KEGG   PATHWAY: pleu04060
Entry
pleu04060                   Pathway                                
Name
Cytokine-cytokine receptor interaction - Peromyscus leucopus (white-footed mouse)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
pleu04060  Cytokine-cytokine receptor interaction
pleu04060

Organism
Peromyscus leucopus (white-footed mouse) [GN:pleu]
Gene
114680656  Bmp10; bone morphogenetic protein 10 [KO:K22670]
114680779  Tnfrsf12a; tumor necrosis factor receptor superfamily member 12A [KO:K05149]
114681161  [KO:K16622]
114681165  [KO:K16622]
114681278  Cx3cr1; CX3C chemokine receptor 1 [KO:K04192]
114681285  Ccr8; C-C chemokine receptor type 8 isoform X1 [KO:K04183]
114681722  Bmpr1b; bone morphogenetic protein receptor type-1B isoform X1 [KO:K13578] [EC:2.7.11.30]
114681748  Il23a; interleukin-23 subunit alpha [KO:K05426]
114681753  Gdf11; LOW QUALITY PROTEIN: growth/differentiation factor 11 [KO:K22679]
114681924  Il4; interleukin-4 [KO:K05430]
114681931  Gdf9; growth/differentiation factor 9 [KO:K22673]
114682475  [KO:K05066]
114682479  [KO:K05078]
114682495  Acvr2b; activin receptor type-2B isoform X1 [KO:K13596] [EC:2.7.11.30]
114682833  Ccr10; C-C chemokine receptor type 10 isoform X1 [KO:K04185]
114682853  Gdf1; embryonic growth/differentiation factor 1 [KO:K05495]
114683286  Tnfrsf13b; tumor necrosis factor receptor superfamily member 13B [KO:K05150]
114683319  Thpo; thrombopoietin isoform X1 [KO:K06854]
114683498  Gdf3; growth/differentiation factor 3 [KO:K22672]
114684059  Il13ra2; LOW QUALITY PROTEIN: interleukin-13 receptor subunit alpha-2 [KO:K05077]
114684168  Il27ra; LOW QUALITY PROTEIN: interleukin-27 receptor subunit alpha [KO:K19598]
114684616  [KO:K22669]
114684655  [KO:K05447]
114685094  Ebi3; interleukin-27 subunit beta [KO:K24476]
114685139  Ifnb1; interferon beta [KO:K05415]
114685140  [KO:K05414]
114685141  [KO:K05414]
114685144  [KO:K05414]
114685147  [KO:K05414]
114685149  [KO:K05414]
114685150  [KO:K05414]
114685151  [KO:K05414]
114685152  [KO:K05414]
114685154  [KO:K05414]
114685155  [KO:K05414]
114685302  Tgfb1; transforming growth factor beta-1 proprotein [KO:K13375]
114685351  Cxcl17; C-X-C motif chemokine 17 [KO:K22627]
114685392  Inhba; inhibin beta A chain [KO:K04667]
114685523  Tnfrsf1b; tumor necrosis factor receptor superfamily member 1B [KO:K05141]
114685526  Tnfrsf8; tumor necrosis factor receptor superfamily member 8 [KO:K05145]
114685750  Bmpr2; bone morphogenetic protein receptor type-2 [KO:K04671] [EC:2.7.11.30]
114685946  [KO:K04177]
114685947  Ccr3; C-C chemokine receptor type 3 [KO:K04178]
114685948  [KO:K04176]
114685951  Ccr1; C-C chemokine receptor type 1 [KO:K04176]
114685952  Xcr1; chemokine XC receptor 1 isoform X1 [KO:K04193]
114685954  Ccr9; C-C chemokine receptor type 9 [KO:K04184]
114685955  Cxcr6; C-X-C chemokine receptor type 6 [KO:K04191]
114685985  Clcf1; cardiotrophin-like cytokine factor 1 isoform X3 [KO:K05421]
114686020  Ccl26; C-C motif chemokine 26 [KO:K21096]
114686062  Ccl25; C-C motif chemokine 25 [KO:K13072]
114686090  [KO:K05132]
114686208  Il17rb; interleukin-17 receptor B [KO:K05165]
114686522  Amh; muellerian-inhibiting factor [KO:K04665]
114686544  Tnfsf14; tumor necrosis factor ligand superfamily member 14 [KO:K05477]
114686671  Il27; interleukin-27 subunit alpha [KO:K22629]
114686767  Epo; erythropoietin [KO:K05437]
114686994  Il20ra; interleukin-20 receptor subunit alpha isoform X2 [KO:K05136]
114687554  Cxcl16; C-X-C motif chemokine 16 [KO:K10035]
114687706  Il11; interleukin-11 [KO:K05417]
