KEGG   PATHWAY: tfn04020
Entry
tfn04020                    Pathway                                
Name
Calcium signaling pathway - Trachypithecus francoisi (Francois's langur)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
tfn04020  Calcium signaling pathway
tfn04020

Other DBs
GO: 0019722
Organism
Trachypithecus francoisi (Francois's langur) [GN:tfn]
Gene
117061979  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
117062078  TACR1; substance-P receptor [KO:K04222]
117062329  LHCGR; lutropin-choriogonadotropic hormone receptor [KO:K04248]
117062348  CALM2; calmodulin-2 [KO:K02183]
117062417  SLC8A1; sodium/calcium exchanger 1 isoform X1 [KO:K05849]
117062665  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
117063252  CYSLTR2; cysteinyl leukotriene receptor 2 isoform X1 [KO:K04323]
117063272  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
117063659  EDNRB; endothelin receptor type B [KO:K04198]
117064164  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
117064180  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
117064215  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
117064735  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
117064804  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
117064830  CAMK4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
117065039  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
117065085  FGF10; fibroblast growth factor 10 [KO:K04358]
117065283  F2R; proteinase-activated receptor 1 isoform X1 [KO:K03914]
117065345  FGFR4; LOW QUALITY PROTEIN: fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
117065371  HRH2; histamine H2 receptor isoform X1 [KO:K04150]
117065373  DRD1; D(1A) dopamine receptor [KO:K04144]
117065449  FGF18; fibroblast growth factor 18 [KO:K04358]
117065532  ADRA1B; alpha-1B adrenergic receptor [KO:K04136]
117065575  ADRB2; beta-2 adrenergic receptor [KO:K04142]
117065596  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
117065600  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
117065679  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
117065686  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
117065867  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
117066110  HTR4; 5-hydroxytryptamine receptor 4 [KO:K04160]
117066424  ADORA2B; adenosine receptor A2b [KO:K04267]
117066643  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
117066654  ADRB1; beta-1 adrenergic receptor [KO:K04141]
117066687  SMIM6; small integral membrane protein 6 [KO:K26468]
117066720  SPHK1; sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
117066858  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 [KO:K05857] [EC:3.1.4.11]
117067088  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
117067229  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
117067396  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
117067605  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
117067885  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
117067902  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
117067903  P2RX1; P2X purinoceptor 1 isoform X1 [KO:K05215]
117067908  P2RX5; P2X purinoceptor 5 isoform X1 [KO:K05219]
117068306  NTSR1; neurotensin receptor type 1 [KO:K04211]
117068469  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
117068471  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
117068503  ADRA1D; alpha-1D adrenergic receptor [KO:K04137]
117068620  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
117068778  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
117068847  TNNC2; troponin C, skeletal muscle [KO:K12042]
117068934  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
117068997  [KO:K04632]
117069000  [KO:K04632]
117069383  SLC8A3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
117069568  [KO:K06856]
117069583  [KO:K06856]
117069585  [KO:K06856]
117069725  [KO:K06856]
117069765  [KO:K06856]
117069878  [KO:K02183]
117069899  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
117069900  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
117069904  LTB4R2; leukotriene B4 receptor 2 [KO:K04297]
117070256  NTRK3; NT-3 growth factor receptor isoform X1 [KO:K05101] [EC:2.7.10.1]
117070455  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
117070685  FGF7; fibroblast growth factor 7 [KO:K04358]
117070827  [KO:K02183]
117070833  ITPKA; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
117070870  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
117070926  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
117070941  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
117071124  RYR3; LOW QUALITY PROTEIN: ryanodine receptor 3 [KO:K04963]
117071446  [KO:K03916]
117071553  CALM1; calmodulin-1 [KO:K02183]
117072419  [KO:K10785]
117072420  [KO:K10785]
117072442  ORAI2; protein orai-2 isoform X1 [KO:K16057]
117072487  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
117072600  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
117072614  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
117072632  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
117072675  [KO:K04323]
117072748  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
117073301  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
117073333  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
117073436  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
117073506  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
117073532  [KO:K00871] [EC:2.7.11.19]
117073652  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
117074128  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
117074223  CASQ1; calsequestrin-1 [KO:K23468]
