KEGG   PATHWAY: pps00590
Entry
pps00590                    Pathway                                
Name
Arachidonic acid metabolism - Pan paniscus (bonobo)
Class
Metabolism; Lipid metabolism
Pathway map
pps00590  Arachidonic acid metabolism
pps00590

Other DBs
GO: 0019369
Organism
Pan paniscus (bonobo) [GN:pps]
Gene
100974871  PLA2G2F; group IIF secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
100975186  PLA2G2D; group IID secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
100975526  PLA2G5; phospholipase A2 group V isoform X2 [KO:K01047] [EC:3.1.1.4]
100990830  PLA2G12B; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
100980595  PLA2G3; group 3 secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
100973733  PLA2G12A; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
100976220  PLA2G2A; phospholipase A2, membrane associated [KO:K01047] [EC:3.1.1.4]
100991821  PLA2G2E; group IIE secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
100974536  PLA2G2C; putative inactive group IIC secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
100971337  PLA2G1B; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
100990946  group 10 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
100986585  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
100986912  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
100984773  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
117976139  cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
100987249  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
100978248  PLA2G4C; cytosolic phospholipase A2 gamma isoform X1 [KO:K16342] [EC:3.1.1.4]
117979213  cytosolic phospholipase A2 beta-like isoform X1 [KO:K16342] [EC:3.1.1.4]
129393987  cytosolic phospholipase A2 beta isoform X1 [KO:K16342] [EC:3.1.1.4]
117977805  cytosolic phospholipase A2 beta-like isoform X1 [KO:K16342] [EC:3.1.1.4]
100973899  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 isoform X6 [KO:K16343] [EC:3.1.1.4]
100977414  PLB1; phospholipase B1, membrane-associated [KO:K14621] [EC:3.1.1.4 3.1.1.5]
100977983  PLAAT3; phospholipase A and acyltransferase 3 isoform X2 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
100977096  PLAAT2; phospholipase A and acyltransferase 2 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
100993705  PTGS1; prostaglandin G/H synthase 1 [KO:K00509] [EC:1.14.99.1]
100985650  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
100988615  PTGES; prostaglandin E synthase [KO:K15729] [EC:5.3.99.3]
100990863  PTGES2; prostaglandin E synthase 2 isoform X1 [KO:K05309] [EC:5.3.99.3]
100967487  PTGES3; prostaglandin E synthase 3 isoform X4 [KO:K15730] [EC:5.3.99.3]
100967263  prostaglandin E synthase 3-like [KO:K15730] [EC:5.3.99.3]
100984486  CBR1; carbonyl reductase [NADPH] 1 isoform X1 [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
100982905  CBR3; carbonyl reductase [NADPH] 3 [KO:K00084] [EC:1.1.1.184]
100989393  PRXL2B; prostamide/prostaglandin F synthase isoform X1 [KO:K15717] [EC:1.11.1.20]
100987384  HPGD; 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform X1 [KO:K00069] [EC:1.1.1.141]
100974860  TBXAS1; thromboxane-A synthase isoform X1 [KO:K01832] [EC:5.3.99.5]
100983768  PTGDS; prostaglandin-H2 D-isomerase [KO:K01830] [EC:5.3.99.2]
100990241  HPGDS; hematopoietic prostaglandin D synthase [KO:K04097] [EC:5.3.99.2 2.5.1.18]
100986388  AKR1C3; aldo-keto reductase family 1 member C3 isoform X2 [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
100987632  LOW QUALITY PROTEIN: aldo-keto reductase family 1 member C15-like [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
100988315  aldo-keto reductase family 1 member C15-like [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
100987973  PTGIS; prostacyclin synthase [KO:K01831] [EC:5.3.99.4]
100979027  ALOX5; polyunsaturated fatty acid 5-lipoxygenase [KO:K00461] [EC:1.13.11.34]
100984721  LTA4H; leukotriene A-4 hydrolase isoform X1 [KO:K01254] [EC:3.3.2.6]
100970515  PTGR3; prostaglandin reductase 3 isoform X1 [KO:K07119] [EC:1.3.1.48]
100972632  PTGR2; prostaglandin reductase 2 isoform X2 [KO:K13949] [EC:1.3.1.48]
100979208  PTGR1; prostaglandin reductase 1 [KO:K13948] [EC:1.3.1.74 1.3.1.48]
