KEGG   PATHWAY: rno04514
Entry
rno04514                    Pathway                                
Name
Cell adhesion molecules - Rattus norvegicus (rat)
Description
Cell adhesion molecules (CAMs) are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cell–cell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordinated brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
rno04514  Cell adhesion molecules
rno04514

Other DBs
GO: 0050839
Organism
Rattus norvegicus (rat) [GN:rno]
Gene
100360390  Cldn25; putative claudin-25 [KO:K06087]
100361422  Cldn34c4; claudin 34C4 [KO:K06087]
102546590  H2-M10.6l; patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
102552482  Cd99l3; uncharacterized protein Cd99l3 [KO:K06520]
114122  Vcan; versican core protein isoform 1 precursor [KO:K06793]
114517  Itga6; integrin alpha-6 precursor [KO:K06485]
114588  Cdh4; cadherin-4 precursor [KO:K06797]
116479  F11r; junctional adhesion molecule A precursor [KO:K06089]
116508  Nrxn3; neurexin-3 precursor [KO:K07377]
116595  Nrxn2; neurexin-2-beta precursor [KO:K07377]
116647  Nlgn1; neuroligin-1 precursor [KO:K07378]
116673  Sdc3; syndecan-3 precursor [KO:K16337]
116690  Nfasc; neurofascin isoform 1 precursor [KO:K06757]
116777  Cdh3; cadherin-3 precursor [KO:K06796]
117096  Nlgn2; neuroligin-2 precursor [KO:K07378]
117258  Cntn1; contactin-1 precursor [KO:K06759]
120093125  RT1-O1l1; H-2 class I histocompatibility antigen, Q7 alpha chain-like [KO:K06751]
155268  Cldn16; claudin-16 [KO:K06087]
171297  Nlgn3; neuroligin-3 precursor [KO:K07378]
171369  Cd40; tumor necrosis factor receptor superfamily member 5 precursor [KO:K03160]
192183  Nectin1; nectin-1 precursor [KO:K06081]
24511  Itgb1; integrin beta-1 precursor [KO:K05719]
24564  Mpz; myelin protein P0 isoform MPZ precursor [KO:K06770]
24586  Ncam1; neural cell adhesion molecule 1 isoform 5 precursor [KO:K06491]
24699  Ptprc; receptor-type tyrosine-protein phosphatase C isoform 4 precursor [KO:K06478] [EC:3.1.3.48]
24747  RT1-M3-1; RT1 class Ib, locus M3-1 precursor [KO:K06751]
24750  RT1-N3; RT1 class Ib, locus N3 [KO:K06751]
24751  RT1-O1; RT1 class Ib, locus O1 [KO:K06751]
24771  Sdc4; syndecan-4 precursor [KO:K16338]
24796  Spn; leukosialin precursor [KO:K06477]
24930  Cd8a; T-cell surface glycoprotein CD8 alpha chain precursor [KO:K06458]
24931  Cd8b; T-cell surface glycoprotein CD8 beta chain precursor [KO:K06459]
24932  Cd4; T-cell surface glycoprotein CD4 precursor [KO:K06454]
24973  RT1-A1; RT1 class Ia, locus A1 precursor [KO:K06751]
24974  RT1-A2; RT1 class Ia, locus A2 precursor [KO:K06751]
24981  RT1-Db2; RT1 class II, locus Db2 precursor [KO:K06752]
24984  RT1-DOa; RT1 class II, locus DOa precursor [KO:K06752]
24986  RT1-Ha; RT1 class II, locus Ha precursor [KO:K06752]
24988  RT1-M2; RT1 class Ib, locus M2 precursor [KO:K06751]
25021  Itgam; integrin alpha-M precursor [KO:K06461]
25066  Pvr; PVR cell adhesion molecule precursor [KO:K06539]
25216  Sdc1; syndecan-1 precursor [KO:K06257]