117074394  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
117074523  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
117074572  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
117074741  TBXA2R; thromboxane A2 receptor [KO:K04264]
117074842  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
117074911  GNA15; guanine nucleotide-binding protein subunit alpha-15 [KO:K04637]
117074964  FGF9; fibroblast growth factor 9 [KO:K04358]
117075332  GRIN3B; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
117075386  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G [KO:K08794] [EC:2.7.11.17]
117075419  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
117075427  NGF; beta-nerve growth factor [KO:K02582]
117075594  ITPKB; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
117075607  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
117075802  AVPR1B; vasopressin V1b receptor [KO:K04227]
117076111  MCOLN1; mucolipin-1 isoform X1 [KO:K04992]
117076189  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
117076274  PTGER1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
117076540  RYR2; ryanodine receptor 2 isoform X1 [KO:K04962]
117076785  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
117076828  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
117076833  CASQ2; calsequestrin-2 [KO:K23445]
117077213  CYSLTR1; cysteinyl leukotriene receptor 1 [KO:K04322]
117077276  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
117077363  [KO:K07190]
117077404  GRPR; gastrin-releasing peptide receptor [KO:K04169]
117077518  CACNA1F; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
117077528  FGF16; fibroblast growth factor 16 [KO:K04358]
117077572  VEGFD; vascular endothelial growth factor D [KO:K05449]
117077879  HTR2C; LOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 2C [KO:K04157]
117077936  [KO:K05863]
117078452  PHKA2; LOW QUALITY PROTEIN: phosphorylase b kinase regulatory subunit alpha, liver isoform [KO:K07190]
117078477  ATP2B3; LOW QUALITY PROTEIN: plasma membrane calcium-transporting ATPase 3 [KO:K05850] [EC:7.2.2.10]
117079026  ADORA2A; LOW QUALITY PROTEIN: adenosine receptor A2a [KO:K04266]
117079182  TRHR; thyrotropin-releasing hormone receptor [KO:K04282]
117079299  ADCY8; LOW QUALITY PROTEIN: adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
117079497  ASPH; aspartyl/asparaginyl beta-hydroxylase isoform X1 [KO:K00476] [EC:1.14.11.16]
117079553  [KO:K02183]
117079898  FGF3; fibroblast growth factor 3 [KO:K04358]
117080013  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
117080117  GRM5; metabotropic glutamate receptor 5 [KO:K04604]
117080426  FGF19; fibroblast growth factor 19 [KO:K22603]
117080608  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
117080722  FGF4; fibroblast growth factor 4 [KO:K04358]
117080785  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
117080811  SLN; sarcolipin [KO:K22642]
117080855  CCKBR; gastrin/cholecystokinin type B receptor [KO:K04195]
117081171  STIM1; stromal interaction molecule 1 isoform X1 [KO:K16059]
117081493  P2RX3; P2X purinoceptor 3 [KO:K05217]
117081515  MST1; hepatocyte growth factor-like protein isoform X1 [KO:K23441]
117081644  MST1R; macrophage-stimulating protein receptor isoform X1 [KO:K05100] [EC:2.7.10.1]
117081719  TPCN2; two pore calcium channel protein 2 isoform X1 [KO:K14077]
117081990  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
117082093  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial isoform X1 [KO:K09565] [EC:5.2.1.8]
117082124  MRLN; myoregulin [KO:K22643]
117082197  CALML3; calmodulin-like protein 3 [KO:K02183]
117082198  CALML5; calmodulin-like protein 5 [KO:K02183]
117082351  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
117082480  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D isoform X1 [KO:K08794] [EC:2.7.11.17]
117082599  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
117082746  VDAC2; voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15040]
117082784  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
117082828  TNNC1; troponin C, slow skeletal and cardiac muscles isoform X1 [KO:K05865]
117082854  TACR2; substance-K receptor isoform X1 [KO:K04223]
117083004  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
117083173  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
117083194  OXTR; oxytocin receptor isoform X1 [KO:K04229]
117083218  CAMK1; calcium/calmodulin-dependent protein kinase type 1 isoform X1 [KO:K08794] [EC:2.7.11.17]
117083249  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
117083254  HRH1; histamine H1 receptor [KO:K04149]
117083396  MYLK; LOW QUALITY PROTEIN: myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
117083595  [KO:K00871] [EC:2.7.11.19]
117083882  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [KO:K05857] [EC:3.1.4.11]
117084057  AGTR1; type-1 angiotensin II receptor [KO:K04166]
117084140  [KO:K06856]
117085041  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
117085174  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
117085241  CCKAR; cholecystokinin receptor type A [KO:K04194]
117085245  STIM2; stromal interaction molecule 2 isoform X1 [KO:K18196]
117085405  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
117085601  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
117085606  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
117085729  TACR3; neuromedin-K receptor [KO:K04224]
117085785  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
117085812  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
117085838  CUNH4orf3; uncharacterized protein C4orf3 homolog [KO:K26467]
117085877  FGF2; fibroblast growth factor 2 [KO:K18497]