100982952  prostaglandin reductase 1-like [KO:K13948] [EC:1.3.1.74 1.3.1.48]
100967411  CYP4F2; cytochrome P450 4F2 [KO:K17726] [EC:1.14.14.78 1.14.14.79 1.14.14.94]
100969141  CYP4F3; cytochrome P450 4F2 isoform X2 [KO:K17726] [EC:1.14.14.78 1.14.14.79 1.14.14.94]
100983593  LTC4S; leukotriene C4 synthase [KO:K00807] [EC:4.4.1.20]
100967282  GGT5; glutathione hydrolase 5 proenzyme isoform X4 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
117977390  GGT1; glutathione hydrolase 1 proenzyme isoform X2 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
100990361  GPX4; phospholipid hydroperoxide glutathione peroxidase GPX4 isoform X2 [KO:K05361] [EC:1.11.1.12]
100981327  CYP2E1; cytochrome P450 2E1 isoform X1 [KO:K07415] [EC:1.14.14.-]
100984148  CYP2J2; cytochrome P450 2J2 isoform X2 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
100993565  CYP2U1; cytochrome P450 2U1 isoform X2 [KO:K07422] [EC:1.14.14.80]
100995695  CYP2C19; cytochrome P450 2C19 [KO:K17721] [EC:1.14.14.51 1.14.14.52 1.14.14.53 1.14.14.75 1.14.14.-]
100970184  CYP4F8; cytochrome P450 4F8 isoform X2 [KO:K17728] [EC:1.14.14.1]
100992721  ALOX12; polyunsaturated fatty acid lipoxygenase ALOX12 [KO:K00458] [EC:1.13.11.31]
100993999  LOW QUALITY PROTEIN: polyunsaturated fatty acid (12S)/(13S)-lipoxygenase, epidermal-type-like [KO:K00458] [EC:1.13.11.31]
100972484  ALOXE3; hydroperoxide isomerase ALOXE3 [KO:K18684] [EC:4.2.1.152 5.4.4.7]
100972159  ALOX12B; arachidonate 12-lipoxygenase, 12R-type [KO:K08021] [EC:1.13.11.-]
100971127  LOW QUALITY PROTEIN: polyunsaturated fatty acid lipoxygenase ALOX15B [KO:K08022] [EC:1.13.11.33 1.13.11.-]
100984180  CYP2B6; cytochrome P450 2B6 [KO:K17709] [EC:1.14.14.-]
100967379  CYP2C8; cytochrome P450 2C8 isoform X1 [KO:K17718] [EC:1.14.14.1]
100996034  CYP2C9; cytochrome P450 2C9 isoform X1 [KO:K17719] [EC:1.14.14.51 1.14.14.52 1.14.14.53 1.14.14.-]
100990932  EPHX2; bifunctional epoxide hydrolase 2 isoform X1 [KO:K08726] [EC:3.3.2.10 3.1.3.76]
100990568  ALOX15; polyunsaturated fatty acid lipoxygenase ALOX15 [KO:K00460] [EC:1.13.11.33]
Compound
C00157  Phosphatidylcholine
C00219  Arachidonate
C00427  Prostaglandin H2
C00584  Prostaglandin E2
C00639  Prostaglandin F2alpha
C00696  Prostaglandin D2
C00909  Leukotriene A4
C01312  Prostaglandin I2
C02165  Leukotriene B4
C02166  Leukotriene C4
C02198  Thromboxane A2
C03577  20-Hydroxyleukotriene E4
C04577  15-OxoETE
C04671  (5Z)-11alpha-Hydroxy-9,15-dioxoprostanoate
C04707  (5Z,13E)-11alpha-Hydroxy-9,15-dioxoprost-5,13-dienoate
C04742  (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate
C04758  (5Z,13E)-9alpha-Hydroxy-11,15-dioxoprosta-5,13-dienoate
C04805  5(S)-HETE
C04822  8(R)-HPETE
C04835  (5Z,13E)-6,9alpha-Epoxy-11alpha-hydroxy-15-oxoprosta-5,13-dienoate
C04853  20-OH-Leukotriene B4
C05356  5(S)-HPETE
C05949  12-Keto-leukotriene B4
C05950  20-COOH-Leukotriene B4
C05951  Leukotriene D4
C05952  Leukotriene E4
C05953  Prostaglandin A2
C05954  Prostaglandin B2
C05955  Prostaglandin C2
C05956  Prostaglandin G2
C05957  Prostaglandin J2
C05958  Delta-12-Prostaglandin J2
C05959  11-epi-Prostaglandin F2alpha
C05960  15-Keto-prostaglandin F2alpha
C05961  6-Keto-prostaglandin F1alpha
C05962  6-Keto-prostaglandin E1
C05963  Thromboxane B2
C05964  11-Dehydro-thromboxane B2
C05965  12(S)-HPETE
C05966  15(S)-HPETE
C06314  Lipoxin A4
C06315  Lipoxin B4
C06462  Leukotriene F4
C13809  9,11,15-Trihydroxy-prosta-5,13-dien-1-oic acid
C14717  15-Deoxy-Delta12,14-PGJ2
C14732  5-OxoETE
C14748  20-HETE
C14749  19(S)-HETE
C14768  5,6-EET
C14769  8,9-EET
C14770  11,12-EET
C14771  14,15-EET
C14772  5,6-DHET
C14773  8,9-DHET
C14774  11,12-DHET
C14775  14,15-DHET
C14776  8(S)-HETE
C14777  12(S)-HETE
C14778  16(R)-HETE
C14779  9(S)-HETE
C14780  11(R)-HETE
C14781  15H-11,12-EETA
C14782  11,12,15-THETA
C14794  2,3-Dinor-8-iso prostaglandin F2alpha
C14795  2,3-Dinor-8-iso prostaglandin F1alpha
C14807  12-OxoETE
C14808  Hepoxilin A3
C14809  Trioxilin A3
C14810  Hepoxilin B3
C14811  Trioxilin B3
C14812  12(R)-HPETE
C14813  11H-14,15-EETA
C14814  11,14,15-THETA
C14815  5,6-Epoxytetraene
C14820  11(R)-HPETE
C14821  9(S)-HPETE
C14822  12(R)-HETE
C14823  8(S)-HPETE
C14824  8(R)-HETE
Reference
PMID:14636671
  Authors
Spector AA, Fang X, Snyder GD, Weintraub NL.
