KEGG   PATHWAY: stru04310
Entry
stru04310                   Pathway                                
Name
Wnt signaling pathway - Salmo trutta (river trout)
Description
Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin.
Class
Environmental Information Processing; Signal transduction
Pathway map
stru04310  Wnt signaling pathway
stru04310

Other DBs
GO: 0016055
Organism
Salmo trutta (river trout) [GN:stru]
Gene
115168081  protein-serine O-palmitoleoyltransferase porcupine-like isoform X1 [KO:K00181] [EC:2.3.1.250]
115168256  protein-serine O-palmitoleoyltransferase porcupine-like isoform X1 [KO:K00181] [EC:2.3.1.250]
115165745  protein-serine O-palmitoleoyltransferase porcupine-like isoform X1 [KO:K00181] [EC:2.3.1.250]
115167848  protein Wnt-1 isoform X1 [KO:K03209]
115165508  protein Wnt-1-like isoform X1 [KO:K03209]
115152320  protein Wnt-2-like isoform X1 [KO:K00182]
115150990  protein Wnt-2b-A-like [KO:K00182]
115207437  protein Wnt-2b-A-like [KO:K00182]
115197546  protein Wnt-2 [KO:K00182]
115169582  protein Wnt-3a [KO:K00312]
115158435  proto-oncogene Wnt-3-like isoform X1 [KO:K00312]
115157195  protein Wnt-3a-like [KO:K00312]
115201053  proto-oncogene Wnt-3 isoform X1 [KO:K00312]
115185210  protein Wnt-4a [KO:K00408]
115188006  protein Wnt-4-like isoform X1 [KO:K00408]
115177195  protein Wnt-4-like [KO:K00408]
115150658  protein Wnt-4a-like [KO:K00408]
115189962  protein Wnt-5b [KO:K00444]
115188256  protein Wnt-5b [KO:K00444]
115168542  wnt5a; protein Wnt-5a [KO:K00444]
115156104  protein Wnt-6-like isoform X1 [KO:K00445]
115160681  protein Wnt-6-like [KO:K00445]
115180496  wnt7b; protein Wnt-7b [KO:K00572]
115192675  protein Wnt-7b isoform X1 [KO:K00572]
115168407  protein Wnt-7a [KO:K00572]
115166130  protein Wnt-7a-like [KO:K00572]
115149919  protein Wnt-7a-like [KO:K00572]
115196973  protein Wnt-7b-like isoform X1 [KO:K00572]
115198639  protein Wnt-7b-like [KO:K00572]
115164692  protein Wnt-8a-like [KO:K00714]
115193596  protein Wnt-8b-like [KO:K00714]
115153350  protein Wnt-8b [KO:K00714]
115164069  protein Wnt-8a-like [KO:K00714]
115169581  protein Wnt-9a-like [KO:K01064]
115171144  protein Wnt-9b-like [KO:K01064]
115157197  protein Wnt-9a-like [KO:K01064]
115198259  protein Wnt-9b-like [KO:K01064]
115167850  protein Wnt-10b-like [KO:K01357]
115165509  protein Wnt-10b-like [KO:K01357]
115156103  protein Wnt-10a-like isoform X1 [KO:K01357]
115160682  protein Wnt-10a isoform X1 [KO:K01357]
115154354  protein Wnt-11-like [KO:K01384]
115154548  protein Wnt-11-like [KO:K01384]
115148245  protein Wnt-11-like [KO:K01384]
115148895  protein Wnt-11-like [KO:K01384]
115180444  protein Wnt-16-like [KO:K01558]
115198810  protein Wnt-16-like [KO:K01558]
115177923  DAN domain family member 5-like [KO:K01645]
115188479  palmitoleoyl-protein carboxylesterase notum1a-like [KO:K19882] [EC:3.1.1.98]
115188481  palmitoleoyl-protein carboxylesterase notum1a-like [KO:K19882] [EC:3.1.1.98]
115171812  palmitoleoyl-protein carboxylesterase notum1a-like [KO:K19882] [EC:3.1.1.98]
115178266  carboxylesterase notum2-like isoform X1 [KO:K19882] [EC:3.1.1.98]
115147277  carboxylesterase notum2-like isoform X1 [KO:K19882] [EC:3.1.1.98]
115207146  palmitoleoyl-protein carboxylesterase notum1a [KO:K19882] [EC:3.1.1.98]
115182049  wnt inhibitory factor 1-like [KO:K01691]
115182050  wnt inhibitory factor 1-like [KO:K01691]
115182952  wnt inhibitory factor 1-like [KO:K01691]
115158416  sclerostin-like [KO:K16834]
115201062  sclerostin-like [KO:K16834]
115191724  dickkopf-related protein 2-like [KO:K02165]
115193761  dickkopf-related protein 1-like [KO:K02165]
115153217  dickkopf-related protein 1-like [KO:K02165]
115157016  dickkopf-related protein 1-like [KO:K02165]
115167659  uncharacterized protein LOC115167659 isoform X1 [KO:K02165]
115167662  dickkopf-related protein 1-like [KO:K02165]
115200848  dickkopf-related protein 1-like [KO:K02165]
115194758  dickkopf-related protein 2-like [KO:K02165]
115202300  dickkopf-related protein 2-like [KO:K02165]
115154389  pigment epithelium-derived factor-like [KO:K19614]
115148934  pigment epithelium-derived factor-like [KO:K19614]
115164269  secreted frizzled-related protein 1-like [KO:K02166]
