KEGG   PATHWAY: salp04910
Entry
salp04910                   Pathway                                
Name
Insulin signaling pathway - Salvelinus sp. IW2-2015 (Arctic char)
Description
Insulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the regulatory subunit of phosphoinositide 3-kinase (PI3K). PI3K activates 3-phosphoinositide-dependent protein kinase 1 (PDK1), which activates Akt, a serine kinase. Akt in turn deactivates glycogen synthase kinase 3 (GSK-3), leading to activation of glycogen synthase (GYS) and thus glycogen synthesis. Activation of Akt also results in the translocation of GLUT4 vesicles from their intracellular pool to the plasma membrane, where they allow uptake of glucose into the cell. Akt also leads to mTOR-mediated activation of protein synthesis by eIF4 and p70S6K. The translocation of GLUT4 protein is also elicited through the CAP/Cbl/TC10 pathway, once Cbl is phosphorylated by INSR.
Other signal transduction proteins interact with IRS including GRB2. GRB2 is part of the cascade including SOS, RAS, RAF and MEK that leads to activation of mitogen-activated protein kinase (MAPK) and mitogenic responses in the form of gene transcription. SHC is another substrate of INSR. When tyrosine phosphorylated, SHC associates with GRB2 and can thus activate the RAS/MAPK pathway independently of IRS-1.
Class
Organismal Systems; Endocrine system
Pathway map
salp04910  Insulin signaling pathway
salp04910

Organism
Salvelinus sp. IW2-2015 (Arctic char) [GN:salp]
Gene
111950763  insulin [KO:K04526]
111981304  insulin [KO:K04526]
111967220  insulin-like [KO:K04526]
111979632  insulin receptor [KO:K04527] [EC:2.7.10.1]
111956472  insulin receptor [KO:K04527] [EC:2.7.10.1]
111960107  insulin receptor substrate 1-B [KO:K16172]
111960647  irs1; insulin receptor substrate 1 isoform X1 [KO:K16172]
111980351  insulin receptor substrate 1-B-like [KO:K16172]
111950155  insulin receptor substrate 1-B-like [KO:K16172]
111953930  insulin receptor substrate 1-like [KO:K16172]
111971054  insulin receptor substrate 2 [KO:K07187]
111953604  insulin receptor substrate 2 [KO:K07187]
112072034  insulin receptor substrate 2-B-like [KO:K07187]
111959252  LOW QUALITY PROTEIN: insulin receptor substrate 2 [KO:K07187]
111979234  insulin receptor substrate 2-like [KO:K07187]
111964378  insulin receptor substrate 2-B-like isoform X1 [KO:K07187]
111952012  insulin receptor substrate 2-B [KO:K07187]
111952984  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
111976090  LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit beta-like [KO:K02649]
111956658  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
111979489  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
111974525  phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
111971393  pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
111961727  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
111979394  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
111975375  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
111966495  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
111956562  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
111949408  LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like [KO:K00922] [EC:2.7.1.153]
111960775  LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like [KO:K00922] [EC:2.7.1.153]
112067753  3-phosphoinositide-dependent protein kinase 1-like isoform X1 [KO:K06276] [EC:2.7.11.1]
111981817  3-phosphoinositide-dependent protein kinase 1-like isoform X1 [KO:K06276] [EC:2.7.11.1]
111977529  3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
111976661  3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
111982815  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111958430  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
111982431  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111968784  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111972741  RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
111968260  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111954329  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111963228  RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
111964418  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112068897  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111950092  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111953459  glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
