KEGG   PATHWAY: vvp05225
Entry
vvp05225                    Pathway                                
Name
Hepatocellular carcinoma - Vulpes vulpes (red fox)
Description
Hepatocellular carcinoma (HCC) is a major type of primary liver cancer and one of the rare human neoplasms etiologically linked to viral factors. It has been shown that, after HBV/HCV infection and alcohol or aflatoxin B1 exposure, genetic and epigenetic changes occur. The recurrent mutated genes were found to be highly enriched in multiple key driver signaling processes, including telomere maintenance, TP53, cell cycle regulation, the Wnt/beta-catenin pathway (CTNNB1 and AXIN1), the phosphatidylinositol-3 kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway. Recent studies using whole-exome sequencing have revealed recurrent mutations in new driver genes involved in the chromatin remodelling (ARID1A and ARID2) and the oxidative stress (NFE2L2) pathways.
Class
Human Diseases; Cancer: specific types
Pathway map
vvp05225  Hepatocellular carcinoma
vvp05225

Organism
Vulpes vulpes (red fox) [GN:vvp]
Gene
112925820  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
112924139  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
112922150  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
112928123  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
112911890  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2-like [KO:K05859] [EC:3.1.4.11]
112912331  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
112920728  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
112908300  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
112909321  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
112907276  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
112918897  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
112935467  SHC2; SHC-transforming protein 2 isoform X1 [KO:K17447]
112908627  SHC3; SHC-transforming protein 3 [KO:K17448]
112920045  SHC4; SHC-transforming protein 4 [KO:K17449]
112920790  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
112921310  SOS2; son of sevenless homolog 2 [KO:K03099]
112935267  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
112914428  HRAS; GTPase HRas isoform X1 [KO:K02833]
112917213  KRAS; GTPase KRas isoform X1 [KO:K07827]
112916766  NRAS; GTPase NRas [KO:K07828]
112907269  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
112907060  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
112933694  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
112935545  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
112929340  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
112907501  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
112924665  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
112926217  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
112934961  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
112914774  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
112913170  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
112935820  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
112931976  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
112928376  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112930303  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
112923528  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
112929738  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
112917940  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
112924182  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
112924315  BAD; bcl2-associated agonist of cell death [KO:K02158]
112909902  BCL2L1; bcl-2-like protein 1 [KO:K04570]
112915979  MYC; myc proto-oncogene protein [KO:K04377]
112933932  RB1; retinoblastoma-associated protein [KO:K06618]
112928157  E2F1; transcription factor E2F1 [KO:K17454]
112930133  E2F2; transcription factor E2F2 [KO:K09389]
112920427  E2F3; transcription factor E2F3 [KO:K06620]
112935454  TERT; telomerase reverse transcriptase [KO:K11126] [EC:2.7.7.49]
112924853  TP53; cellular tumor antigen p53 [KO:K04451]
112913942  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
112908633  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
112910526  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
112935608  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
112931372  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
112913897  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
112924073  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
112919752  POLK; DNA polymerase kappa isoform X1 [KO:K03511] [EC:2.7.7.7]
112911644  CDKN2A; cyclin-dependent kinase inhibitor 2A isoform X1 [KO:K06621]
112922331  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
