KEGG   PATHWAY: tge04115
Entry
tge04115                    Pathway                                
Name
p53 signaling pathway - Theropithecus gelada (gelada)
Description
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
Class
Cellular Processes; Cell growth and death
Pathway map
tge04115  p53 signaling pathway
tge04115

Organism
Theropithecus gelada (gelada) [GN:tge]
Gene
112606480  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
112633701  CHEK2; serine/threonine-protein kinase Chk2 isoform X1 [KO:K06641] [EC:2.7.11.1]
112619167  ATR; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
112606274  CHEK1; serine/threonine-protein kinase Chk1 isoform X1 [KO:K02216] [EC:2.7.11.1]
112614086  GORAB; RAB6-interacting golgin isoform X1 [KO:K19748]
112607787  cyclin-dependent kinase inhibitor 2A isoform X1 [KO:K06621]
112607790  tumor suppressor ARF-like [KO:K06621]
112634274  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
112608959  MDM4; protein Mdm4 isoform X1 [KO:K10127]
112610199  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
112613625  PPP1R13L; relA-associated inhibitor isoform X1 [KO:K27356]
112623750  CDKN1A; cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
112605640  CCND1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
112634321  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
112622480  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
112634055  CDK4; cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
112620347  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
112629797  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
112612586  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
112633979  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
112606392  SFN; 14-3-3 protein sigma [KO:K06644]
112636298  RPRM; protein reprimo [KO:K10128]
112625921  CCNB1; G2/mitotic-specific cyclin-B1 isoform X1 [KO:K05868]
112627365  CCNB2; G2/mitotic-specific cyclin-B2 [KO:K21770]
112632151  CDK1; cyclin-dependent kinase 1 isoform X1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
112626501  cyclin-dependent kinase 1-like isoform X1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
112608708  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
112611273  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
112612483  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta isoform X1 [KO:K04402]
112633379  GTSE1; G2 and S phase-expressed protein 1 [KO:K10129]
112633973  ZNF385A; zinc finger protein 385A isoform X1 [KO:K26543]
112631569  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
112605584  PIDD1; p53-induced death domain-containing protein 1 isoform X1 [KO:K10130]
112630107  TNFRSF10A; tumor necrosis factor receptor superfamily member 10A [KO:K04722]
112630735  TNFRSF10B; tumor necrosis factor receptor superfamily member 10B isoform X1 [KO:K04722]
112636264  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
112632621  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
112613606  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
112611835  BBC3; bcl-2-binding component 3 [KO:K10132]
112629474  SIVA1; apoptosis regulatory protein Siva isoform X1 [KO:K22744]
112632856  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
112611529  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
112604624  TP53I3; quinone oxidoreductase PIG3 [KO:K10133] [EC:1.-.-.-]
112604625  LOW QUALITY PROTEIN: quinone oxidoreductase PIG3-like [KO:K10133] [EC:1.-.-.-]
112606277  EI24; etoposide-induced protein 2.4 homolog isoform X1 [KO:K10134]
112619447  SHISA5; protein shisa-5 isoform X1 [KO:K10135]
112622259  PERP; p53 apoptosis effector related to PMP-22 [KO:K10136]
112618897  ZMAT3; zinc finger matrin-type protein 3 [KO:K10137]
112613773  SIAH1; E3 ubiquitin-protein ligase SIAH1 isoform X1 [KO:K04506] [EC:2.3.2.27]
112616416  E3 ubiquitin-protein ligase SIAH1-like [KO:K04506] [EC:2.3.2.27]
112620387  cytochrome c, somatic [KO:K08738]
112621297  cytochrome c [KO:K08738]
112622774  cytochrome c-like [KO:K08738]
112623008  cytochrome c-like [KO:K08738]
112608628  cytochrome c-like [KO:K08738]
112614550  cytochrome c-like [KO:K08738]
112625466  cytochrome c [KO:K08738]
112611588  cytochrome c-like [KO:K08738]
112626808  cytochrome c-like [KO:K08738]
112634215  cytochrome c-like [KO:K08738]
112605628  cytochrome c-like [KO:K08738]
112618713  cytochrome c-like [KO:K08738]
112634060  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
112628633  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
112622580  LOW QUALITY PROTEIN: caspase-3-like [KO:K02187] [EC:3.4.22.56]
112625066  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
112630958  AIFM2; apoptosis-inducing factor 2 isoform X1 [KO:K22745]
112620335  IGFBP3; insulin-like growth factor-binding protein 3 isoform X1 [KO:K10138]
112635504  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
112620079  SERPINE1; plasminogen activator inhibitor 1 isoform X1 [KO:K03982]
112630319  ADGRB1; adhesion G protein-coupled receptor B1 [KO:K04596]
112606086  CD82; CD82 antigen isoform X1 [KO:K06509]
112628028  THBS1; thrombospondin-1 isoform X1 [KO:K16857]
112611638  SERPINB5; serpin B5 [KO:K10139]
112606094  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
112630580  RRM2B; LOW QUALITY PROTEIN: ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
112605368  RRM2; ribonucleoside-diphosphate reductase subunit M2 isoform X1 [KO:K10808] [EC:1.17.4.1]
112622376  SESN1; sestrin-1 isoform X1 [KO:K10141]
112606091  SESN3; sestrin-3 isoform X1 [KO:K10141]
112606203  SESN2; sestrin-2 [KO:K20394]
112631315  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
112614277  TSC2; tuberin isoform X1 [KO:K07207]
112617118  metalloreductase STEAP3-like [KO:K10142] [EC:1.16.1.-]
112617156  metalloreductase STEAP3 isoform X1 [KO:K10142] [EC:1.16.1.-]
112635463  COP1; E3 ubiquitin-protein ligase COP1 isoform X1 [KO:K10143] [EC:2.3.2.27]
112624520  RCHY1; RING finger and CHY zinc finger domain-containing protein 1 isoform X1 [KO:K10144] [EC:2.3.2.27]
112625792  CCNG1; cyclin-G1 isoform X1 [KO:K10145]
112625025  CCNG2; cyclin-G2 [KO:K10146]
112610312  PPM1D; protein phosphatase 1D [KO:K10147] [EC:3.1.3.16]
112634664  TP73; tumor protein p73 isoform X1 [KO:K10148]
Reference
PMID:16557269
  Authors
Levine AJ, Hu W, Feng Z.