115200384  secreted frizzled-related protein 1-like [KO:K02166]
115192035  secreted frizzled-related protein 2-like [KO:K02176]
115206590  secreted frizzled-related protein 2-like isoform X1 [KO:K02176]
115202077  secreted frizzled-related protein 2-like [KO:K02176]
115155667  secreted frizzled-related protein 3-like [KO:K25481]
115161010  secreted frizzled-related protein 3-like isoform X1 [KO:K25481]
115193535  secreted frizzled-related protein 5-like [KO:K02222]
115153396  sfrp5; secreted frizzled-related protein 5 [KO:K02222]
115176912  R-spondin-1-like [KO:K19471]
115177179  rspo1; R-spondin-1 [KO:K19471]
115176013  R-spondin-2-like isoform X1 [KO:K23097]
115177335  R-spondin-2-like isoform X1 [KO:K23097]
115181496  R-spondin-3-like isoform X1 [KO:K23098]
115176882  R-spondin-3-like isoform X1 [KO:K23098]
115201518  R-spondin-3-like [KO:K23098]
115167119  leucine-rich repeat-containing G-protein coupled receptor 4-like [KO:K04309]
115203215  leucine-rich repeat-containing G-protein coupled receptor 4-like [KO:K04309]
115189731  leucine-rich repeat-containing G-protein coupled receptor 5-like [KO:K04308]
115197534  leucine-rich repeat-containing G-protein coupled receptor 5-like [KO:K04308]
115165248  LOW QUALITY PROTEIN: leucine-rich repeat-containing G-protein coupled receptor 6-like [KO:K08399]
115153896  rnf43; E3 ubiquitin-protein ligase RNF43 [KO:K15694] [EC:2.3.2.27]
115148431  E3 ubiquitin-protein ligase RNF43-like [KO:K15694] [EC:2.3.2.27]
115164117  E3 ubiquitin-protein ligase znrf3-like isoform X1 [KO:K16273] [EC:2.3.2.27]
115200516  E3 ubiquitin-protein ligase znrf3-like isoform X1 [KO:K16273] [EC:2.3.2.27]
115181837  frizzled-1-like [KO:K02432]
115175800  frizzled-1-like isoform X1 [KO:K02432]
115176472  frizzled-1-like [KO:K02432]
115155413  frizzled-7-A-like isoform X1 [KO:K02432]
115179315  frizzled-7-A-like [KO:K02432]
115196030  frizzled-7-A-like [KO:K02432]
115171126  frizzled-2-like [KO:K02235]
115198123  frizzled-2-like [KO:K02235]
115174538  frizzled-3-like [KO:K02329]
115162503  frizzled-3-like [KO:K02329]
115167114  frizzled-3-like isoform X1 [KO:K02329]
115172796  frizzled-3-like [KO:K02329]
115163703  fzd4; frizzled-4 [KO:K02354]
115206582  frizzled-4-like [KO:K02354]
115169824  frizzled-8-like [KO:K02375]
115153600  frizzled-8-like [KO:K02375]
115155564  frizzled-5-like [KO:K02375]
115160889  frizzled-5-like [KO:K02375]
115156871  frizzled-8-like [KO:K02375]
115179743  frizzled-5-like [KO:K02375]
115196473  frizzled-5-like [KO:K02375]
115182202  frizzled-6-like [KO:K02376]
115176348  frizzled-6-like [KO:K02376]
115154203  frizzled-9-like [KO:K02842]
115163206  frizzled-9-like [KO:K02842]
115164603  frizzled-10-like [KO:K02842]
115148709  frizzled-9 [KO:K02842]
115200042  frizzled-10-like isoform X1 [KO:K02842]
115206151  frizzled-9-like [KO:K02842]
115151831  low-density lipoprotein receptor-related protein 5-like [KO:K03068]
115196935  low-density lipoprotein receptor-related protein 5-like isoform X1 [KO:K03068]
115153825  BMP and activin membrane-bound inhibitor homolog [KO:K10162]
115195897  BMP and activin membrane-bound inhibitor homolog [KO:K10162]
115170201  protein APCDD1-like [KO:K25812]
115156483  protein APCDD1-like [KO:K25812]
115148095  protein APCDD1-like [KO:K25812]
115150078  protein APCDD1-like [KO:K25812]
115195574  protein APCDD1-like [KO:K25812]
115208385  protein APCDD1-like [KO:K25812]
115153599  casein kinase I-like [KO:K08960] [EC:2.7.11.1]
115171304  casein kinase I-like [KO:K08960] [EC:2.7.11.1]
115201335  casein kinase I-like [KO:K08960] [EC:2.7.11.1]
115200137  casein kinase I [KO:K08960] [EC:2.7.11.1]
115162144  ccdc88c; protein Daple isoform X1 [KO:K25811]
115172417  protein Daple-like [KO:K25811]
115168869  segment polarity protein dishevelled homolog DVL-1-like [KO:K02353]
115169930  segment polarity protein dishevelled homolog DVL-3-like [KO:K02353]
115155022  segment polarity protein dishevelled homolog DVL-2-like isoform X1 [KO:K02353]
115162875  segment polarity protein dishevelled homolog DVL-3-like [KO:K02353]
115156765  segment polarity protein dishevelled homolog DVL-3-like isoform X1 [KO:K02353]
115194276  segment polarity protein dishevelled homolog DVL-2-like [KO:K02353]