114687905  Cd70; CD70 antigen [KO:K05470]
114687914  Tnfsf9; tumor necrosis factor ligand superfamily member 9 [KO:K05472]
114688001  [KO:K24476]
114688453  [KO:K05414]
114688454  [KO:K05414]
114688456  [KO:K05414]
114688459  [KO:K05414]
114688460  [KO:K05414]
114688461  [KO:K05414]
114688462  [KO:K05414]
114688463  [KO:K05414]
114688884  Il9; interleukin-9 [KO:K05432]
114688894  Cxcl14; C-X-C motif chemokine 14 [KO:K10033]
114689321  [KO:K05414]
114689322  [KO:K05414]
114689395  [KO:K24476]
114689608  Il17re; interleukin-17 receptor E [KO:K05168]
114689609  Il17rc; interleukin-17 receptor C isoform X1 [KO:K05166]
114689656  Cxcl12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
114689756  Il6; interleukin-6 [KO:K05405]
114689882  Il12b; interleukin-12 subunit beta [KO:K05425]
114689971  Faslg; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
114690020  [KO:K05507]
114690027  Tnfsf18; tumor necrosis factor ligand superfamily member 18 [KO:K05479]
114690028  Tnfsf4; tumor necrosis factor ligand superfamily member 4 [KO:K05469]
114690242  Il18; interleukin-18 [KO:K05482]
114690275  Bmp5; bone morphogenetic protein 5 [KO:K04663]
114690474  [KO:K05438]
114690812  Il1r1; interleukin-1 receptor type 1 [KO:K04386]
114690813  Il1rl2; interleukin-1 receptor-like 2 [KO:K05172]
114690845  Il1rl1; interleukin-1 receptor-like 1 isoform X1 [KO:K05171]
114690861  Il1r2; interleukin-1 receptor type 2 isoform X2 [KO:K04387]
114690862  Il18r1; interleukin-18 receptor 1 [KO:K05173]
114690863  [KO:K05174]
114690920  [KO:K04674] [EC:2.7.11.30]
114691117  [KO:K05424]
114691198  Il10ra; interleukin-10 receptor subunit alpha isoform X1 [KO:K05134]
114691292  Cxcr5; C-X-C chemokine receptor type 5 [KO:K04190]
114691397  Ccr6; C-C chemokine receptor type 6 [KO:K04181]
114691549  [KO:K05509]
114691550  [KO:K14624]
114691551  [KO:K16597]
114691605  [KO:K14624]
114691606  [KO:K16596]
114691607  Ccl1; C-C motif chemokine 1 [KO:K05514]
114691681  [KO:K05436]
114691738  Il12a; interleukin-12 subunit alpha [KO:K05406]
114691745  [KO:K04674] [EC:2.7.11.30]
114692035  [KO:K20013]
114692223  Il4r; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
114692225  Il21r; interleukin-21 receptor isoform X2 [KO:K05075]
114692387  Il17f; interleukin-17F [KO:K05494]
114692388  Il17a; interleukin-17A [KO:K05489]
114692413  Rell1; RELT-like protein 1 [KO:K26541]
114692638  Cd40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
114692729  [KO:K05485]
114692730  [KO:K05487]
114692731  Il36a; interleukin-36 alpha [KO:K05484]
114692751  Il1rn; interleukin-1 receptor antagonist protein isoform X1 [KO:K05481]
114692837  Il36b; interleukin-36 beta isoform X3 [KO:K05486]
114692838  Il36rn; interleukin-36 receptor antagonist protein isoform X2 [KO:K05483]
114692839  Il1f10; interleukin-1 family member 10 [KO:K05488]
114692912  Ngfr; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
114693180  [KO:K05474]
114693181  Tnfsf13; tumor necrosis factor ligand superfamily member 13 [KO:K05475]
114693330  Ifng; interferon gamma [KO:K04687]
114693331  Il22; interleukin-22 [KO:K05445]
114693519  Ackr4; atypical chemokine receptor 4 [KO:K04186]
114693550  Il20rb; interleukin-20 receptor subunit beta [KO:K05137]
114693727  Lepr; leptin receptor isoform X1 [KO:K05062]
114693825  Tnfrsf19; tumor necrosis factor receptor superfamily member 19 [KO:K05155]
114693855  Il17d; interleukin-17D [KO:K05492]
114694090  Osm; oncostatin-M [KO:K05418]
114694102  Lif; leukemia inhibitory factor isoform X1 [KO:K05419]
