KEGG   PATHWAY: pvp04518
Entry
pvp04518                    Pathway                                
Name
Integrin signaling - Pteropus vampyrus (large flying fox)
Description
Integrins act as the primary transmembrane receptors for cell adhesion, enabling cells to interact with the extracellular matrix (ECM) or counter-receptors on other cells. Through these connections, integrins help control essential cellular functions, including movement, polarity, proliferation, and viability. Ligand binding triggers integrin clustering and recruits actin filaments and various signaling proteins to their cytoplasmic domains, thereby activating downstream pathways.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
pvp04518  Integrin signaling
pvp04518

Organism
Pteropus vampyrus (large flying fox) [GN:pvp]
Gene
105288434  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
105288488  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
105288504  [KO:K06238]
105288515  [KO:K06238]
105288620  THBS1; thrombospondin-1 [KO:K16857]
105288745  ITGA9; integrin alpha-9 [KO:K06585]
105288810  FBN1; fibrillin-1 [KO:K06825]
105288870  VCL; vinculin isoform X1 [KO:K05700]
105289271  [KO:K05760]
105289571  SPP1; osteopontin [KO:K06250]
105289573  IBSP; bone sialoprotein 2 [KO:K06253]
105289574  DMP1; dentin matrix acidic phosphoprotein 1 isoform X1 [KO:K23328]
105289621  DSPP; dentin sialophosphoprotein [KO:K23573]
105289673  ITGAV; LOW QUALITY PROTEIN: integrin alpha-V [KO:K06487]
105290270  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
105290328  CTNNB1; catenin beta-1 [KO:K02105]
105290414  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
105290433  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
105291118  ITGB6; integrin beta-6 isoform X4 [KO:K06589]
105291123  FN1; fibronectin [KO:K05717]
105291179  LAMA2; laminin subunit alpha-2 [KO:K05637]
105291916  ITGA4; integrin alpha-4 [KO:K06483]
105291990  ITGAE; LOW QUALITY PROTEIN: integrin alpha-E [KO:K06524]
105292010  VTN; vitronectin [KO:K06251]
105292131  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
105292188  FGB; fibrinogen beta chain [KO:K03904]
105292189  FGG; fibrinogen gamma chain isoform X1 [KO:K03905]
105292199  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
105292224  FGA; fibrinogen alpha chain [KO:K03903]
105292271  LAMA3; laminin subunit alpha-3 isoform X2 [KO:K06240]
105292427  FRAS1; extracellular matrix protein FRAS1 [KO:K23379]
105292688  TNC; tenascin [KO:K06252]
105292803  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
105292827  LAMC1; laminin subunit gamma-1 isoform X1 [KO:K05635]
105292869  LAMC2; laminin subunit gamma-2 [KO:K06246]
105292894  TNR; tenascin-R [KO:K06252]
105292895  TNN; tenascin-N [KO:K06252]
105293013  NPNT; nephronectin isoform X8 [KO:K06824]
105293045  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
105293261  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
105293425  ITGB4; integrin beta-4 [KO:K06525]
105293771  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
105293808  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
105293829  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
105293998  VEGFD; vascular endothelial growth factor D [KO:K05449]
105294314  TLN2; talin-2 [KO:K06271]
105294361  COL1A2; collagen alpha-2(I) chain [KO:K06236]
105294429  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
105294449  LIMS2; LIM and senescent cell antigen-like-containing domain protein 2 [KO:K23354]
105294565  ACTB; actin, cytoplasmic 1 isoform X1 [KO:K05692]
105294593  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
105294623  RAC1; LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1 [KO:K04392]
105294764  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
105294766  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
105295219  LAMA4; laminin subunit alpha-4 [KO:K06241]
105295400  CHAD; chondroadherin [KO:K06248]
105295411  ITGA3; integrin alpha-3 isoform X2 [KO:K06482]
105295430  COL1A1; collagen alpha-1(I) chain [KO:K06236]
105295497  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
105295521  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
105295604  FREM1; FRAS1-related extracellular matrix protein 1 [KO:K23380]
105296024  VWF; von Willebrand factor [KO:K03900]
105296119  [KO:K06237]
105296151  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
105296207  LAMA1; LOW QUALITY PROTEIN: laminin subunit alpha-1 [KO:K05637]
105296367  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
105296513  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
105296582  COMP; cartilage oligomeric matrix protein isoform X1 [KO:K04659]
105296605  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
105297140  [KO:K02649]
105297442  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
105297528  ITGB5; integrin beta-5 [KO:K06588]
105297551  VCAM1; vascular cell adhesion protein 1 [KO:K06527]
105297573  COL2A1; collagen alpha-1(II) chain [KO:K19719]
105297718  ICAM2; intercellular adhesion molecule 2 isoform X1 [KO:K06523]
105297781  ITGA10; integrin alpha-10 [KO:K06586]
105297842  FERMT3; fermitin family homolog 3 [KO:K17084]
105297988  VEGFB; vascular endothelial growth factor B [KO:K16858]
105298078  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
105298668  LAMC3; laminin subunit gamma-3 [KO:K06247]
105298702  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105298710  FERMT1; fermitin family homolog 1 [KO:K17082]
105298743  [KO:K19862]
105298753  NCK2; cytoplasmic protein NCK2 [KO:K19862]
105299223  PGF; placenta growth factor isoform X1 [KO:K16859]
105299371  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649]
