KEGG   PATHWAY: sgh04625
Entry
sgh04625                    Pathway                                
Name
C-type lectin receptor signaling pathway - Sinocyclocheilus grahami (golden-line barbel)
Description
C-type lectin receptors (CLRs) are a large superfamily of proteins characterized by the presence of one or more C-type lectin-like domains (CTLDs). CLRs function as pattern-recognition receptors (PRRs) for pathogen-derived ligands in dendric cells, macrophages, neutrophils, etc., such as Dectin-1 and Dectin-2 for recognition of fungi-derived B-glucan and high mannose-type carbohydrates. Upon ligand binding, CLRs stimulate intracellular signaling cascades that induce the production of inflammatory cytokines and chemokines, consequently triggering innate and adaptive immunity to pathogens.
Class
Organismal Systems; Immune system
Pathway map
sgh04625  C-type lectin receptor signaling pathway
sgh04625

Organism
Sinocyclocheilus grahami (golden-line barbel) [GN:sgh]
Gene
107562835  GTPase HRas-like isoform X1 [KO:K02833]
107558311  GTPase HRas-like [KO:K02833]
107600445  GTPase HRas-like [KO:K02833]
107596435  GTPase HRas isoform X1 [KO:K02833]
107567516  GTPase HRas-like [KO:K07827]
107549277  ras-like protein isoform X1 [KO:K07827]
107560753  GTPase HRas-like [KO:K07827]
107595236  ras-like protein isoform X1 [KO:K07827]
107598969  GTPase NRas-like [KO:K07828]
107566814  GTPase NRas [KO:K07828]
107587007  ras-related protein M-Ras-like [KO:K07831]
107600440  ras-related protein M-Ras [KO:K07831]
107551943  ras-related protein M-Ras-like isoform X1 [KO:K07831]
107593037  ras-related protein M-Ras-like [KO:K07831]
107585947  rras2; ras-related protein R-Ras2 [KO:K07830]
107594274  ras-related protein R-Ras2-like [KO:K07830]
107554112  ras-related protein R-Ras-like [KO:K07830]
107583016  ras-related protein R-Ras-like [KO:K07830]
107564278  raf1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
107571214  RAF proto-oncogene serine/threonine-protein kinase-like isoform X1 [KO:K04366] [EC:2.7.11.1]
107555780  RAF proto-oncogene serine/threonine-protein kinase-like [KO:K04366] [EC:2.7.11.1]
107574010  rela; transcription factor p65 isoform X1 [KO:K04735]
107573921  transcription factor p65-like [KO:K04735]
107582588  transcription factor RelB homolog isoform X1 [KO:K09253]
107554269  transcription factor RelB-like isoform X1 [KO:K09253]
107551286  interleukin-12 subunit alpha-like [KO:K05406]
107602578  interleukin-12 subunit beta-like [KO:K05425]
107554450  interleukin-12 subunit beta-like [KO:K05425]
107554524  interleukin-1 beta-like [KO:K04519]
107589025  interleukin-1 beta-like [KO:K04519]
107581079  interleukin-1 beta-like [KO:K04519]
107558251  tyrosine-protein kinase SYK-like [KO:K05855] [EC:2.7.10.2]
107560409  syk; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
107602222  tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
107593936  tyrosine-protein phosphatase non-receptor type 11-like isoform X1 [KO:K07293] [EC:3.1.3.48]
107591094  tyrosine-protein phosphatase non-receptor type 11-like isoform X1 [KO:K07293] [EC:3.1.3.48]
107590367  mitogen-activated protein kinase kinase kinase 14-like isoform X1 [KO:K04466] [EC:2.7.11.25]
107601304  mitogen-activated protein kinase kinase kinase 14-like [KO:K04466] [EC:2.7.11.25]
107554607  STE20-like serine/threonine-protein kinase [KO:K04466] [EC:2.7.11.25]
107599747  uncharacterized protein LOC107599747 [KO:K04466] [EC:2.7.11.25]
107559325  inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
107601877  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
107563053  nuclear factor NF-kappa-B p100 subunit-like [KO:K04469]
107601822  nuclear factor NF-kappa-B p100 subunit-like isoform X1 [KO:K04469]
107587040  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2-like [KO:K05859] [EC:3.1.4.11]
107587041  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2-like [KO:K05859] [EC:3.1.4.11]
107559804  plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
107581741  inositol 1,4,5-trisphosphate receptor type 1-like [KO:K04958]
107582692  inositol 1,4,5-trisphosphate receptor type 1-like [KO:K04958]
