KEGG   PATHWAY: rno04612
Entry
rno04612                    Pathway                                
Name
Antigen processing and presentation - Rattus norvegicus (rat)
Class
Organismal Systems; Immune system
Pathway map
rno04612  Antigen processing and presentation
rno04612

Other DBs
GO: 0019885 0019886 0042591
Organism
Rattus norvegicus (rat) [GN:rno]
Gene
100362709  [KO:K06697]
102546590  H2-M10.6l; patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
108348108  Hspa1b; heat shock 70 kDa protein 1B [KO:K03283]
120093125  RT1-O1l1; H-2 class I histocompatibility antigen, Q7 alpha chain-like [KO:K06751]
24223  B2m; beta-2-microglobulin precursor [KO:K08055]
24468  Hspa8; heat shock cognate 71 kDa protein [KO:K03283]
24472  Hspa1a; heat shock 70 kDa protein 1A [KO:K03283]
24747  RT1-M3-1; RT1 class Ib, locus M3-1 precursor [KO:K06751]
24750  RT1-N3; RT1 class Ib, locus N3 [KO:K06751]
24751  RT1-O1; RT1 class Ib, locus O1 [KO:K06751]
24811  Tap1; antigen peptide transporter 1 precursor [KO:K05653] [EC:7.4.2.14]
24812  Tap2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
24835  Tnf; tumor necrosis factor [KO:K03156]
24930  Cd8a; T-cell surface glycoprotein CD8 alpha chain precursor [KO:K06458]
24931  Cd8b; T-cell surface glycoprotein CD8 beta chain precursor [KO:K06459]
24932  Cd4; T-cell surface glycoprotein CD4 precursor [KO:K06454]
24963  Hspa1l; heat shock 70 kDa protein 1-like [KO:K03283]
24973  RT1-A1; RT1 class Ia, locus A1 precursor [KO:K06751]
24974  RT1-A2; RT1 class Ia, locus A2 precursor [KO:K06751]
24981  RT1-Db2; RT1 class II, locus Db2 precursor [KO:K06752]
24984  RT1-DOa; RT1 class II, locus DOa precursor [KO:K06752]
24986  RT1-Ha; RT1 class II, locus Ha precursor [KO:K06752]
24988  RT1-M2; RT1 class Ib, locus M2 precursor [KO:K06751]
25110  Klrd1; natural killer cells antigen CD94 [KO:K06516]
25217  Tapbp; tapasin precursor [KO:K08058]
25336  Nfyb; nuclear transcription factor Y subunit beta [KO:K08065]
25337  Nfyc; nuclear transcription factor Y subunit gamma [KO:K08066]
25599  Cd74; H-2 class II histocompatibility antigen gamma chain [KO:K06505]
25617  Hspa5; endoplasmic reticulum chaperone BiP precursor [KO:K09490] [EC:3.6.4.10]
25697  Ctsl; procathepsin L preproprotein [KO:K01365] [EC:3.4.22.15]
25712  Ifng; interferon gamma precursor [KO:K04687]
266759  Hspa4; heat shock 70 kDa protein 4 [KO:K09489]
287716  Psme3; proteasome activator complex subunit 3 [KO:K06698]
290644  Ifi30; gamma-interferon-inducible lysosomal thiol reductase precursor [KO:K08059]
29144  Canx; calnexin precursor [KO:K08054]
294213  RT1-M1-4; RT1 class I, locus M1, gene 4 precursor [KO:K06751]
294228  RT1-S3; RT1 class Ib, locus S3 precursor [KO:K06751]
294269  RT1-Da; RT1 class II, locus Da precursor [KO:K06752]
294270  RT1-Db1; rano class II histocompatibility antigen, D-1 beta chain precursor [KO:K06752]
294273  RT1-DMb; RT1 class II, DM beta precursor [KO:K06752]
294274  RT1-DMa; RT1 class II, DM alpha precursor [KO:K06752]
29468  Pdia3; protein disulfide-isomerase A3 precursor [KO:K08056] [EC:5.3.4.1]
29508  Nfya; nuclear transcription factor Y subunit alpha isoform 2 [KO:K08064]
29614  Psme2; proteasome activator complex subunit 2 [KO:K06697]