111970998  glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
111979128  glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
111951492  gys2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
111957760  serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
111977895  serine/threonine-protein phosphatase alpha-2 isoform [KO:K06269] [EC:3.1.3.16]
112068674  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
111954331  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
111974671  serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
112075309  serine/threonine-protein phosphatase alpha-2 isoform-like [KO:K06269] [EC:3.1.3.16]
111980195  serine/threonine-protein phosphatase alpha-2 isoform [KO:K06269] [EC:3.1.3.16]
112072390  protein phosphatase 1 regulatory subunit 3D-like [KO:K07189]
111966637  uncharacterized protein LOC111966637 [KO:K07189]
111950731  nestin-like [KO:K07189]
111967770  protein phosphatase 1 regulatory subunit 3C-B [KO:K07189]
112069900  protein phosphatase 1 regulatory subunit 3E-like [KO:K07189]
111978823  protein phosphatase 1 regulatory subunit 3C-B [KO:K07189]
112067843  uncharacterized protein LOC112067843 [KO:K07189]
111961539  protein phosphatase 1 regulatory subunit 3C-B [KO:K07189]
111971792  uncharacterized protein LOC111971792 [KO:K07189]
111952020  protein phosphatase 1 regulatory subunit 3C-B isoform X1 [KO:K07189]
111961412  protein phosphatase 1 regulatory subunit 3B isoform X1 [KO:K07189]
111982157  ppp1r3b; protein phosphatase 1 regulatory subunit 3B isoform X1 [KO:K07189]
112069604  protein phosphatase 1 regulatory subunit 3E-like [KO:K07189]
112077053  protein phosphatase 1 regulatory subunit 3D-like [KO:K07189]
111978222  ppp1r3c; protein phosphatase 1 regulatory subunit 3C isoform X1 [KO:K07189]
111962179  protein phosphatase 1 regulatory subunit 3A [KO:K07189]
111966472  protein phosphatase 1 regulatory subunit 3D [KO:K07189]
111982583  phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform-like [KO:K00871] [EC:2.7.11.19]
111956767  phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform-like [KO:K00871] [EC:2.7.11.19]
111977401  phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X1 [KO:K00871] [EC:2.7.11.19]
111969247  phkb; LOW QUALITY PROTEIN: phosphorylase b kinase regulatory subunit beta [KO:K07190]
111974181  LOW QUALITY PROTEIN: phosphorylase b kinase regulatory subunit beta-like [KO:K07190]
111964166  calmodulin isoform X1 [KO:K02183]
111962084  calmodulin-like protein 4 isoform X1 [KO:K02183]
112076507  LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
111972950  calmodulin [KO:K02183]
111951811  calm2; calmodulin-2 [KO:K02183]
111954258  calmodulin [KO:K02183]
111960601  calmodulin [KO:K02183]
111977843  calmodulin [KO:K02183]
111963424  calmodulin [KO:K02183]
111950244  calmodulin [KO:K02183]
111968561  calmodulin [KO:K02183]
111949612  calmodulin [KO:K02183]
111955163  glycogen phosphorylase, muscle form [KO:K00688] [EC:2.4.1.1]
111951810  glycogen phosphorylase, brain form [KO:K00688] [EC:2.4.1.1]
111960301  glycogen phosphorylase, muscle form isoform X1 [KO:K00688] [EC:2.4.1.1]
112069975  LOW QUALITY PROTEIN: glycogen phosphorylase, liver form-like [KO:K00688] [EC:2.4.1.1]
111950664  glycogen phosphorylase, muscle form [KO:K00688] [EC:2.4.1.1]
111969490  cGMP-inhibited 3',5'-cyclic phosphodiesterase B isoform X1 [KO:K13296] [EC:3.1.4.17]
112071492  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
111979502  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
111975986  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
112077218  cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
112079295  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
111963183  cAMP-dependent protein kinase type II-alpha regulatory subunit-like [KO:K04739]
111950367  cAMP-dependent protein kinase type II-beta regulatory subunit [KO:K04739]
112070340  cAMP-dependent protein kinase type II-beta regulatory subunit-like [KO:K04739]
111952783  cAMP-dependent protein kinase type II-beta regulatory subunit [KO:K04739]
111966273  cAMP-dependent protein kinase type II-alpha regulatory subunit isoform X1 [KO:K04739]
112077029  cAMP-dependent protein kinase type I-alpha regulatory subunit-like [KO:K04739]
111978216  cAMP-dependent protein kinase type I-alpha regulatory subunit [KO:K04739]
111970390  cAMP-dependent protein kinase type II-alpha regulatory subunit [KO:K04739]
