KEGG   PATHWAY: sclv04148
Entry
sclv04148                   Pathway                                
Name
Efferocytosis - Styela clava (leathery sea squirt)
Class
Cellular Processes; Transport and catabolism
Pathway map
sclv04148  Efferocytosis
sclv04148

Organism
Styela clava (leathery sea squirt) [GN:sclv]
Gene
120343279  caspase-3-like [KO:K02187] [EC:3.4.22.56]
120329950  caspase-3-like [KO:K02187] [EC:3.4.22.56]
120330440  caspase-3-like [KO:K02187] [EC:3.4.22.56]
120334940  caspase-2-like [KO:K04397] [EC:3.4.22.60]
120347763  caspase-3-like isoform X1 [KO:K04397] [EC:3.4.22.60]
120331606  caspase-3-like [KO:K04397] [EC:3.4.22.60]
120332051  caspase-3-like [KO:K04397] [EC:3.4.22.60]
120332231  uncharacterized protein LOC120332231 [KO:K04397] [EC:3.4.22.60]
120333241  caspase-1-like [KO:K04397] [EC:3.4.22.60]
120342079  caspase-3-like [KO:K04397] [EC:3.4.22.60]
120341167  sphingosine kinase 2-like [KO:K04718] [EC:2.7.1.91]
120341186  sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
120327779  sphingosine 1-phosphate receptor 5-like [KO:K04288]
120329474  sphingosine 1-phosphate receptor 3-like [KO:K04288]
120347936  85/88 kDa calcium-independent phospholipase A2-like [KO:K16343] [EC:3.1.1.4]
120335282  phospholipid-transporting ATPase ABCA1-like isoform X1 [KO:K05641]
120332865  ADAM 17-like protease [KO:K06059] [EC:3.4.24.86]
120336775  disintegrin and metalloproteinase domain-containing protein 10-like [KO:K06704] [EC:3.4.24.81]
120325681  hypoxia-inducible factor 1-alpha-like [KO:K08268]
120337228  LOW QUALITY PROTEIN: aryl hydrocarbon receptor nuclear translocator-like [KO:K09097]
120331479  aryl hydrocarbon receptor nuclear translocator-like [KO:K09097]
120331480  aryl hydrocarbon receptor nuclear translocator-like [KO:K09097]
120340363  aryl hydrocarbon receptor nuclear translocator-like [KO:K09097]
120338196  tyrosine-protein kinase JAK2-like [KO:K04447] [EC:2.7.10.2]
120338197  tyrosine-protein kinase JAK2-like isoform X1 [KO:K04447] [EC:2.7.10.2]
120342060  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
120326797  lactadherin-like [KO:K17253]
120337121  lactadherin-like [KO:K17253]
120337334  lactadherin-like isoform X1 [KO:K17253]
120337699  lactadherin-like isoform X1 [KO:K17253]
120329487  lactadherin-like [KO:K17253]
120329488  lactadherin-like [KO:K17253]
120329490  lactadherin-like [KO:K17253]
120329492  lactadherin-like [KO:K17253]
120329494  lactadherin-like [KO:K17253]
120338113  lactadherin-like [KO:K17253]
120346805  lactadherin-like isoform X1 [KO:K17253]
120340494  lactadherin-like [KO:K17253]
120341871  lactadherin-like [KO:K17253]
120342019  lactadherin-like isoform X1 [KO:K17253]
120333542  lactadherin-like [KO:K17253]
120342854  lactadherin-like [KO:K17253]
120338493  tyrosine-protein kinase Mer-like [KO:K05117] [EC:2.7.10.1]
120327866  platelet glycoprotein 4-like [KO:K06259]
120328810  platelet glycoprotein 4-like [KO:K06259]
120326371  thrombospondin-1-like [KO:K16857]
120334253  dual specificity mitogen-activated protein kinase kinase 1-like [KO:K04368] [EC:2.7.12.2]
120331187  prostaglandin G/H synthase 2-like [KO:K11987] [EC:1.14.99.1]
120340042  prostaglandin G/H synthase 2-like [KO:K11987] [EC:1.14.99.1]
120348034  prostaglandin G/H synthase 2-like [KO:K11987] [EC:1.14.99.1]
120348654  prostaglandin G/H synthase 2-like [KO:K11987] [EC:1.14.99.1]
120348658  prostaglandin G/H synthase 2-like [KO:K11987] [EC:1.14.99.1]
120344363  prostaglandin E2 receptor EP4 subtype-like [KO:K04261]
120344366  thromboxane A2 receptor-like [KO:K04261]
120325393  prostaglandin E2 receptor EP4 subtype-like [KO:K04261]
120332857  DNA (cytosine-5)-methyltransferase 3A-like isoform X1 [KO:K17398] [EC:2.1.1.37]
120342108  cyclic AMP-responsive element-binding protein 1-like [KO:K05870]
120339068  sarcoplasmic/endoplasmic reticulum calcium ATPase 1-like [KO:K05853] [EC:7.2.2.10]
120330847  sarcoplasmic/endoplasmic reticulum calcium ATPase 1-like [KO:K05853] [EC:7.2.2.10]