115198278  segment polarity protein dishevelled homolog DVL-2-like [KO:K02353]
115205843  segment polarity protein dishevelled homolog DVL-3-like isoform X1 [KO:K02353]
115176643  GSK-3-binding protein-like [KO:K03096]
115179625  GSK-3-binding protein-like [KO:K03096]
115185756  casein kinase II subunit alpha-like [KO:K03097] [EC:2.7.11.1]
115174049  casein kinase II subunit alpha-like isoform X1 [KO:K03097] [EC:2.7.11.1]
115175558  casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
115176623  casein kinase II subunit alpha-like [KO:K03097] [EC:2.7.11.1]
115166713  casein kinase II subunit alpha'-like isoform X1 [KO:K03097] [EC:2.7.11.1]
115151855  casein kinase II subunit alpha' isoform X1 [KO:K03097] [EC:2.7.11.1]
115150132  casein kinase II subunit alpha-like [KO:K03097] [EC:2.7.11.1]
115208343  casein kinase II subunit alpha isoform X1 [KO:K03097] [EC:2.7.11.1]
115196912  casein kinase II subunit alpha'-like isoform X1 [KO:K03097] [EC:2.7.11.1]
115203596  casein kinase II subunit alpha'-like [KO:K03097] [EC:2.7.11.1]
115185845  casein kinase II subunit beta-like isoform X1 [KO:K03115]
115176017  casein kinase II subunit beta [KO:K03115]
115176651  casein kinase II subunit beta-like isoform X1 [KO:K03115]
115173331  casein kinase II subunit beta isoform X1 [KO:K03115]
115187609  protein naked cuticle homolog 2-like [KO:K03213]
115187614  protein naked cuticle homolog 2-like [KO:K03213]
115167032  protein naked cuticle homolog 1-like isoform X1 [KO:K03213]
115203289  protein naked cuticle homolog 1-like [KO:K03213]
115174000  protein naked cuticle homolog 2-like isoform X1 [KO:K03213]
115175509  protein naked cuticle homolog 2-like isoform X1 [KO:K03213]
115191709  CXXC-type zinc finger protein 4 [KO:K03344]
115198022  uncharacterized protein LOC115198022 [KO:K03344]
115179173  sentrin-specific protease 2-like isoform X1 [KO:K03345] [EC:3.4.22.68]
115196143  sentrin-specific protease 2-like isoform X1 [KO:K03345] [EC:3.4.22.68]
115155817  glycogen synthase kinase-3 beta-like isoform X1 [KO:K03083] [EC:2.7.11.26]
115161154  glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
115179842  glycogen synthase kinase-3 beta-like isoform X1 [KO:K03083] [EC:2.7.11.26]
115195960  glycogen synthase kinase-3 beta-like isoform X1 [KO:K03083] [EC:2.7.11.26]
115185143  catenin beta-1 isoform X1 [KO:K02105]
115177148  catenin beta-1-like isoform X1 [KO:K02105]
115184100  axin-1-like [KO:K02157]
115171165  axin-1-like isoform X1 [KO:K02157]
115178127  axin-1-like isoform X1 [KO:K02157]
115198550  axin-1-like isoform X1 [KO:K02157]
115171662  axin-2-like [KO:K04385]
115178919  axin-2-like isoform X1 [KO:K04385]
115208607  axin-2-like [KO:K04385]
115205333  axin-2-like [KO:K04385]
115158078  apc2; adenomatous polyposis coli protein 2 [KO:K02085]
115159183  adenomatous polyposis coli protein-like isoform X1 [KO:K02085]
115151644  adenomatous polyposis coli protein 2-like [KO:K02085]
115149367  adenomatous polyposis coli protein-like [KO:K02085]
115174846  casein kinase I-like isoform X1 [KO:K08957] [EC:2.7.11.1]
115205450  casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
115154022  lymphoid enhancer-binding factor 1-like isoform X1 [KO:K02620]
115148559  lymphoid enhancer-binding factor 1-like isoform X1 [KO:K02620]
115159747  transcription factor 7-like 1-B isoform X1 [KO:K04490]
115164508  transcription factor 7-like 1-B isoform X1 [KO:K04490]
115203917  transcription factor 7-like 1-B isoform X1 [KO:K04490]
115200136  transcription factor 7-like 1-B isoform X1 [KO:K04490]
115158068  transcription factor 7-like 2 isoform X1 [KO:K04491]
115201081  transcription factor 7-like 2 isoform X1 [KO:K04491]
115191730  lef1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
115200959  leucine zipper putative tumor suppressor 2 homolog [KO:K26471]
115159072  leucine zipper putative tumor suppressor 2 homolog [KO:K26471]
115153388  leucine zipper putative tumor suppressor 2 homolog isoform X1 [KO:K26471]
115193550  leucine zipper putative tumor suppressor 2 homolog isoform X1 [KO:K26471]
115165911  ctnnbip1; beta-catenin-interacting protein 1 [KO:K04493]
115201330  cby1; protein chibby homolog 1 isoform X1 [KO:K23402]
115205134  protein chibby homolog 1-like [KO:K23402]
