KEGG   PATHWAY: pvp04150
Entry
pvp04150                    Pathway                                
Name
mTOR signaling pathway - Pteropus vampyrus (large flying fox)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
pvp04150  mTOR signaling pathway
pvp04150

Organism
Pteropus vampyrus (large flying fox) [GN:pvp]
Gene
105298829  SLC7A5; large neutral amino acids transporter small subunit 1 [KO:K13780]
105297822  SLC3A2; 4F2 cell-surface antigen heavy chain [KO:K06519]
105305812  sodium-coupled neutral amino acid transporter 9 [KO:K14995]
105299369  sodium-coupled neutral amino acid transporter 9-like [KO:K14995]
105303967  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
105296552  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
105295753  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
105295447  ATP6V1C2; LOW QUALITY PROTEIN: V-type proton ATPase subunit C 2 [KO:K02148]
105300870  ATP6V1C1; V-type proton ATPase subunit C 1 isoform X1 [KO:K02148]
105309961  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
105297242  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
105292922  ATP6V1E2; V-type proton ATPase subunit E 2 [KO:K02150]
105290186  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
105296889  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
105305327  ATP6V1G2; V-type proton ATPase subunit G 2 [KO:K02152]
105292645  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
105291392  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
105303660  LAMTOR1; ragulator complex protein LAMTOR1 [KO:K20397]
105296351  LAMTOR2; ragulator complex protein LAMTOR2 [KO:K20398]
105293038  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
105299760  LAMTOR4; ragulator complex protein LAMTOR4 isoform X2 [KO:K20399]
105297046  LAMTOR5; ragulator complex protein LAMTOR5 [KO:K16344]
105291339  FLCN; folliculin isoform X2 [KO:K09594]
105293537  FNIP1; folliculin-interacting protein 1 isoform X1 [KO:K20400]
105294499  FNIP2; folliculin-interacting protein 2 [KO:K20401]
105308979  RRAGB; ras-related GTP-binding protein B isoform X7 [KO:K16185]
105295591  RRAGA; ras-related GTP-binding protein A [KO:K16185]
105296976  RRAGD; ras-related GTP-binding protein D isoform X1 [KO:K16186]
105306386  RRAGC; ras-related GTP-binding protein C [KO:K16186]
105290528  SESN2; sestrin-2 [KO:K20394]
105300951  cytosolic arginine sensor for mTORC1 subunit 1-like [KO:K23080]
105300915  cytosolic arginine sensor for mTORC1 subunit 1 isoform X1 [KO:K23080]
105296715  CASTOR2; cytosolic arginine sensor for mTORC1 subunit 2 [KO:K23081]
105294119  MIOS; GATOR complex protein MIOS isoform X1 [KO:K20407]
105306361  SEH1L; nucleoporin SEH1 isoform X1 [KO:K14299]
105303273  WDR24; GATOR complex protein WDR24 [KO:K20408]
105305350  WDR59; GATOR complex protein WDR59 isoform X1 [KO:K20409]
105299081  SEC13; protein SEC13 homolog isoform X1 [KO:K14004]
105308355  DEPDC5; GATOR complex protein DEPDC5 [KO:K20404]
105295141  NPRL2; GATOR complex protein NPRL2 isoform X2 [KO:K20405]
105303369  NPRL3; GATOR complex protein NPRL3 [KO:K20406]
105307445  SKP2; S-phase kinase-associated protein 2 isoform X2 [KO:K03875]
105292721  RNF152; E3 ubiquitin-protein ligase RNF152 [KO:K15705] [EC:2.3.2.27]
105301186  RPTOR; regulatory-associated protein of mTOR [KO:K07204]
105301726  AKT1S1; proline-rich AKT1 substrate 1 isoform X2 [KO:K16184]
105294429  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
105292254  DEP domain-containing mTOR-interacting protein-like [KO:K20402]
105303344  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
105303305  TELO2; telomere length regulation protein TEL2 homolog isoform X1 [KO:K11137]
105296514  TTI1; TELO2-interacting protein 1 homolog [KO:K20403]
105289187  CLIP1; CAP-Gly domain-containing linker protein 1 isoform X4 [KO:K10421]
105303564  growth factor receptor-bound protein 10 [KO:K20064]
105296504  LPIN3; phosphatidate phosphatase LPIN3 isoform X1 [KO:K15728] [EC:3.1.3.4]
105295464  LPIN1; phosphatidate phosphatase LPIN1 [KO:K15728] [EC:3.1.3.4]
105292299  LPIN2; phosphatidate phosphatase LPIN2 isoform X2 [KO:K15728] [EC:3.1.3.4]
105299561  ULK1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
105291380  ULK2; serine/threonine-protein kinase ULK2 [KO:K08269] [EC:2.7.11.1]
105300185  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
105289536  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
105305994  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
105293632  EIF4E1B; eukaryotic translation initiation factor 4E type 1B isoform X1 [KO:K03259]
105306550  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
105302100  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
105302672  EIF4B; eukaryotic translation initiation factor 4B isoform X2 [KO:K03258]
105295596  RPS6; 40S ribosomal protein S6 [KO:K02991]
105297729  STRADA; STE20-related kinase adapter protein alpha isoform X4 [KO:K08271]
105298123  STRADB; STE20-related kinase adapter protein beta isoform X1 [KO:K17532]
105302230  STK11; LOW QUALITY PROTEIN: serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
105306128  CAB39; calcium-binding protein 39 [KO:K08272]
105298866  CAB39L; calcium-binding protein 39-like [KO:K08272]
105299096  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
105298997  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
