase-like isoform X1 [KO:K03783] [EC:2.4.2.1]
120929639  LACC1; purine nucleoside phosphorylase LACC1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
120913628  HPRT1; hypoxanthine-guanine phosphoribosyltransferase isoform X1 [KO:K00760] [EC:2.4.2.8]
120931599  IMPDH1; inosine-5'-monophosphate dehydrogenase 1 isoform X1 [KO:K00088] [EC:1.1.1.205]
120945065  IMPDH2; inosine-5'-monophosphate dehydrogenase 2 isoform X1 [KO:K00088] [EC:1.1.1.205]
120930376  LOW QUALITY PROTEIN: nucleoside diphosphate kinase A2 [KO:K00940] [EC:2.7.4.6]
120931583  NME6; nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
120943321  NME4; nucleoside diphosphate kinase, mitochondrial [KO:K00940] [EC:2.7.4.6]
120943377  NME3; nucleoside diphosphate kinase 3 [KO:K00940] [EC:2.7.4.6]
120926990  NME7; nucleoside diphosphate kinase 7 [KO:K00940] [EC:2.7.4.6]
120937201  AK9; adenylate kinase 9 isoform X1 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
120946766  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 isoform X1 [KO:K01510] [EC:3.6.1.5]
120940285  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
120914061  ectonucleoside triphosphate diphosphohydrolase 8-like isoform X1 [KO:K01510] [EC:3.6.1.5]
120914062  ectonucleoside triphosphate diphosphohydrolase 8-like [KO:K01510] [EC:3.6.1.5]
120918883  CANT1; soluble calcium-activated nucleotidase 1 [KO:K12304] [EC:3.6.1.6]
120933083  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
120937636  ENTPD6; ectonucleoside triphosphate diphosphohydrolase 6 [KO:K01511] [EC:3.6.1.6]
120921007  ENTPD5; ectonucleoside triphosphate diphosphohydrolase 5 [KO:K01511] [EC:3.6.1.6]
120913203  U8 snoRNA-decapping enzyme-like [KO:K16855] [EC:3.6.1.62 3.6.1.64]
120945753  ITPA; inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
120937824  XDH; xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
120925594  NUDT2; bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] [KO:K01518] [EC:3.6.1.17]
120936682  GMPS; GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
120940738  GMPR; GMP reductase 1 [KO:K00364] [EC:1.7.1.7]
120941376  GMPR2; GMP reductase 2 [KO:K00364] [EC:1.7.1.7]
120943241  GDA; guanine deaminase [KO:K01487] [EC:3.5.4.3]
120939818  GUK1; guanylate kinase isoform X1 [KO:K00942] [EC:2.7.4.8]
120936348  RRM2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
120937288  HDDC2; 5'-deoxynucleotidase HDDC2 [KO:K07023] [EC:3.1.3.89]
120932121  deoxyguanosine kinase, mitochondrial-like [KO:K00904] [EC:2.7.1.113]
120932441  deoxycytidine kinase 2-like isoform X1 [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
120915487  DCK; deoxycytidine kinase [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
120931232  HDDC3; guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 [KO:K21138] [EC:3.1.7.2]
120920170  PRUNE1; exopolyphosphatase PRUNE1 [KO:K01514] [EC:3.6.1.11]
120940455  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
120936026  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
120940456  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
120944286  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
120929589  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
120917430  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
120941534  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
120943333  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
120929052  GUCY1A2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
120920203  GUCY1A1; guanylate cyclase soluble subunit alpha-1 [KO:K12318] [EC:4.6.1.2]
120928211  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
120920211  GUCY1B1; guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
120936634  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
120933532  GUCY2D; retinal guanylyl cyclase 1 isoform X1 [KO:K12321] [EC:4.6.1.2]
120928919  retinal guanylyl cyclase 2-like isoform X1 [KO:K12322] [EC:4.6.1.2]
120913723  GUCY2F; retinal guanylyl cyclase 2 isoform X1 [KO:K12322] [EC:4.6.1.2]
120920616  NPR1; atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
120946239  atrial natriuretic peptide receptor 2-like [KO:K12324] [EC:4.6.1.2]
120922123  NPR2; atrial natriuretic peptide receptor 2 [KO:K12324] [EC:4.6.1.2]
120929376  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
120940422  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
120943946  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
120932782  PDE3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A isoform X1 [KO:K19021] [EC:3.1.4.17]
120916934  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