115169494  chromodomain-helicase-DNA-binding protein 8-like isoform X1 [KO:K04494] [EC:5.6.2.-]
115157310  chromodomain-helicase-DNA-binding protein 8-like isoform X1 [KO:K04494] [EC:5.6.2.-]
115159519  colorectal mutant cancer protein isoform X1 [KO:K26734]
115204121  colorectal mutant cancer protein-like isoform X1 [KO:K26734]
115159787  cell cycle and apoptosis regulator protein 2-like [KO:K25816]
115194015  NAD-dependent protein deacetylase sirtuin-1-like [KO:K11411] [EC:2.3.1.286]
115152999  NAD-dependent protein deacetylase sirtuin-1-like [KO:K11411] [EC:2.3.1.286]
115154663  transcription factor Sox-17-alpha-A-like [KO:K04495]
115195773  transcription factor Sox-17-alpha-A-like [KO:K04495]
115183653  uncharacterized protein LOC115183653 [KO:K04496] [EC:1.1.1.428]
115183936  C-terminal-binding protein 2 isoform X1 [KO:K04496] [EC:1.1.1.428]
115193715  YLP motif-containing protein 1-like isoform X1 [KO:K04496] [EC:1.1.1.428]
115174653  C-terminal-binding protein 2 isoform X1 [KO:K04496] [EC:1.1.1.428]
115175139  C-terminal-binding protein 1-like isoform X1 [KO:K04496] [EC:1.1.1.428]
115153243  ctbp2; C-terminal-binding protein 2 isoform X1 [KO:K04496] [EC:1.1.1.428]
115153938  C-terminal-binding protein 1-like isoform X1 [KO:K04496] [EC:1.1.1.428]
115148478  C-terminal-binding protein 1-like isoform X1 [KO:K04496] [EC:1.1.1.428]
115205421  C-terminal-binding protein 1-like isoform X1 [KO:K04496] [EC:1.1.1.428]
115205487  ctbp1; C-terminal-binding protein 1 isoform X1 [KO:K04496] [EC:1.1.1.428]
115164956  transducin-like enhancer protein 1 isoform X1 [KO:K04497]
115185007  transducin-like enhancer protein 3-B isoform X1 [KO:K04497]
115192598  transducin-like enhancer protein 1 isoform X1 [KO:K04497]
115192599  transducin-like enhancer protein 4 [KO:K04497]
115192954  transducin-like enhancer protein 3-B isoform X1 [KO:K04497]
115158278  transducin-like enhancer protein 1 isoform X1 [KO:K04497]
115158279  transducin-like enhancer protein 4 isoform X1 [KO:K04497]
115166797  transducin-like enhancer protein 3-B isoform X1 [KO:K04497]
115199713  transducin-like enhancer protein 1 isoform X1 [KO:K04497]
115152342  catenin delta-2-like isoform X1 [KO:K23491]
115169712  catenin delta-2-like isoform X1 [KO:K23491]
115157060  catenin delta-2-like isoform X1 [KO:K23491]
115195395  catenin delta-2-like isoform X1 [KO:K23491]
115152698  histone acetyltransferase p300-like [KO:K04498] [EC:2.3.1.48]
115171283  histone acetyltransferase p300-like isoform X1 [KO:K04498] [EC:2.3.1.48]
115171774  CREB-binding protein-like isoform X1 [KO:K04498] [EC:2.3.1.48]
115178827  CREB-binding protein-like isoform X1 [KO:K04498] [EC:2.3.1.48]
115147398  CREB-binding protein-like isoform X1 [KO:K04498] [EC:2.3.1.48]
115206430  CREB-binding protein-like isoform X1 [KO:K04498] [EC:2.3.1.48]
115201319  histone acetyltransferase p300-like isoform X1 [KO:K04498] [EC:2.3.1.48]
115199931  histone acetyltransferase p300-like [KO:K04498] [EC:2.3.1.48]
115150553  ruvB-like 1 [KO:K04499] [EC:5.6.2.4]
115207856  ruvB-like 1 [KO:K04499] [EC:5.6.2.4]
115164984  smad4; LOW QUALITY PROTEIN: mothers against decapentaplegic homolog 4 [KO:K04501]
115173628  mothers against decapentaplegic homolog 4-like isoform X1 [KO:K04501]
115175837  mothers against decapentaplegic homolog 4-like isoform X1 [KO:K04501]
115176558  mothers against decapentaplegic homolog 4-like isoform X1 [KO:K04501]
115159360  mothers against decapentaplegic homolog 4-like isoform X1 [KO:K04501]
115180008  mothers against decapentaplegic homolog 4-like isoform X1 [KO:K04501]
115149222  mothers against decapentaplegic homolog 4-like isoform X1 [KO:K04501]
115199711  mothers against decapentaplegic homolog 4-like [KO:K04501]
115192958  smad3; mothers against decapentaplegic homolog 3 [KO:K23605]
115166794  mothers against decapentaplegic homolog 3 [KO:K23605]
115174914  mitogen-activated protein kinase kinase kinase 7-like isoform X1 [KO:K04427] [EC:2.7.11.25]
115162495  mitogen-activated protein kinase kinase kinase 7-like [KO:K04427] [EC:2.7.11.25]
115172787  mitogen-activated protein kinase kinase kinase 7-like [KO:K04427] [EC:2.7.11.25]
115194264  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
115192155  serine/threonine-protein kinase NLK2-like [KO:K04468] [EC:2.7.11.24]