29630  Psme1; proteasome activator complex subunit 1 [KO:K06696]
29683  Klrc1; killer cell lectin-like receptor subfamily C, member 1 [KO:K06541]
297602  Tapbpl; tapasin-related protein precursor [KO:K28445]
299331  Hsp90aa1; heat shock protein HSP 90-alpha [KO:K04079]
301252  Hsp90ab1; heat shock protein HSP 90-beta [KO:K04079]
306353  Rfxank; DNA-binding protein RFXANK [KO:K08062]
309584  RT1-M4; RT1 class Ib, locus M4 precursor [KO:K06751]
309600  RT1-CE12; RT1 class I, locus CE12 precursor [KO:K06751]
309603  RT1-CE1; RT1 class I, locus CE1 precursor [KO:K06751]
309607  RT1-CE5; RT1 class I, locus CE5 isoform 1 precursor [KO:K06751]
309621  RT1-Ba; rano class II histocompatibility antigen, B alpha chain precursor [KO:K06752]
309622  RT1-Bb; rano class II histocompatibility antigen, B-1 beta chain precursor [KO:K06752]
309627  RT1-A3; RT1 class I, locus A3 precursor [KO:K06751]
310659  Rfx5; DNA-binding protein RFX5 [KO:K08061]
353253  Kir3dl1; killer cell immunoglobulin-like receptor 3DL1 precursor [KO:K07980]
360323  RT1-N2; RT1 class Ib, locus N2 precursor [KO:K06751]
361787  RT1-T24-1; RT1 class I, locus T24, gene 1 isoform 1 [KO:K06751]
365527  RT1-M6-2; RT1 class I, locus M6, gene 2 precursor [KO:K06751]
365542  RT1-DOb; RT1 class II, DO beta isoform 1 [KO:K06752]
368153  RT1-CE7; RT1 class I, locus CE7 precursor [KO:K06751]
406194  RT1-T18; RT1 class Ib, locus T18 precursor [KO:K06751]
414779  RT1-CE2; RT1 class I, locus CE2 precursor [KO:K06751]
414783  RT1-CE4; RT1 class I, locus CE4 precursor [KO:K06751]
414784  RT1-T24-4; RT1 class I, locus T24, gene 4 [KO:K06751]
414785  RT1-M6-1; RT1 class I, locus M6, gene 1 precursor [KO:K06751]
414786  RT1-M1-2; RT1 class I, locus M1, gene 2 precursor [KO:K06751]
414788  RT1-T24-3; RT1 class I, locus T24, gene 3 [KO:K06751]
414789  RT1-CE15; RT1 class I, locus CE15 precursor [KO:K06751]
414790  RT1-CE13; RT1 class I, locus CE13 precursor [KO:K06751]
414791  RT1-CE11; RT1 class I, locus CE11 precursor [KO:K06751]
414792  RT1-CE10; RT1 class I, locus CE10 precursor [KO:K06751]
414793  RT1-CE3; RT1 class I, locus CE3 precursor [KO:K06751]
414819  RT1-CE16; RT1 class I, locus CE16 precursor [KO:K06751]
499400  RT1-M5; RT1 class Ib, locus M5 isoform 2 precursor [KO:K06751]
499402  H2-Q7-ps1; LOW QUALITY PROTEIN: H-2 class I histocompatibility antigen, Q7 alpha chain-like [KO:K06751]
499617  Rfxap; regulatory factor X-associated protein [KO:K08063]
50654  Ctss; cathepsin S preproprotein [KO:K01368] [EC:3.4.22.27]
60460  Hspa2; heat shock-related 70 kDa protein 2 [KO:K26598]
63865  Lgmn; legumain precursor [KO:K01369] [EC:3.4.22.34]
64202  Calr; calreticulin precursor [KO:K08057]
64529  Ctsb; cathepsin B preproprotein [KO:K01363] [EC:3.4.22.1]
680121  Haus8l2; heat shock cognate 71 kDa protein-like [KO:K03283]
680842  RT1-M1-5; RT1 class I, M1, gene 5 precursor [KO:K06751]
689537  Calr4; calreticulin isoform X1 [KO:K08057]
81646  Creb1; cyclic AMP-responsive element-binding protein 1 isoform A [KO:K05870]
85483  Ciita; MHC class II transactivator isoform 2 [KO:K08060] [EC:2.7.11.1]
Reference
PMID:15771591
  Authors
Trombetta ES, Mellman I.