107585177  inositol 1,4,5-trisphosphate receptor type 1-like [KO:K04958]
107553933  itpr2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
107583890  inositol 1,4,5-trisphosphate receptor type 2-like [KO:K04959]
107549213  itpr3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
107555587  LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 3-like [KO:K04960]
107581490  calmodulin [KO:K02183]
107597846  calmodulin-like [KO:K02183]
107548236  calmodulin [KO:K02183]
107582745  calmodulin [KO:K02183]
107582783  calmodulin [KO:K02183]
107593483  calmodulin-like isoform X1 [KO:K02183]
107549625  calmodulin-like protein 4 isoform X1 [KO:K02183]
107559413  calmodulin [KO:K02183]
107561747  calmodulin-A isoform X1 [KO:K02183]
107550044  calmodulin [KO:K02183]
107590878  calmodulin [KO:K02183]
107586481  calmodulin [KO:K02183]
107563455  calmodulin-like protein 4 [KO:K02183]
107553107  calmodulin-like protein 4 [KO:K02183]
107590004  calm2; calmodulin [KO:K02183]
107589094  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
107586120  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
107553709  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
107557026  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like [KO:K04348] [EC:3.1.3.16]
107559267  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like [KO:K04348] [EC:3.1.3.16]
107595030  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like [KO:K04348] [EC:3.1.3.16]
107559060  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like [KO:K04348] [EC:3.1.3.16]
107587417  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like [KO:K04348] [EC:3.1.3.16]
107571543  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
107577029  calcineurin subunit B type 1-like [KO:K06268]
107558205  calcineurin subunit B type 1-like [KO:K06268]
107594412  calcineurin subunit B type 1-like isoform X1 [KO:K06268]
107561987  ppp3r1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
107583200  calcineurin subunit B type 1-like [KO:K06268]
107563708  nuclear factor of activated T-cells, cytoplasmic 1-like [KO:K04446]
107592032  nuclear factor of activated T-cells, cytoplasmic 1-like [KO:K04446]
107590470  nuclear factor of activated T-cells, cytoplasmic 2-like isoform X1 [KO:K17332]
107560498  nuclear factor of activated T-cells, cytoplasmic 1-like [KO:K17332]
107587592  nuclear factor of activated T-cells, cytoplasmic 2-like [KO:K17332]
107558753  nuclear factor of activated T-cells, cytoplasmic 2-like isoform X1 [KO:K17332]
107566268  nuclear factor of activated T-cells, cytoplasmic 3-like [KO:K17333]
107563458  nuclear factor of activated T-cells, cytoplasmic 3-like isoform X1 [KO:K17333]
107555722  nuclear factor of activated T-cells, cytoplasmic 3-like [KO:K17333]
107548920  nuclear factor of activated T-cells, cytoplasmic 3-like [KO:K17333]
107591355  nuclear factor of activated T-cells, cytoplasmic 4-like isoform X1 [KO:K17334]
107557669  nuclear factor of activated T-cells, cytoplasmic 4-like isoform X1 [KO:K17334]
107590185  interleukin-10-like [KO:K05443]
107555708  interleukin-10-like [KO:K05443]
107593522  early growth response protein 2b [KO:K12496]
107561671  early growth response protein 2b-like [KO:K12496]
107586831  early growth response protein 2b-like [KO:K12496]
107596611  early growth response protein 2b-like [KO:K12496]
107596614  early growth response protein 2b-like [KO:K12496]
107562644  early growth response protein 3-like [KO:K12497]
107553505  prostaglandin G/H synthase 2-like [KO:K11987] [EC:1.14.99.1]
107594645  prostaglandin G/H synthase 2-like [KO:K11987] [EC:1.14.99.1]
107599092  prostaglandin G/H synthase 2-like [KO:K11987] [EC:1.14.99.1]
107589869  prostaglandin G/H synthase 2-like [KO:K11987] [EC:1.14.99.1]
107558893  prkcd; protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
107582675  protein kinase C delta type-like isoform X1 [KO:K06068] [EC:2.7.11.13]
107600299  protein kinase C delta type-like [KO:K06068] [EC:2.7.11.13]
107590568  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
