KEGG   PATHWAY: tmu04151
Entry
tmu04151                    Pathway                                
Name
PI3K-Akt signaling pathway - Trichechus manatus latirostris (Florida manatee)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
tmu04151  PI3K-Akt signaling pathway
tmu04151

Other DBs
GO: 0043491
Organism
Trichechus manatus latirostris (Florida manatee) [GN:tmu]
Gene
101355971  pro-epidermal growth factor [KO:K04357]
101355918  protransforming growth factor alpha isoform X1 [KO:K08774]
101346158  proepiregulin [KO:K09784]
101356196  amphiregulin [KO:K09782]
101359380  fibroblast growth factor 1 isoform X1 [KO:K18496]
101342442  LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
101347308  fibroblast growth factor 8 isoform X3 [KO:K04358]
101361747  fibroblast growth factor 18 [KO:K04358]
101360972  fibroblast growth factor 9 [KO:K04358]
101344975  fibroblast growth factor 20 [KO:K04358]
101357665  fibroblast growth factor 7 [KO:K04358]
101348610  fibroblast growth factor 16 [KO:K04358]
101356322  fibroblast growth factor 17 isoform X1 [KO:K04358]
101356591  fibroblast growth factor 10 [KO:K04358]
101353258  fibroblast growth factor 3 [KO:K04358]
101350986  fibroblast growth factor 6 [KO:K04358]
101351769  fibroblast growth factor 22 [KO:K04358]
101347190  fibroblast growth factor 5 isoform X1 [KO:K04358]
101354028  fibroblast growth factor 19 [KO:K22603]
101356236  fibroblast growth factor 21 [KO:K22429]
101351251  fibroblast growth factor 23 [KO:K22428]
101341922  beta-nerve growth factor [KO:K02582]
101350169  brain-derived neurotrophic factor isoform X1 [KO:K04355]
101349059  neurotrophin-3 [KO:K04356]
101355026  neurotrophin-4 [KO:K12457]
101346705  insulin [KO:K04526]
101361934  insulin-like growth factor I isoform X1 [KO:K05459]
101344666  platelet-derived growth factor subunit A [KO:K04359]
101344115  platelet-derived growth factor subunit B [KO:K17386]
101358075  platelet-derived growth factor C isoform X1 [KO:K05450]
101360702  platelet-derived growth factor D [KO:K05450]
101357438  macrophage colony-stimulating factor 1 isoform X3 [KO:K05453]
101350740  kit ligand [KO:K05461]
101352641  fms-related tyrosine kinase 3 ligand isoform X2 [KO:K05454]
101341920  vascular endothelial growth factor A [KO:K05448]
101352912  vascular endothelial growth factor B [KO:K16858]
101355158  placenta growth factor isoform X1 [KO:K16859]
101344331  vascular endothelial growth factor D [KO:K05449]
101360380  vascular endothelial growth factor C [KO:K05449]
101344799  hepatocyte growth factor isoform X3 [KO:K05460]
101344008  angiopoietin-1 isoform X1 [KO:K05465]
101341636  angiopoietin-2 [KO:K05466]
101342215  angiopoietin-4 [KO:K05467]
101354975  ephrin-A4 [KO:K05462]
101355486  ephrin-A1 isoform X1 [KO:K05462]
101355917  ephrin-A3 isoform X1 [KO:K05462]
101347678  ephrin-A2 [KO:K05462]
101345541  ephrin-A5 [KO:K05462]
101345158  glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
101354007  neurturin [KO:K25414]
101360392  artemin isoform X1 [KO:K25415]
101352890  persephin [KO:K25416]
111820941  persephin [KO:K25416]
101356822  epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
101354844  receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
101354434  receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
101360755  receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
101342270  fibroblast growth factor receptor 1 isoform X2 [KO:K04362] [EC:2.7.10.1]
101357035  fibroblast growth factor receptor 2 isoform X6 [KO:K05093] [EC:2.7.10.1]
101341002  fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
101344195  fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
101358935  tumor necrosis factor receptor superfamily member 16 isoform X1 [KO:K02583]
101351378  high affinity nerve growth factor receptor isoform X2 [KO:K03176] [EC:2.7.10.1]
101342178  BDNF/NT-3 growth factors receptor isoform X5 [KO:K04360] [EC:2.7.10.1]
101360415  insulin receptor [KO:K04527] [EC:2.7.10.1]
101355333  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
101348884  platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
101360003  platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
101360266  macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
101357486  mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