105299436  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
105299636  VEGFC; vascular endothelial growth factor C [KO:K05449]
105299870  FLNB; filamin-B [KO:K27392]
105300011  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
105300159  [KO:K04456] [EC:2.7.11.1]
105300184  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
105300269  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
105300311  [KO:K06244]
105300342  LAMB4; laminin subunit beta-4 [KO:K06245]
105300344  LAMB1; laminin subunit beta-1 [KO:K05636]
105301109  C3; complement C3 [KO:K03990]
105301137  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
105301152  ACTG1; actin, cytoplasmic 2 [KO:K05692]
105301304  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
105301330  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
105301331  COL4A2; collagen alpha-2(IV) chain isoform X1 [KO:K06237]
105301444  LAMA5; laminin subunit alpha-5 [KO:K06240]
105301451  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
105301472  PARVA; alpha-parvin [KO:K06275]
105302277  MADCAM1; mucosal addressin cell adhesion molecule 1 [KO:K06779]
105302419  LAMB2; laminin subunit beta-2 [KO:K06243]
105302420  [KO:K06243]
105302494  FLNA; filamin-A isoform X1 [KO:K04437]
105302613  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
105302663  ITGB7; integrin beta-7 [KO:K06590]
105302702  ITGA5; integrin alpha-5 [KO:K06484]
105303008  ITGB1; integrin beta-1 [KO:K05719]
105303028  ITGB2; integrin beta-2 [KO:K06464]
105303446  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
105303529  ITGA2B; integrin alpha-IIb [KO:K06476]
105303667  THBS4; thrombospondin-4 [KO:K04659]
105303727  THBS2; thrombospondin-2 [KO:K04659]
105303899  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105304051  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
105304500  ITGAX; integrin alpha-X [KO:K06462]
105304501  ITGAM; integrin alpha-M isoform X1 [KO:K06461]
105304532  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
105305015  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
105305336  TNXB; LOW QUALITY PROTEIN: tenascin-X [KO:K06252]
105305589  ICAM4; intercellular adhesion molecule 4 [KO:K06581]
105305590  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
105305592  ICAM3; intercellular adhesion molecule 3 [KO:K06486]
105305756  CDH1; cadherin-1 isoform X1 [KO:K05689]
105305972  [KO:K06238]
105306141  [KO:K04361] [EC:2.7.10.1]
105306467  TLN1; talin-1 [KO:K06271]
105307049  ARHGEF6; rho guanine nucleotide exchange factor 6 isoform X3 [KO:K05729]
105307128  [KO:K04503]
105307215  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105307458  PARVG; gamma-parvin [KO:K06275]
105307463  [KO:K06275]
105307498  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
105307575  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105307748  PTK2; focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
105307777  [KO:K05096] [EC:2.7.10.1]
105307927  ITGA2; integrin alpha-2 isoform X1 [KO:K06481]
105307929  ITGA1; integrin alpha-1 [KO:K06480]
105307945  TGFB1; transforming growth factor beta-1 [KO:K13375]
105308049  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
105308677  COL6A5; collagen alpha-5(VI) chain [KO:K06238]
105308836  COL6A2; collagen alpha-2(VI) chain [KO:K06238]
105308956  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
105309085  ILK; integrin-linked protein kinase isoform X1 [KO:K06272] [EC:2.7.11.1]
105309417  FREM2; FRAS1-related extracellular matrix protein 2 isoform X1 [KO:K23380]
105310197  FERMT2; fermitin family homolog 2 [KO:K17083]
105310261  ITGA11; integrin alpha-11 [KO:K06587]
105310314  LIMS1; LIM and senescent cell antigen-like-containing domain protein 1 isoform X1 [KO:K23354]
105310714  IGF1; insulin-like growth factor I isoform X3 [KO:K05459]
105311532  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X2 [KO:K07860]
Reference
PMID:36588107
  Authors
Pang X, He X, Qiu Z, Zhang H, Xie R, Liu Z, Gu Y, Zhao N, Xiang Q, Cui Y
  Title
Targeting integrin pathways: mechanisms and advances in therapy.
  Journal
Signal Transduct Target Ther 8:1 (2023)
DOI:10.1038/s41392-022-01259-6
Reference
PMID:40001469
  Authors
Katoh K
  Title
Integrin and Its Associated Proteins as a Mediator for Mechano-Signal Transduction.
  Journal
Biomolecules 15:biom15020166 (2025)
DOI:10.3390/biom15020166
Reference
PMID:24467163
  Authors
Morse EM, Brahme NN, Calderwood DA
  Title
Integrin cytoplasmic tail interactions.
  Journal
Biochemistry 53:810-20 (2014)
DOI:10.1021/bi401596q
Reference
PMID:12743027
  Authors
Brakebusch C, Fassler R
  Title
The integrin-actin connection, an eternal love affair.
  Journal
EMBO J 22:2324-33 (2003)
DOI:10.1093/emboj/cdg245
Reference
PMID:40748480
  Authors
Ain U, Fatma B, Firdaus H
  Title
The ILK-PINCH-parvin complex: a conserved primary adhesome regulating biological processes.
  Journal
Histochem Cell Biol 163:78 (2025)
DOI:10.1007/s00418-025-02408-y
Reference
PMID:35804980
  Authors
McDonald PC, Dedhar S
  Title
New Perspectives on the Role of Integrin-Linked Kinase (ILK) Signaling in Cancer Metastasis.
  Journal
Cancers (Basel) 14:cancers14133209 (2022)
DOI:10.3390/cancers14133209
Reference
PMID:24904821
  Authors
Shishido S, Bonig H, Kim YM
  Title
Role of integrin alpha4 in drug resistance of leukemia.
  Journal
Front Oncol 4:99 (2014)
DOI:10.3389/fonc.2014.00099
Related
pathway
pvp04010  MAPK signaling pathway
pvp04110  Cell cycle
pvp04150  mTOR signaling pathway
pvp04151  PI3K-Akt signaling pathway
pvp04310  Wnt signaling pathway
pvp04510  Focal adhesion
pvp04810  Regulation of actin cytoskeleton
KO pathway
ko04518   

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