115170822  serine/threonine-protein kinase NLK2-like [KO:K04468] [EC:2.7.11.24]
115163594  serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
115206491  serine/threonine-protein kinase NLK-like [KO:K04468] [EC:2.7.11.24]
115154720  transcriptional regulator Myc-like [KO:K04377]
115156503  myc; myc proto-oncogene protein [KO:K04377]
115195764  transcriptional regulator Myc [KO:K04377]
115208402  transcriptional regulator Myc-2-like [KO:K04377]
115151122  transcriptional regulator Myc-2-like [KO:K04377]
115192441  transcription factor AP-1-like [KO:K04448]
115169534  transcription factor AP-1-like [KO:K04448]
115158459  transcription factor AP-1-like [KO:K04448]
115157247  transcription factor AP-1-like [KO:K04448]
115149542  transcription factor AP-1-like [KO:K04448]
115160168  transcription factor AP-1-like [KO:K04448]
115152358  G1/S-specific cyclin-D1-like [KO:K04503]
115167492  G1/S-specific cyclin-D1 [KO:K04503]
115202965  G1/S-specific cyclin-D1-like [KO:K04503]
115197603  G1/S-specific cyclin-D1-like [KO:K04503]
115152238  G1/S-specific cyclin-D2 isoform X1 [KO:K10151]
115180633  G1/S-specific cyclin-D2-like [KO:K10151]
115170698  G1/S-specific cyclin-D2-like [KO:K10151]
115197442  G1/S-specific cyclin-D2-like isoform X1 [KO:K10151]
115204775  G1/S-specific cyclin-D2-like [KO:K10151]
115198916  G1/S-specific cyclin-D2-like [KO:K10151]
115150620  G1/S-specific cyclin-D2-like [KO:K10152]
115187700  WNT1-inducible-signaling pathway protein 1-like [KO:K22471]
115174046  WNT1-inducible-signaling pathway protein 1-like isoform X1 [KO:K22471]
115175555  WNT1-inducible-signaling pathway protein 1-like isoform X1 [KO:K22471]
115169027  peroxisome proliferator-activated receptor delta-like [KO:K04504]
115165438  ppard; peroxisome proliferator-activated receptor delta isoform X1 [KO:K04504]
115208152  peroxisome proliferator-activated receptor delta-like isoform X1 [KO:K04504]
115173027  presenilin-1-like [KO:K04505] [EC:3.4.23.-]
115157937  prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
115181703  cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
115169621  cAMP-dependent protein kinase catalytic subunit beta-like isoform X1 [KO:K04345] [EC:2.7.11.11]
115171557  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
115178387  cAMP-dependent protein kinase catalytic subunit alpha-like [KO:K04345] [EC:2.7.11.11]
115157154  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
115204162  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
115154926  cellular tumor antigen p53 [KO:K04451]
115194175  cellular tumor antigen p53-like [KO:K04451]
115198177  cellular tumor antigen p53-like isoform X1 [KO:K04451]
115151925  E3 ubiquitin-protein ligase Siah1-like isoform X1 [KO:K04506] [EC:2.3.2.27]
115196839  siah1; E3 ubiquitin-protein ligase SIAH1 isoform X1 [KO:K04506] [EC:2.3.2.27]
115169772  cacybp; calcyclin-binding protein [KO:K04507]
115154025  S-phase kinase-associated protein 1 [KO:K03094]
115148560  S-phase kinase-associated protein 1 [KO:K03094]
115192473  F-box-like/WD repeat-containing protein TBL1XR1 isoform X1 [KO:K04508]
115170060  F-box-like/WD repeat-containing protein TBL1XR1 [KO:K04508]
115158419  tbl1xr1; F-box-like/WD repeat-containing protein TBL1XR1 isoform X1 [KO:K04508]
115155786  F-box-like/WD repeat-containing protein TBL1X [KO:K04508]
115156660  F-box-like/WD repeat-containing protein TBL1XR1 [KO:K04508]
115161124  F-box-like/WD repeat-containing protein TBL1X [KO:K04508]
115154601  F-box/WD repeat-containing protein 11-like [KO:K03362]
115173518  F-box/WD repeat-containing protein 11-like isoform X1 [KO:K03362]
115149144  F-box/WD repeat-containing protein 11-like [KO:K03362]
115205340  F-box/WD repeat-containing protein 11 isoform X1 [KO:K03362]
115152091  cullin-1-like [KO:K03347]
115169709  cullin-1 [KO:K03347]
115157067  cullin-1-like [KO:K03347]
115171287  RING-box protein 1 [KO:K03868] [EC:2.3.2.32]
115199956  RING-box protein 1 isoform X1 [KO:K03868] [EC:2.3.2.32]
115160597  glypican-6-like isoform X1 [KO:K08110]
115205553  glypican-4-like isoform X1 [KO:K08110]
115192231  inactive tyrosine-protein kinase transmembrane receptor ROR1-like isoform X1 [KO:K05122] [EC:2.7.10.1]