25258  Glycam1; glycosylation-dependent cell adhesion molecule 1 precursor [KO:K06815]
25356  Cntn2; contactin-2 precursor [KO:K06760]
25361  Vcam1; vascular cell adhesion protein 1 precursor [KO:K06527]
25408  Cd80; T-lymphocyte activation antigen CD80 [KO:K05412]
25464  Icam1; intercellular adhesion molecule 1 precursor [KO:K06490]
25529  Ptprs; receptor-type tyrosine-protein phosphatase S precursor [KO:K06778] [EC:3.1.3.48]
25544  Sele; E-selectin precursor [KO:K06494]
25615  Sdc2; syndecan-2 precursor [KO:K16336]
25651  Selp; P-selectin precursor [KO:K06496]
25660  Cd28; T-cell-specific surface glycoprotein CD28 precursor [KO:K06470]
25713  Itgb7; integrin beta-7 precursor [KO:K06590]
25752  Cd6; T-cell differentiation antigen CD6 precursor [KO:K06456]
287098  Cldn6; claudin-6 precursor [KO:K06087]
287099  Cldn9; claudin-9 [KO:K06087]
288124  Nectin3; nectin-3 isoform 2 [KO:K06592]
288280  Ncam2; neural cell adhesion molecule 2 precursor [KO:K06491]
288521  Spnl1; sialophorin like 1 precursor [KO:K06477]
290467  Slitrk6; SLIT and NTRK-like protein 6 precursor [KO:K25837]
290485  Cldn10; claudin-10 [KO:K06087]
290789  Cldn23; claudin-23 [KO:K06087]
29259  Sell; L-selectin precursor [KO:K06495]
29409  Mag; myelin-associated glycoprotein precursor [KO:K06771]
294213  RT1-M1-4; RT1 class I, locus M1, gene 4 precursor [KO:K06751]
294228  RT1-S3; RT1 class Ib, locus S3 precursor [KO:K06751]
294269  RT1-Da; RT1 class II, locus Da precursor [KO:K06752]
294270  RT1-Db1; rano class II histocompatibility antigen, D-1 beta chain precursor [KO:K06752]
294273  RT1-DMb; RT1 class II, DM beta precursor [KO:K06752]
294274  RT1-DMa; RT1 class II, DM alpha precursor [KO:K06752]
29476  Glg1; Golgi apparatus protein 1 precursor [KO:K06816]
295322  Vtcn1; V-set domain-containing T-cell activation inhibitor 1 precursor [KO:K06747]
295382  Ntng1; netrin-G1 precursor [KO:K07522]
29583  Pecam1; platelet endothelial cell adhesion molecule precursor [KO:K06471]
29616  Ptprm; receptor-type tyrosine-protein phosphatase mu precursor [KO:K05693] [EC:3.1.3.48]
296456  Itgav; integrin alpha-V isoform 1 precursor [KO:K06487]
298487  Cldn19; claudin-19 [KO:K06087]
300519  Esam; endothelial cell-selective adhesion molecule precursor [KO:K06787]
300920  Cldn2; claudin-2 [KO:K06087]
301626  Pdcd1; programmed cell death protein 1 precursor [KO:K06744]
302473  Slitrk4; SLIT and NTRK-like protein 4 precursor [KO:K25835]
303926  Igsf11; immunoglobulin superfamily member 11 precursor [KO:K06791]
304073  Cldn14; claudin-14 [KO:K06087]
304124  Cldn8; claudin-8 [KO:K06087]
304125  Cldn17; claudin-17 [KO:K06087]
304388  Cldn15; claudin-15 [KO:K06087]
304407  Cldn4; claudin-4 [KO:K06087]
305081  Cd34; hematopoietic progenitor cell antigen CD34 isoform 1 precursor [KO:K06474]
306147  Slitrk1; SLIT and NTRK-like protein 1 precursor [KO:K25832]
306152  Slitrk5; SLIT and NTRK-like protein 5 [KO:K25836]
306454  Cldn22; claudin-22 [KO:K06087]