101352048  receptor-type tyrosine-protein kinase FLT3 isoform X2 [KO:K05092] [EC:2.7.10.1]
101352737  vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
101340931  vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
101348626  vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
101345595  hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
101351895  angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
101355264  ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
101357522  proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
101359012  growth factor receptor-bound protein 2 [KO:K04364]
101359592  son of sevenless homolog 1 isoform X1 [KO:K03099]
101347392  son of sevenless homolog 2 isoform X1 [KO:K03099]
101342804  GTPase HRas isoform X2 [KO:K02833]
101347525  GTPase KRas isoform X3 [KO:K07827]
101344230  GTPase NRas isoform X1 [KO:K07828]
101357840  RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
101343332  dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
101341078  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
101340589  mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101358526  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101356151  insulin receptor substrate 1 [KO:K16172]
101342847  toll-like receptor 2 [KO:K10159]
101353470  toll-like receptor 4 [KO:K10160]
101356054  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
111820845  LOW QUALITY PROTEIN: uncharacterized protein LOC111820845 [KO:K06856]
101351806  tyrosine-protein kinase SYK isoform X2 [KO:K05855] [EC:2.7.10.2]
101357503  B-lymphocyte antigen CD19 [KO:K06465]
101350518  phosphoinositide 3-kinase adapter protein 1 isoform X1 [KO:K12230]
101353229  somatotropin [KO:K05438]
101346160  prolactin isoform X1 [KO:K05439]
101357379  oncostatin-M [KO:K05418]
101360180  interleukin-2 [KO:K05429]
101351590  interleukin-6 [KO:K05405]
101341010  interleukin-4 [KO:K05430]
101345060  interleukin-7 isoform X1 [KO:K05431]
101341058  interferon alpha-5-like [KO:K05414]
101341314  interferon alpha-5-like [KO:K05414]
101341564  interferon alpha-5-like [KO:K05414]
101343075  interferon alpha-5-like [KO:K05414]
101342581  interferon alpha-5-like [KO:K05414]
101342828  interferon alpha-5-like [KO:K05414]
101350125  interferon alpha-5-like [KO:K05414]
101344616  interferon alpha-5-like [KO:K05414]
101343586  interferon alpha-5-like [KO:K05414]
101345099  interferon alpha-5-like [KO:K05414]
101349610  interferon beta [KO:K05415]
101346088  erythropoietin isoform X1 [KO:K05437]
101359464  granulocyte colony-stimulating factor [KO:K05423]
101353524  growth hormone receptor [KO:K05080]
101347282  prolactin receptor [KO:K05081]
101348045  oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
101342095  interleukin-2 receptor subunit alpha [KO:K05068]
101344371  interleukin-2 receptor subunit beta [KO:K05069]
101359472  cytokine receptor common subunit gamma isoform X1 [KO:K05070]
101359308  interleukin-3 receptor subunit alpha isoform X1 [KO:K04737]
101356003  interleukin-6 receptor subunit alpha isoform X1 [KO:K05055]
101351007  interleukin-4 receptor subunit alpha [KO:K05071]
101351100  interleukin-7 receptor subunit alpha isoform X2 [KO:K05072]
101361715  interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
101354122  interferon alpha/beta receptor 2 [KO:K05131]
101349119  erythropoietin receptor [KO:K05079]
101343066  granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
101346613  tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
101354918  tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
101345231  tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
101354262  collagen alpha-1(I) chain [KO:K06236]
101341020  collagen alpha-2(I) chain isoform X2 [KO:K06236]
101343281  collagen alpha-1(II) chain [KO:K19719]
101358346  collagen alpha-4(IV) chain [KO:K06237]
101349964  collagen alpha-5(IV) chain isoform X2 [KO:K06237]
101345305  collagen alpha-1(IV) chain [KO:K06237]
101345564  collagen alpha-2(IV) chain [KO:K06237]
101349706  collagen alpha-6(IV) chain [KO:K06237]
101355897  collagen alpha-3(IV) chain [KO:K06237]
105756545  LOW QUALITY PROTEIN: collagen alpha-5(VI) chain [KO:K06238]
101344163  collagen alpha-3(VI) chain [KO:K06238]
101359051  collagen alpha-4(VI) chain-like [KO:K06238]
101341513  collagen alpha-2(VI) chain [KO:K06238]