  Title
The P53 pathway: what questions remain to be explored?
  Journal
Cell Death Differ 13:1027-36 (2006)
DOI:10.1038/sj.cdd.4401910
Reference
PMID:15838523
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
PMID:11747320
  Authors
Balint E E, Vousden KH.
  Title
Activation and activities of the p53 tumour suppressor protein.
  Journal
Br J Cancer 85:1813-23 (2001)
DOI:10.1054/bjoc.2001.2128
Reference
PMID:11313928
  Authors
Taylor WR, Stark GR.
  Title
Regulation of the G2/M transition by p53.
  Journal
Oncogene 20:1803-15 (2001)
DOI:10.1038/sj.onc.1204252
Reference
PMID:15116721
  Authors
Hofseth LJ, Hussain SP, Harris CC.
  Title
p53: 25 years after its discovery.
  Journal
Trends Pharmacol Sci 25:177-81 (2004)
DOI:10.1016/j.tips.2004.02.009
Reference
PMID:12505356
  Authors
Pietenpol JA, Stewart ZA.
  Title
Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.
  Journal
Toxicology 181-182:475-81 (2002)
DOI:10.1016/S0300-483X(02)00460-2
Reference
PMID:10714958
  Authors
Tokino T, Nakamura Y.
  Title
The role of p53-target genes in human cancer.
  Journal
Crit Rev Oncol Hematol 33:1-6 (2000)
DOI:10.1016/S1040-8428(99)00051-7
Reference
PMID:16697662
  Authors
Hermeking H, Benzinger A.
  Title
14-3-3 proteins in cell cycle regulation.
  Journal
Semin Cancer Biol 16:183-92 (2006)
DOI:10.1016/j.semcancer.2006.03.002
Reference
PMID:16915296
  Authors
Sherr CJ.
  Title
Divorcing ARF and p53: an unsettled case.
  Journal
Nat Rev Cancer 6:663-73 (2006)
DOI:10.1038/nrc1954
Reference
PMID:17409411
  Authors
Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ.
  Title
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
  Journal
Cancer Res 67:3043-53 (2007)
DOI:10.1158/0008-5472.CAN-06-4149
Reference
PMID:26037915
  Authors
Resnick-Silverman L, Manfredi JJ
  Title
Two Faces of SIVA.
  Journal
Cancer Discov 5:581-3 (2015)
DOI:10.1158/2159-8290.CD-15-0484
Reference
PMID:19584092
  Authors
Resch U, Schichl YM, Winsauer G, Gudi R, Prasad K, de Martin R
  Title
Siva1 is a XIAP-interacting protein that balances NFkappaB and JNK signalling to promote apoptosis.
  Journal
J Cell Sci 122:2651-61 (2009)
DOI:10.1242/jcs.049940
Reference
PMID:19240372
  Authors
Barkinge JL, Gudi R, Sarah H, Chu F, Borthakur A, Prabhakar BS, Prasad KV
  Title
The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis.
  Journal
J Carcinog 8:2 (2009)
DOI:10.4103/1477-3163.45389
Reference
PMID:12135761
  Authors
Ohiro Y, Garkavtsev I, Kobayashi S, Sreekumar KR, Nantz R, Higashikubo BT, Duffy SL, Higashikubo R, Usheva A, Gius D, Kley N, Horikoshi N
  Title
A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF).
  Journal
FEBS Lett 524:163-71 (2002)
DOI:10.1016/S0014-5793(02)03049-1
Reference
PMID:26646590
  Authors
Hu Y, Ge W, Wang X, Sutendra G, Zhao K, Dedeic Z, Slee EA, Baer C, Lu X
  Title
Caspase cleavage of iASPP potentiates its ability to inhibit p53 and NF-kappaB.
  Journal
Oncotarget 6:42478-90 (2015)
DOI:10.18632/oncotarget.6478
Related
pathway
tge04110  Cell cycle
tge04210  Apoptosis
tge04218  Cellular senescence
KO pathway
ko04115   
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