KEGG   PATHWAY: xla00380
Entry
xla00380                    Pathway                                
Name
Tryptophan metabolism - Xenopus laevis (African clawed frog)
Class
Metabolism; Amino acid metabolism
Pathway map
xla00380  Tryptophan metabolism
xla00380

Module
xla_M00037  Melatonin biosynthesis, animals, tryptophan => serotonin => melatonin [PATH:xla00380]
xla_M00038  Tryptophan metabolism, tryptophan => kynurenine => 2-aminomuconate [PATH:xla00380]
xla_M00912  NAD biosynthesis, tryptophan => quinolinate => NAD [PATH:xla00380]
Other DBs
GO: 0006568 0009851
Organism
Xenopus laevis (African clawed frog) [GN:xla]
Gene
495495  tdo2.L; tryptophan 2,3-dioxygenase [KO:K00453] [EC:1.13.11.11]
100037099  ido1.L; indoleamine 2,3-dioxygenase 1 L homeolog [KO:K00463] [EC:1.13.11.52]
108701014  afmid.L; kynurenine formamidase isoform X1 [KO:K01432] [EC:3.5.1.9]
734866  kmo.L; kynurenine 3-monooxygenase isoform X1 [KO:K00486] [EC:1.14.13.9]
108701316  kynu.L; kynureninase [KO:K01556] [EC:3.7.1.3]
398998  haao.L; 3-hydroxyanthranilate 3,4-dioxygenase [KO:K00452] [EC:1.13.11.6]
733325  acmsd.S; 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase isoform X2 [KO:K03392] [EC:4.1.1.45]
108701279  acmsd.L; 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase [KO:K03392] [EC:4.1.1.45]
108716151  aldh8a1.L; 2-aminomuconic semialdehyde dehydrogenase [KO:K23234] [EC:1.2.1.32]
403360  dhtkd1.L; probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial [KO:K15791] [EC:1.2.4.-]
380395  dlst.S; dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial [KO:K00658] [EC:2.3.1.61]
108698673  dlst.L; dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial [KO:K00658] [EC:2.3.1.61]
380588  dld.S; dihydrolipoamide dehydrogenase S homeolog [KO:K00382] [EC:1.8.1.4]
108711180  dld.L; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
446458  gcdh.L; glutaryl-CoA dehydrogenase L homeolog [KO:K00252] [EC:1.3.8.6]
444044  hadha.S; hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha S homeolog [KO:K07515] [EC:4.2.1.17 1.1.1.211]
108717268  hadha.L; trifunctional enzyme subunit alpha, mitochondrial [KO:K07515] [EC:4.2.1.17 1.1.1.211]
108703045  ehhadh.S; peroxisomal bifunctional enzyme [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
733431  echs1.L; enoyl-CoA hydratase, short chain, 1, mitochondrial L homeolog [KO:K07511] [EC:4.2.1.17]
380594  hadh.L; hydroxyacyl-CoA dehydrogenase L homeolog [KO:K00022] [EC:1.1.1.35]
379569  acat2.L; acetyl-CoA acetyltransferase 2 L homeolog [KO:K00626] [EC:2.3.1.9]
444457  acat1.S; acetyl-CoA acetyltransferase B, mitochondrial precursor [KO:K00626] [EC:2.3.1.9]
414622  MGC81403; uncharacterized protein LOC414622 [KO:K00626] [EC:2.3.1.9]
414639  acat1.L; acetyl-CoA acetyltransferase A, mitochondrial precursor [KO:K00626] [EC:2.3.1.9]
380432  kyat3.L; kynurenine aminotransferase 3 L homeolog [KO:K00816] [EC:2.6.1.7 4.4.1.13 2.6.1.64]
734936  kyat1.L; kynurenine aminotransferase 1 L homeolog [KO:K00816] [EC:2.6.1.7 4.4.1.13 2.6.1.64]
108715667  kyat3.S; kynurenine--oxoglutarate transaminase 3 isoform X1 [KO:K00816] [EC:2.6.1.7 4.4.1.13 2.6.1.64]
398787  aadat.L; uncharacterized protein LOC398787 [KO:K00825] [EC:2.6.1.7 2.6.1.39]
432067  aadat.S; kynurenine/alpha-aminoadipate aminotransferase, mitochondrial isoform X1 [KO:K00825] [EC:2.6.1.7 2.6.1.39]
