KEGG   PATHWAY: pcw00380
Entry
pcw00380                    Pathway                                
Name
Tryptophan metabolism - Phascolarctos cinereus (koala)
Class
Metabolism; Amino acid metabolism
Pathway map
pcw00380  Tryptophan metabolism
pcw00380

Module
pcw_M00037  Melatonin biosynthesis, animals, tryptophan => serotonin => melatonin [PATH:pcw00380]
pcw_M00038  Tryptophan metabolism, tryptophan => kynurenine => 2-aminomuconate [PATH:pcw00380]
pcw_M00912  NAD biosynthesis, tryptophan => quinolinate => NAD [PATH:pcw00380]
Other DBs
GO: 0006568 0009851
Organism
Phascolarctos cinereus (koala) [GN:pcw]
Gene
110213705  TDO2; tryptophan 2,3-dioxygenase isoform X1 [KO:K00453] [EC:1.13.11.11]
110203204  IDO1; LOW QUALITY PROTEIN: indoleamine 2,3-dioxygenase 1 [KO:K00463] [EC:1.13.11.52]
110203211  IDO2; indoleamine 2,3-dioxygenase 2 isoform X1 [KO:K00463] [EC:1.13.11.52]
110193878  AFMID; kynurenine formamidase [KO:K01432] [EC:3.5.1.9]
110205462  KMO; kynurenine 3-monooxygenase isoform X1 [KO:K00486] [EC:1.14.13.9]
110207149  KYNU; kynureninase isoform X1 [KO:K01556] [EC:3.7.1.3]
110218560  HAAO; 3-hydroxyanthranilate 3,4-dioxygenase isoform X1 [KO:K00452] [EC:1.13.11.6]
110223765  ACMSD; 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase isoform X1 [KO:K03392] [EC:4.1.1.45]
110208907  ALDH8A1; aldehyde dehydrogenase family 8 member A1 [KO:K23234] [EC:1.2.1.32]
110217338  DHTKD1; probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial isoform X1 [KO:K15791] [EC:1.2.4.-]
110208325  DLST; LOW QUALITY PROTEIN: dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial [KO:K00658] [EC:2.3.1.61]
110207017  DLD; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
110214417  GCDH; glutaryl-CoA dehydrogenase, mitochondrial [KO:K00252] [EC:1.3.8.6]
110206510  HADHA; trifunctional enzyme subunit alpha, mitochondrial [KO:K07515] [EC:4.2.1.17 1.1.1.211]
110221285  EHHADH; peroxisomal bifunctional enzyme [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
110214032  ECHS1; enoyl-CoA hydratase, mitochondrial [KO:K07511] [EC:4.2.1.17]
110218606  HADH; hydroxyacyl-coenzyme A dehydrogenase, mitochondrial [KO:K00022] [EC:1.1.1.35]
110208607  ACAT2; acetyl-CoA acetyltransferase, cytosolic [KO:K00626] [EC:2.3.1.9]
110214997  ACAT1; acetyl-CoA acetyltransferase, mitochondrial isoform X1 [KO:K00626] [EC:2.3.1.9]
110210007  KYAT3; LOW QUALITY PROTEIN: kynurenine--oxoglutarate transaminase 3 [KO:K00816] [EC:2.6.1.7 4.4.1.13 2.6.1.64]
110193638  KYAT1; kynurenine--oxoglutarate transaminase 1 [KO:K00816] [EC:2.6.1.7 4.4.1.13 2.6.1.64]
110216000  AADAT; kynurenine/alpha-aminoadipate aminotransferase, mitochondrial [KO:K00825] [EC:2.6.1.7 2.6.1.39]
110221097  TPH1; LOW QUALITY PROTEIN: tryptophan 5-hydroxylase 1 [KO:K00502] [EC:1.14.16.4]
110195961  TPH2; LOW QUALITY PROTEIN: tryptophan 5-hydroxylase 2 [KO:K00502] [EC:1.14.16.4]
110205002  DDC; aromatic-L-amino-acid decarboxylase [KO:K01593] [EC:4.1.1.28 4.1.1.105]
110214802  MAOA; LOW QUALITY PROTEIN: amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
110214856  amine oxidase [flavin-containing] B isoform X1 [KO:K00274] [EC:1.4.3.4]
110196807  ALDH2; aldehyde dehydrogenase, mitochondrial [KO:K00128] [EC:1.2.1.3]
110222089  ALDH3A2; fatty aldehyde dehydrogenase isoform X1 [KO:K00128] [EC:1.2.1.3]
110220571  ALDH1B1; LOW QUALITY PROTEIN: aldehyde dehydrogenase X, mitochondrial [KO:K00128] [EC:1.2.1.3]
110219698  ALDH16A1; LOW QUALITY PROTEIN: aldehyde dehydrogenase family 16 member A1 [KO:K00128] [EC:1.2.1.3]
110223911  ALDH7A1; alpha-aminoadipic semialdehyde dehydrogenase isoform X1 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
110202730  ALDH9A1; 4-trimethylaminobutyraldehyde dehydrogenase [KO:K00149] [EC:1.2.1.47 1.2.1.3]
110207269  aldehyde oxidase 3-like isoform X1 [KO:K00157] [EC:1.2.3.1]
110207271  AOX1; aldehyde oxidase [KO:K00157] [EC:1.2.3.1]