101359739  collagen alpha-6(VI) chain [KO:K06238]
101347197  collagen alpha-1(VI) chain [KO:K06238]
101344924  collagen alpha-3(IX) chain [KO:K08131]
101352859  collagen alpha-2(IX) chain [KO:K08131]
101358160  collagen alpha-1(IX) chain [KO:K08131]
101356509  laminin subunit alpha-2 [KO:K05637]
101347367  laminin subunit alpha-1 [KO:K05637]
101357684  laminin subunit alpha-5 [KO:K06240]
101356677  laminin subunit alpha-3 isoform X1 [KO:K06240]
101352772  laminin subunit alpha-4 [KO:K06241]
101351432  laminin subunit beta-1 [KO:K05636]
101342634  LOW QUALITY PROTEIN: laminin subunit beta-1-like [KO:K05636]
101354877  laminin subunit beta-2 [KO:K06243]
101340544  laminin subunit beta-3 [KO:K06244]
101360165  LOW QUALITY PROTEIN: laminin subunit beta-4 [KO:K06245]
101360306  laminin subunit gamma-1 [KO:K05635]
101360565  laminin subunit gamma-2 [KO:K06246]
101342240  laminin subunit gamma-3 [KO:K06247]
101353058  chondroadherin [KO:K06248]
101361669  reelin [KO:K06249] [EC:3.4.21.-]
101344047  thrombospondin-1 [KO:K16857]
101352874  thrombospondin-4 [KO:K04659]
101352934  thrombospondin-3 isoform X1 [KO:K04659]
101358103  thrombospondin-2 [KO:K04659]
101348197  cartilage oligomeric matrix protein [KO:K04659]
101361092  fibronectin isoform X3 [KO:K05717]
101343228  osteopontin [KO:K06250]
101356068  vitronectin [KO:K06251]
101346466  tenascin-N isoform X1 [KO:K06252]
101347147  tenascin-R isoform X1 [KO:K06252]
101355074  tenascin [KO:K06252]
101352437  tenascin-X isoform X1 [KO:K06252]
101349323  von Willebrand factor [KO:K03900]
101341045  bone sialoprotein 2 [KO:K06253]
101348015  integrin alpha-1 [KO:K06480]
101358848  integrin alpha-2 [KO:K06481]
101348507  integrin alpha-IIb [KO:K06476]
101356045  integrin alpha-3 [KO:K06482]
101351755  integrin alpha-4 [KO:K06483]
101340808  integrin alpha-5 [KO:K06484]
101342079  integrin alpha-6 isoform X1 [KO:K06485]
101359730  integrin alpha-7 isoform X1 [KO:K06583]
101345639  integrin alpha-8 [KO:K06584]
101342329  integrin alpha-9 [KO:K06585]
101352987  integrin alpha-10 isoform X1 [KO:K06586]
101353305  LOW QUALITY PROTEIN: integrin alpha-11 [KO:K06587]
101356496  integrin alpha-V isoform X1 [KO:K06487]
101360881  integrin beta-1 [KO:K05719]
101359355  integrin beta-3 [KO:K06493]
101357545  integrin beta-4 isoform X2 [KO:K06525]
101345527  integrin beta-5 [KO:K06588]
101360058  integrin beta-6 isoform X1 [KO:K06589]
101357623  integrin beta-7 isoform X1 [KO:K06590]
101355358  integrin beta-8 [KO:K06591]
101351714  focal adhesion kinase 1 isoform X2 [KO:K05725] [EC:2.7.10.2]
101358678  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101346849  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101359658  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
101351035  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
101343804  phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101347746  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
101358047  proteinase-activated receptor 1 [KO:K03914]
101360696  muscarinic acetylcholine receptor M1 [KO:K04129]
101349646  muscarinic acetylcholine receptor M2 [KO:K04130]
101344103  lysophosphatidic acid receptor 1 [KO:K04289]
101360086  lysophosphatidic acid receptor 2 [KO:K04291]
101346095  lysophosphatidic acid receptor 3 [KO:K04294]
101346400  lysophosphatidic acid receptor 4 [KO:K04275]
101343136  lysophosphatidic acid receptor 5 [KO:K08390]
101356213  lysophosphatidic acid receptor 6 [KO:K04273]
101350742  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
101345319  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
101355136  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
101348280  guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
101341327  guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
101352593  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X1 [KO:K07826]
101342107  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
101357541  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
101345326  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
101347845  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 isoform X2 [KO:K04543]
111821467  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
111819711  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
101341777  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