107599610  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
107599134  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
107567791  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
107575476  apoptosis-associated speck-like protein containing a CARD [KO:K12799]
107592608  apoptosis-associated speck-like protein containing a CARD [KO:K12799]
107570904  caspase-1-A-like [KO:K01370] [EC:3.4.22.36]
107571890  caspase-1-A-like [KO:K01370] [EC:3.4.22.36]
107574341  caspase-1-like [KO:K01370] [EC:3.4.22.36]
107558420  caspase-1-like [KO:K01370] [EC:3.4.22.36]
107573577  caspase-1-A-like [KO:K01370] [EC:3.4.22.36]
107571421  caspase-1-A-like isoform X1 [KO:K01370] [EC:3.4.22.36]
107600521  caspase-1-like [KO:K01370] [EC:3.4.22.36]
107592160  caspase-1-like [KO:K01370] [EC:3.4.22.36]
107555475  caspase recruitment domain-containing protein 9-like [KO:K12794]
107587541  caspase recruitment domain-containing protein 9-like [KO:K12794]
107562861  bcl10; B-cell lymphoma/leukemia 10 isoform X1 [KO:K07368]
107561899  mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog [KO:K07369] [EC:3.4.22.-]
107567134  malt1; mucosa-associated lymphoid tissue lymphoma translocation protein 1 [KO:K07369] [EC:3.4.22.-]
107588074  mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog [KO:K07369] [EC:3.4.22.-]
107562120  mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog [KO:K07369] [EC:3.4.22.-]
107567895  mucosa-associated lymphoid tissue lymphoma translocation protein 1-like [KO:K07369] [EC:3.4.22.-]
107587532  mucosa-associated lymphoid tissue lymphoma translocation protein 1-like [KO:K07369] [EC:3.4.22.-]
107578688  mucosa-associated lymphoid tissue lymphoma translocation protein 1-like [KO:K07369] [EC:3.4.22.-]
107566313  caspase-8-like [KO:K04398] [EC:3.4.22.61]
107555445  caspase-8-like [KO:K04398] [EC:3.4.22.61]
107597346  caspase-8-like isoform X1 [KO:K04398] [EC:3.4.22.61]
107555418  caspase-8-like [KO:K04398] [EC:3.4.22.61]
107560797  caspase-8-like [KO:K04398] [EC:3.4.22.61]
107560912  NF-kappa-B essential modulator-like isoform X1 [KO:K07210]
107562470  NF-kappa-B essential modulator-like isoform X1 [KO:K07210]
107559596  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
107581491  NF-kappa-B inhibitor alpha-like [KO:K04734]
107597844  NF-kappa-B inhibitor alpha-like [KO:K04734]
107589639  NF-kappa-B inhibitor alpha-like isoform X1 [KO:K04734]
107586612  NF-kappa-B inhibitor alpha-like isoform X1 [KO:K04734]
107587053  nuclear factor NF-kappa-B p105 subunit-like [KO:K02580]
107595780  nuclear factor NF-kappa-B p105 subunit-like [KO:K02580]
107597453  tumor necrosis factor-like [KO:K03156]
107570916  interleukin-6-like [KO:K05405]
107571360  interleukin-6-like [KO:K05405]
107583896  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
107598961  mitogen-activated protein kinase 13-like [KO:K04441] [EC:2.7.11.24]
107551519  mitogen-activated protein kinase 14-like [KO:K04441] [EC:2.7.11.24]
107555985  mitogen-activated protein kinase 14B-like [KO:K04441] [EC:2.7.11.24]
107570980  mitogen-activated protein kinase 13-like isoform X1 [KO:K04441] [EC:2.7.11.24]
107583837  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
107583972  mitogen-activated protein kinase 11-like [KO:K04441] [EC:2.7.11.24]
107592575  mitogen-activated protein kinase 14B-like [KO:K04441] [EC:2.7.11.24]
107553980  mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
107591834  mitogen-activated protein kinase 14A-like isoform X1 [KO:K04441] [EC:2.7.11.24]
107559857  mitogen-activated protein kinase 14A-like isoform X1 [KO:K04441] [EC:2.7.11.24]
107579544  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
107579565  mitogen-activated protein kinase 11-like [KO:K04441] [EC:2.7.11.24]
107549963  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
107566214  mitogen-activated protein kinase 9-like isoform X1 [KO:K04440] [EC:2.7.11.24]
107565387  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
107584639  mitogen-activated protein kinase 10-like [KO:K04440] [EC:2.7.11.24]
107588610  mitogen-activated protein kinase 8B isoform X1 [KO:K04440] [EC:2.7.11.24]
