KEGG   PATHWAY: tfn05020
Entry
tfn05020                    Pathway                                
Name
Prion disease - Trachypithecus francoisi (Francois's langur)
Description
Prion diseases, also termed transmissible spongiform encephalopathies (TSEs), are a group of fatal neurodegenerative diseases that affect humans and a number of other animal species. The etiology of these diseases is thought to be associated with the conversion of a normal protein, PrPC, into an infectious, pathogenic form, PrPSc. The conversion is induced by prion infections (for example, variant Creutzfeldt-Jakob disease (vCJD), iatrogenic CJD, Kuru), mutations (familial CJD, Gerstmann-Straussler-Scheinker syndrome, fatal familial insomnia (FFI)) or unknown factors (sporadic CJD (sCJD)), and is thought to occur after PrPC has reached the plasma membrane or is re-internalized for degradation. The PrPSc form shows greater protease resistance than PrPC and accumulates in affected individuals, often in the form of extracellular plaques. Pathways that may lead to neuronal death comprise oxidative stress, regulated activation of complement, ubiquitin-proteasome and endosomal-lysosomal systems, synaptic alterations and dendritic atrophy, corticosteroid response, and endoplasmic reticulum stress. In addition, the conformational transition could lead to the lost of a beneficial activity of the natively folded protein, PrPC.
Class
Human Diseases; Neurodegenerative disease
Pathway map
tfn05020  Prion disease
tfn05020

Organism
Trachypithecus francoisi (Francois's langur) [GN:tfn]
Gene
117068501  PRNP; major prion protein [KO:K05634]
117079881  NCAM1; neural cell adhesion molecule 1 isoform X1 [KO:K06491]
117095616  NCAM2; neural cell adhesion molecule 2 isoform X1 [KO:K06491]
117076850  LAMC1; laminin subunit gamma-1 [KO:K05635]
117079239  LOW QUALITY PROTEIN: superoxide dismutase [Cu-Zn]-like [KO:K04565] [EC:1.15.1.1]
117095687  SOD1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
117080617  STIP1; stress-induced-phosphoprotein 1 isoform X1 [KO:K09553]
117098498  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
117092158  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
117074523  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
117091541  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
117096942  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
117099100  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
117097668  glutamate receptor ionotropic, NMDA 2A [KO:K05209]
117090480  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
117066643  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
117091505  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
117098894  GRIN3A; glutamate receptor ionotropic, NMDA 3A isoform X1 [KO:K05213]
117075332  GRIN3B; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
117099070  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
117090701  voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
117083004  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
117077518  CACNA1F; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
117076828  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
117071315  HSPA5; endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
117062173  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
117069444  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
117096463  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
117089884  DDIT3; DNA damage-inducible transcript 3 protein isoform X1 [KO:K04452]
117092481  RYR1; ryanodine receptor 1 [KO:K04961]
117076540  RYR2; ryanodine receptor 2 isoform X1 [KO:K04962]
117071124  RYR3; LOW QUALITY PROTEIN: ryanodine receptor 3 [KO:K04963]
117083173  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
117090367  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
117087057  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
117064180  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
117082599  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
117093193  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
117098896  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
117099768  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
117080612  BAD; bcl2-associated agonist of cell death [KO:K02158]
117098307  voltage-dependent anion-selective channel protein 1-like [KO:K05862]
117065867  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
117082746  VDAC2; voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15040]
117095701  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
117077936  ADP/ATP translocase 2-like [KO:K05863]
117076189  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
117085890  SLC25A31; ADP/ATP translocase 4 isoform X1 [KO:K05863]
117086204  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
117077276  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
117082093  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial isoform X1 [KO:K09565] [EC:5.2.1.8]
117089565  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
117078921  cytochrome c-like [KO:K08738]
117078953  cytochrome c-like [KO:K08738]
117096842  cytochrome c-like [KO:K08738]
117079868  cytochrome c-like [KO:K08738]
117097957  cytochrome c-like [KO:K08738]
117098492  cytochrome c-like [KO:K08738]
117080718  cytochrome c-like [KO:K08738]
117072525  cytochrome c [KO:K08738]
117072825  cytochrome c-like [KO:K08738]
117081557  cytochrome c-like [KO:K08738]