  Title
Cell biology of antigen processing in vitro and in vivo.
  Journal
Annu Rev Immunol 23:975-1028 (2005)
DOI:10.1146/annurev.immunol.22.012703.104538
Reference
PMID:15814328
  Authors
Inaba K, Inaba M.
  Title
Antigen recognition and presentation by dendritic cells.
  Journal
Int J Hematol 81:181-7 (2005)
DOI:10.1532/IJH97.04200
Reference
PMID:11905820
  Authors
Heath WR, Carbone FR.
  Title
Cross-presentation in viral immunity and self-tolerance.
  Journal
Nat Rev Immunol 1:126-34 (2001)
DOI:10.1038/35100512
Reference
PMID:15304636
  Authors
Abele R, Tampe R.
  Title
The ABCs of immunology: structure and function of TAP, the transporter associated with antigen processing.
  Journal
Physiology (Bethesda) 19:216-24 (2004)
DOI:10.1152/physiol.00002.2004
Reference
PMID:16200082
  Authors
Reith W, LeibundGut-Landmann S, Waldburger JM.
  Title
Regulation of MHC class II gene expression by the class II transactivator.
  Journal
Nat Rev Immunol 5:793-806 (2005)
DOI:10.1038/nri1708
Reference
PMID:12776207
  Authors
Honey K, Rudensky AY.
  Title
Lysosomal cysteine proteases regulate antigen presentation.
  Journal
Nat Rev Immunol 3:472-82 (2003)
DOI:10.1038/nri1110
Reference
PMID:12974477
  Authors
Sercarz EE, Maverakis E.
  Title
Mhc-guided processing: binding of large antigen fragments.
  Journal
Nat Rev Immunol 3:621-9 (2003)
DOI:10.1038/nri1149
Reference
PMID:15224093
  Authors
Ackerman AL, Cresswell P.
  Title
Cellular mechanisms governing cross-presentation of exogenous antigens.
  Journal
Nat Immunol 5:678-84 (2004)
DOI:10.1038/ni1082
Reference
PMID:16181333
  Authors
Cresswell P, Ackerman AL, Giodini A, Peaper DR, Wearsch PA.
  Title
Mechanisms of MHC class I-restricted antigen processing and cross-presentation.
  Journal
Immunol Rev 207:145-57 (2005)
DOI:10.1111/j.0105-2896.2005.00316.x
Reference
PMID:15653312
  Authors
Zika E, Ting JP.
  Title
Epigenetic control of MHC-II: interplay between CIITA and histone-modifying enzymes.
  Journal
Curr Opin Immunol 17:58-64 (2005)
DOI:10.1016/j.coi.2004.11.008
Reference
PMID:11244040
  Authors
Reith W, Mach B.
  Title
The bare lymphocyte syndrome and the regulation of MHC expression.
  Journal
Annu Rev Immunol 19:331-73 (2001)
DOI:10.1146/annurev.immunol.19.1.331
Reference
PMID:15745856
  Authors
Lizee G, Basha G, Jefferies WA.
  Title
Tails of wonder: endocytic-sorting motifs key for exogenous antigen presentation.
  Journal
Trends Immunol 26:141-9 (2005)
DOI:10.1016/j.it.2005.01.005
Reference
PMID:15224094
  Authors
Watts C.
  Title
The exogenous pathway for antigen presentation on major histocompatibility complex class II and CD1 molecules.
  Journal
Nat Immunol 5:685-92 (2004)
DOI:10.1038/ni1088
Reference
PMID:15653315
  Authors
Kaufmann SH, Schaible UE.
  Title
Antigen presentation and recognition in bacterial infections.
  Journal
Curr Opin Immunol 17:79-87 (2005)
DOI:10.1016/j.coi.2004.12.004
Reference
PMID:20010787
  Authors
Groettrup M, Kirk CJ, Basler M
  Title
Proteasomes in immune cells: more than peptide producers?
  Journal
Nat Rev Immunol 10:73-8 (2010)
DOI:10.1038/nri2687
Related
pathway
rno03050  Proteasome
rno04650  Natural killer cell mediated cytotoxicity
rno04660  T cell receptor signaling pathway
KO pathway
ko04612   

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