387560  tph1.L; tryptophan 5-hydroxylase [KO:K00502] [EC:1.14.16.4]
108713144  tph2.S; tryptophan 5-hydroxylase 2 [KO:K00502] [EC:1.14.16.4]
108710258  tryptophan 5-hydroxylase 2 [KO:K00502] [EC:1.14.16.4]
100126640  ddc.L; dopa decarboxylase L homeolog [KO:K01593] [EC:4.1.1.28 4.1.1.105]
495197  maoa.L; monoamine oxidase A L homeolog [KO:K00274] [EC:1.4.3.4]
108708197  amine oxidase [flavin-containing] [KO:K00274] [EC:1.4.3.4]
108709414  amine oxidase [flavin-containing] [KO:K00274] [EC:1.4.3.4]
108709415  amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
446968  maob.L; amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
446857  aldh2.L; aldehyde dehydrogenase 2 family (mitochondrial) L homeolog [KO:K00128] [EC:1.2.1.3]
443767  aldh3a2.S; aldehyde dehydrogenase 3 family member A2 S homeolog [KO:K00128] [EC:1.2.1.3]
734715  aldh16a1.S; aldehyde dehydrogenase 16 family member A1 S homeolog [KO:K00128] [EC:1.2.1.3]
496316  aldh3a2.L; uncharacterized protein LOC496316 [KO:K00128] [EC:1.2.1.3]
414586  aldh16a1.L; aldehyde dehydrogenase family 16 member A1 [KO:K00128] [EC:1.2.1.3]
108713458  aldh1b1.L; aldehyde dehydrogenase X, mitochondrial [KO:K00128] [EC:1.2.1.3]
447522  aldh7a1.L; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
108707197  aldh7a1.S; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
379229  aldh9a1.S; aldehyde dehydrogenase 9 family member A1 S homeolog [KO:K00149] [EC:1.2.1.47 1.2.1.3]
444490  aox1.S; aldehyde oxidase 1 S homeolog precursor [KO:K00157] [EC:1.2.3.1]
108701448  aldehyde oxidase 2 isoform X1 [KO:K00157] [EC:1.2.3.1]
108701449  aox1.L; aldehyde oxidase 1 isoform X1 [KO:K00157] [EC:1.2.3.1]
108701447  aldehyde oxidase [KO:K00157] [EC:1.2.3.1]
108709071  asmt.S; acetylserotonin O-methyltransferase [KO:K00543] [EC:2.1.1.4]
100335045  aanat.S; aralkylamine N-acetyltransferase S homeolog [KO:K00669] [EC:2.3.1.87]
100335046  aanat.L; aralkylamine N-acetyltransferase L homeolog [KO:K00669] [EC:2.3.1.87]
108717803  cyp1b1.S; cytochrome P450 1B1 [KO:K07410] [EC:1.14.14.1]
108716653  cyp1b1.L; cytochrome P450 1B1 [KO:K07410] [EC:1.14.14.1]
399013  inmt.L; indolethylamine N-methyltransferase L homeolog [KO:K00562] [EC:2.1.1.49 2.1.1.96]
108697004  indolethylamine N-methyltransferase [KO:K00562] [EC:2.1.1.49 2.1.1.96]
108697006  indolethylamine N-methyltransferase isoform X1 [KO:K00562] [EC:2.1.1.49 2.1.1.96]
108696501  indolethylamine N-methyltransferase isoform X1 [KO:K00562] [EC:2.1.1.49 2.1.1.96]
108696502  indolethylamine N-methyltransferase [KO:K00562] [EC:2.1.1.49 2.1.1.96]
108699501  indolethylamine N-methyltransferase [KO:K00562] [EC:2.1.1.49 2.1.1.96]
379432  nnmt.L; nicotinamide N-methyltransferase L homeolog [KO:K00562] [EC:2.1.1.49 2.1.1.96]
108696644  il4i1.L; L-amino-acid oxidase [KO:K03334] [EC:1.4.3.2]
108696562  L-amino-acid oxidase [KO:K03334] [EC:1.4.3.2]
108705560  amiloride-sensitive amine oxidase [copper-containing]-like [KO:K11182] [EC:1.4.3.22]
108695581  aoc1.S; amiloride-sensitive amine oxidase [copper-containing] [KO:K11182] [EC:1.4.3.22]
121394786  amiloride-sensitive amine oxidase [copper-containing]-like [KO:K11182] [EC:1.4.3.22]
495840  cat.1.L; catalase, gene 1 L homeolog [KO:K03781] [EC:1.11.1.6]