  Title
Epoxyeicosatrienoic acids (EETs): metabolism and biochemical function.
  Journal
Prog Lipid Res 43:55-90 (2004)
DOI:10.1016/S0163-7827(03)00049-3
Reference
PMID:15292194
  Authors
Harman CA, Rieke CJ, Garavito RM, Smith WL.
  Title
Crystal structure of arachidonic acid bound to a mutant of prostaglandin endoperoxide H synthase-1 that forms predominantly 11-hydroperoxyeicosatetraenoic acid.
  Journal
J Biol Chem 279:42929-35 (2004)
DOI:10.1074/jbc.M403013200
Reference
PMID:15205388
  Authors
Poloyac SM, Tortorici MA, Przychodzin DI, Reynolds RB, Xie W, Frye RF, Zemaitis MA.
  Title
The effect of isoniazid on CYP2E1- and CYP4A-mediated hydroxylation of arachidonic acid in the rat liver and kidney.
  Journal
Drug Metab Dispos 32:727-33 (2004)
DOI:10.1124/dmd.32.7.727
Reference
PMID:14660610
  Authors
Chuang SS, Helvig C, Taimi M, Ramshaw HA, Collop AH, Amad M, White JA, Petkovich M, Jones G, Korczak B.
  Title
CYP2U1, a novel human thymus- and brain-specific cytochrome P450, catalyzes omega- and (omega-1)-hydroxylation of fatty acids.
  Journal
J Biol Chem 279:6305-14 (2004)
DOI:10.1074/jbc.M311830200
Reference
PMID:14626496
  Authors
Sacerdoti D, Gatta A, McGiff JC.
  Title
Role of cytochrome P450-dependent arachidonic acid metabolites in liver physiology and pathophysiology.
  Journal
Prostaglandins Other Lipid Mediat 72:51-71 (2003)
DOI:10.1016/S1098-8823(03)00077-7
Reference
PMID:14622984
  Authors
Pfister SL, Spitzbarth N, Zeldin DC, Lafite P, Mansuy D, Campbell WB.
  Title
Rabbit aorta converts 15-HPETE to trihydroxyeicosatrienoic acids: potential role of cytochrome P450.
  Journal
Arch Biochem Biophys 420:142-52 (2003)
DOI:10.1016/j.abb.2003.09.026
Reference
PMID:11679404
  Authors
Fleming I.
  Title
Cytochrome p450 and vascular homeostasis.
  Journal
Circ Res 89:753-62 (2001)
DOI:10.1161/hh2101.099268
Reference
PMID:11328810
  Authors
Qu W, Bradbury JA, Tsao CC, Maronpot R, Harry GJ, Parker CE, Davis LS, Breyer MD, Waalkes MP, Falck JR, Chen J, Rosenberg RL, Zeldin DC.
  Title
Cytochrome P450 CYP2J9, a new mouse arachidonic acid omega-1 hydroxylase predominantly expressed in brain.
  Journal
J Biol Chem 276:25467-79 (2001)
DOI:10.1074/jbc.M100545200
Reference
PMID:10908295
  Authors
Tsao CC, Foley J, Coulter SJ, Maronpot R, Zeldin DC, Goldstein JA.
  Title
CYP2C40, a unique arachidonic acid 16-hydroxylase, is the major CYP2C in murine intestinal tract.
  Journal
Mol Pharmacol 58:279-87 (2000)
DOI:10.1124/mol.58.2.279
Reference
PMID:9812980
  Authors
Pfister SL, Spitzbarth N, Nithipatikom K, Edgemond WS, Falck JR, Campbell WB.
  Title
Identification of the 11,14,15- and 11,12, 15-trihydroxyeicosatrienoic acids as endothelium-derived relaxing factors of rabbit aorta.
  Journal
J Biol Chem 273:30879-87 (1998)
DOI:10.1074/jbc.273.47.30879
Related
pathway
pps00591  Linoleic acid metabolism
KO pathway
ko00590   
LinkDB

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