115158724  inactive tyrosine-protein kinase transmembrane receptor ROR1-like [KO:K05122] [EC:2.7.10.1]
115160118  ror2; tyrosine-protein kinase transmembrane receptor ROR2 isoform X1 [KO:K05123] [EC:2.7.10.1]
115158884  tyrosine-protein kinase RYK-like isoform X1 [KO:K05128] [EC:2.7.10.1]
115151460  ryk; tyrosine-protein kinase RYK isoform X1 [KO:K05128] [EC:2.7.10.1]
115169514  vang-like protein 2 [KO:K04510]
115155797  vang-like protein 1 [KO:K04510]
115161135  vang-like protein 1 [KO:K04510]
115179835  vang-like protein 1 isoform X1 [KO:K04510]
115157285  vang-like protein 2 [KO:K04510]
115194482  vang-like protein 2 [KO:K04510]
115196127  vang-like protein 1 [KO:K04510]
115198460  vang-like protein 2 [KO:K04510]
115152359  prickle-like protein 1 [KO:K04511]
115168065  protein prickle-like [KO:K04511]
115188431  prickle-like protein 1 isoform X1 [KO:K04511]
115188432  prickle-like protein 1 isoform X1 [KO:K04511]
115165728  prickle-like protein 1 [KO:K04511]
115166330  prickle-like protein 2 [KO:K04511]
115150767  prickle-like protein 2 isoform X1 [KO:K04511]
115207658  prickle2; prickle-like protein 2 [KO:K04511]
115197607  prickle-like protein 1 [KO:K04511]
115180994  inversin-like [KO:K19626]
115181004  inversin-like [KO:K19626]
115174669  disheveled-associated activator of morphogenesis 1-like isoform X1 [KO:K04512]
115162116  disheveled-associated activator of morphogenesis 1-like isoform X1 [KO:K04512]
115172389  disheveled-associated activator of morphogenesis 1-like isoform X1 [KO:K04512]
115202808  disheveled-associated activator of morphogenesis 2-like isoform X1 [KO:K04512]
115168240  rho-related GTP-binding protein RhoA-C [KO:K04513]
115168296  rho-related GTP-binding protein RhoA-B-like [KO:K04513]
115165260  rho-related GTP-binding protein RhoA-C-like [KO:K04513]
115165905  rho-related GTP-binding protein RhoA-C-like isoform X1 [KO:K04513]
115166252  rho-related GTP-binding protein RhoA-B [KO:K04513]
115150994  rho-related GTP-binding protein RhoA-D [KO:K04513]
115150254  transforming protein RhoA-like [KO:K04513]
115208179  transforming protein RhoA-like [KO:K04513]
115175052  rho-associated protein kinase 2-like isoform X1 [KO:K17388] [EC:2.7.11.1]
115162175  rho-associated protein kinase 2-like isoform X1 [KO:K17388] [EC:2.7.11.1]
115172456  rho-associated protein kinase 2-like isoform X1 [KO:K17388] [EC:2.7.11.1]
115195645  rho-associated protein kinase 2-like [KO:K17388] [EC:2.7.11.1]
115152908  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
115171654  ras-related C3 botulinum toxin substrate 1-like isoform X1 [KO:K04392]
115201416  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
115205281  ras-related C3 botulinum toxin substrate 1-like isoform X1 [KO:K04392]
115171460  ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
115147435  ras-related C3 botulinum toxin substrate 2-like [KO:K07860]
115202895  ras-related C3 botulinum toxin substrate 2-like [KO:K07860]
115152909  ras-related C3 botulinum toxin substrate 3-like isoform X1 [KO:K07861]
115171935  ras-related C3 botulinum toxin substrate 3-like [KO:K07861]
115201417  rac3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
115208641  ras-related C3 botulinum toxin substrate 3-like [KO:K07861]
115194041  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
115157756  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
115174527  mitogen-activated protein kinase 9-like isoform X1 [KO:K04440] [EC:2.7.11.24]
115152965  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
115159070  mitogen-activated protein kinase 10-like isoform X1 [KO:K04440] [EC:2.7.11.24]
115149487  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
115201108  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
115204538  mitogen-activated protein kinase 9-like [KO:K04440] [EC:2.7.11.24]
115184997  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3-like isoform X1 [KO:K05858] [EC:3.1.4.11]
115174482  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like isoform X1 [KO:K05858] [EC:3.1.4.11]
115174483  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4-like isoform X1 [KO:K05858] [EC:3.1.4.11]
115162398  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