101351188  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
111819060  putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
101351136  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
101342034  guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
101360148  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
101354532  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
101352786  phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
101343689  phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
101353040  3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
101354514  serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
101346784  5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
101360368  5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
101358419  DNA damage-inducible transcript 4 protein [KO:K08270]
101347417  hamartin isoform X1 [KO:K07206]
101358131  tuberin [KO:K07207]
101360739  GTP-binding protein Rheb isoform X2 [KO:K07208]
101359268  target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
101343808  serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
101343081  LOW QUALITY PROTEIN: regulatory-associated protein of mTOR [KO:K07204]
101361891  eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
101357351  eukaryotic translation initiation factor 4E type 1B [KO:K03259]
101352426  eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
101351130  eukaryotic translation initiation factor 4E [KO:K03259]
101343535  ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
101354510  ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
101355083  eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
101348417  40S ribosomal protein S6 [KO:K02991]
101348250  protein kinase C alpha type isoform X2 [KO:K02677] [EC:2.7.11.13]
101347479  serine/threonine-protein kinase N1 [KO:K06071] [EC:2.7.11.13]
101357807  serine/threonine-protein kinase N2 isoform X6 [KO:K23691] [EC:2.7.11.13]
101354923  serine/threonine-protein kinase N3 isoform X1 [KO:K23692] [EC:2.7.11.13]
101349244  serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
101357765  serine/threonine-protein kinase Sgk2 [KO:K13303] [EC:2.7.11.1]
101343492  serine/threonine-protein kinase Sgk3 isoform X1 [KO:K13304] [EC:2.7.11.1]
101360493  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101356099  RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101350197  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101355396  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 [KO:K05631]
101342387  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 [KO:K05629]
101355243  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
101360029  acyl-coenzyme A thioesterase THEM4 isoform X1 [KO:K16339] [EC:3.1.2.2]
101358337  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
101350333  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
101344236  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X3 [KO:K03456]
101347357  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
101347198  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
101343363  protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
101352293  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X2 [KO:K04354]
101358479  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
101356463  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
101353925  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
101360090  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta [KO:K11583]
101349860  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
101345308  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
101353776  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
101350461  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X4 [KO:K11584]
101355704  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
101341605  heat shock protein HSP 90-alpha-like isoform X1 [KO:K04079]
101348117  LOW QUALITY PROTEIN: heat shock protein HSP 90-alpha-like [KO:K04079]
101349955  heat shock protein HSP 90-alpha isoform X1 [KO:K04079]
101343785  heat shock protein HSP 90-beta [KO:K04079]
101341641  endoplasmin [KO:K09487]
101357378  hsp90 co-chaperone Cdc37 [KO:K09554]
101344998  CREB-regulated transcription coactivator 2 [KO:K16333]
101355703  PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