112080419  cAMP-dependent protein kinase type I-alpha regulatory subunit-like [KO:K04739]
111951497  cAMP-dependent protein kinase type II-beta regulatory subunit [KO:K04739]
111976701  cAMP-dependent protein kinase type II-alpha regulatory subunit isoform X1 [KO:K04739]
111958912  hormone-sensitive lipase [KO:K07188] [EC:3.1.1.79]
111978396  hormone-sensitive lipase [KO:K07188] [EC:3.1.1.79]
111955344  hormone-sensitive lipase [KO:K07188] [EC:3.1.1.79]
111966155  protein kinase C zeta type-like [KO:K18952] [EC:2.7.11.13]
111977153  prkcz; LOW QUALITY PROTEIN: protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
111979223  protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
111956705  protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
111954898  solute carrier family 2, facilitated glucose transporter member 4-like isoform X1 [KO:K07191]
111960221  solute carrier family 2, facilitated glucose transporter member 4 [KO:K07191]
111981736  flotillin-2a isoform X1 [KO:K07192]
111964957  flotillin-1 [KO:K07192]
112074364  flotillin-1-like [KO:K07192]
111982826  flotillin-2 [KO:K07192]
111958958  flotillin-2 [KO:K07192]
111955205  flotillin-1 [KO:K07192]
111950510  flotillin-2a isoform X1 [KO:K07192]
111982087  SH2B adapter protein 2 [KO:K07193]
112070793  SH2B adapter protein 2-like isoform X1 [KO:K07193]
111978221  sorbin and SH3 domain-containing protein 1 isoform X1 [KO:K06086]
111951617  sorbin and SH3 domain-containing protein 1 isoform X1 [KO:K06086]
111949371  cbl; E3 ubiquitin-protein ligase CBL isoform X1 [KO:K04707] [EC:2.3.2.27]
111981389  E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
111951111  E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
111950986  cblb; E3 ubiquitin-protein ligase CBL-B [KO:K22517] [EC:2.3.2.27]
111961672  crk-like protein [KO:K04438]
111982820  adapter molecule crk [KO:K04438]
111981973  adapter molecule crk [KO:K04438]
111963980  crk-like protein [KO:K04438]
111960498  adapter molecule crk [KO:K04438]
111950713  adapter molecule crk [KO:K04438]
111960909  LOW QUALITY PROTEIN: rap guanine nucleotide exchange factor 1-like [KO:K06277]
111964466  rap guanine nucleotide exchange factor 1 [KO:K06277]
111957802  rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
111974844  rap guanine nucleotide exchange factor 1-like isoform X1 [KO:K06277]
112080758  rho-related GTP-binding protein RhoQ [KO:K07194]
111951902  rho-related GTP-binding protein RhoQ isoform X1 [KO:K07194]
111977623  exoc7; exocyst complex component 7 isoform X1 [KO:K07195]
111981990  LOW QUALITY PROTEIN: cdc42-interacting protein 4 homolog [KO:K07196]
112078866  srebf1; sterol regulatory element-binding protein 1 [KO:K07197]
111950119  acetyl-CoA carboxylase isoform X1 [KO:K11262] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
111981031  acetyl-CoA carboxylase 1 isoform X1 [KO:K11262] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
111974209  acetyl-CoA carboxylase 2-like isoform X1 [KO:K01946] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
111957851  acetyl-CoA carboxylase isoform X1 [KO:K01946] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
111978091  LOW QUALITY PROTEIN: fatty acid synthase-like [KO:K00665] [EC:2.3.1.85]
112080426  LOW QUALITY PROTEIN: fatty acid synthase-like [KO:K00665] [EC:2.3.1.85]
111957358  hexokinase-2-like isoform X1 [KO:K00844] [EC:2.7.1.1]
111957360  hexokinase-2-like [KO:K00844] [EC:2.7.1.1]
111974120  hexokinase-2 [KO:K00844] [EC:2.7.1.1]
111978431  putative hexokinase HKDC1 [KO:K00844] [EC:2.7.1.1]
112068013  hexokinase-1-like [KO:K00844] [EC:2.7.1.1]
111968131  hexokinase-1 [KO:K00844] [EC:2.7.1.1]
111980190  hexokinase-2-like [KO:K00844] [EC:2.7.1.1]
111982354  hexokinase-1 [KO:K00844] [EC:2.7.1.1]
111957731  LOW QUALITY PROTEIN: glucokinase-like [KO:K12407] [EC:2.7.1.2]
111974003  gck; glucokinase [KO:K12407] [EC:2.7.1.2]
111961799  5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
111972285  prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
111976168  5'-AMP-activated protein kinase catalytic subunit alpha-2-like isoform X1 [KO:K07198] [EC:2.7.11.31]
111963854  5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
111961538  5'-AMP-activated protein kinase subunit beta-1 isoform X1 [KO:K07199]
111979520  5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
111956349  5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