117085890  SLC25A31; ADP/ATP translocase 4 isoform X1 [KO:K05863]
117085996  EDNRA; endothelin-1 receptor isoform X1 [KO:K04197]
117086157  VEGFC; vascular endothelial growth factor C [KO:K05449]
117086204  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
117086289  DRD5; D(1B) dopamine receptor [KO:K05840]
117086505  HTR7; 5-hydroxytryptamine receptor 7 isoform X1 [KO:K04163]
117086614  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
117087057  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
117087200  TFEB; transcription factor EB isoform X1 [KO:K15590]
117087278  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
117087485  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
117087574  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
117087666  PHKG2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X1 [KO:K00871] [EC:2.7.11.19]
117087680  ORAI3; protein orai-3 isoform X1 [KO:K16058]
117087736  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
117087742  PHKB; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
117087765  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
117088112  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
117088478  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
117089146  P2RX2; P2X purinoceptor 2 isoform X1 [KO:K05216]
117089273  ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056]
117089332  NOS1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
117089363  TPCN1; two pore calcium channel protein 1 isoform X1 [KO:K16896]
117089420  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
117089644  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
117089829  AVPR1A; vasopressin V1a receptor [KO:K04226]
117089952  ERBB3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
117089984  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
117090367  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
117090427  PLCZ1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X1 [KO:K05861] [EC:3.1.4.11]
117090480  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
117090673  FGF6; fibroblast growth factor 6 [KO:K04358]
117090674  FGF23; fibroblast growth factor 23 [KO:K22428]
117090701  [KO:K04850]
117091446  CALM3; calmodulin-3 [KO:K02183]
117091475  SLC8A2; sodium/calcium exchanger 2 isoform X1 [KO:K05849]
117091505  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
117091509  SPHK2; sphingosine kinase 2 isoform X1 [KO:K04718] [EC:2.7.1.91]
117091554  HRC; sarcoplasmic reticulum histidine-rich calcium-binding protein isoform X1 [KO:K23450]
117091710  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
117091932  ITPKC; inositol-trisphosphate 3-kinase C isoform X1 [KO:K00911] [EC:2.7.1.127]
117091955  [KO:K05860] [EC:3.1.4.11]
117092092  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260]
117092120  FGF20; fibroblast growth factor 20 [KO:K04358]
117092142  PTGFR; prostaglandin F2-alpha receptor [KO:K04262]
117092158  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
117092178  MCOLN3; mucolipin-3 isoform X1 [KO:K04994]
117092180  MCOLN2; mucolipin-2 isoform X1 [KO:K04993]
117092481  RYR1; ryanodine receptor 1 [KO:K04961]
117092974  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
117093016  PTAFR; platelet-activating factor receptor [KO:K04279]
117093193  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
117093204  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
117093728  ADRA1A; alpha-1A adrenergic receptor isoform X1 [KO:K04135]
117093783  FGF21; fibroblast growth factor 21 [KO:K22429]
117093809  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
117093967  CALML6; calmodulin-like protein 6 isoform X1 [KO:K02183]
117094169  [KO:K05085] [EC:2.7.10.1]
117094228  [KO:K04161]
117094393  HTR2B; 5-hydroxytryptamine receptor 2B [KO:K04157]
117094517  PLCD4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1 [KO:K05857] [EC:3.1.4.11]
117094771  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
117094774  ADRB3; LOW QUALITY PROTEIN: beta-3 adrenergic receptor [KO:K04143]
117094867  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
117095064  [KO:K02183]
117095065  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
117095701  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
117096460  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856]
117096471  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
117096624  P2RX6; P2X purinoceptor 6 isoform X1 [KO:K05221]
117096992  PLN; cardiac phospholamban [KO:K05852]
117097014  TRDN; triadin isoform X1 [KO:K23449]
117097320  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
117097668  [KO:K05209]
117097725  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
117097871  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
117097913  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
117098307  [KO:K05862]
117098409  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
117098435  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
117098437  GNA14; guanine nucleotide-binding protein subunit alpha-14 isoform X1 [KO:K04636]
117098498  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
117098894  GRIN3A; glutamate receptor ionotropic, NMDA 3A isoform X1 [KO:K05213]
117098896  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
117099070  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
117099100  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
117099768  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
tfn04010  MAPK signaling pathway
tfn04070  Phosphatidylinositol signaling system
tfn04210  Apoptosis
tfn04720  Long-term potentiation
tfn04730  Long-term depression
KO pathway
ko04020   

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