117083033  cytochrome c-like [KO:K08738]
117093380  cytochrome c-like [KO:K08738]
117093253  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
117083313  caspase-3-like isoform X1 [KO:K02187] [EC:3.4.22.56]
117075139  caspase-3-like isoform X1 [KO:K02187] [EC:3.4.22.56]
117086196  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
117082784  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
18985085  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
18985073  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
18985079  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
18985081  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
18985080  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
18985082  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
18985083  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
117081005  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
117064141  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial isoform X1 [KO:K03943] [EC:7.1.1.2]
117095835  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
117089611  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
117077312  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
117096655  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2-like [KO:K03946]
117065757  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
117087695  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
117063629  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
117093658  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 isoform X1 [KO:K03947]
117077670  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
117089896  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
117072332  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
117082326  cytochrome c oxidase subunit NDUFA4 [KO:K03948]
117092233  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
117095320  LOW QUALITY PROTEIN: cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
117097361  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like [KO:K03949]
117072292  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
117084391  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like [KO:K03949]
117076830  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like isoform X1 [KO:K03949]
117096387  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
117076742  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
117098726  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 isoform X1 [KO:K03952]
117090671  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
117094305  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform X1 [KO:K03954]
117087492  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
117093644  LOW QUALITY PROTEIN: acyl carrier protein, mitochondrial-like [KO:K03955]
117075517  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11-like [KO:K03956]
117075518  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11-like [KO:K03956]
117075723  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 isoform X1 [KO:K03956]
117089604  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 isoform X1 [KO:K11352]
117076644  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 isoform X1 [KO:K11353]
117071524  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
117063948  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
117072298  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
117079196  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
117071184  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3-like [KO:K03959]
117095227  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
117071291  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4-like [KO:K03960]
117083450  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
117084440  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4-like [KO:K03960]
117068009  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4-like [KO:K03960]
117083769  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform X1 [KO:K03961]
117098709  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 isoform X1 [KO:K03962]
117069703  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7-like [KO:K03963]
117076186  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
117069794  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial-like [KO:K03964]
117068386  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
117079542  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
117097828  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
117078337  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
117086072  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial-like [KO:K11351]
117094614  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial isoform X1 [KO:K03934] [EC:7.1.1.2]
117076373  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial isoform X1 [KO:K03935] [EC:7.1.1.2]
117080186  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial isoform X1 [KO:K03936] [EC:7.1.1.2]
117065109  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial isoform X1 [KO:K03937]
117065203  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
117092829  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 isoform X1 [KO:K03938]
117075209  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
117064716  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
117076663  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1 [KO:K03940] [EC:7.1.1.2]