114694223  Csf2rb; cytokine receptor common subunit beta isoform X3 [KO:K04738]
114694224  [KO:K04738]
114694353  Il2rb; interleukin-2 receptor subunit beta isoform X2 [KO:K05069]
114694367  Tnfrsf13c; tumor necrosis factor receptor superfamily member 13C isoform X1 [KO:K05151]
114694497  Cx3cl1; fractalkine [KO:K05508]
114694559  Ccl17; C-C motif chemokine 17 [KO:K21083]
114694560  Ccl22; C-C motif chemokine 22 [KO:K21095]
114694843  Tnfrsf11b; tumor necrosis factor receptor superfamily member 11B [KO:K05148]
114695124  Tnfsf13b; tumor necrosis factor ligand superfamily member 13B [KO:K05476]
114695247  Epor; LOW QUALITY PROTEIN: erythropoietin receptor [KO:K05079]
114695551  Tnfrsf17; tumor necrosis factor receptor superfamily member 17 [KO:K05153]
114695638  Acvr1; activin receptor type-1 [KO:K04675] [EC:2.7.11.30]
114695722  Bmp3; bone morphogenetic protein 3 isoform X1 [KO:K05496]
114695739  Cxcl13; C-X-C motif chemokine 13 [KO:K10032]
114695884  Acvr1c; activin receptor type-1C [KO:K13568] [EC:2.7.11.30]
114696047  Bmp4; bone morphogenetic protein 4 [KO:K04662]
114696228  Il16; pro-interleukin-16 isoform X2 [KO:K22628]
114696396  Ccl20; C-C motif chemokine 20 isoform X3 [KO:K14625]
114696624  Amhr2; anti-Muellerian hormone type-2 receptor [KO:K04672] [EC:2.7.11.30]
114696657  Acvr1b; activin receptor type-1B isoform X1 [KO:K13567] [EC:2.7.11.30]
114696658  Acvrl1; serine/threonine-protein kinase receptor R3 [KO:K13594] [EC:2.7.11.30]
114696942  Il24; interleukin-24 [KO:K22668]
114696964  Cxcr4; C-X-C chemokine receptor type 4 isoform X1 [KO:K04189]
114697095  [KO:K04723]
114697151  Il22ra1; interleukin-22 receptor subunit alpha-1 isoform X1 [KO:K05138]
114697237  Ifnlr1; interferon lambda receptor 1 [KO:K05140]
114697322  Lifr; leukemia inhibitory factor receptor [KO:K05058]
114697329  Ghr; growth hormone receptor isoform X2 [KO:K05080]
114697347  Osmr; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
114697551  Tnfsf10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
114697904  Tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
114698036  Il20; LOW QUALITY PROTEIN: interleukin-20 [KO:K22667]
114698037  Il19; interleukin-19 isoform X1 [KO:K05444]
114698039  Il10; interleukin-10 [KO:K05443]
114698210  Tgfb2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
114698356  Ifne; interferon epsilon [KO:K05442]
114698434  Ifngr2; interferon gamma receptor 2 isoform X1 [KO:K05133]
114698435  Ifnar1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
114698436  Il10rb; interleukin-10 receptor subunit beta [KO:K05135]
114698437  Ifnar2; LOW QUALITY PROTEIN: interferon alpha/beta receptor 2 [KO:K05131]
114698577  Ngf; beta-nerve growth factor [KO:K02582]
114698730  Relt; tumor necrosis factor receptor superfamily member 19L isoform X1 [KO:K05156]
114699318  Gdf2; growth/differentiation factor 2 [KO:K05503]
114699332  Bmpr1a; bone morphogenetic protein receptor type-1A isoform X1 [KO:K04673] [EC:2.7.11.30]
114699344  Gdf10; growth/differentiation factor 10 [KO:K22674]
114699420  Ifnk; interferon kappa [KO:K05441]
114699428  [KO:K20012]
114699539  Bmp2; bone morphogenetic protein 2 isoform X1 [KO:K21283]
114699851  Tnfsf11; tumor necrosis factor ligand superfamily member 11 [KO:K05473]
114700000  Csf1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
114700235  Inhbb; LOW QUALITY PROTEIN: inhibin beta B chain [KO:K22687]
114700391  Csf2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
114700430  [KO:K04736]
114700439  Acvr2a; activin receptor type-2A isoform X1 [KO:K04670] [EC:2.7.11.30]