307199  Cd226; CD226 antigen precursor [KO:K06567]
307618  Cdh5; cadherin-5 [KO:K06533]
308417  Nectin2; nectin-2 precursor [KO:K06531]
308501  Cd22; B-cell receptor CD22 precursor [KO:K06467]
308571  Lrrc4b; leucine-rich repeat-containing protein 4B precursor [KO:K16360]
308995  Itgal; integrin alpha-L precursor [KO:K05718]
309304  Pdcd1lg2; programmed cell death 1 ligand 2 precursor [KO:K06708]
309349  Slitrk2; SLIT and NTRK-like protein 2 precursor [KO:K25833]
309584  RT1-M4; RT1 class Ib, locus M4 precursor [KO:K06751]
309600  RT1-CE12; RT1 class I, locus CE12 precursor [KO:K06751]
309603  RT1-CE1; RT1 class I, locus CE1 precursor [KO:K06751]
309607  RT1-CE5; RT1 class I, locus CE5 isoform 1 precursor [KO:K06751]
309621  RT1-Ba; rano class II histocompatibility antigen, B alpha chain precursor [KO:K06752]
309622  RT1-Bb; rano class II histocompatibility antigen, B-1 beta chain precursor [KO:K06752]
309627  RT1-A3; RT1 class I, locus A3 precursor [KO:K06751]
309684  Itgb2; integrin beta-2 precursor [KO:K06464]
310519  Slitrk3; SLIT and NTRK-like protein 3 precursor [KO:K25834]
311144  Itga4; integrin alpha-4 [KO:K06483]
311236  Lrrc4c; leucine-rich repeat-containing protein 4C precursor [KO:K07523]
311426  Siglec1; sialoadhesin precursor [KO:K06548]
311836  Ntng2; netrin-G2 precursor [KO:K16359]
313278  Ptprd; receptor-type tyrosine-protein phosphatase delta isoform X14 [KO:K06777] [EC:3.1.3.48]
315509  Jam3; junctional adhesion molecule C precursor [KO:K06785]
315610  Jaml; junctional adhesion molecule-like [KO:K28137]
315716  Cd276; CD276 antigen precursor [KO:K06746]
315953  Cldn18; claudin-18 precursor [KO:K06087]
360323  RT1-N2; RT1 class Ib, locus N2 precursor [KO:K06751]
360406  Ptprf; receptor-type tyrosine-protein phosphatase F precursor [KO:K05695] [EC:3.1.3.48]
360647  Icam2; intercellular adhesion molecule 2 precursor [KO:K06523]
360882  Cadm3; cell adhesion molecule 3 isoform 2 precursor [KO:K06780]
361432  Cdh15; cadherin-15 precursor [KO:K06809]
361787  RT1-T24-1; RT1 class I, locus T24, gene 1 isoform 1 [KO:K06751]
362800  Itgb8; integrin beta-8 precursor [KO:K06591]
363058  Cadm1; cell adhesion molecule 1 precursor [KO:K06781]
363784  Tigit; T-cell immunoreceptor with Ig and ITIM domains [KO:K16350]
363930  Selplg; P-selectin glycoprotein ligand 1 precursor [KO:K06544]
364786  Itga8; integrin alpha-8 [KO:K06584]
365527  RT1-M6-2; RT1 class I, locus M6, gene 2 precursor [KO:K06751]
365542  RT1-DOb; RT1 class II, DO beta isoform 1 [KO:K06752]
368153  RT1-CE7; RT1 class I, locus CE7 precursor [KO:K06751]
406194  RT1-T18; RT1 class Ib, locus T18 precursor [KO:K06751]
414779  RT1-CE2; RT1 class I, locus CE2 precursor [KO:K06751]
414783  RT1-CE4; RT1 class I, locus CE4 precursor [KO:K06751]
414784  RT1-T24-4; RT1 class I, locus T24, gene 4 [KO:K06751]
414785  RT1-M6-1; RT1 class I, locus M6, gene 1 precursor [KO:K06751]
414786  RT1-M1-2; RT1 class I, locus M1, gene 2 precursor [KO:K06751]