117080942  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X1 [KO:K03941] [EC:7.1.1.2]
117085925  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
117079974  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
117064660  LOW QUALITY PROTEIN: succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial-like [KO:K00234] [EC:1.3.5.1]
117064675  SDHA; LOW QUALITY PROTEIN: succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
117064676  LOW QUALITY PROTEIN: succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial-like [KO:K00234] [EC:1.3.5.1]
117062944  succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial-like [KO:K00235] [EC:1.3.5.1]
117093237  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial isoform X1 [KO:K00235] [EC:1.3.5.1]
117074342  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236]
117092766  succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like [KO:K00236]
117074969  succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like [KO:K00236]
117073294  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
117092025  cytochrome b-c1 complex subunit Rieske, mitochondrial-like [KO:K00411] [EC:7.1.1.8]
117092255  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
18985084  CYTB; cytochrome b [KO:K00412]
117079304  cytochrome c1, heme protein, mitochondrial isoform X1 [KO:K00413]
117080933  cytochrome b-c1 complex subunit 1, mitochondrial isoform X1 [KO:K00414]
117087515  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
117092657  cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416]
117079397  cytochrome b-c1 complex subunit 7 [KO:K00417]
117095688  cytochrome b-c1 complex subunit 7-like [KO:K00417]
117065879  cytochrome b-c1 complex subunit 8 [KO:K00418]
117096163  cytochrome b-c1 complex subunit 9 isoform X1 [KO:K00419]
117075323  cytochrome b-c1 complex subunit 10 [KO:K00420]
18985078  COX3; cytochrome c oxidase subunit III [KO:K02262]
18985074  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
18985075  COX2; cytochrome c oxidase subunit II [KO:K02261]
117068615  cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X1 [KO:K02263]
117088155  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
117073003  cytochrome c oxidase subunit 4 isoform 1, mitochondrial-like [KO:K02263]
117070355  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
117096477  cytochrome c oxidase subunit 5B, mitochondrial-like [KO:K02265]
117099609  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
117085400  cytochrome c oxidase subunit 5B, mitochondrial-like [KO:K02265]
117087707  cytochrome c oxidase subunit 6A2, mitochondrial isoform X1 [KO:K02266]
117089300  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
117081344  cytochrome c oxidase subunit 6A1, mitochondrial-like [KO:K02266]
117091738  cytochrome c oxidase subunit 6B2 [KO:K02267]
117092366  cytochrome c oxidase subunit 6B1 [KO:K02267]
117067730  cytochrome c oxidase subunit 6B1-like [KO:K02267]
117078869  cytochrome c oxidase subunit 6C [KO:K02268]
117078078  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 7A-related protein, mitochondrial-like [KO:K02270]
117087463  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
117062413  cytochrome c oxidase subunit 7A-related protein, mitochondrial isoform X1 [KO:K02270]
117095749  cytochrome c oxidase subunit 7A2, mitochondrial-like [KO:K02270]
117078522  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
117085655  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
117076746  cytochrome c oxidase subunit 7B, mitochondrial-like [KO:K02271]
117068693  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
117077892  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
117077947  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
117088659  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
117070928  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
117071608  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
117080679  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
117072476  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
117064943  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
117065132  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
117093179  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
117084864  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
117093839  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
117067104  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
117077366  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
117095431  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
117071500  cytochrome c oxidase subunit 8C, mitochondrial [KO:K02273]
117081060  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
117081585  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 8B, mitochondrial-like [KO:K02273]
117063944  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
117089918  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
117071177  LOW QUALITY PROTEIN: ATP synthase subunit gamma, mitochondrial-like [KO:K02136]
117082510  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
117076305  ATP5F1D; ATP synthase subunit delta, mitochondrial [KO:K02134]
117069010  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
18985077  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
117075856  LOW QUALITY PROTEIN: ATP synthase subunit a-like [KO:K02126]
117075878  ATP synthase subunit a-like [KO:K02126]