110197327  aldehyde oxidase 2-like isoform X1 [KO:K00157] [EC:1.2.3.1]
110212828  ASMT; acetylserotonin O-methyltransferase isoform X1 [KO:K00543] [EC:2.1.1.4]
110219333  AANAT; serotonin N-acetyltransferase isoform X1 [KO:K00669] [EC:2.3.1.87]
110213927  cytochrome P450 1A1 [KO:K07408] [EC:1.14.14.1]
110213926  LOW QUALITY PROTEIN: cytochrome P450 1A2 [KO:K07409] [EC:1.14.14.1]
110201392  cytochrome P450 1B1 isoform X1 [KO:K07410] [EC:1.14.14.1]
110194214  L-amino-acid oxidase-like [KO:K03334] [EC:1.4.3.2]
110205983  LOW QUALITY PROTEIN: L-amino-acid oxidase-like [KO:K03334] [EC:1.4.3.2]
110219789  IL4I1; L-amino-acid oxidase isoform X1 [KO:K03334] [EC:1.4.3.2]
110201979  AOC1; amiloride-sensitive amine oxidase [copper-containing] [KO:K11182] [EC:1.4.3.22]
110192623  CAT; catalase [KO:K03781] [EC:1.11.1.6]
Compound
C00024  Acetyl-CoA
C00078  L-Tryptophan
C00108  Anthranilate
C00322  2-Oxoadipate
C00328  L-Kynurenine
C00331  Indolepyruvate
C00332  Acetoacetyl-CoA
C00398  Tryptamine
C00463  Indole
C00527  Glutaryl-CoA
C00632  3-Hydroxyanthranilate
C00637  Indole-3-acetaldehyde
C00643  5-Hydroxy-L-tryptophan
C00780  Serotonin
C00877  Crotonoyl-CoA
C00954  Indole-3-acetate
C00955  Indole-3-ethanol
C00978  N-Acetylserotonin
C01111  7,8-Dihydroxykynurenate
C01144  (S)-3-Hydroxybutanoyl-CoA
C01249  7,8-Dihydro-7,8-dihydroxykynurenate
C01252  4-(2-Aminophenyl)-2,4-dioxobutanoate
C01598  Melatonin
C01717  4-Hydroxy-2-quinolinecarboxylic acid
C01987  2-Aminophenol
C02161  2-Aminophenoxazin-3-one
C02172  N-Acetylisatin
C02220  2-Aminomuconate
C02298  N-Acetylindoxyl
C02470  Xanthurenic acid
C02693  (Indol-3-yl)acetamide
C02700  L-Formylkynurenine
C02775  2,3-Dihydroxyindole
C02937  Indole-3-acetaldehyde oxime
C02938  3-Indoleacetonitrile
C03227  3-Hydroxy-L-kynurenine
C03230  (Indol-3-yl)glycolaldehyde
C03453  gamma-Oxalocrotonate
C03574  2-Formylaminobenzaldehyde
C03722  Quinolinate
C03824  2-Aminomuconate semialdehyde
C04409  2-Amino-3-carboxymuconate semialdehyde
C05634  5-Hydroxyindoleacetaldehyde
C05635  5-Hydroxyindoleacetate
C05636  3-Hydroxykynurenamine
C05637  4,8-Dihydroxyquinoline
C05638  5-Hydroxykynurenamine
C05639  4,6-Dihydroxyquinoline
C05640  Cinnavalininate
C05641  5-(3'-Carboxy-3'-oxopropenyl)-4,6-dihydroxypicolinate
C05642  Formyl-N-acetyl-5-methoxykynurenamine
C05643  6-Hydroxymelatonin
C05644  3-Methylindolepyruvate
C05645  4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate
C05646  5-Hydroxyindolepyruvate
C05647  Formyl-5-hydroxykynurenamine
C05648  5-Hydroxy-N-formylkynurenine
C05651  5-Hydroxykynurenine
C05652  4-(2-Amino-5-hydroxyphenyl)-2,4-dioxobutanoate
C05653  Formylanthranilate
C05654  5-(2'-Formylethyl)-4,6-dihydroxypicolinate
C05655  5-(2'-Carboxyethyl)-4,6-dihydroxypicolinate
C05656  5-(3'-Carboxy-3'-oxopropyl)-4,6-dihydroxypicolinate
C05658  Indoxyl
C05659  5-Methoxytryptamine
C05660  5-Methoxyindoleacetate
C05663  6-Hydroxykynurenate
C05830  8-Methoxykynurenate
C05831  3-Methoxyanthranilate
C05832  5-Hydroxyindoleacetylglycine
C05834  3-Methyldioxyindole
C05835  2-Formaminobenzoylacetate
C05837  Glucobrassicin
C06212  N-Methylserotonin
C06213  N-Methyltryptamine
C08313  Skatole
C10164  Picolinic acid
C16516  Indolylmethylthiohydroximate
C16517  Indolylmethyl-desulfoglucosinolate
C16518  S-(Indolylmethylthiohydroximoyl)-L-cysteine
C17203  N-Hydroxyl-tryptamine
C22006  (R)-(Indol-3-yl)lactate
C22202  2-Oxoindole-3-acetate
Reference
PMID:15749753
  Authors
Woodward AW, Bartel B
  Title
Auxin: regulation, action, and interaction.
  Journal
Ann Bot 95:707-35 (2005)
DOI:10.1093/aob/mci083
Related
pathway
pcw00010  Glycolysis / Gluconeogenesis
pcw00400  Phenylalanine, tyrosine and tryptophan biosynthesis
pcw00760  Nicotinate and nicotinamide metabolism
KO pathway
ko00380   
LinkDB

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