Entry Name T cell receptor signaling pathway - Rattus norvegicus (rat)
Description Activation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. Engagement of these receptors through the interaction with a foreign antigen associated with major histocompatibility complex molecules and CD28 counter-receptors B7.1/B7.2, respectively, results in a series of signaling cascades. These cascades comprise an array of protein-tyrosine kinases, phosphatases, GTP-binding proteins and adaptor proteins that regulate generic and specialised functions, leading to T-cell proliferation, cytokine production and differentiation into effector cells.
Class Organismal Systems; Immune systemBRITE hierarchy
Pathway map rno04660 T cell receptor signaling pathway
Other DBs Organism Rattus norvegicus (rat) [GN:
rno ]
Gene 100361818 Nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform 1 [KO:K04446 ]
100362453 Ppp2cal1; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform-like [KO:K04382 ] [EC:3.1.3.16 ]
100363332 Card11; caspase recruitment domain-containing protein 11 [KO:K07367 ]
116630 Csf2; granulocyte-macrophage colony-stimulating factor precursor [KO:K05427 ]
117104 Ppp2r2a; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354 ]
117256 Ppp2r2c; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform isoform 1 [KO:K04354 ]
117281 Ppp2r1a; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456 ]
170911 Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
171378 Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348 ] [EC:3.1.3.16 ]
246255 Ppp2r2d; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354 ]
24672 Ppp2ca; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382 ] [EC:3.1.3.16 ]
24673 Ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382 ] [EC:3.1.3.16 ]
24675 Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform [KO:K04348 ] [EC:3.1.3.16 ]
24699 Ptprc; receptor-type tyrosine-protein phosphatase C isoform 4 precursor [KO:K06478 ] [EC:3.1.3.48 ]
24930 Cd8a; T-cell surface glycoprotein CD8 alpha chain precursor [KO:K06458 ]
24931 Cd8b; T-cell surface glycoprotein CD8 beta chain precursor [KO:K06459 ]
24932 Cd4; T-cell surface glycoprotein CD4 precursor [KO:K06454 ]
25252 Dlg1; disks large homolog 1 isoform 1 [KO:K12076 ]
25300 Cd247; T-cell surface glycoprotein CD3 zeta chain isoform 2 precursor [KO:K06453 ]
25513 Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649 ]
25622 Ptpn11; tyrosine-protein phosphatase non-receptor type 11 isoform 2 [KO:K07293 ] [EC:3.1.3.48 ]
25660 Cd28; T-cell-specific surface glycoprotein CD28 precursor [KO:K06470 ]
25710 Cd3d; T-cell surface glycoprotein CD3 delta chain precursor [KO:K06450 ]
25738 Plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116 ] [EC:3.1.4.11 ]
29434 Rasgrp1; RAS guanyl-releasing protein 1 [KO:K04350 ]
295378 Vav3; guanine nucleotide exchange factor VAV3 [KO:K05730 ]
296603 Vav2; guanine nucleotide exchange factor VAV2 [KO:K05730 ]
297173 RSA-14-44; ras homolog gene family, member A [KO:K04513 ]
29741 Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
299147 Ppp2r5e; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [KO:K11584 ]
300678 Cd3g; T-cell surface glycoprotein CD3 gamma chain precursor [KO:K06452 ]
301626 Pdcd1; programmed cell death protein 1 precursor [KO:K06744 ]
307366 Malt1; mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform 1 [KO:K07369 ] [EC:3.4.22.-]
309179 Ppp2r5b; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584 ]
311658 Nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332 ]
312754 Ppp2r5a; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584 ]
315609 Cd3e; T-cell surface glycoprotein CD3 epsilon chain precursor [KO:K06451 ]
315648 Ppp2r1b; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456 ]
361400 Nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333 ]
362739 Ppp2r3c; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma [KO:K11583 ]
363122 Ppp2r3a; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha [KO:K11583 ]
363193 Ppp2r5d; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584 ]
363855 Map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform 1 [KO:K04431 ] [EC:2.7.12.2 ]
366508 Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
367858 Hrasl1; HRas proto-oncogene, GTPase like 1 [KO:K02833 ]
58960 Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369 ] [EC:2.7.12.2 ]
60660 Ppp2r2b; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform 1 [KO:K04354 ]
60664 Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
63835 Ctla4; cytotoxic T-lymphocyte protein 4 precursor [KO:K06538 ]
64465 Cdc42; cell division control protein 42 homolog [KO:K04393 ]
64545 Icos; inducible T-cell costimulator precursor [KO:K06713 ]
682033 Ppp2r3b; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta [KO:K11583 ]
691318 Ppp2r5c; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform 4 [KO:K11584 ]
81504 Grb2; growth factor receptor-bound protein 2 [KO:K04364 ]
81511 Lat; linker for activation of T-cells family member 1 [KO:K07362 ]
81736 Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform 2 [KO:K02580 ]
85243 Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
Compound C01245 D-myo-Inositol 1,4,5-trisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Chen L.