117070400  ATP synthase F(0) complex subunit B1, mitochondrial-like [KO:K02127]
117074996  ATP synthase F(0) complex subunit B1, mitochondrial-like [KO:K02127]
117076037  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial isoform X1 [KO:K02127]
117062157  ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128]
117090028  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial isoform X1 [KO:K02128]
117099787  LOW QUALITY PROTEIN: ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128]
117082240  LOW QUALITY PROTEIN: ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128]
117075702  ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128]
117067177  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
117094831  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
117066659  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
117085388  ATP synthase subunit d, mitochondrial [KO:K02138]
117087884  ATP synthase subunit O, mitochondrial-like [KO:K02137]
117095055  ATP synthase subunit O, mitochondrial-like [KO:K02137]
117095725  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
117095627  ATP5PF; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
18985076  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
117069813  PSMA6; proteasome subunit alpha type-6 isoform X1 [KO:K02730] [EC:3.4.25.1]
117073263  PSMA2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
117084476  LOW QUALITY PROTEIN: proteasome subunit alpha type-2-like [KO:K02726] [EC:3.4.25.1]
117087739  proteasome subunit alpha type-4-like [KO:K02728] [EC:3.4.25.1]
117070318  PSMA4; proteasome subunit alpha type-4 isoform X1 [KO:K02728] [EC:3.4.25.1]
117069034  PSMA7; proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
117064038  PSMA8; proteasome subunit alpha-type 8 isoform X1 [KO:K02731] [EC:3.4.25.1]
117075732  PSMA5; proteasome subunit alpha type-5 isoform X1 [KO:K02729] [EC:3.4.25.1]
117081555  PSMA1; proteasome subunit alpha type-1 isoform X1 [KO:K02725] [EC:3.4.25.1]
117069576  PSMA3; proteasome subunit alpha type-3 [KO:K02727] [EC:3.4.25.1]
117082220  proteasome subunit beta type-6-like [KO:K02738] [EC:3.4.25.1]
117067872  PSMB6; proteasome subunit beta type-6 isoform X1 [KO:K02738] [EC:3.4.25.1]
117070977  PSMB7; proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
117067118  PSMB3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
117095317  proteasome subunit beta type-3-like [KO:K02735] [EC:3.4.25.1]
117089559  proteasome subunit beta type-2 [KO:K02734] [EC:3.4.25.1]
117092898  PSMB2; proteasome subunit beta type-2 [KO:K02734] [EC:3.4.25.1]
117069984  PSMB5; proteasome subunit beta type-5 isoform X1 [KO:K02737] [EC:3.4.25.1]
117096846  PSMB1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
117075932  PSMB4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
117080458  LOW QUALITY PROTEIN: 26S proteasome regulatory subunit 7-like [KO:K03061]
117073224  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
117071556  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
117080779  LOW QUALITY PROTEIN: 26S proteasome regulatory subunit 4-like [KO:K03062]
117095682  26S proteasome regulatory subunit 4-like [KO:K03062]
117092536  PSMC4; 26S proteasome regulatory subunit 6B [KO:K03063]
117069640  PSMC6; 26S proteasome regulatory subunit 10B isoform X1 [KO:K03064]
117080413  PSMC3; 26S proteasome regulatory subunit 6A [KO:K03065]
117067435  PSMC5; 26S proteasome regulatory subunit 8 isoform X1 [KO:K03066]
117083822  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
117094392  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
117067078  PSMD3; LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
117089263  PSMD9; 26S proteasome non-ATPase regulatory subunit 9 [KO:K06693]
117067390  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
117067543  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 isoform X1 [KO:K03036]
117098684  LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 6-like [KO:K03037]
117083084  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 isoform X1 [KO:K03037]
117087981  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
117081580  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 isoform X1 [KO:K03039]
117074672  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X1 [KO:K03029]
117094952  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
117092474  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
117069039  ADRM1; proteasomal ubiquitin receptor ADRM1 isoform X1 [KO:K06691]
117062240  26S proteasome complex subunit SEM1 [KO:K10881]
117098742  C5; complement C5 isoform X1 [KO:K03994]
117065060  C6; LOW QUALITY PROTEIN: complement component C6 [KO:K03995]
117065057  C7; complement component C7 isoform X1 [KO:K03996]
117091974  C8A; complement component C8 alpha chain [KO:K03997]
117091975  C8B; complement component C8 beta chain [KO:K03998]
117099134  C8G; complement component C8 gamma chain [KO:K03999]
117065049  C9; complement component C9 [KO:K04000]
117093156  C1QA; complement C1q subcomponent subunit A [KO:K03986]
117093154  C1QB; complement C1q subcomponent subunit B [KO:K03987]
117093155  C1QC; complement C1q subcomponent subunit C isoform X1 [KO:K03988]
117081565  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
117074574  HSPA6; LOW QUALITY PROTEIN: heat shock 70 kDa protein 6 [KO:K03283]
117086685  heat shock cognate 71 kDa protein-like [KO:K03283]
117086963  HSPA1A; LOW QUALITY PROTEIN: heat shock 70 kDa protein 1A [KO:K03283]