101360015  PH domain leucine-rich repeat-containing protein phosphatase 2 isoform X1 [KO:K16340] [EC:3.1.3.16]
101346740  T-cell leukemia/lymphoma protein 1A [KO:K10167]
101360472  protein p13 MTCP-1 [KO:K16837]
101356953  nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
101356605  breast cancer type 1 susceptibility protein [KO:K10605] [EC:2.3.2.27]
101349186  glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
101357774  glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
101355539  glycogen [starch] synthase, muscle isoform X1 [KO:K00693] [EC:2.4.1.11]
101350173  phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
101343675  phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
101358292  glucose-6-phosphatase isoform X1 [KO:K01084] [EC:3.1.3.9]
101352258  glucose-6-phosphatase 3 isoform X2 [KO:K01084] [EC:3.1.3.9]
101352450  glucose-6-phosphatase 2 isoform X1 [KO:K01084] [EC:3.1.3.9]
101349786  myc proto-oncogene protein [KO:K04377]
101359745  G1/S-specific cyclin-D1 [KO:K04503]
101342008  cyclin-dependent kinase inhibitor 1 isoform X2 [KO:K06625]
101360273  cyclin-dependent kinase inhibitor 1B [KO:K06624]
101355616  cyclin-dependent kinase 2 isoform X2 [KO:K02206] [EC:2.7.11.22]
101355276  cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
101351510  G1/S-specific cyclin-D2 isoform X1 [KO:K10151]
101351688  G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
101361662  G1/S-specific cyclin-E2 [KO:K06626]
101344099  G1/S-specific cyclin-E1 [KO:K06626]
101354741  forkhead box protein O3 [KO:K09408]
101360818  retinoblastoma-like protein 2 isoform X1 [KO:K16332]
101344408  tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
101352493  bcl-2-like protein 11 isoform X2 [KO:K16341]
101352499  14-3-3 protein beta/alpha isoform X2 [KO:K16197]
101351914  14-3-3 protein zeta/delta [KO:K16197]
101350286  14-3-3 protein theta [KO:K16197]
101343175  14-3-3 protein epsilon [KO:K06630]
101346170  14-3-3 protein gamma [KO:K16198]
101349204  14-3-3 protein eta [KO:K16198]
101352047  bcl2-associated agonist of cell death [KO:K02158]
101346361  bcl-2-like protein 1 isoform X1 [KO:K04570]
101347007  apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
101355103  caspase-9 [KO:K04399] [EC:3.4.22.62]
101356881  cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
101359884  cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
101345357  cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
101355964  cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
101349137  cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
101344337  cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
101344076  cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
101352607  cyclic AMP-responsive element-binding protein 3 [KO:K09048]
101345798  cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
101359783  cyclic AMP-dependent transcription factor ATF-6 beta [KO:K09049]
101350934  induced myeloid leukemia cell differentiation protein Mcl-1 isoform X1 [KO:K02539]
101353449  retinoic acid receptor RXR-alpha [KO:K08524]
101346441  nuclear receptor subfamily 4 group A member 1 isoform X2 [KO:K04465]
101347574  NF-kappa-B essential modulator isoform X1 [KO:K07210]
101341290  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
101351256  inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
101361706  transcription factor p65 [KO:K04735]
101351866  nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
101347120  transcriptional activator Myb isoform X3 [KO:K09420]
101349408  E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
101351852  cellular tumor antigen p53 [KO:K04451]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
tmu00010  Glycolysis / Gluconeogenesis
tmu04010  MAPK signaling pathway
tmu04012  ErbB signaling pathway
tmu04062  Chemokine signaling pathway
tmu04064  NF-kappa B signaling pathway
tmu04068  FoxO signaling pathway
tmu04110  Cell cycle
tmu04115  p53 signaling pathway
tmu04150  mTOR signaling pathway
tmu04210  Apoptosis
tmu04370  VEGF signaling pathway
tmu04510  Focal adhesion
tmu04620  Toll-like receptor signaling pathway
tmu04630  JAK-STAT signaling pathway
tmu04662  B cell receptor signaling pathway
tmu04910  Insulin signaling pathway
KO pathway
ko04151   
LinkDB

DBGET integrated database retrieval system