120918562  PDE5A; cGMP-specific 3',5'-cyclic phosphodiesterase isoform X1 [KO:K13762] [EC:3.1.4.35]
120932253  PDE6A; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha isoform X1 [KO:K08718] [EC:3.1.4.35]
120913940  rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta-like [KO:K13756] [EC:3.1.4.35]
120946932  PDE6C; cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' [KO:K13757] [EC:3.1.4.35]
120936910  PDE6D; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta [KO:K13758]
120919026  PDE6G; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13759]
120944916  PDE6H; retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13760]
120921678  PDE9A; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1 [KO:K13761] [EC:3.1.4.35]
120915707  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A-like [KO:K13761] [EC:3.1.4.35]
120937417  PDE10A; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X1 [KO:K18438] [EC:3.1.4.17 3.1.4.35]
120943967  PDE11A; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A [KO:K13298] [EC:3.1.4.17 3.1.4.35]
120920992  ADSS1; adenylosuccinate synthetase isozyme 1 [KO:K01939] [EC:6.3.4.4]
120927025  AMPD1; AMP deaminase 1 [KO:K01490] [EC:3.5.4.6]
120927161  AMPD2; AMP deaminase 2 isoform X1 [KO:K01490] [EC:3.5.4.6]
120917000  AMPD3; AMP deaminase 3 isoform X1 [KO:K01490] [EC:3.5.4.6]
120909048  ADK; adenosine kinase isoform X1 [KO:K00856] [EC:2.7.1.20]
120918941  adenosine deaminase-like [KO:K01488] [EC:3.5.4.4]
120919339  ADA; adenosine deaminase isoform X1 [KO:K01488] [EC:3.5.4.4]
120932716  ADA2; adenosine deaminase 2 [KO:K19572] [EC:3.5.4.4]
120946004  AK5; adenylate kinase isoenzyme 5 isoform X1 [KO:K00939] [EC:2.7.4.3]
120946062  AK4; adenylate kinase 4, mitochondrial [KO:K00939] [EC:2.7.4.3]
120921175  AK7; adenylate kinase 7 [KO:K00939] [EC:2.7.4.3]
120914011  AK8; adenylate kinase 8 [KO:K00939] [EC:2.7.4.3]
120914195  AK1; adenylate kinase isoenzyme 1 isoform X1 [KO:K00939] [EC:2.7.4.3]
120926799  AK2; adenylate kinase 2, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
120930384  AK6; adenylate kinase isoenzyme 6 [KO:K18532] [EC:2.7.4.3]
120943842  AK3; GTP:AMP phosphotransferase AK3, mitochondrial [KO:K00944] [EC:2.7.4.10]
120914032  ENTPD2; ectonucleoside triphosphate diphosphohydrolase 2 [KO:K01509] [EC:3.6.1.-]
120937439  NTPCR; cancer-related nucleoside-triphosphatase [KO:K06928] [EC:3.6.1.15]
120937319  ENPP3; ectonucleotide pyrophosphatase/phosphodiesterase family member 3 isoform X1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
120937321  ENPP1; ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
120928642  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1 [KO:K13293] [EC:3.1.4.53]
120946054  PDE4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
120933290  PDE4A; cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X1 [KO:K13293] [EC:3.1.4.53]
120916138  PDE4C; cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform X1 [KO:K13293] [EC:3.1.4.53]
120937342  PDE7B; cAMP-specific 3',5'-cyclic phosphodiesterase 7B isoform X1 [KO:K18436] [EC:3.1.4.53]
120941064  PDE7A; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X1 [KO:K18436] [EC:3.1.4.53]
120929458  PDE8B; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X1 [KO:K18437] [EC:3.1.4.53]
120931292  PDE8A; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1 [KO:K18437] [EC:3.1.4.53]
120936237  ENPP4; bis(5'-adenosyl)-triphosphatase ENPP4 [KO:K18424] [EC:3.6.1.29]
120917990  PAPSS1; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
120947075  PAPSS2; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform X1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
120945980  uricase-like isoform X1 [KO:K00365] [EC:1.7.3.3]
120917174  5-hydroxyisourate hydrolase-like isoform X1 [KO:K07127] [EC:3.5.2.17]
120929199  URAD; putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase [KO:K13485] [EC:4.1.1.97]
120936509  allantoinase, mitochondrial-like isoform X1 [KO:K01466] [EC:3.5.2.5]
120936374  ALLC; probable allantoicase [KO:K01477] [EC:3.5.3.4]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
rtem00030  Pentose phosphate pathway
rtem00220  Arginine biosynthesis
rtem00250  Alanine, aspartate and glutamate metabolism
rtem00260  Glycine, serine and threonine metabolism
rtem00340  Histidine metabolism
rtem00630  Glyoxylate and dicarboxylate metabolism
rtem00730  Thiamine metabolism
rtem00740  Riboflavin metabolism
rtem00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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