117086964  HSPA1L; heat shock 70 kDa protein 1-like [KO:K03283]
117099151  NOTCH1; neurogenic locus notch homolog protein 1 [KO:K02599]
117073439  CAV1; caveolin-1 isoform X1 [KO:K06278]
117073440  CAV2; caveolin-2 isoform X1 [KO:K12958]
117083193  CAV3; caveolin-3 [KO:K12959]
117083761  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
117084122  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
117093348  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
117065206  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
117092662  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
117075022  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
117082999  PRKCD; protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
117078537  cytochrome b-245 heavy chain isoform X1 [KO:K21421] [EC:1.-.-.-]
117088204  cytochrome b-245 light chain [KO:K08009]
117095969  NCF4; neutrophil cytosol factor 4 isoform X1 [KO:K08012]
117072588  NCF1; neutrophil cytosol factor 1 [KO:K08011]
117074547  NCF2; neutrophil cytosol factor 2 isoform X1 [KO:K08010]
117073672  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
117085754  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
117070036  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
117087120  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
117087121  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
117096273  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
117096276  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
117082864  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
117065429  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
117085362  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
117087606  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
117096627  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
117094598  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
117094833  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
117079895  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
117099006  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
117073578  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
117075642  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
117072944  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
117086987  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
117065800  EGR1; early growth response protein 1 [KO:K09203]
117067484  CCL5; C-C motif chemokine 5 [KO:K12499]
117062187  IL1A; interleukin-1 alpha [KO:K04383]
117062188  IL1B; interleukin-1 beta [KO:K04519]
117072793  IL6; interleukin-6 isoform X1 [KO:K05405]
117086926  TNF; tumor necrosis factor isoform X1 [KO:K03156]
117083458  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
117068593  CSNK2A1; casein kinase II subunit alpha isoform X1 [KO:K03097] [EC:2.7.11.1]
117087870  CSNK2A2; casein kinase II subunit alpha' isoform X1 [KO:K03097] [EC:2.7.11.1]
117086944  CSNK2B; casein kinase II subunit beta isoform X1 [KO:K03115]
117089867  KIF5A; kinesin heavy chain [KO:K10396]
117082738  KIF5B; kinesin-1 heavy chain [KO:K10396]
117095022  KIF5C; kinesin heavy chain [KO:K10396]
117087240  KLC4; kinesin light chain 4 [KO:K10407]
117088583  kinesin light chain 2-like [KO:K10407]
117080478  KLC2; kinesin light chain 2 [KO:K10407]
117071314  KLC1; kinesin light chain 1 isoform X1 [KO:K10407]
117091396  KLC3; kinesin light chain 3 isoform X1 [KO:K10407]
117096062  TUBA8; tubulin alpha-8 chain isoform X1 [KO:K07374]
117087546  tubulin alpha-3 chain [KO:K07374]
117090172  tubulin alpha-1A chain isoform X1 [KO:K07374]
117090173  TUBA1C; tubulin alpha-1C chain [KO:K07374]
117090175  tubulin alpha-1B chain [KO:K07374]
117072720  LOW QUALITY PROTEIN: tubulin alpha-3 chain-like [KO:K07374]
117082443  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
117073751  tubulin alpha-1B chain-like [KO:K07374]
117084835  tubulin alpha-3 chain [KO:K07374]
117094495  tubulin alpha-4A chain isoform X1 [KO:K07374]
117069008  TUBB1; tubulin beta-1 chain [KO:K07375]
117079278  tubulin beta-8 chain-like [KO:K07375]
117088263  tubulin beta-3 chain isoform X1 [KO:K07375]
117088384  TUBB; tubulin beta chain [KO:K07375]
117099095  TUBB4B; tubulin beta-4B chain [KO:K07375]
117099374  tubulin beta chain [KO:K07375]
117064172  TUBB6; tubulin beta-6 chain [KO:K07375]
117064808  LOW QUALITY PROTEIN: tubulin beta-8 chain-like [KO:K07375]
117074655  TUBB4A; tubulin beta-4A chain [KO:K07375]
117075478  tubulin beta-4B chain-like [KO:K07375]
117084498  tubulin beta-8 chain-like [KO:K07375]
117086238  tubulin beta-8 chain isoform X1 [KO:K07375]
117086624  TUBB2A; tubulin beta-2A chain [KO:K07375]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00575  3',5'-Cyclic AMP
C00704  Superoxide
C02140  Corticosterone
Reference
PMID:27055367
  Authors
Saa P, Harris DA, Cervenakova L
  Title
Mechanisms of prion-induced neurodegeneration.
  Journal
Expert Rev Mol Med 18:e5 (2016)
DOI:10.1017/erm.2016.8
Reference
PMID:25584786
  Authors
Goold R, McKinnon C, Tabrizi SJ
  Title
Prion degradation pathways: Potential for therapeutic intervention.
  Journal
Mol Cell Neurosci 66:12-20 (2015)
DOI:10.1016/j.mcn.2014.12.009
Reference
PMID:20889378
  Authors
Soto C, Satani N
  Title
The intricate mechanisms of neurodegeneration in prion diseases.
  Journal
Trends Mol Med 17:14-24 (2011)
DOI:10.1016/j.molmed.2010.09.001
Reference
PMID:27060771
  Authors
Mays CE, Soto C
  Title
The stress of prion disease.