112923889  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
112924157  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
112928349  TGFB1; transforming growth factor beta-1 isoform X1 [KO:K13375]
112914338  TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
112927298  TGFB3; transforming growth factor beta-3 [KO:K13377]
112930794  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
112921591  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
112918856  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
112929830  SMAD3; mothers against decapentaplegic homolog 3 [KO:K23605]
112919269  SMAD4; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
112921098  WNT1; proto-oncogene Wnt-1 isoform X1 [KO:K03209]
112907938  WNT2B; protein Wnt-2b isoform X1 [KO:K00182]
112929869  WNT2; protein Wnt-2 [KO:K00182]
112911970  WNT3A; protein Wnt-3a [KO:K00312]
112920633  WNT3; proto-oncogene Wnt-3 [KO:K00312]
112929848  WNT4; protein Wnt-4 isoform X1 [KO:K00408]
112909974  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
112917420  WNT5B; protein Wnt-5b [KO:K00444]
112922542  WNT6; protein Wnt-6 [KO:K00445]
112914456  WNT7A; protein Wnt-7a [KO:K00572]
112935842  WNT7B; protein Wnt-7b isoform X1 [KO:K00572]
112914893  WNT8B; protein Wnt-8b [KO:K00714]
112921902  WNT8A; protein Wnt-8a [KO:K00714]
112911976  WNT9A; protein Wnt-9a [KO:K01064]
112920632  WNT9B; protein Wnt-9b [KO:K01064]
112922477  WNT10A; protein Wnt-10a [KO:K01357]
112921097  WNT10B; protein Wnt-10b [KO:K01357]
112928634  WNT11; protein Wnt-11 [KO:K01384]
112910612  WNT16; protein Wnt-16 [KO:K01558]
112923874  FZD1; frizzled-1 [KO:K02432]
112922796  FZD7; frizzled-7 [KO:K02432]
112910678  FZD2; frizzled-2 [KO:K02235]
112926772  FZD3; frizzled-3 [KO:K02329]
112932336  FZD4; frizzled-4 [KO:K02354]
112922465  FZD5; frizzled-5 [KO:K02375]
112921504  FZD8; LOW QUALITY PROTEIN: frizzled-8 [KO:K02375]
112916996  FZD6; frizzled-6 [KO:K02376]
112933856  FZD10; frizzled-10 [KO:K02842]
112935737  FZD9; frizzled-9 [KO:K02842]
112917281  LRP6; low-density lipoprotein receptor-related protein 6 [KO:K03068]
112924019  LRP5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
112926256  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
112924817  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
112926150  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
112908489  FRAT1; proto-oncogene FRAT1 [KO:K03069]
112909220  FRAT2; GSK-3-binding protein FRAT2 [KO:K03096]
112913469  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
112909128  AXIN1; axin-1 isoform X1 [KO:K02157]
112920730  AXIN2; axin-2 isoform X1 [KO:K04385]
112935524  APC2; adenomatous polyposis coli protein 2 [KO:K02085]
112915436  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
112921625  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
112927455  CSNK1A1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
112917059  TCF7; LOW QUALITY PROTEIN: transcription factor 7 [KO:K02620]
112916685  TCF7L1; transcription factor 7-like 1 [KO:K04490]
112916157  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
112934208  LEF1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
112908040  KEAP1; kelch-like ECH-associated protein 1 [KO:K10456]
112916374  NFE2L2; nuclear factor erythroid 2-related factor 2 isoform X1 [KO:K05638]
112929075  HMOX1; heme oxygenase 1 [KO:K00510] [EC:1.14.14.18]
112929475  NQO1; NAD(P)H dehydrogenase [quinone] 1 [KO:K00355] [EC:1.6.5.2]
112918276  GSTM3; glutathione S-transferase Mu 3 isoform X1 [KO:K00799] [EC:2.5.1.18]
112915861  GSTO1; glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
112915906  glutathione S-transferase omega-2 [KO:K00799] [EC:2.5.1.18]
112907494  glutathione S-transferase theta-2B-like [KO:K00799] [EC:2.5.1.18]
112917247  MGST1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
112918367  glutathione S-transferase Mu 4-like [KO:K00799] [EC:2.5.1.18]
112914066  glutathione S-transferase-like isoform X1 [KO:K00799] [EC:2.5.1.18]
112914067  glutathione S-transferase A3 [KO:K00799] [EC:2.5.1.18]
112914068  glutathione S-transferase A4-like [KO:K00799] [EC:2.5.1.18]
112914069  GSTA4; glutathione S-transferase A4 isoform X1 [KO:K00799] [EC:2.5.1.18]
112934933  MGST2; microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
112907522  glutathione S-transferase theta-3-like [KO:K00799] [EC:2.5.1.18]
112907532  glutathione S-transferase theta-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
112907537  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
112907552  glutathione S-transferase theta-4 [KO:K00799] [EC:2.5.1.18]
112914314  MGST3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
112924174  glutathione S-transferase P [KO:K23790] [EC:2.5.1.18]
112924175  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