Title Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity.
Journal Reference Authors Macian F.
Title NFAT proteins: key regulators of T-cell development and function.
Journal Reference Authors Berg LJ, Finkelstein LD, Lucas JA, Schwartzberg PL.
Title Tec family kinases in T lymphocyte development and function.
Journal Reference Authors Huang Y, Wange RL.
Title T cell receptor signaling: beyond complex complexes.
Journal Reference Authors Schmitz ML, Bacher S, Dienz O.
Title NF-kappaB activation pathways induced by T cell costimulation.
Journal Reference Authors Alegre ML, Frauwirth KA, Thompson CB.
Title T-cell regulation by CD28 and CTLA-4.
Journal Reference Authors Horejsi V, Zhang W, Schraven B.
Title Transmembrane adaptor proteins: organizers of immunoreceptor signalling.
Journal Reference Authors Baniyash M.
Title TCR zeta-chain downregulation: curtailing an excessive inflammatory immune response.
Journal Reference Authors Sechi AS, Wehland J.
Title Interplay between TCR signalling and actin cytoskeleton dynamics.
Journal Reference Authors Okkenhaug K, Vanhaesebroeck B.
Title PI3K in lymphocyte development, differentiation and activation.
Journal Reference Authors Palacios EH, Weiss A.
Title Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation.
Journal Reference Authors Kane LP, Lin J, Weiss A.
Title It's all Rel-ative: NF-kappaB and CD28 costimulation of T-cell activation.
Journal Reference Authors Acuto O, Michel F.
Title CD28-mediated co-stimulation: a quantitative support for TCR signalling.
Journal Reference Authors Finkelstein LD, Schwartzberg PL.
Title Tec kinases: shaping T-cell activation through actin.
Journal Reference Authors Duan L, Reddi AL, Ghosh A, Dimri M, Band H.
Title The Cbl family and other ubiquitin ligases: destructive forces in control of antigen receptor signaling.
Journal Reference Authors Schrum AG, Turka LA, Palmer E.
Title Surface T-cell antigen receptor expression and availability for long-term antigenic signaling.
Journal Reference Authors Smith-Garvin JE, Koretzky GA, Jordan MS
Title T cell activation.
Journal Reference Authors Diehn M, Alizadeh AA, Rando OJ, Liu CL, Stankunas K, Botstein D, Crabtree GR, Brown PO
Title Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activation.
Journal Reference Authors Blonska M, Lin X
Title CARMA1-mediated NF-kappaB and JNK activation in lymphocytes.
Journal Reference Authors Rebeaud F, Hailfinger S, Thome M
Title Dlgh1 and Carma1 MAGUK proteins contribute to signal specificity downstream of TCR activation.
Journal Reference Authors Ashwell JD
Title The many paths to p38 mitogen-activated protein kinase activation in the immune system.
Journal Reference Authors Round JL, Humphries LA, Tomassian T, Mittelstadt P, Zhang M, Miceli MC
Title Scaffold protein Dlgh1 coordinates alternative p38 kinase activation, directing T cell receptor signals toward NFAT but not NF-kappaB transcription factors.
Journal Related rno04514 Cell adhesion molecule (CAM) interaction
rno04810 Regulation of actin cytoskeleton
KO pathway