107548633  mitogen-activated protein kinase 8B isoform X1 [KO:K04440] [EC:2.7.11.24]
107590058  mitogen-activated protein kinase 9-like [KO:K04440] [EC:2.7.11.24]
107571265  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
107581481  transcription factor AP-1-like [KO:K04448]
107597804  transcription factor AP-1-like [KO:K04448]
107563389  transcription factor AP-1-like isoform X1 [KO:K04448]
107548831  E3 ubiquitin-protein ligase CBL-B-like [KO:K22517] [EC:2.3.2.27]
107576804  E3 ubiquitin-protein ligase CBL-B-like [KO:K22517] [EC:2.3.2.27]
107558432  high affinity immunoglobulin epsilon receptor subunit gamma-like isoform X1 [KO:K07983]
107597895  high affinity immunoglobulin epsilon receptor subunit gamma-like isoform X1 [KO:K07983]
107576360  high affinity immunoglobulin epsilon receptor subunit gamma-like [KO:K07983]
107573598  CD209 antigen-like protein 2 [KO:K06563]
107594307  CD209 antigen-like protein 2 [KO:K06563]
107600769  rho guanine nucleotide exchange factor 12-like isoform X1 [KO:K07532]
107556420  rho guanine nucleotide exchange factor 12-like [KO:K07532]
107586229  rho guanine nucleotide exchange factor 12-like isoform X1 [KO:K07532]
107601722  rho guanine nucleotide exchange factor 12-like isoform X1 [KO:K07532]
107579050  transforming protein RhoA-like [KO:K04513]
107549297  rho-related GTP-binding protein RhoA-D-like [KO:K04513]
107562777  rho-related GTP-binding protein RhoA-D-like isoform X1 [KO:K04513]
107569805  rho-related GTP-binding protein RhoA-D [KO:K04513]
107599000  rho-related GTP-binding protein RhoA-A-like [KO:K04513]
107603137  rho-related GTP-binding protein RhoA-A [KO:K04513]
107558917  rho-related GTP-binding protein RhoA-C [KO:K04513]
107571578  rho-related GTP-binding protein RhoA-D-like [KO:K04513]
107556503  rho-related GTP-binding protein RhoA-B-like [KO:K04513]
107591763  rho-related GTP-binding protein RhoA-D-like [KO:K04513]
107591788  rho-related GTP-binding protein RhoA-B [KO:K04513]
107594372  pak1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
107583358  kinase suppressor of Ras 1-like isoform X1 [KO:K14958]
107587380  kinase suppressor of Ras 1-like [KO:K14958]
107592917  kinase suppressor of Ras 1-like isoform X1 [KO:K14958]
107557223  serine/threonine-protein kinase PLK3-like [KO:K08862] [EC:2.7.11.21]
107563563  serine/threonine-protein kinase PLK3-like [KO:K08862] [EC:2.7.11.21]
107590469  proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
107558752  proto-oncogene tyrosine-protein kinase Src-like isoform X1 [KO:K05704] [EC:2.7.10.2]
107590150  inhibitor of nuclear factor kappa-B kinase subunit epsilon-like isoform X1 [KO:K07211] [EC:2.7.11.10]
107555619  inhibitor of nuclear factor kappa-B kinase subunit epsilon-like [KO:K07211] [EC:2.7.11.10]
107586991  signal transducer and activator of transcription 1-alpha/beta-like [KO:K11220]
107565020  signal transducer and activator of transcription 1-like [KO:K11220]
107602152  signal transducer and activator of transcription 1-like [KO:K11220]
107600977  signal transducer and activator of transcription 1-alpha/beta-like isoform X1 [KO:K11220]
107556768  interferon regulatory factor 8-like isoform X1 [KO:K04693]
107551847  interferon regulatory factor 9-like isoform X1 [KO:K04693]
107582712  signal transducer and activator of transcription 1-alpha/beta-like [KO:K11221]
107585138  signal transducer and activator of transcription 1-alpha/beta-like isoform X1 [KO:K11221]
107597382  interleukin-17D-like [KO:K05492]
107574178  ubiquitin carboxyl-terminal hydrolase CYLD-like [KO:K08601] [EC:3.4.19.12]
107551493  ubiquitin carboxyl-terminal hydrolase CYLD-like isoform X1 [KO:K08601] [EC:3.4.19.12]
107591203  uncharacterized protein LOC107591203 [KO:K08601] [EC:3.4.19.12]
107594643  ubiquitin carboxyl-terminal hydrolase CYLD-like [KO:K08601] [EC:3.4.19.12]
107556989  ubiquitin carboxyl-terminal hydrolase CYLD-like [KO:K08601] [EC:3.4.19.12]
107563013  ubiquitin carboxyl-terminal hydrolase CYLD-like [KO:K08601] [EC:3.4.19.12]
107550272  ubiquitin carboxyl-terminal hydrolase CYLD-like [KO:K08601] [EC:3.4.19.12]