  Journal
Brain Res 1648:553-560 (2016)
DOI:10.1016/j.brainres.2016.04.009
Reference
PMID:32565065
  Authors
Jones E, Mead S
  Title
Genetic risk factors for Creutzfeldt-Jakob disease.
  Journal
Neurobiol Dis 142:104973 (2020)
DOI:10.1016/j.nbd.2020.104973
Reference
PMID:18245809
  Authors
Kovacs GG, Budka H
  Title
Prion diseases: from protein to cell pathology.
  Journal
Am J Pathol 172:555-65 (2008)
DOI:10.2353/ajpath.2008.070442
Reference
PMID:15695097
  Authors
Campana V, Sarnataro D, Zurzolo C
  Title
The highways and byways of prion protein trafficking.
  Journal
Trends Cell Biol 15:102-11 (2005)
DOI:10.1016/j.tcb.2004.12.002
Reference
PMID:17051207
  Authors
Caughey B, Baron GS
  Title
Prions and their partners in crime.
  Journal
Nature 443:803-10 (2006)
DOI:10.1038/nature05294
Reference
PMID:11592845
  Authors
Chiesa R, Harris DA
  Title
Prion diseases: what is the neurotoxic molecule?
  Journal
Neurobiol Dis 8:743-63 (2001)
DOI:10.1006/nbdi.2001.0433
Reference
PMID:17085779
  Authors
Fasano C, Campana V, Zurzolo C
  Title
Prions: protein only or something more? Overview of potential prion cofactors.
  Journal
J Mol Neurosci 29:195-214 (2006)
DOI:10.1385/JMN:29:3:195
Reference
PMID:14705136
  Authors
Roucou X, Gains M, LeBlanc AC
  Title
Neuroprotective functions of prion protein.
  Journal
J Neurosci Res 75:153-61 (2004)
DOI:10.1002/jnr.10864
Reference
PMID:10398674
  Authors
Harris DA
  Title
Cellular biology of prion diseases.
  Journal
Clin Microbiol Rev 12:429-44 (1999)
Reference
PMID:15890824
  Authors
Novakofski J, Brewer MS, Mateus-Pinilla N, Killefer J, McCusker RH
  Title
Prion biology relevant to bovine spongiform encephalopathy.
  Journal
J Anim Sci 83:1455-76 (2005)
DOI:10.2527/2005.8361455x
Reference
PMID:27581199
  Authors
Peggion C, Bertoli A, Sorgato MC
  Title
Almost a century of prion protein(s): From pathology to physiology, and back to pathology.
  Journal
Biochem Biophys Res Commun 483:1148-1155 (2017)
DOI:10.1016/j.bbrc.2016.07.118
Reference
PMID:31618844
  Authors
Ryskalin L, Busceti CL, Biagioni F, Limanaqi F, Familiari P, Frati A, Fornai F
  Title
Prion Protein in Glioblastoma Multiforme.
  Journal
Int J Mol Sci 20:E5107 (2019)
DOI:10.3390/ijms20205107
Reference
PMID:31795242
  Authors
Ureshino RP, Erustes AG, Bassani TB, Wachilewski P, Guarache GC, Nascimento AC, Costa AJ, Smaili SS, Pereira GJDS
  Title
The Interplay between Ca(2+) Signaling Pathways and Neurodegeneration.
  Journal
Int J Mol Sci 20:E6004 (2019)
DOI:10.3390/ijms20236004
Reference
PMID:30710214
  Authors
Meneghetti E, Gasperini L, Virgilio T, Moda F, Tagliavini F, Benetti F, Legname G
  Title
Prions Strongly Reduce NMDA Receptor S-Nitrosylation Levels at Pre-symptomatic and Terminal Stages of Prion Diseases.
  Journal
Mol Neurobiol 56:6035-6045 (2019)
DOI:10.1007/s12035-019-1505-6
Reference
PMID:23439666
  Authors
Song Z, Zhao D, Yang L
  Title
Molecular mechanisms of neurodegeneration mediated by dysfunctional subcellular organelles in transmissible spongiform encephalopathies.