114700693  Ackr3; atypical chemokine receptor 3 [KO:K04304]
114700744  Il17ra; interleukin-17 receptor A isoform X1 [KO:K05164]
114700907  Il23r; interleukin-23 receptor [KO:K05065]
114700924  Il12rb2; LOW QUALITY PROTEIN: interleukin-12 receptor subunit beta-2 [KO:K05064]
114700933  Il17c; interleukin-17C [KO:K05491]
114701659  Il15; interleukin-15 isoform X1 [KO:K05433]
114701716  [KO:K05506]
114701717  [KO:K10029]
114701718  [KO:K05407]
114701719  [KO:K05505]
114701721  Prl; prolactin [KO:K05439]
114701735  [KO:K05505]
114701736  [KO:K05505]
114701738  [KO:K05439]
114701749  [KO:K05439]
114701751  Cxcl9; C-X-C motif chemokine 9 [KO:K05416]
114701753  Cxcl11; C-X-C motif chemokine 11 [KO:K12672]
114701754  Cxcl10; C-X-C motif chemokine 10 [KO:K12671]
114701759  [KO:K05439]
114701771  [KO:K05439]
114701802  [KO:K05439]
114701853  [KO:K05439]
114701863  [KO:K05439]
114701884  [KO:K05439]
114702114  [KO:K05439]
114702123  [KO:K05439]
114702144  [KO:K05439]
114702170  [KO:K05439]
114702177  [KO:K05439]
114702344  Tgfbr1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
114702599  Tnfrsf9; tumor necrosis factor receptor superfamily member 9 [KO:K05146]
114702618  Tnfrsf25; tumor necrosis factor receptor superfamily member 25 isoform X1 [KO:K05160]
114702690  [KO:K04722]
114702813  Tnfrsf11a; tumor necrosis factor receptor superfamily member 11A isoform X1 [KO:K05147]
114703172  Eda; ectodysplasin-A isoform X1 [KO:K05480]
114703228  Il11ra; interleukin-11 receptor subunit alpha [KO:K05056]
114703230  [KO:K16598]
114703234  Cntfr; LOW QUALITY PROTEIN: ciliary neurotrophic factor receptor subunit alpha [KO:K05059]
114703284  Ccl21; C-C motif chemokine 21 [KO:K16062]
114703285  Ccl19; C-C motif chemokine 19 isoform X2 [KO:K05512]
114703385  Cntf; ciliary neurotrophic factor [KO:K05420]
114703579  Il6st; LOW QUALITY PROTEIN: interleukin-6 receptor subunit beta [KO:K05060]
114704150  Il31ra; interleukin-31 receptor subunit alpha [KO:K22630]
114704246  Ccl28; C-C motif chemokine 28 [KO:K05513]
114704288  Csf3r; granulocyte colony-stimulating factor receptor isoform X2 [KO:K05061]
114704383  [KO:K05422]
114704385  [KO:K24382]
114704496  Il31; interleukin-31 [KO:K22631]
114704728  Nodal; nodal homolog [KO:K04666]
114704780  Inhbc; inhibin beta C chain [KO:K22688]
114704830  Inhbe; inhibin beta E chain [KO:K22689]
114704977  Tgfbr2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
114705041  Il5ra; interleukin-5 receptor subunit alpha [KO:K05067]
114705150  Mstn; growth/differentiation factor 8 [KO:K05497]
114705388  Tnfrsf21; tumor necrosis factor receptor superfamily member 21 [KO:K05157]
114705427  Il13ra1; interleukin-13 receptor subunit alpha-1 [KO:K05076]
114705803  Lta; lymphotoxin-alpha [KO:K05468]
114705817  Tnf; tumor necrosis factor [KO:K03156]
114705820  Ltb; lymphotoxin-beta isoform X2 [KO:K03157]
114706502  Eda2r; tumor necrosis factor receptor superfamily member 27 isoform X2 [KO:K05163]
114706531  Gdf5; growth/differentiation factor 5 [KO:K04664]
114706899  Csf3; granulocyte colony-stimulating factor [KO:K05423]
114706957  Ccr7; C-C chemokine receptor type 7 [KO:K04182]
114707173  Il21; interleukin-21 [KO:K05434]
114707177  Il2; interleukin-2 [KO:K05429]
114707230  Cd40lg; CD40 ligand [KO:K03161]
114707382  Csf1r; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
114707404  Il17b; interleukin-17B [KO:K05490]
114707598  [KO:K20012]
114707629  Il7; interleukin-7 isoform X1 [KO:K05431]
114707716  Ccl16; C-C motif chemokine 16 [KO:K21093]