120339188  sarcoplasmic/endoplasmic reticulum calcium ATPase 1-like [KO:K05853] [EC:7.2.2.10]
120339733  sarcoplasmic/endoplasmic reticulum calcium ATPase 1-like [KO:K05853] [EC:7.2.2.10]
120339734  sarcoplasmic/endoplasmic reticulum calcium ATPase 1-like [KO:K05853] [EC:7.2.2.10]
120339735  sarcoplasmic/endoplasmic reticulum calcium ATPase 1-like [KO:K05853] [EC:7.2.2.10]
120339736  sarcoplasmic/endoplasmic reticulum calcium ATPase 1-like [KO:K05853] [EC:7.2.2.10]
120339930  sarcoplasmic/endoplasmic reticulum calcium ATPase 1-like [KO:K05853] [EC:7.2.2.10]
120340003  sarcoplasmic/endoplasmic reticulum calcium ATPase 1-like [KO:K05853] [EC:7.2.2.10]
120348548  sarcoplasmic/endoplasmic reticulum calcium ATPase 1-like isoform X1 [KO:K05853] [EC:7.2.2.10]
120340457  sarcoplasmic/endoplasmic reticulum calcium ATPase 1-like [KO:K05853] [EC:7.2.2.10]
120347288  calcium/calmodulin-dependent protein kinase type II delta chain-like isoform X1 [KO:K04515] [EC:2.7.11.17]
120340616  mitogen-activated protein kinase 14-like [KO:K04441] [EC:2.7.11.24]
120327656  allene oxide synthase-lipoxygenase protein-like isoform X1 [KO:K00461] [EC:1.13.11.34]
120328067  allene oxide synthase-lipoxygenase protein-like [KO:K00461] [EC:1.13.11.34]
120330915  allene oxide synthase-lipoxygenase protein-like [KO:K00461] [EC:1.13.11.34]
120339739  allene oxide synthase-lipoxygenase protein-like [KO:K00461] [EC:1.13.11.34]
120339931  allene oxide synthase-lipoxygenase protein-like isoform X1 [KO:K00461] [EC:1.13.11.34]
120339932  allene oxide synthase-lipoxygenase protein-like [KO:K00461] [EC:1.13.11.34]
120342283  allene oxide synthase-lipoxygenase protein-like [KO:K00461] [EC:1.13.11.34]
120342991  allene oxide synthase-lipoxygenase protein-like [KO:K00461] [EC:1.13.11.34]
120330721  uncharacterized protein LOC120330721 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
120339863  dual specificity protein phosphatase 6-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
120343571  anoctamin-4-like isoform X1 [KO:K19499]
120328995  anoctamin-7-like [KO:K19501]
120342298  anoctamin-7-like [KO:K19501]
120345331  uncharacterized protein LOC120345331 [KO:K26811]
120341670  phospholipid-transporting ATPase IB-like isoform X1 [KO:K14802] [EC:7.6.2.1]
120327770  cell cycle control protein 50A-like [KO:K26935]
120327601  cell cycle control protein 50A-like [KO:K26935]
120331829  stabilin-2-like isoform X1 [KO:K19013]
120345501  focal adhesion kinase 1-like isoform X1 [KO:K05725] [EC:2.7.10.2]
120343516  crk-like protein [KO:K04438]
120347407  engulfment and cell motility protein 1-like [KO:K12366]
120343527  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
120329443  ras-related protein Rac1 [KO:K04392]
120329732  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
120347417  LOW QUALITY PROTEIN: calreticulin-like [KO:K08057]
120329279  low-density lipoprotein receptor-related protein 1-like isoform X1 [KO:K04550]
120330143  EGF-like domain-containing protein comC [KO:K24068]
120330427  protein draper-like [KO:K24068]
120329439  ras-related protein Rab-5B-like [KO:K07888]
120347513  transforming growth factor-beta receptor-associated protein 1-like [KO:K20177]
120331440  vacuolar protein sorting-associated protein 8 homolog isoform X1 [KO:K20178]
120342118  vacuolar protein sorting-associated protein 11 homolog [KO:K20179]
120327557  vacuolar protein sorting-associated protein 16 homolog [KO:K20180]
120325733  vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
120345700  vacuolar protein sorting-associated protein 33A-like [KO:K20182]
120344228  ras-related protein Rab-14 [KO:K07881]
120325970  vam6/Vps39-like protein [KO:K20183]
120342037  vacuolar protein sorting-associated protein 41 homolog [KO:K20184]
120327668  ras-related protein Rab-7a-like [KO:K07897]
120328930  lysosomal amino acid transporter 1 homolog [KO:K23678]
120326953  antizyme inhibitor 2-like [KO:K01581] [EC:4.1.1.17]
120336555  ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
120336556  ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