  Journal
Acta Biochim Biophys Sin (Shanghai) 45:452-64 (2013)
DOI:10.1093/abbs/gmt014
Reference
PMID:28643372
  Authors
Halliday M, Hughes D, Mallucci GR
  Title
Fine-tuning PERK signaling for neuroprotection.
  Journal
J Neurochem 142:812-826 (2017)
DOI:10.1111/jnc.14112
Reference
PMID:29194372
  Authors
Hughes D, Halliday M
  Title
What Is Our Current Understanding of PrP(Sc)-Associated Neurotoxicity and Its Molecular Underpinnings?
  Journal
Pathogens 6:E63 (2017)
DOI:10.3390/pathogens6040063
Reference
PMID:24619348
  Authors
Hetz C, Mollereau B
  Title
Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases.
  Journal
Nat Rev Neurosci 15:233-49 (2014)
DOI:10.1038/nrn3689
Reference
PMID:29476642
  Authors
Hughes D, Mallucci GR
  Title
The unfolded protein response in neurodegenerative disorders - therapeutic modulation of the PERK pathway.
  Journal
FEBS J 286:342-355 (2019)
DOI:10.1111/febs.14422
Reference
PMID:21722302
  Authors
Doyle KM, Kennedy D, Gorman AM, Gupta S, Healy SJ, Samali A
  Title
Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders.
  Journal
J Cell Mol Med 15:2025-39 (2011)
DOI:10.1111/j.1582-4934.2011.01374.x
Reference
PMID:18420416
  Authors
Ferreiro E, Oliveira CR, Pereira CM
  Title
The release of calcium from the endoplasmic reticulum induced by amyloid-beta and prion peptides activates the mitochondrial apoptotic pathway.
  Journal
Neurobiol Dis 30:331-42 (2008)
DOI:10.1016/j.nbd.2008.02.003
Reference
PMID:16844381
  Authors
Ferreiro E, Resende R, Costa R, Oliveira CR, Pereira CM
  Title
An endoplasmic-reticulum-specific apoptotic pathway is involved in prion and amyloid-beta peptides neurotoxicity.
  Journal
Neurobiol Dis 23:669-78 (2006)
DOI:10.1016/j.nbd.2006.05.011
Reference
PMID:21980554
  Authors
Torres M, Encina G, Soto C, Hetz C
  Title
Abnormal calcium homeostasis and protein folding stress at the ER: A common factor in familial and infectious prion disorders.
  Journal
Commun Integr Biol 4:258-61 (2011)
DOI:10.4161/cib.4.3.15019
Reference
PMID:25766616
  Authors
Ciechanover A, Kwon YT
  Title
Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategies.
  Journal
Exp Mol Med 47:e147 (2015)
DOI:10.1038/emm.2014.117
Reference
PMID:17466621
  Authors
Kristiansen M, Deriziotis P, Dimcheff DE, Jackson GS, Ovaa H, Naumann H, Clarke AR, van Leeuwen FW, Menendez-Benito V, Dantuma NP, Portis JL, Collinge J, Tabrizi SJ
  Title
Disease-associated prion protein oligomers inhibit the 26S proteasome.
  Journal
Mol Cell 26:175-88 (2007)
DOI:10.1016/j.molcel.2007.04.001
Reference
PMID:10195903
  Authors
Wang HG, Pathan N, Ethell IM, Krajewski S, Yamaguchi Y, Shibasaki F, McKeon F, Bobo T, Franke TF, Reed JC.
  Title
Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD.
  Journal
Science 284:339-43 (1999)
DOI:10.1126/science.284.5412.339
Reference
PMID:14532116
  Authors
Hetz C, Russelakis-Carneiro M, Maundrell K, Castilla J, Soto C
  Title
Caspase-12 and endoplasmic reticulum stress mediate neurotoxicity of pathological prion protein.
  Journal
EMBO J 22:5435-45 (2003)
DOI:10.1093/emboj/cdg537
Reference
PMID:31417367
  Authors
Zamponi E, Pigino GF
  Title
Protein Misfolding, Signaling Abnormalities and Altered Fast Axonal Transport: Implications for Alzheimer and Prion Diseases.