112932685  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
112929034  TXNRD1; thioredoxin reductase 1, cytoplasmic isoform X1 [KO:K22182] [EC:1.8.1.9]
112914490  TXNRD3; thioredoxin reductase 3 [KO:K22182] [EC:1.8.1.9]
112907520  TXNRD2; thioredoxin reductase 2, mitochondrial isoform X1 [KO:K22182] [EC:1.8.1.9]
112925397  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
112929871  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
112911650  GAB1; GRB2-associated-binding protein 1 [KO:K09593]
112920888  ACTG1; LOW QUALITY PROTEIN: actin, cytoplasmic 2 [KO:K05692]
112929326  ACTB; LOW QUALITY PROTEIN: actin, cytoplasmic 1 [KO:K05692]
112926222  ACTL6A; actin-like protein 6A isoform X1 [KO:K11340]
112935668  ACTL6B; actin-like protein 6B isoform X1 [KO:K11652]
112916248  SMARCD3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 [KO:K11650]
112920709  SMARCD2; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 [KO:K11650]
112921128  SMARCD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 isoform X1 [KO:K11650]
112925196  PHF10; PHD finger protein 10 isoform X1 [KO:K22197]
112927240  DPF3; zinc finger protein DPF3 [KO:K22198]
112928426  DPF1; zinc finger protein neuro-d4 isoform X1 [KO:K22198]
112931792  ARID1A; AT-rich interactive domain-containing protein 1A isoform X1 [KO:K11653]
112935151  ARID1B; LOW QUALITY PROTEIN: AT-rich interactive domain-containing protein 1B [KO:K11653]
112917760  SMARCE1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 isoform X1 [KO:K11651]
112907555  SMARCB1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 isoform X1 [KO:K11648]
112922388  SMARCC2; SWI/SNF complex subunit SMARCC2 [KO:K11649]
112908749  SMARCC1; SWI/SNF complex subunit SMARCC1 [KO:K11649]
112908164  SMARCA4; transcription activator BRG1 isoform X1 [KO:K11647] [EC:5.6.2.-]
112922132  SMARCA2; probable global transcription activator SNF2L2 [KO:K11647] [EC:5.6.2.-]
112921066  ARID2; AT-rich interactive domain-containing protein 2 isoform X1 [KO:K11765]
112910293  PBRM1; protein polybromo-1 isoform X1 [KO:K11757]
112929603  BRD7; bromodomain-containing protein 7 isoform X1 [KO:K11723]
Compound
C00027  Hydrogen peroxide
C00039  DNA
C00076  Calcium cation
C00165  Diacylglycerol
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01471  Acrolein
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06793  Vinyl chloride
C06800  Aflatoxin B1
C16844  Hydroxyl radical
C21641  Hydroperoxyl radical
C21642  4-Hydroxynonenal
Reference
PMID:20639898
  Authors
Whittaker S, Marais R, Zhu AX
  Title
The role of signaling pathways in the development and treatment of hepatocellular carcinoma.
  Journal
Oncogene 29:4989-5005 (2010)
DOI:10.1038/onc.2010.236
Reference
PMID:26099527
  Authors
Zucman-Rossi J, Villanueva A, Nault JC, Llovet JM
  Title
Genetic Landscape and Biomarkers of Hepatocellular Carcinoma.
  Journal
Gastroenterology 149:1226-1239.e4 (2015)
DOI:10.1053/j.gastro.2015.05.061
Reference
PMID:17295177
  Authors
Villanueva A, Newell P, Chiang DY, Friedman SL, Llovet JM.
  Title
Genomics and signaling pathways in hepatocellular carcinoma.
  Journal
Semin Liver Dis 27:55-76 (2007)
DOI:10.1055/s-2006-960171
Reference
PMID:16799620
  Authors
Breuhahn K, Longerich T, Schirmacher P
  Title
Dysregulation of growth factor signaling in human hepatocellular carcinoma.
  Journal
Oncogene 25:3787-800 (2006)
DOI:10.1038/sj.onc.1209556
Reference
PMID:19387255
  Authors
Minguez B, Tovar V, Chiang D, Villanueva A, Llovet JM
  Title
Pathogenesis of hepatocellular carcinoma and molecular therapies.
  Journal
Curr Opin Gastroenterol 25:186-94 (2009)
DOI:10.1097/MOG.0b013e32832962a1
Reference
PMID:21829020
  Authors
Kudo M
  Title
Signaling pathway and molecular-targeted therapy for hepatocellular carcinoma.
  Journal
Dig Dis 29:289-302 (2011)
DOI:10.1159/000327562
Reference
PMID:23994386
  Authors
Nault JC, Zucman-Rossi J
  Title
Genetics of hepatocellular carcinoma: the next generation.
  Journal
J Hepatol 60:224-6 (2014)
DOI:10.1016/j.jhep.2013.08.019
Reference
PMID:11935086
  Authors
Rocken C, Carl-McGrath S.
  Title
Pathology and pathogenesis of hepatocellular carcinoma.
  Journal
Dig Dis 19:269-78 (2001)
DOI:10.1159/000050693
Reference
PMID:21303380
  Authors
Cornella H, Alsinet C, Villanueva A
  Title
Molecular pathogenesis of hepatocellular carcinoma.
  Journal
Alcohol Clin Exp Res 35:821-5 (2011)
DOI:10.1111/j.1530-0277.2010.01406.x
Reference
PMID:27895396
  Authors
Niu ZS, Niu XJ, Wang WH
  Title
Genetic alterations in hepatocellular carcinoma: An update.
  Journal
World J Gastroenterol 22:9069-9095 (2016)
DOI:10.3748/wjg.v22.i41.9069
Reference
PMID:11956813
  Authors
Tannapfel A, Wittekind C
  Title
Genes involved in hepatocellular carcinoma: deregulation in cell cycling and apoptosis.
