KEGG   PATHWAY: tmu04152
Entry
tmu04152                    Pathway                                
Name
AMPK signaling pathway - Trichechus manatus latirostris (Florida manatee)
Description
AMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in the cellular AMP:ATP ratio caused by metabolic stresses that either interfere with ATP production (eg, deprivation for glucose or oxygen) or that accelerate ATP consumption (eg, muscle contraction). Several upstream kinases, including liver kinase B1 (LKB1), calcium/calmodulin kinase kinase-beta (CaMKK beta), and TGF-beta-activated kinase-1 (TAK-1), can activate AMPK by phosphorylating a threonine residue on its catalytic alpha-subunit. Once activated, AMPK leads to a concomitant inhibition of energy-consuming biosynthetic pathways, such as protein, fatty acid and glycogen synthesis, and activation of ATP-producing catabolic pathways, such as fatty acid oxidation and glycolysis.
Class
Environmental Information Processing; Signal transduction
Pathway map
tmu04152  AMPK signaling pathway
tmu04152

Other DBs
GO: 2000479
Organism
Trichechus manatus latirostris (Florida manatee) [GN:tmu]
Gene
101346094  mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
101354514  serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
101354586  calcium-binding protein 39-like [KO:K08272]
101356692  calcium-binding protein 39 isoform X1 [KO:K08272]
101354748  STE20-related kinase adapter protein alpha isoform X4 [KO:K08271]
101344961  STE20-related kinase adapter protein beta isoform X1 [KO:K17532]
101357146  leptin [KO:K05424]
101347718  leptin receptor isoform X1 [KO:K05062]
101347848  LOW QUALITY PROTEIN: calcium/calmodulin-dependent protein kinase kinase 2 [KO:K07359] [EC:2.7.11.17]
101353836  alpha-1A adrenergic receptor isoform X1 [KO:K04135]
101352214  adiponectin [KO:K07296]
101360161  adiponectin receptor protein 2 isoform X1 [KO:K07297]
101360663  adiponectin receptor protein 1 [KO:K07297]
101346784  5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
101360368  5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
101356476  5'-AMP-activated protein kinase subunit beta-2 isoform X2 [KO:K07199]
101361359  5'-AMP-activated protein kinase subunit beta-1 isoform X2 [KO:K07199]
101341480  5'-AMP-activated protein kinase subunit gamma-3 [KO:K07200]
101352672  5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
101349182  5'-AMP-activated protein kinase subunit gamma-2 isoform X2 [KO:K07200]
101341535  LOW QUALITY PROTEIN: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 [KO:K19028] [EC:2.7.1.105 3.1.3.46]
101341321  6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 2 isoform X1 [KO:K19029] [EC:2.7.1.105 3.1.3.46]
101356475  6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 3 isoform X2 [KO:K01103] [EC:2.7.1.105 3.1.3.46]
101349584  6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 4 isoform X3 [KO:K19030] [EC:2.7.1.105 3.1.3.46]
101345556  fructose-1,6-bisphosphatase isozyme 2 [KO:K03841] [EC:3.1.3.11]
101345811  fructose-1,6-bisphosphatase 1 isoform X1 [KO:K03841] [EC:3.1.3.11]
101345312  ATP-dependent 6-phosphofructokinase, liver type [KO:K00850] [EC:2.7.1.11]
101352081  ATP-dependent 6-phosphofructokinase, platelet type [KO:K00850] [EC:2.7.1.11]
101342778  ATP-dependent 6-phosphofructokinase, muscle type [KO:K00850] [EC:2.7.1.11]
101354483  hepatocyte nuclear factor 4-alpha isoform X1 [KO:K07292]
101358292  glucose-6-phosphatase isoform X1 [KO:K01084] [EC:3.1.3.9]
101352258  glucose-6-phosphatase 3 isoform X2 [KO:K01084] [EC:3.1.3.9]
101352450  glucose-6-phosphatase 2 isoform X1 [KO:K01084] [EC:3.1.3.9]
101350173  phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
101343675  phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
101344998  CREB-regulated transcription coactivator 2 [KO:K16333]
101356881  cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
101355964  cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
101349137  cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
101344337  cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
101344076  cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