107596570  receptor-interacting serine/threonine-protein kinase 4-like isoform X1 [KO:K09258]
107593656  B-cell lymphoma 3 protein homolog isoform X1 [KO:K09258]
107549293  MAP kinase-activated protein kinase 2-like [KO:K04443] [EC:2.7.11.1]
107590153  MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
107576554  MAP kinase-activated protein kinase 2-like [KO:K04443] [EC:2.7.11.1]
107550950  MAP kinase-activated protein kinase 2-like isoform X1 [KO:K04443] [EC:2.7.11.1]
107559693  C-type lectin domain family 4 member F-like [KO:K10059]
107551672  CD209 antigen-like protein C [KO:K10059]
107592690  C-type lectin domain family 4 member E-like [KO:K10059]
107589493  C-type lectin domain family 4 member E-like [KO:K10059]
107550941  C-type lectin domain family 4 member E-like [KO:K10059]
107582056  CD209 antigen-like protein C isoform X1 [KO:K10059]
107554434  C-type lectin domain family 4 member E-like [KO:K10059]
107574159  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
107567258  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like isoform X1 [KO:K00922] [EC:2.7.1.153]
107551780  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
107571432  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
107571564  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform-like [KO:K00922] [EC:2.7.1.153]
107586517  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
107598784  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like isoform X1 [KO:K00922] [EC:2.7.1.153]
107550618  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
107594617  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
107586063  phosphatidylinositol 3-kinase regulatory subunit beta-like [KO:K02649]
107595995  phosphatidylinositol 3-kinase regulatory subunit alpha-like [KO:K02649]
107556985  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
107600587  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
107593753  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
107564028  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
107550532  RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
107565536  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
107557843  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
107598536  RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
107587842  akt3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
107565462  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
107585271  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
107572728  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
107572734  RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
107594289  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
107556775  E3 ubiquitin-protein ligase Mdm2-like [KO:K06643] [EC:2.3.2.27]
107590969  E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
107603236  interferon regulatory factor 1-like [KO:K09444]
107570439  interferon regulatory factor 1-like [KO:K09444]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00159  D-Mannose
C00165  Diacylglycerol
C00584  Prostaglandin E2
C00965  1,3-beta-D-Glucan
C01019  L-Fucose
C01245  D-myo-Inositol 1,4,5-trisphosphate
C16844  Hydroxyl radical
C21790  Mycobacterial trehalose dimycolate
C21791  Rhodocytin
G13115  Mannose-capped lipoarabinomannan
Reference
PMID:27291962
  Authors
Geijtenbeek TB, Gringhuis SI
  Title
C-type lectin receptors in the control of T helper cell differentiation.
  Journal
Nat Rev Immunol 16:433-48 (2016)
DOI:10.1038/nri.2016.55
Reference
PMID:21350579
  Authors
Hajishengallis G, Lambris JD
  Title
Microbial manipulation of receptor crosstalk in innate immunity.
  Journal
Nat Rev Immunol 11:187-200 (2011)
DOI:10.1038/nri2918
Reference
PMID:28604735
  Authors
Iliev ID, Leonardi I
  Title
Fungal dysbiosis: immunity and interactions at mucosal barriers.
  Journal
Nat Rev Immunol 17:635-646 (2017)
DOI:10.1038/nri.2017.55
Reference
PMID:25002863
  Authors
Richardson MB, Williams SJ
  Title
MCL and Mincle: C-Type Lectin Receptors That Sense Damaged Self and Pathogen-Associated Molecular Patterns.