105298655  TSC1; hamartin isoform X1 [KO:K07206]
105303335  TSC2; LOW QUALITY PROTEIN: tuberin [KO:K07207]
105293959  TBC1 domain family member 7 isoform X1 [KO:K20396]
105303777  RHEB; GTP-binding protein Rheb [KO:K07208]
105288832  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
105297529  WNT1; proto-oncogene Wnt-1 [KO:K03209]
105296814  WNT2B; protein Wnt-2b isoform X1 [KO:K00182]
105308466  WNT2; protein Wnt-2 [KO:K00182]
105299958  WNT3A; protein Wnt-3a [KO:K00312]
105303453  WNT3; proto-oncogene Wnt-3 [KO:K00312]
105290434  WNT4; protein Wnt-4 [KO:K00408]
105297256  WNT5B; protein Wnt-5b isoform X1 [KO:K00444]
105299863  WNT5A; protein Wnt-5a isoform X5 [KO:K00444]
105291052  WNT6; protein Wnt-6 isoform X2 [KO:K00445]
105302044  WNT7B; protein Wnt-7b [KO:K00572]
105294978  WNT7A; protein Wnt-7a [KO:K00572]
105304667  WNT8B; protein Wnt-8b [KO:K00714]
105293607  WNT8A; protein Wnt-8a [KO:K00714]
105300002  WNT9A; protein Wnt-9a [KO:K01064]
105303454  WNT9B; protein Wnt-9b [KO:K01064]
105297527  WNT10B; protein Wnt-10b [KO:K01357]
105291051  WNT10A; protein Wnt-10a [KO:K01357]
105297627  WNT11; protein Wnt-11 [KO:K01384]
105290156  WNT16; protein Wnt-16 [KO:K01558]
105298116  FZD7; frizzled-7 [KO:K02432]
105294552  FZD1; frizzled-1 [KO:K02432]
105303480  FZD2; frizzled-2 [KO:K02235]
105291512  FZD3; frizzled-3 isoform X1 [KO:K02329]
105294187  FZD4; frizzled-4 [KO:K02354]
105307149  FZD8; frizzled-8 [KO:K02375]
105298400  FZD5; frizzled-5 [KO:K02375]
105300873  FZD6; frizzled-6 isoform X1 [KO:K02376]
105299568  FZD10; frizzled-10 [KO:K02842]
105299684  FZD9; frizzled-9 [KO:K02842]
105306578  LRP5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
105302799  LRP6; low-density lipoprotein receptor-related protein 6 [KO:K03068]
105291733  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
105307126  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
105303599  DVL1; segment polarity protein dishevelled homolog DVL-1 [KO:K02353]
105301304  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
105305325  TNF; tumor necrosis factor [KO:K03156]
105295979  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
105301022  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
105310714  IGF1; insulin-like growth factor I isoform X3 [KO:K05459]
105307438  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
105290270  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
105293353  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
105292949  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
105309535  SOS2; son of sevenless homolog 2 [KO:K03099]
105305933  HRAS; GTPase HRas isoform X1 [KO:K02833]
105294059  KRAS; GTPase KRas isoform X2 [KO:K07827]
105296550  NRAS; GTPase NRas isoform X1 [KO:K07828]
105291659  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
105299021  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
105309827  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
105306744  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
105289326  MAPK1; mitogen-activated protein kinase 1 isoform X2 [KO:K04371] [EC:2.7.11.24]
105304566  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
105307369  ribosomal protein S6 kinase alpha-2-like [KO:K04373] [EC:2.7.11.1]
105290495  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
105292768  RPS6KA6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
105294032  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X3 [KO:K04373] [EC:2.7.11.1]
105294748  IRS1; insulin receptor substrate 1 [KO:K16172]
105296605  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
105297140  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
105299371  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649]
105307215  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105307575  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105308956  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
105293112  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X2 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
105303144  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
105303899  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105300159  RAC-beta serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
105298702  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105304619  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
105294855  MAPKAP1; target of rapamycin complex 2 subunit MAPKAP1 isoform X1 [KO:K20410]
105299101  RICTOR; rapamycin-insensitive companion of mTOR isoform X2 [KO:K08267]
105289980  PRR5L; proline-rich protein 5-like isoform X1 [KO:K20411]
105302033  PRR5; proline-rich protein 5 isoform X3 [KO:K20411]
105302383  RHOA; transforming protein RhoA [KO:K04513]
105297702  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
105308818  protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
105309462  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
105289483  serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
pvp00561  Glycerolipid metabolism
pvp04010  MAPK signaling pathway
pvp04140  Autophagy - animal
pvp04151  PI3K-Akt signaling pathway
pvp04152  AMPK signaling pathway
pvp04810  Regulation of actin cytoskeleton
pvp04910  Insulin signaling pathway
KO pathway
ko04150   
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