380236  cat.2.L; catalase, gene 2 L homeolog [KO:K03781] [EC:1.11.1.6]
100125664  cat.3.L; uncharacterized protein LOC100125664 [KO:K03781] [EC:1.11.1.6]
108713455  catalase [KO:K03781] [EC:1.11.1.6]
108715227  cat.2.S; catalase [KO:K03781] [EC:1.11.1.6]
108715253  cat.3.S; catalase [KO:K03781] [EC:1.11.1.6]
Compound
C00024  Acetyl-CoA
C00078  L-Tryptophan
C00108  Anthranilate
C00322  2-Oxoadipate
C00328  L-Kynurenine
C00331  Indolepyruvate
C00332  Acetoacetyl-CoA
C00398  Tryptamine
C00463  Indole
C00527  Glutaryl-CoA
C00632  3-Hydroxyanthranilate
C00637  Indole-3-acetaldehyde
C00643  5-Hydroxy-L-tryptophan
C00780  Serotonin
C00877  Crotonoyl-CoA
C00954  Indole-3-acetate
C00955  Indole-3-ethanol
C00978  N-Acetylserotonin
C01111  7,8-Dihydroxykynurenate
C01144  (S)-3-Hydroxybutanoyl-CoA
C01249  7,8-Dihydro-7,8-dihydroxykynurenate
C01252  4-(2-Aminophenyl)-2,4-dioxobutanoate
C01598  Melatonin
C01717  4-Hydroxy-2-quinolinecarboxylic acid
C01987  2-Aminophenol
C02161  2-Aminophenoxazin-3-one
C02172  N-Acetylisatin
C02220  2-Aminomuconate
C02298  N-Acetylindoxyl
C02470  Xanthurenic acid
C02693  (Indol-3-yl)acetamide
C02700  L-Formylkynurenine
C02775  2,3-Dihydroxyindole
C02937  Indole-3-acetaldehyde oxime
C02938  3-Indoleacetonitrile
C03227  3-Hydroxy-L-kynurenine
C03230  (Indol-3-yl)glycolaldehyde
C03453  gamma-Oxalocrotonate
C03574  2-Formylaminobenzaldehyde
C03722  Quinolinate
C03824  2-Aminomuconate semialdehyde
C04409  2-Amino-3-carboxymuconate semialdehyde
C05634  5-Hydroxyindoleacetaldehyde
C05635  5-Hydroxyindoleacetate
C05636  3-Hydroxykynurenamine
C05637  4,8-Dihydroxyquinoline
C05638  5-Hydroxykynurenamine
C05639  4,6-Dihydroxyquinoline
C05640  Cinnavalininate
C05641  5-(3'-Carboxy-3'-oxopropenyl)-4,6-dihydroxypicolinate
C05642  Formyl-N-acetyl-5-methoxykynurenamine
C05643  6-Hydroxymelatonin
C05644  3-Methylindolepyruvate
C05645  4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate
C05646  5-Hydroxyindolepyruvate
C05647  Formyl-5-hydroxykynurenamine
C05648  5-Hydroxy-N-formylkynurenine
C05651  5-Hydroxykynurenine
C05652  4-(2-Amino-5-hydroxyphenyl)-2,4-dioxobutanoate
C05653  Formylanthranilate
C05654  5-(2'-Formylethyl)-4,6-dihydroxypicolinate
C05655  5-(2'-Carboxyethyl)-4,6-dihydroxypicolinate
C05656  5-(3'-Carboxy-3'-oxopropyl)-4,6-dihydroxypicolinate
C05658  Indoxyl
C05659  5-Methoxytryptamine
C05660  5-Methoxyindoleacetate
C05663  6-Hydroxykynurenate
C05830  8-Methoxykynurenate
C05831  3-Methoxyanthranilate
C05832  5-Hydroxyindoleacetylglycine
C05834  3-Methyldioxyindole
C05835  2-Formaminobenzoylacetate
C05837  Glucobrassicin
C06212  N-Methylserotonin
C06213  N-Methyltryptamine
C08313  Skatole
C10164  Picolinic acid
C16516  Indolylmethylthiohydroximate
C16517  Indolylmethyl-desulfoglucosinolate
C16518  S-(Indolylmethylthiohydroximoyl)-L-cysteine
C17203  N-Hydroxyl-tryptamine
C22006  (R)-(Indol-3-yl)lactate
C22202  2-Oxoindole-3-acetate
Reference
PMID:15749753
  Authors
Woodward AW, Bartel B
  Title
Auxin: regulation, action, and interaction.
  Journal
Ann Bot 95:707-35 (2005)
DOI:10.1093/aob/mci083
Related
pathway
xla00010  Glycolysis / Gluconeogenesis
xla00400  Phenylalanine, tyrosine and tryptophan biosynthesis
xla00760  Nicotinate and nicotinamide metabolism
KO pathway
ko00380   
LinkDB

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