  Journal
Front Cell Neurosci 13:350 (2019)
DOI:10.3389/fncel.2019.00350
Reference
PMID:29261664
  Authors
Zamponi E, Buratti F, Cataldi G, Caicedo HH, Song Y, Jungbauer LM, LaDu MJ, Bisbal M, Lorenzo A, Ma J, Helguera PR, Morfini GA, Brady ST, Pigino GF
  Title
Prion protein inhibits fast axonal transport through a mechanism involving casein kinase 2.
  Journal
PLoS One 12:e0188340 (2017)
DOI:10.1371/journal.pone.0188340
Reference
PMID:21196165
  Authors
Schneider B, Pietri M, Pradines E, Loubet D, Launay JM, Kellermann O, Mouillet-Richard S
  Title
Understanding the neurospecificity of Prion protein signaling.
  Journal
Front Biosci (Landmark Ed) 16:169-86 (2011)
DOI:10.2741/3682
Reference
PMID:23479001
  Authors
Didonna A
  Title
Prion protein and its role in signal transduction.
  Journal
Cell Mol Biol Lett 18:209-30 (2013)
DOI:10.2478/s11658-013-0085-0
Reference
PMID:28507517
  Authors
Shah SZA, Zhao D, Hussain T, Yang L
  Title
The Role of Unfolded Protein Response and Mitogen-Activated Protein Kinase Signaling in Neurodegenerative Diseases with Special Focus on Prion Diseases.
  Journal
Front Aging Neurosci 9:120 (2017)
DOI:10.3389/fnagi.2017.00120
Reference
PMID:15528202
  Authors
Marella M, Gaggioli C, Batoz M, Deckert M, Tartare-Deckert S, Chabry J
  Title
Pathological prion protein exposure switches on neuronal mitogen-activated protein kinase pathway resulting in microglia recruitment.
  Journal
J Biol Chem 280:1529-34 (2005)
DOI:10.1074/jbc.M410966200
Reference
PMID:15640354
  Authors
Ishikura N, Clever JL, Bouzamondo-Bernstein E, Samayoa E, Prusiner SB, Huang EJ, DeArmond SJ
  Title
Notch-1 activation and dendritic atrophy in prion disease.
  Journal
Proc Natl Acad Sci U S A 102:886-91 (2005)
DOI:10.1073/pnas.0408612101
Reference
PMID:20205843
  Authors
Dearmond SJ, Bajsarowicz K
  Title
PrPSc accumulation in neuronal plasma membranes links Notch-1 activation to dendritic degeneration in prion diseases.
  Journal
Mol Neurodegener 5:6 (2010)
DOI:10.1186/1750-1326-5-6
Reference
PMID:29998397
  Authors
Hirsch TZ, Martin-Lanneree S, Reine F, Hernandez-Rapp J, Herzog L, Dron M, Privat N, Passet B, Halliez S, Villa-Diaz A, Lacroux C, Klein V, Haik S, Andreoletti O, Torres JM, Vilotte JL, Beringue V, Mouillet-Richard S
  Title
Epigenetic Control of the Notch and Eph Signaling Pathways by the Prion Protein: Implications for Prion Diseases.
  Journal
Mol Neurobiol 56:2159-2173 (2019)
DOI:10.1007/s12035-018-1193-7
Reference
PMID:28714865
  Authors
Aguzzi A, Zhu C
  Title
Microglia in prion diseases.
  Journal
J Clin Invest 127:3230-3239 (2017)
DOI:10.1172/JCI90605
Reference
PMID:15342004
  Authors
Mabbott NA
  Title
The complement system in prion diseases.
  Journal
Curr Opin Immunol 16:587-93 (2004)
DOI:10.1016/j.coi.2004.07.002
Reference
PMID:15611724
  Authors
Mallucci G, Collinge J
  Title
Rational targeting for prion therapeutics.
  Journal
Nat Rev Neurosci 6:23-34 (2005)
DOI:10.1038/nrn1584
Related
pathway
tfn00190  Oxidative phosphorylation
tfn03050  Proteasome
tfn04020  Calcium signaling pathway
tfn04140  Autophagy - animal
tfn04141  Protein processing in endoplasmic reticulum
tfn04142  Lysosome
tfn04144  Endocytosis
tfn04210  Apoptosis
tfn04330  Notch signaling pathway
tfn04610  Complement and coagulation cascades
tfn04668  TNF signaling pathway
KO pathway
ko05020   
LinkDB

DBGET integrated database retrieval system