111975033  5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
111953401  5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
111979452  5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
111957022  5'-AMP-activated protein kinase subunit gamma-1-like isoform X1 [KO:K07200]
111966758  LOW QUALITY PROTEIN: 5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
112079032  LOW QUALITY PROTEIN: 5'-AMP-activated protein kinase subunit gamma-1-like [KO:K07200]
111970087  5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
111953278  5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
112067743  5'-AMP-activated protein kinase subunit gamma-1-like [KO:K07200]
112071347  forkhead box protein O1-A-like [KO:K07201]
111951028  foxo1; forkhead box protein O1 [KO:K07201]
111962019  forkhead box protein O1-A-like [KO:K07201]
111960358  peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1 [KO:K07202]
111977777  glucose-6-phosphatase [KO:K01084] [EC:3.1.3.9]
111967688  glucose-6-phosphatase [KO:K01084] [EC:3.1.3.9]
111967689  glucose-6-phosphatase [KO:K01084] [EC:3.1.3.9]
111974825  g6pc2; glucose-6-phosphatase 2 isoform X1 [KO:K01084] [EC:3.1.3.9]
111977591  glucose-6-phosphatase-like [KO:K01084] [EC:3.1.3.9]
112070087  glucose-6-phosphatase-like [KO:K01084] [EC:3.1.3.9]
111967986  g6pc3; glucose-6-phosphatase 3 [KO:K01084] [EC:3.1.3.9]
111981111  fructose-1,6-bisphosphatase 1 [KO:K03841] [EC:3.1.3.11]
111961314  fructose-1,6-bisphosphatase 1 [KO:K03841] [EC:3.1.3.11]
112077719  fructose-1,6-bisphosphatase 1-like [KO:K03841] [EC:3.1.3.11]
111972759  phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
111961621  pck1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
111953319  phosphoenolpyruvate carboxykinase, cytosolic [GTP] isoform X1 [KO:K01596] [EC:4.1.1.32]
112068245  LOW QUALITY PROTEIN: serine/threonine-protein kinase mTOR-like [KO:K07203] [EC:2.7.11.1]
112080951  regulatory-associated protein of mTOR-like [KO:K07204]
111982470  rptor; regulatory-associated protein of mTOR [KO:K07204]
111958210  ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
112071022  ribosomal protein S6 kinase beta-2-like isoform X1 [KO:K04688] [EC:2.7.11.1]
111949774  ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
111951073  ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
111980213  ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
111958360  ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
112072530  40S ribosomal protein S6 [KO:K02991]
111971515  40S ribosomal protein S6 [KO:K02991]
112080070  eukaryotic translation initiation factor 4E-binding protein 3-like [KO:K07205]
111957660  eukaryotic translation initiation factor 4E-binding protein 2 [KO:K07205]
111960854  LOW QUALITY PROTEIN: eukaryotic translation initiation factor 4E-binding protein 1-like [KO:K07205]
111951941  eukaryotic translation initiation factor 4E-like isoform X1 [KO:K03259]
111968618  eukaryotic translation initiation factor 4E [KO:K03259]
111978162  eukaryotic translation initiation factor 4E isoform X1 [KO:K03259]
111965823  eukaryotic translation initiation factor 4E-1A [KO:K03259]
112076927  eukaryotic translation initiation factor 4E type 2-like [KO:K03259]
111964321  eukaryotic translation initiation factor 4E-1B isoform X1 [KO:K03259]
111963377  eukaryotic translation initiation factor 4E [KO:K03259]
111958124  eif4e2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
111964075  hamartin isoform X1 [KO:K07206]
111961557  hamartin [KO:K07206]
111974703  tsc1; hamartin isoform X1 [KO:K07206]
111953960  GTP-binding protein Rheb isoform X1 [KO:K07208]
111972164  GTP-binding protein Rheb [KO:K07208]
112068573  GTP-binding protein Rheb isoform X1 [KO:K07208]
111970088  GTP-binding protein Rheb [KO:K07208]
111966742  GTP-binding protein Rheb [KO:K07208]
111964172  bcl2-associated agonist of cell death [KO:K02158]
112076205  bcl2-associated agonist of cell death-like [KO:K02158]
111950212  bcl2-associated agonist of cell death-like [KO:K02158]
111959065  shc1; SHC-transforming protein 1 isoform X1 [KO:K06279]
111972117  SHC-transforming protein 2 isoform X1 [KO:K17447]
111976010  SHC-transforming protein 2-like [KO:K17447]
111980239  LOW QUALITY PROTEIN: SHC-transforming protein 3-like [KO:K17448]
111980424  growth factor receptor-bound protein 2-like [KO:K04364]
111980548  growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
112067754  growth factor receptor-bound protein 2-like [KO:K04364]