115172491  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like isoform X1 [KO:K05858] [EC:3.1.4.11]
115172765  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4-like isoform X1 [KO:K05858] [EC:3.1.4.11]
115198619  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3-like isoform X1 [KO:K05858] [EC:3.1.4.11]
115199598  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like [KO:K05858] [EC:3.1.4.11]
115194123  calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
115189418  calcium/calmodulin-dependent protein kinase type II delta chain-like isoform X1 [KO:K04515] [EC:2.7.11.17]
115180818  calcium/calmodulin-dependent protein kinase type II delta 2 chain-like [KO:K04515] [EC:2.7.11.17]
115193805  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
115153189  calcium/calmodulin-dependent protein kinase type II subunit gamma-like isoform X1 [KO:K04515] [EC:2.7.11.17]
115154883  calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
115159892  calcium/calmodulin-dependent protein kinase type II subunit beta-like [KO:K04515] [EC:2.7.11.17]
115164110  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
115156739  calcium/calmodulin-dependent protein kinase type II delta 1 chain-like isoform X1 [KO:K04515] [EC:2.7.11.17]
115200524  calcium/calmodulin-dependent protein kinase type II subunit beta-like [KO:K04515] [EC:2.7.11.17]
115201212  calcium/calmodulin-dependent protein kinase type II subunit gamma-like isoform X1 [KO:K04515] [EC:2.7.11.17]
115203793  calcium/calmodulin-dependent protein kinase type II subunit beta-like isoform X1 [KO:K04515] [EC:2.7.11.17]
115198135  calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
115204505  calcium/calmodulin-dependent protein kinase type II subunit alpha-like isoform X1 [KO:K04515] [EC:2.7.11.17]
115169125  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
115154819  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
115159283  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
115164273  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
115149273  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
115194217  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
115204432  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
115198233  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
115205560  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
115200380  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
115177589  calcineurin subunit B type 1 [KO:K06268]
115156000  calcineurin subunit B type 1-like [KO:K06268]
115201738  calcineurin subunit B type 1-like [KO:K06268]
115208572  calcineurin subunit B type 1 [KO:K06268]
115171658  protein kinase C alpha type-like [KO:K02677] [EC:2.7.11.13]
115177626  protein kinase C alpha type-like [KO:K02677] [EC:2.7.11.13]
115208609  protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
115205322  protein kinase C alpha type-like isoform X1 [KO:K02677] [EC:2.7.11.13]
115181935  protein kinase C beta type-like isoform X1 [KO:K19662] [EC:2.7.11.13]
115182231  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
115176114  nuclear factor of activated T-cells, cytoplasmic 1-like [KO:K04446]
115176121  nuclear factor of activated T-cells, cytoplasmic 1-like isoform X1 [KO:K04446]
115177327  nuclear factor of activated T-cells, cytoplasmic 1-like isoform X1 [KO:K04446]
115173373  nuclear factor of activated T-cells, cytoplasmic 1-like [KO:K04446]
115167938  nuclear factor of activated T-cells, cytoplasmic 2-like isoform X1 [KO:K17332]
115165591  nuclear factor of activated T-cells, cytoplasmic 2-like isoform X1 [KO:K17332]
115150081  nuclear factor of activated T-cells, cytoplasmic 2-like isoform X1 [KO:K17332]
115152297  nuclear factor of activated T-cells, cytoplasmic 3-like [KO:K17333]
115203318  nuclear factor of activated T-cells, cytoplasmic 3-like isoform X1 [KO:K17333]
115197507  nuclear factor of activated T-cells, cytoplasmic 3-like [KO:K17333]
115169508  nuclear factor of activated T-cells, cytoplasmic 4-like isoform X1 [KO:K17334]
115157289  nuclear factor of activated T-cells, cytoplasmic 4-like [KO:K17334]
Compound
C00076  Calcium cation
Reference
PMID:14635791
  Authors
Hatsell S, Rowlands T, Hiremath M, Cowin P.