120337928  antizyme inhibitor 2-like isoform X1 [KO:K01581] [EC:4.1.1.17]
120331293  ornithine decarboxylase 1-like [KO:K01581] [EC:4.1.1.17]
120331294  ornithine decarboxylase 1-like [KO:K01581] [EC:4.1.1.17]
120331445  ornithine decarboxylase 1-like [KO:K01581] [EC:4.1.1.17]
120331583  ornithine decarboxylase 1-like isoform X1 [KO:K01581] [EC:4.1.1.17]
120331585  ornithine decarboxylase 1-like [KO:K01581] [EC:4.1.1.17]
120331586  ornithine decarboxylase 1-like [KO:K01581] [EC:4.1.1.17]
120333121  ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
120333350  ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
120333359  ornithine decarboxylase-like isoform X1 [KO:K01581] [EC:4.1.1.17]
120333369  ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
120334156  ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
120343134  ornithine decarboxylase 1-like isoform X1 [KO:K01581] [EC:4.1.1.17]
120345747  cholesterol 25-hydroxylase-like protein 1, member 2 [KO:K10223] [EC:1.14.99.38]
120348064  cholesterol 25-hydroxylase-like protein [KO:K10223] [EC:1.14.99.38]
120348184  carnitine O-palmitoyltransferase 1, liver isoform-like [KO:K08765] [EC:2.3.1.21]
120336444  cytochrome b-c1 complex subunit Rieske, mitochondrial-like [KO:K00411] [EC:7.1.1.8]
120347059  NAD-dependent protein deacetylase sirtuin-1-like [KO:K11411] [EC:2.3.1.286]
120328105  gastric triacylglycerol lipase-like [KO:K01052] [EC:3.1.1.13]
120342091  lysosomal acid lipase/cholesteryl ester hydrolase-like isoform X1 [KO:K01052] [EC:3.1.1.13]
120327684  phospholipase A2 group XV-like [KO:K06129] [EC:3.1.1.5]
120329735  solute carrier family 2, facilitated glucose transporter member 1-like [KO:K07299]
120330374  solute carrier family 2, facilitated glucose transporter member 1-like [KO:K07299]
120330483  solute carrier family 2, facilitated glucose transporter member 3-like [KO:K07299]
120333692  solute carrier family 2, facilitated glucose transporter member 1-like [KO:K07299]
120327787  tyrosine-protein phosphatase non-receptor type 11-like [KO:K07293] [EC:3.1.3.48]
Compound
C00002  ATP
C00003  NAD+
C00019  S-Adenosyl-L-methionine
C00031  D-Glucose
C00062  L-Arginine
C00073  L-Methionine
C00075  UTP
C00077  L-Ornithine
C00134  Putrescine
C00162  Fatty acid
C00186  (S)-Lactate
C00187  Cholesterol
C00584  Prostaglandin E2
C02530  Cholesterol ester
C02737  Phosphatidylserine
C04230  1-Acyl-sn-glycero-3-phosphocholine
C06124  Sphingosine 1-phosphate
C06314  Lipoxin A4
C15519  25-Hydroxycholesterol
C15610  Cholest-5-ene-3beta,26-diol
C18178  Resolvin D1
Reference
PMID:31822793
  Authors
Doran AC, Yurdagul A Jr, Tabas I
  Title
Efferocytosis in health and disease.
  Journal
Nat Rev Immunol 20:254-267 (2020)
DOI:10.1038/s41577-019-0240-6
Reference
PMID:36028471
  Authors
Zhang J, Ding W, Zhao M, Liu J, Xu Y, Wan J, Wang M
  Title
Mechanisms of efferocytosis in determining inflammation resolution: Therapeutic potential and the association with cardiovascular disease.
  Journal
Br J Pharmacol 179:5151-5171 (2022)
DOI:10.1111/bph.15939
Reference
PMID:30165442
  Authors
Kawano M, Nagata S
  Title
Efferocytosis and autoimmune disease.
  Journal
Int Immunol 30:551-558 (2018)
DOI:10.1093/intimm/dxy055
Reference
PMID:35650427
  Authors
Mehrotra P, Ravichandran KS
  Title
Drugging the efferocytosis process: concepts and opportunities.
  Journal
Nat Rev Drug Discov 21:601-620 (2022)
DOI:10.1038/s41573-022-00470-y
Reference
PMID:28496201
  Authors
Park SY, Kim IS
  Title
Engulfment signals and the phagocytic machinery for apoptotic cell clearance.
  Journal
Exp Mol Med 49:e331 (2017)
DOI:10.1038/emm.2017.52
Reference
PMID:28137963
  Authors
Kojima Y, Weissman IL, Leeper NJ
  Title
The Role of Efferocytosis in Atherosclerosis.
  Journal
Circulation 135:476-489 (2017)
DOI:10.1161/CIRCULATIONAHA.116.025684
Related
pathway
sclv00010  Glycolysis / Gluconeogenesis
sclv04140  Autophagy - animal
sclv04145  Phagosome
KO pathway
ko04148   
LinkDB

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