101352607  cyclic AMP-responsive element-binding protein 3 [KO:K09048]
101345798  cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
101340445  peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1 [KO:K07202]
101347922  ELAV-like protein 1 [KO:K13088]
101359745  G1/S-specific cyclin-D1 [KO:K04503]
101341432  cyclin-A2 [KO:K06627]
101347141  cyclin-A1 [KO:K06627]
101351746  eukaryotic elongation factor 2 kinase [KO:K08292] [EC:2.7.11.20]
101341582  elongation factor 2 [KO:K03234]
101340503  LOW QUALITY PROTEIN: forkhead box protein O1 [KO:K07201]
101354741  forkhead box protein O3 [KO:K09408]
101342951  NAD-dependent protein deacetylase sirtuin-1 isoform X1 [KO:K11411] [EC:2.3.1.286]
101358486  solute carrier family 2, facilitated glucose transporter member 4 isoform X1 [KO:K07191]
101357774  glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
101355539  glycogen [starch] synthase, muscle isoform X1 [KO:K00693] [EC:2.4.1.11]
101361564  hormone-sensitive lipase [KO:K07188] [EC:3.1.1.79]
101360660  3-hydroxy-3-methylglutaryl-Coenzyme A reductase isoform X1 [KO:K00021] [EC:1.1.1.34]
101352805  sterol regulatory element-binding protein 1 [KO:K07197]
101361851  fatty acid synthase [KO:K00665] [EC:2.3.1.85]
101350305  acetyl-CoA carboxylase 1 isoform X3 [KO:K11262] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
101342048  acyl-CoA desaturase [KO:K00507] [EC:1.14.19.1]
101356568  stearoyl-CoA desaturase 5 [KO:K00507] [EC:1.14.19.1]
101351597  acetyl-CoA carboxylase 2 [KO:K01946] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
101348009  malonyl-CoA decarboxylase, mitochondrial [KO:K01578] [EC:4.1.1.9]
101360516  carnitine O-palmitoyltransferase 1, liver isoform [KO:K08765] [EC:2.3.1.21]
101354017  carnitine O-palmitoyltransferase 1, muscle isoform isoform X1 [KO:K19523] [EC:2.3.1.21]
101347610  carnitine O-palmitoyltransferase 1, brain isoform isoform X1 [KO:K19524] [EC:2.3.1.21]
101350415  cell death activator CIDE-A [KO:K25893]
101358337  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
101350333  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
101344236  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X3 [KO:K03456]
101347357  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
101347198  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
101343363  protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
101352293  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X2 [KO:K04354]
101358479  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
101356463  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
101353925  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
101360090  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta [KO:K11583]
101349860  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
101345308  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
101353776  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
101350461  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X4 [KO:K11584]
101355704  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
101358956  TBC1 domain family member 1 isoform X1 [KO:K18341]
101348838  ras-related protein Rab-2A [KO:K07877]
101353683  ras-related protein Rab-8A [KO:K07901]
101352710  ras-related protein Rab-10 [KO:K07903]
101348686  ras-related protein Rab-11B [KO:K07905]
101349795  ras-related protein Rab-14 [KO:K07881]
101346801  cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
101343794  platelet glycoprotein 4 [KO:K06259]
101361934  insulin-like growth factor I isoform X1 [KO:K05459]
101355333  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
101346705  insulin [KO:K04526]
101360415  insulin receptor [KO:K04527] [EC:2.7.10.1]
101356151  insulin receptor substrate 1 [KO:K16172]
101345051  insulin receptor substrate 2 [KO:K07187]
101362072  insulin receptor substrate 1-like [KO:K17445]
101350401  insulin receptor substrate 4 isoform X1 [KO:K17446]
101358678  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101346849  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101359658  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