  Journal
Front Immunol 5:288 (2014)
DOI:10.3389/fimmu.2014.00288
Reference
PMID:21924922
  Authors
Vautier S, MacCallum DM, Brown GD
  Title
C-type lectin receptors and cytokines in fungal immunity.
  Journal
Cytokine 58:89-99 (2012)
DOI:10.1016/j.cyto.2011.08.031
Reference
PMID:22170181
  Authors
Gauglitz GG, Callenberg H, Weindl G, Korting HC
  Title
Host defence against Candida albicans and the role of pattern-recognition receptors.
  Journal
Acta Derm Venereol 92:291-8 (2012)
DOI:10.2340/00015555-1250
Reference
PMID:22973279
  Authors
Cunha C, Carvalho A, Esposito A, Bistoni F, Romani L
  Title
DAMP signaling in fungal infections and diseases.
  Journal
Front Immunol 3:286 (2012)
DOI:10.3389/fimmu.2012.00286
Reference
PMID:29449845
  Authors
Tang J, Lin G, Langdon WY, Tao L, Zhang J
  Title
Regulation of C-Type Lectin Receptor-Mediated Antifungal Immunity.
  Journal
Front Immunol 9:123 (2018)
DOI:10.3389/fimmu.2018.00123
Reference
PMID:27999992
  Authors
Mayer S, Raulf MK, Lepenies B
  Title
C-type lectins: their network and roles in pathogen recognition and immunity.
  Journal
Histochem Cell Biol 147:223-237 (2017)
DOI:10.1007/s00418-016-1523-7
Reference
PMID:23570314
  Authors
Plato A, Willment JA, Brown GD
  Title
C-type lectin-like receptors of the dectin-1 cluster: ligands and signaling pathways.
  Journal
Int Rev Immunol 32:134-56 (2013)
DOI:10.3109/08830185.2013.777065
Reference
PMID:22344277
  Authors
Dupaul-Chicoine J, Saleh M
  Title
A new path to IL-1beta production controlled by caspase-8.
  Journal
Nat Immunol 13:211-2 (2012)
DOI:10.1038/ni.2241
Reference
PMID:24009832
  Authors
Batbayar S, Lee DH, Kim HW
  Title
Immunomodulation of Fungal beta-Glucan in Host Defense Signaling by Dectin-1.
  Journal
Biomol Ther (Seoul) 20:433-45 (2012)
DOI:10.4062/biomolther.2012.20.5.433
Reference
PMID:28606994
  Authors
Bendickova K, Tidu F, Fric J
  Title
Calcineurin-NFAT signalling in myeloid leucocytes: new prospects and pitfalls in immunosuppressive therapy.
  Journal
EMBO Mol Med 9:990-999 (2017)
DOI:10.15252/emmm.201707698
Reference
PMID:18998127
  Authors
den Dunnen J, Gringhuis SI, Geijtenbeek TB
  Title
Innate signaling by the C-type lectin DC-SIGN dictates immune responses.
  Journal
Cancer Immunol Immunother 58:1149-57 (2009)
DOI:10.1007/s00262-008-0615-1
Reference
PMID:28640912
  Authors
Marakalala MJ, Ndlovu H
  Title
Signaling C-type lectin receptors in antimycobacterial immunity.
  Journal
PLoS Pathog 13:e1006333 (2017)
DOI:10.1371/journal.ppat.1006333
Reference
PMID:24867235
  Authors
Gringhuis SI, Kaptein TM, Wevers BA, Mesman AW, Geijtenbeek TB
  Title
Fucose-specific DC-SIGN signalling directs T helper cell type-2 responses via IKKepsilon- and CYLD-dependent Bcl3 activation.
  Journal
Nat Commun 5:3898 (2014)
DOI:10.1038/ncomms4898
Reference
PMID:19521399
  Authors
Geijtenbeek TB, Gringhuis SI
  Title
Signalling through C-type lectin receptors: shaping immune responses.
  Journal
Nat Rev Immunol 9:465-79 (2009)
DOI:10.1038/nri2569
Reference
PMID:19122653
  Authors
Gringhuis SI, den Dunnen J, Litjens M, van der Vlist M, Wevers B, Bruijns SC, Geijtenbeek TB
  Title
Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-kappaB activation through Raf-1 and Syk.
  Journal
Nat Immunol 10:203-13 (2009)
DOI:10.1038/ni.1692
KO pathway
ko04625   
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