Entry Name Malaria - Rattus norvegicus (rat)
Description Plasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop into the merozoite form.
Class Human Diseases; Infectious disease: parasiticBRITE hierarchy
Pathway map Disease Organism Rattus norvegicus (rat) [GN:
rno ]
Gene 120093104 Ly49si3l1; killer cell lectin-like receptor 5 isoform X2 [KO:K23459 ]
171369 Cd40; tumor necrosis factor receptor superfamily member 5 precursor [KO:K03160 ]
24446 Hgf; hepatocyte growth factor preproprotein [KO:K05460 ]
24770 Ccl2; C-C motif chemokine 2 precursor [KO:K14624 ]
24933 Klra22; killer cell lectin-like receptor subfamily A, member 22 [KO:K23459 ]
24934 Klrk1; NKG2-D type II integral membrane protein [KO:K06728 ]
25192 Klrb1b; killer cell lectin-like receptor subfamily B member 1B [KO:K06543 ]
25304 Comp; cartilage oligomeric matrix protein precursor [KO:K04659 ]
25361 Vcam1; vascular cell adhesion protein 1 precursor [KO:K06527 ]
25464 Icam1; intercellular adhesion molecule 1 precursor [KO:K06490 ]
25610 Csf3; granulocyte colony-stimulating factor precursor [KO:K05423 ]
25717 Tgfb3; transforming growth factor beta-3 proprotein preproprotein [KO:K13377 ]
287562 Ccl12; C-C motif chemokine ligand 12 precursor [KO:K14624 ]
29583 Pecam1; platelet endothelial cell adhesion molecule precursor [KO:K06471 ]
297666 Klra5; killer cell lectin-like receptor, subfamily A, member 5 [KO:K23459 ]
299858 Lrp1; prolow-density lipoprotein receptor-related protein 1 precursor [KO:K04550 ]
301059 Myd88; myeloid differentiation primary response protein MyD88 [KO:K04729 ]
361619 Hbb-b1; hemoglobin, beta adult major chain [KO:K13823 ]
362443 Klrb1a; killer cell lectin-like receptor subfamily B member 1A [KO:K06543 ]
445442 Thbs1; thrombospondin-1 isoform 1 precursor [KO:K16857 ]
494193 Klra1; killer cell lectin-like receptor, subfamily A, member 1 [KO:K23459 ]
494194 Klra2; killer cell lectin-like receptor 2 [KO:K23459 ]
502908 Ly49s8; killer cell lectin-like receptor 4 [KO:K23459 ]
54243 Cr1l; complement component receptor 1-like protein isoform 2 precursor [KO:K04011 ]
59086 Tgfb1; transforming growth factor beta-1 proprotein precursor [KO:K13375 ]
683758 Klrb1c; killer cell lectin-like receptor subfamily B member 1F [KO:K06543 ]
689817 Klrb1; killer cell lectin-like receptor subfamily B member 1 [KO:K06543 ]
690020 Klra4; killer cell lectin-like receptor 2 isoform X4 [KO:K23459 ]
690045 Klra17; killer cell lectin-like receptor, subfamily A, member 17 [KO:K23459 ]
690127 Ly49s5l1; killer cell lectin-like receptor 7 [KO:K23459 ]
81809 Tgfb2; transforming growth factor beta-2 proprotein precursor [KO:K13376 ]
84405 Il12a; interleukin-12 subunit alpha precursor [KO:K05406 ]
Compound Reference Authors Morahan BJ, Wang L, Coppel RL
Title No TRAP, no invasion.
Journal Reference Authors Shakibaei M, Frevert U
Title Dual interaction of the malaria circumsporozoite protein with the low density lipoprotein receptor-related protein (LRP) and heparan sulfate proteoglycans.
Journal Reference Authors Silvie O, Franetich JF, Renia L, Mazier D
Title Malaria sporozoite: migrating for a living.
Journal Reference Authors Mota MM, Giordano S, Rodriguez A
Title Targeting Plasmodium host cells: survival within hepatocytes.
Journal Reference Authors Cowman AF, Crabb BS
Title The Plasmodium falciparum genome--a blueprint for erythrocyte invasion.
Journal Reference Authors O'Donnell RA, Blackman MJ
Title The role of malaria merozoite proteases in red blood cell invasion.
Journal Reference Authors Iyer J, Gruner AC, Renia L, Snounou G, Preiser PR
Title Invasion of host cells by malaria parasites: a tale of two protein families.
Journal Reference Authors Chitnis CE
Title Molecular insights into receptors used by malaria parasites for erythrocyte invasion.
Journal Reference Authors Rasti N, Wahlgren M, Chen Q
Title Molecular aspects of malaria pathogenesis.
Journal Reference Authors Clark IA, Rockett KA, Cowden WB
Title Proposed link between cytokines, nitric oxide and human cerebral malaria.
Journal Reference Authors Hisaeda H, Tetsutani K, Imai T, Moriya C, Tu L, Hamano S, Duan X, Chou B, Ishida H, Aramaki A, Shen J, Ishii KJ, Coban C, Akira S, Takeda K, Yasutomo K, Torii M, Himeno K
Title Malaria parasites require TLR9 signaling for immune evasion by activating regulatory T cells.
Journal Reference Authors Chen Q, Schlichtherle M, Wahlgren M
Title Molecular aspects of severe malaria.
Journal Reference Authors Miller LH, Baruch DI, Marsh K, Doumbo OK
Title The pathogenic basis of malaria.
Journal Reference Authors Faille D, El-Assaad F, Alessi MC, Fusai T, Combes V, Grau GE
Title Platelet-endothelial cell interactions in cerebral malaria: the end of a cordial understanding.
Journal Reference Authors Schofield L, Grau GE
Title Immunological processes in malaria pathogenesis.
Journal Reference Authors Ishino T, Yano K, Chinzei Y, Yuda M
Title Cell-passage activity is required for the malarial parasite to cross the liver sinusoidal cell layer.
Journal Reference Authors Kariu T, Ishino T, Yano K, Chinzei Y, Yuda M
Title CelTOS, a novel malarial protein that mediates transmission to mosquito and vertebrate hosts.
Journal Reference Authors Cox D, McConkey S
Title The role of platelets in the pathogenesis of cerebral malaria.
Journal Related rno04514 Cell adhesion molecule (CAM) interaction
rno04610 Complement and coagulation cascades
rno04620 Toll-like receptor signaling pathway
KO pathway