112067730  growth factor receptor-bound protein 2-like [KO:K04364]
111957031  son of sevenless homolog 1 [KO:K03099]
112069263  LOW QUALITY PROTEIN: son of sevenless homolog 2-like [KO:K03099]
112074558  LOW QUALITY PROTEIN: son of sevenless homolog 2-like [KO:K03099]
112080716  son of sevenless homolog 1-like isoform X1 [KO:K03099]
111952380  GTPase HRas-like [KO:K02833]
111962576  GTPase HRas [KO:K02833]
112076192  GTPase HRas-like [KO:K07827]
111962485  GTPase KRas isoform X1 [KO:K07827]
111952297  GTPase KRas isoform X1 [KO:K07827]
111957871  serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
111973909  serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
111966206  RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
111976869  RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
111972098  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
111975763  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
111956577  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
111978999  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
111982013  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
111971459  LOW QUALITY PROTEIN: mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
111972161  MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
111952284  MAP kinase-interacting serine/threonine-protein kinase 1 [KO:K04372] [EC:2.7.11.1]
111975534  MAP kinase-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K04372] [EC:2.7.11.1]
112069764  ETS domain-containing protein Elk-1-like isoform X1 [KO:K04375]
112079923  suppressor of cytokine signaling 1-like [KO:K04694]
111955951  suppressor of cytokine signaling 2-like [KO:K04695]
111976262  suppressor of cytokine signaling 2 [KO:K04695]
111968144  suppressor of cytokine signaling 3 [KO:K04696]
112077116  LOW QUALITY PROTEIN: suppressor of cytokine signaling 3-like [KO:K04696]
111978620  suppressor of cytokine signaling 3 [KO:K04696]
112068333  suppressor of cytokine signaling 4-like [KO:K04697]
112080246  suppressor of cytokine signaling 4-like [KO:K04697]
112068776  suppressor of cytokine signaling 4-like [KO:K04697]
111976473  tyrosine-protein phosphatase non-receptor type 1 isoform X1 [KO:K05696] [EC:3.1.3.48]
111966691  tyrosine-protein phosphatase non-receptor type 1 isoform X1 [KO:K05696] [EC:3.1.3.48]
111969625  receptor-type tyrosine-protein phosphatase T-like [KO:K05695] [EC:3.1.3.48]
111972382  receptor-type tyrosine-protein phosphatase F [KO:K05695] [EC:3.1.3.48]
111975557  LOW QUALITY PROTEIN: receptor-type tyrosine-protein phosphatase F-like [KO:K05695] [EC:3.1.3.48]
112071722  LOW QUALITY PROTEIN: receptor-type tyrosine-protein phosphatase F-like [KO:K05695] [EC:3.1.3.48]
111965385  mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
111978139  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
111961224  mitogen-activated protein kinase 10-like isoform X1 [KO:K04440] [EC:2.7.11.24]
111981403  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
111951896  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
111967720  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
111964417  mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
111978569  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
111958214  LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit beta-like [KO:K07209] [EC:2.7.11.10]
111967166  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2B-like [KO:K15909] [EC:3.1.3.86]
112071327  inppl1; LOW QUALITY PROTEIN: phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 [KO:K15909] [EC:3.1.3.86]
111965672  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2B [KO:K15909] [EC:3.1.3.86]
111977840  type I inositol 1,4,5-trisphosphate 5-phosphatase isoform X1 [KO:K01106] [EC:3.1.3.56]
111951802  type I inositol 1,4,5-trisphosphate 5-phosphatase-like isoform X1 [KO:K01106] [EC:3.1.3.56]
Compound
C00031  D-Glucose
C00369  Starch
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
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Reference
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Related
pathway
salp00010  Glycolysis / Gluconeogenesis
salp00061  Fatty acid biosynthesis
salp00500  Starch and sucrose metabolism
salp04010  MAPK signaling pathway
salp04070  Phosphatidylinositol signaling system
salp04210  Apoptosis
KO pathway
ko04910   
LinkDB

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