114707719  [KO:K12964]
114707726  [KO:K12964]
114707727  [KO:K12964]
114707728  [KO:K12964]
114707732  [KO:K05408]
114707747  Ccl5; C-C motif chemokine 5 [KO:K12499]
114707748  Ccl15; C-C motif chemokine 15 [KO:K05511]
114707920  Il6r; LOW QUALITY PROTEIN: interleukin-6 receptor subunit alpha [KO:K05055]
114708081  Il34; interleukin-34 isoform X3 [KO:K22633]
114708198  Il15ra; interleukin-15 receptor subunit alpha isoform X1 [KO:K05074]
114708274  Tnfrsf4; tumor necrosis factor receptor superfamily member 4 isoform X1 [KO:K05142]
114708275  Tnfrsf18; tumor necrosis factor receptor superfamily member 18 isoform X1 [KO:K05154]
114708279  Tnfrsf14; tumor necrosis factor receptor superfamily member 14 isoform X1 [KO:K05152]
114708644  Cxcr3; C-X-C chemokine receptor type 3 [KO:K04188]
114708654  Il2rg; cytokine receptor common subunit gamma [KO:K05070]
114708732  Il25; interleukin-25 [KO:K05493]
114708790  Il2ra; interleukin-2 receptor subunit alpha [KO:K05068]
114708799  Tnfrsf1a; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 1A [KO:K03158]
114708805  Cd27; CD27 antigen isoform X2 [KO:K05144]
114708810  Ltbr; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 3 [KO:K03159]
114708820  Cd4; T-cell surface glycoprotein CD4 isoform X2 [KO:K06454]
114708888  Edar; tumor necrosis factor receptor superfamily member EDAR [KO:K05162]
114709026  Tnfsf8; tumor necrosis factor ligand superfamily member 8 [KO:K05471]
114709036  Tnfsf15; tumor necrosis factor ligand superfamily member 15 [KO:K05478]
114709238  Ccr4; LOW QUALITY PROTEIN: C-C chemokine receptor type 4 [KO:K04179]
114709293  Inha; inhibin alpha chain [KO:K05500]
114709324  [KO:K05050]
114709325  [KO:K04175]
114709393  Mpl; thrombopoietin receptor isoform X1 [KO:K05082]
114709504  [KO:K05073]
114709520  Il1b; interleukin-1 beta [KO:K04519]
114709525  Il1a; interleukin-1 alpha [KO:K04383]
114709820  Bmp7; bone morphogenetic protein 7 [KO:K16621]
114710001  Bmp15; bone morphogenetic protein 15 [KO:K05498]
114710332  Ccl24; LOW QUALITY PROTEIN: C-C motif chemokine 24 [KO:K21097]
114710493  Il33; LOW QUALITY PROTEIN: interleukin-33 [KO:K12967]
114710567  Bmp6; bone morphogenetic protein 6 [KO:K16620]
114710798  Prlr; prolactin receptor isoform X1 [KO:K05081]
114710803  Il7r; interleukin-7 receptor subunit alpha [KO:K05072]
119088756  [KO:K22672]
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Reference
PMID:21106488
  Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
  Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
  Journal
Hum Genomics 5:30-55 (2010)
DOI:10.1186/1479-7364-5-1-30
Reference
PMID:27577879
  Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
  Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
  Journal
J Allergy Clin Immunol 138:984-1010 (2016)
DOI:10.1016/j.jaci.2016.06.033
Reference
PMID:15500860
  Authors
Boulanger MJ, Garcia KC
  Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
  Journal
Adv Protein Chem 68:107-46 (2004)
DOI:10.1016/S0065-3233(04)68004-1
Reference
PMID:16034365
  Authors
Allan SM, Tyrrell PJ, Rothwell NJ
  Title
Interleukin-1 and neuronal injury.
  Journal
Nat Rev Immunol 5:629-40 (2005)
DOI:10.1038/nri1664
Reference
PMID:23847622
  Authors
Lopetuso LR, Chowdhry S, Pizarro TT
  Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
  Journal
Front Immunol 4:181 (2013)
DOI:10.3389/fimmu.2013.00181
Reference
PMID:21349428
  Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
  Title
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