  Title
Beta-catenin and Tcfs in mammary development and cancer.
  Journal
J Mammary Gland Biol Neoplasia 8:145-58 (2003)
DOI:10.1023/A:1025944723047
Reference
PMID:14745971
  Authors
Yang Y.
  Title
Wnts and wing: Wnt signaling in vertebrate limb development and musculoskeletal morphogenesis.
  Journal
Birth Defects Res Part C Embryo Today 69:305-17 (2003)
DOI:10.1002/bdrc.10026
Reference
PMID:12446114
  Authors
Kalderon D.
  Title
Similarities between the Hedgehog and Wnt signaling pathways.
  Journal
Trends Cell Biol 12:523-31 (2002)
DOI:10.1016/S0962-8924(02)02388-7
Reference
PMID:14530294
  Authors
Nusse R.
  Title
Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface.
  Journal
Development 130:5297-305 (2003)
DOI:10.1242/dev.00821
Reference
PMID:15102436
  Authors
Jope RS, Johnson GV.
  Title
The glamour and gloom of glycogen synthase kinase-3.
  Journal
Trends Biochem Sci 29:95-102 (2004)
DOI:10.1016/j.tibs.2003.12.004
Reference
PMID:12967557
  Authors
Veeman MT, Axelrod JD, Moon RT.
  Title
A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling.
  Journal
Dev Cell 5:367-77 (2003)
DOI:10.1016/S1534-5807(03)00266-1
Reference
PMID:11433294
  Authors
Sun TQ, Lu B, Feng JJ, Reinhard C, Jan YN, Fantl WJ, Williams LT.
  Title
PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling.
  Journal
Nat Cell Biol 3:628-36 (2001)
DOI:10.1038/35083016
Reference
PMID:23256519
  Authors
Saito-Diaz K, Chen TW, Wang X, Thorne CA, Wallace HA, Page-McCaw A, Lee E
  Title
The way Wnt works: Components and mechanism.
  Journal
Growth Factors 31:1-31 (2013)
DOI:10.3109/08977194.2012.752737
Reference
PMID:19482104
  Authors
Carethers JM
  Title
Intersection of transforming growth factor-beta and Wnt signaling pathways in colorectal cancer and metastasis.
  Journal
Gastroenterology 137:33-6 (2009)
DOI:10.1053/j.gastro.2009.05.011
Reference
PMID:18838381
  Authors
Lin Z, Gao C, Ning Y, He X, Wu W, Chen YG
  Title
The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt/beta-catenin signaling.
  Journal
J Biol Chem 283:33053-8 (2008)
DOI:10.1074/jbc.M804039200
Reference
PMID:23151663
  Authors
Niehrs C
  Title
The complex world of WNT receptor signalling.
  Journal
Nat Rev Mol Cell Biol 13:767-79 (2012)
DOI:10.1038/nrm3470
Reference
PMID:28522145
  Authors
Abou Ziki MD, Mani A
  Title
Wnt signaling, a novel pathway regulating blood pressure? State of the art review.
  Journal
Atherosclerosis 262:171-178 (2017)
DOI:10.1016/j.atherosclerosis.2017.05.001
Reference
PMID:25808920
  Authors
He Y, Ki H, Kim H, Kim K
  Title
delta-Catenin interacts with LEF-1 and negatively regulates its transcriptional activity.
  Journal
Cell Biol Int 39:954-61 (2015)
DOI:10.1002/cbin.10465
Reference
PMID:32888647
  Authors
Esaki N, Enomoto A, Takagishi M, Mizutani Y, Iida T, Ushida K, Shiraki Y, Mii S, Takahashi M
  Title
The Daple-CK1epsilon complex regulates Dvl2 phosphorylation and canonical Wnt signaling.
  Journal
Biochem Biophys Res Commun 532:406-413 (2020)
DOI:10.1016/j.bbrc.2020.08.066
Reference
PMID:28242765
  Authors
Yiew NKH, Chatterjee TK, Tang YL, Pellenberg R, Stansfield BK, Bagi Z, Fulton DJ, Stepp DW, Chen W, Patel V, Kamath VM, Litwin SE, Hui DY, Rudich SM, Kim HW, Weintraub NL
  Title
A novel role for the Wnt inhibitor APCDD1 in adipocyte differentiation: Implications for diet-induced obesity.
  Journal
J Biol Chem 292:6312-6324 (2017)
DOI:10.1074/jbc.M116.758078
Related
pathway
stru04010  MAPK signaling pathway
stru04110  Cell cycle
stru04115  p53 signaling pathway
stru04120  Ubiquitin mediated proteolysis
stru04350  TGF-beta signaling pathway
stru04510  Focal adhesion
stru04520  Adherens junction
KO pathway
ko04310   
LinkDB

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