101351035  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
101343804  phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101347746  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
101353040  3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
101360493  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101356099  RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101350197  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101358131  tuberin [KO:K07207]
101347417  hamartin isoform X1 [KO:K07206]
101360739  GTP-binding protein Rheb isoform X2 [KO:K07208]
101343808  serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
101343081  LOW QUALITY PROTEIN: regulatory-associated protein of mTOR [KO:K07204]
101345300  LOW QUALITY PROTEIN: proline-rich AKT1 substrate 1 [KO:K16184]
101343535  ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
101354510  ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
101361891  eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
101356506  peroxisome proliferator-activated receptor gamma isoform X2 [KO:K08530]
101357581  serine/threonine-protein kinase ULK1 [KO:K21357] [EC:2.7.11.1]
Compound
C00003  NAD+
C00008  ADP
C00020  AMP
C00022  Pyruvate
C00024  Acetyl-CoA
C00031  D-Glucose
C00040  Acyl-CoA
C00076  Calcium cation
C00083  Malonyl-CoA
C00085  D-Fructose 6-phosphate
C00162  Fatty acid
C00354  D-Fructose 1,6-bisphosphate
C00389  Quercetin
C00665  beta-D-Fructose 2,6-bisphosphate
C00668  alpha-D-Glucose 6-phosphate
C00698  Cl-
C00757  Berberine
C01172  beta-D-Glucose 6-phosphate
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C07151  Metformin
C09731  Epigallocatechin gallate
D08351  Phenformin (BAN)
Reference
PMID:19584320
  Authors
Steinberg GR, Kemp BE
  Title
AMPK in Health and Disease.
  Journal
Physiol Rev 89:1025-78 (2009)
DOI:10.1152/physrev.00011.2008
Reference
PMID:15509864
  Authors
Hardie DG.
  Title
The AMP-activated protein kinase pathway--new players upstream and downstream.
  Journal
J Cell Sci 117:5479-87 (2004)
DOI:10.1242/jcs.01540
Reference
PMID:23747347
  Authors
Russo GL, Russo M, Ungaro P
  Title
AMP-activated protein kinase: a target for old drugs against diabetes and cancer.
  Journal
Biochem Pharmacol 86:339-50 (2013)
DOI:10.1016/j.bcp.2013.05.023
Reference
PMID:19393004
  Authors
Ronnett GV, Ramamurthy S, Kleman AM, Landree LE, Aja S
  Title
AMPK in the brain: its roles in energy balance and neuroprotection.
  Journal
J Neurochem 109 Suppl 1:17-23 (2009)
DOI:10.1111/j.1471-4159.2009.05916.x
Reference
PMID:20010958
  Authors
Li J, McCullough LD
  Title
Effects of AMP-activated protein kinase in cerebral ischemia.
  Journal
J Cereb Blood Flow Metab 30:480-92 (2010)
DOI:10.1038/jcbfm.2009.255
Reference
PMID:22700795
  Authors
Sanchez AM, Candau RB, Csibi A, Pagano AF, Raibon A, Bernardi H
  Title
The role of AMP-activated protein kinase in the coordination of skeletal muscle turnover and energy homeostasis.
  Journal
Am J Physiol Cell Physiol 303:C475-85 (2012)
DOI:10.1152/ajpcell.00125.2012
Reference
PMID:16644802
  Authors
Viollet B, Foretz M, Guigas B, Horman S, Dentin R, Bertrand L, Hue L, Andreelli F
  Title
Activation of AMP-activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders.
  Journal
J Physiol 574:41-53 (2006)
DOI:10.1113/jphysiol.2006.108506
Reference
PMID:19629071
  Authors
Shackelford DB, Shaw RJ
  Title
The LKB1-AMPK pathway: metabolism and growth control in tumour suppression.
  Journal
Nat Rev Cancer 9:563-75 (2009)
DOI:10.1038/nrc2676
Reference
PMID:22885100
  Authors
Chung JH, Manganiello V, Dyck JR
  Title
Resveratrol as a calorie restriction mimetic: therapeutic implications.
  Journal
Trends Cell Biol 22:546-54 (2012)
DOI:10.1016/j.tcb.2012.07.004
Reference
PMID:20357764
  Authors
Iwabu M, Yamauchi T, Okada-Iwabu M, Sato K, Nakagawa T, Funata M, Yamaguchi M, Namiki S, Nakayama R, Tabata M, Ogata H, Kubota N, Takamoto I, Hayashi YK, Yamauchi N, Waki H, Fukayama M, Nishino I, Tokuyama K, Ueki K, Oike Y, Ishii S, Hirose K, Shimizu T, Touhara K, Kadowaki T
  Title
Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca(2+) and AMPK/SIRT1.