414788  RT1-T24-3; RT1 class I, locus T24, gene 3 [KO:K06751]
414789  RT1-CE15; RT1 class I, locus CE15 precursor [KO:K06751]
414790  RT1-CE13; RT1 class I, locus CE13 precursor [KO:K06751]
414791  RT1-CE11; RT1 class I, locus CE11 precursor [KO:K06751]
414792  RT1-CE10; RT1 class I, locus CE10 precursor [KO:K06751]
414793  RT1-CE3; RT1 class I, locus CE3 precursor [KO:K06751]
414819  RT1-CE16; RT1 class I, locus CE16 precursor [KO:K06751]
497761  Cd2; T-cell surface antigen CD2 precursor [KO:K06449]
497815  Nrcam; neuronal cell adhesion molecule precursor [KO:K06756]
499342  Cd274; programmed cell death 1 ligand 1 precursor [KO:K06745]
499400  RT1-M5; RT1 class Ib, locus M5 isoform 2 precursor [KO:K06751]
499402  H2-Q7-ps1; LOW QUALITY PROTEIN: H-2 class I histocompatibility antigen, Q7 alpha chain-like [KO:K06751]
499415  Icoslg; ICOS ligand isoform X1 [KO:K06710]
500000  Cldn12; claudin-12 [KO:K06087]
500105  Cntnap2; contactin-associated protein-like 2 isoform X1 [KO:K07380]
502083  Cldn24; putative claudin-24 [KO:K06087]
50687  L1cam; neural cell adhesion molecule L1 precursor [KO:K06550]
54266  Madcam1; mucosal addressin cell adhesion molecule 1 precursor [KO:K06779]
56822  Cd86; T-lymphocyte activation antigen CD86 precursor [KO:K05413]
59318  Negr1; neuronal growth regulator 1 precursor [KO:K06775]
60391  Nrxn1; neurexin-1 precursor [KO:K07377]
619374  Jam2; junctional adhesion molecule B precursor [KO:K06735]
63835  Ctla4; cytotoxic T-lymphocyte protein 4 precursor [KO:K06538]
641521  Lrrc4; leucine-rich repeat-containing protein 4 precursor [KO:K16351]
64545  Icos; inducible T-cell costimulator precursor [KO:K06713]
65129  Cldn1; claudin-1 [KO:K06087]
65130  Cldn3; claudin-3 [KO:K06087]
65131  Cldn5; claudin-5 [KO:K06087]
65132  Cldn7; claudin-7 precursor [KO:K06087]
652929  Cd99; CD99 antigen precursor [KO:K06520]
680178  Cldn20; claudin-20 precursor [KO:K06087]
680370  Cldn34d; claudin 34D [KO:K06087]
680489  Cldn34e; uncharacterized protein LOC680489 [KO:K06087]
680842  RT1-M1-5; RT1 class I, M1, gene 5 precursor [KO:K06751]
685004  Itga9; integrin alpha-9 precursor [KO:K06585]
690899  Vsir; V-type immunoglobulin domain-containing suppressor of T-cell activation isoform 1 [KO:K23268]
79559  Alcam; CD166 antigen precursor [KO:K06547]
81735  Neo1; neogenin precursor [KO:K06766]
83497  Ocln; occludin [KO:K06088]
83501  Cdh2; cadherin-2 precursor [KO:K06736]
83502  Cdh1; cadherin-1 precursor [KO:K05689]
84008  Cntnap1; contactin-associated protein 1 precursor [KO:K07379]
84349  Cd40lg; CD40 ligand [KO:K03161]
84588  Cldn11; claudin-11 [KO:K06087]
89843  Cxadr; coxsackievirus and adenovirus receptor homolog isoform 2 precursor [KO:K06788]
Reference
PMID:14690046
  Authors
Barclay AN.
  Title
Membrane proteins with immunoglobulin-like domains--a master superfamily of interaction molecules.
  Journal
Semin Immunol 15:215-23 (2003)
DOI:10.1016/S1044-5323(03)00047-2
Reference
PMID:11910893
  Authors
Sharpe AH, Freeman GJ.