  Journal
Virchows Arch 440:345-52 (2002)
DOI:10.1007/s00428-002-0617-x
Reference
PMID:23426905
  Authors
Shiraha H, Yamamoto K, Namba M
  Title
Human hepatocyte carcinogenesis (review).
  Journal
Int J Oncol 42:1133-8 (2013)
DOI:10.3892/ijo.2013.1829
Reference
PMID:23887712
  Authors
Nault JC, Mallet M, Pilati C, Calderaro J, Bioulac-Sage P, Laurent C, Laurent A, Cherqui D, Balabaud C, Zucman-Rossi J
  Title
High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions.
  Journal
Nat Commun 4:2218 (2013)
DOI:10.1038/ncomms3218
Reference
PMID:22561517
  Authors
Guichard C, Amaddeo G, Imbeaud S, Ladeiro Y, Pelletier L, Maad IB, Calderaro J, Bioulac-Sage P, Letexier M, Degos F, Clement B, Balabaud C, Chevet E, Laurent A, Couchy G, Letouze E, Calvo F, Zucman-Rossi J
  Title
Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma.
  Journal
Nat Genet 44:694-8 (2012)
DOI:10.1038/ng.2256
Reference
  Authors
Praslicka BJ, Kerins MJ, Ooi A
  Title
The complex role of NRF2 in cancer: a genomic view
  Journal
Curr Opin Toxicol 1:37-45 (2016)
DOI:10.1016/j.cotox.2016.09.003
Reference
PMID:24024136
  Authors
Kansanen E, Kuosmanen SM, Leinonen H, Levonen AL
  Title
The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer.
  Journal
Redox Biol 1:45-9 (2013)
DOI:10.1016/j.redox.2012.10.001
Reference
PMID:21251164
  Authors
Taguchi K, Motohashi H, Yamamoto M
  Title
Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution.
  Journal
Genes Cells 16:123-40 (2011)
DOI:10.1111/j.1365-2443.2010.01473.x
Reference
PMID:20019356
  Authors
Klaunig JE, Kamendulis LM, Hocevar BA
  Title
Oxidative stress and oxidative damage in carcinogenesis.
  Journal
Toxicol Pathol 38:96-109 (2010)
DOI:10.1177/0192623309356453
Reference
PMID:11193292
  Authors
Krupp G, Bonatz G, Parwaresch R
  Title
Telomerase, immortality and cancer.
  Journal
Biotechnol Annu Rev 6:103-40 (2000)
DOI:10.1016/S1387-2656(00)06020-8
Reference
PMID:27323951
  Authors
Jafri MA, Ansari SA, Alqahtani MH, Shay JW
  Title
Roles of telomeres and telomerase in cancer, and advances in telomerase-targeted therapies.
  Journal
Genome Med 8:69 (2016)
DOI:10.1186/s13073-016-0324-x
Reference
PMID:27029895
  Authors
Shay JW
  Title
Role of Telomeres and Telomerase in Aging and Cancer.
  Journal
Cancer Discov 6:584-93 (2016)
DOI:10.1158/2159-8290.CD-16-0062
Reference
PMID:27508192
  Authors
Granito A, Guidetti E, Gramantieri L
  Title
c-MET receptor tyrosine kinase as a molecular target in advanced hepatocellular carcinoma.
  Journal
J Hepatocell Carcinoma 2:29-38 (2015)
DOI:10.2147/JHC.S77038
Reference
PMID:16934487
  Authors
Vita M, Henriksson M
  Title
The Myc oncoprotein as a therapeutic target for human cancer.
  Journal
Semin Cancer Biol 16:318-30 (2006)
DOI:10.1016/j.semcancer.2006.07.015
Reference
PMID:24096051
  Authors
Qu A, Jiang C, Cai Y, Kim JH, Tanaka N, Ward JM, Shah YM, Gonzalez FJ
  Title
Role of Myc in hepatocellular proliferation and hepatocarcinogenesis.
  Journal
J Hepatol 60:331-8 (2014)
DOI:10.1016/j.jhep.2013.09.024
Related
pathway
vvp04010  MAPK signaling pathway
vvp04020  Calcium signaling pathway
vvp04110  Cell cycle
vvp04115  p53 signaling pathway
vvp04151  PI3K-Akt signaling pathway
vvp04310  Wnt signaling pathway
vvp04350  TGF-beta signaling pathway
vvp04932  Non-alcoholic fatty liver disease
vvp04936  Alcoholic liver disease
vvp05160  Hepatitis C
vvp05161  Hepatitis B
KO pathway
ko05225   
LinkDB

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