  Journal
Nature 464:1313-9 (2010)
DOI:10.1038/nature08991
Reference
PMID:17307971
  Authors
Towler MC, Hardie DG
  Title
AMP-activated protein kinase in metabolic control and insulin signaling.
  Journal
Circ Res 100:328-41 (2007)
DOI:10.1161/01.RES.0000256090.42690.05
Reference
PMID:23899560
  Authors
Richter EA, Hargreaves M
  Title
Exercise, GLUT4, and skeletal muscle glucose uptake.
  Journal
Physiol Rev 93:993-1017 (2013)
DOI:10.1152/physrev.00038.2012
Reference
PMID:16054041
  Authors
Kahn BB, Alquier T, Carling D, Hardie DG
  Title
AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism.
  Journal
Cell Metab 1:15-25 (2005)
DOI:10.1016/j.cmet.2004.12.003
Reference
PMID:23565491
  Authors
Minokoshi Y, Toda C, Okamoto S
  Title
Regulatory role of leptin in glucose and lipid metabolism in skeletal muscle.
  Journal
Indian J Endocrinol Metab 16:S562-8 (2012)
DOI:10.4103/2230-8210.105573
Reference
PMID:16723978
  Authors
Guggino WB, Stanton BA
  Title
New insights into cystic fibrosis: molecular switches that regulate CFTR.
  Journal
Nat Rev Mol Cell Biol 7:426-36 (2006)
DOI:10.1038/nrm1949
Reference
PMID:16479585
  Authors
Cheng A, Saltiel AR
  Title
More TORC for the gluconeogenic engine.
  Journal
Bioessays 28:231-4 (2006)
DOI:10.1002/bies.20375
Reference
PMID:19197243
  Authors
Herrero-Martin G, Hoyer-Hansen M, Garcia-Garcia C, Fumarola C, Farkas T, Lopez-Rivas A, Jaattela M
  Title
TAK1 activates AMPK-dependent cytoprotective autophagy in TRAIL-treated epithelial cells.
  Journal
EMBO J 28:677-85 (2009)
DOI:10.1038/emboj.2009.8
Reference
PMID:19724019
  Authors
Morris DL, Rui L
  Title
Recent advances in understanding leptin signaling and leptin resistance.
  Journal
Am J Physiol Endocrinol Metab 297:E1247-59 (2009)
DOI:10.1152/ajpendo.00274.2009
Reference
PMID:18725075
  Authors
Minokoshi Y, Shiuchi T, Lee S, Suzuki A, Okamoto S
  Title
Role of hypothalamic AMP-kinase in food intake regulation.
  Journal
Nutrition 24:786-90 (2008)
DOI:10.1016/j.nut.2008.06.002
Reference
PMID:23024365
  Authors
Miyamoto L, Ebihara K, Kusakabe T, Aotani D, Yamamoto-Kataoka S, Sakai T, Aizawa-Abe M, Yamamoto Y, Fujikura J, Hayashi T, Hosoda K, Nakao K
  Title
Leptin activates hepatic 5'-AMP-activated protein kinase through sympathetic nervous system and alpha1-adrenergic receptor: a potential mechanism for improvement of fatty liver in lipodystrophy by leptin.
  Journal
J Biol Chem 287:40441-7 (2012)
DOI:10.1074/jbc.M112.384545
Related
pathway
tmu00010  Glycolysis / Gluconeogenesis
tmu00061  Fatty acid biosynthesis
tmu00500  Starch and sucrose metabolism
tmu01040  Biosynthesis of unsaturated fatty acids
tmu04110  Cell cycle
tmu04140  Autophagy - animal
tmu04150  mTOR signaling pathway
tmu04151  PI3K-Akt signaling pathway
tmu04910  Insulin signaling pathway
tmu04920  Adipocytokine signaling pathway
KO pathway
ko04152   
LinkDB

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