  Title
The B7-CD28 superfamily.
  Journal
Nat Rev Immunol 2:116-26 (2002)
DOI:10.1038/nri727
Reference
PMID:9597126
  Authors
Grewal IS, Flavell RA.
  Title
CD40 and CD154 in cell-mediated immunity.
  Journal
Annu Rev Immunol 16:111-35 (1998)
DOI:10.1146/annurev.immunol.16.1.111
Reference
PMID:16034094
  Authors
Dardalhon V, Schubart AS, Reddy J, Meyers JH, Monney L, Sabatos CA, Ahuja R, Nguyen K, Freeman GJ, Greenfield EA, Sobel RA, Kuchroo VK.
  Title
CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions.
  Journal
J Immunol 175:1558-65 (2005)
DOI:10.4049/jimmunol.175.3.1558
Reference
PMID:12234363
  Authors
Montoya MC, Sancho D, Vicente-Manzanares M, Sanchez-Madrid F.
  Title
Cell adhesion and polarity during immune interactions.
  Journal
Immunol Rev 186:68-82 (2002)
DOI:10.1034/j.1600-065X.2002.18607.x
Reference
PMID:15071551
  Authors
Dejana E.
  Title
Endothelial cell-cell junctions: happy together.
  Journal
Nat Rev Mol Cell Biol 5:261-70 (2004)
DOI:10.1038/nrm1357
Reference
PMID:14519386
  Authors
Bazzoni G.
  Title
The JAM family of junctional adhesion molecules.
  Journal
Curr Opin Cell Biol 15:525-30 (2003)
DOI:10.1016/S0955-0674(03)00104-2
Reference
PMID:10798271
  Authors
Becker BF, Heindl B, Kupatt C, Zahler S.
  Title
Endothelial function and hemostasis.
  Journal
Z Kardiol 89:160-7 (2000)
DOI:10.1007/PL00007320
Reference
PMID:9150551
  Authors
Elangbam CS, Qualls CW Jr, Dahlgren RR.
  Title
Cell adhesion molecules--update.
  Journal
Vet Pathol 34:61-73 (1997)
DOI:10.1177/030098589703400113
Reference
PMID:12810109
  Authors
Muller WA.
  Title
Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response.
  Journal
Trends Immunol 24:327-34 (2003)
DOI:10.1016/S1471-4906(03)00117-0
Reference
PMID:14519398
  Authors
Yamagata M, Sanes JR, Weiner JA.
  Title
Synaptic adhesion molecules.
  Journal
Curr Opin Cell Biol 15:621-32 (2003)
DOI:10.1016/S0955-0674(03)00107-8
Reference
PMID:15882774
  Authors
Ethell IM, Pasquale EB.
  Title
Molecular mechanisms of dendritic spine development and remodeling.
  Journal
Prog Neurobiol 75:161-205 (2005)
DOI:10.1016/j.pneurobio.2005.02.003
Reference
PMID:11050419
  Authors
Benson DL, Schnapp LM, Shapiro L, Huntley GW.
  Title
Making memories stick: cell-adhesion molecules in synaptic plasticity.
  Journal
Trends Cell Biol 10:473-82 (2000)
DOI:10.1016/S0962-8924(00)01838-9
Reference
PMID:11860281
  Authors
Rosdahl JA, Mourton TL, Brady-Kalnay SM.
  Title
Protein kinase C delta (PKCdelta) is required for protein tyrosine phosphatase mu (PTPmu)-dependent neurite outgrowth.
  Journal
Mol Cell Neurosci 19:292-306 (2002)
DOI:10.1006/mcne.2001.1071
Reference
PMID:10964748
  Authors
Dunican DJ, Doherty P.
  Title
The generation of localized calcium rises mediated by cell adhesion molecules and their role in neuronal growth cone motility.
  Journal
Mol Cell Biol Res Commun 3:255-63 (2000)
DOI:10.1006/mcbr.2000.0225
Reference
PMID:12367625
  Authors
Girault JA, Peles E.
  Title
Development of nodes of Ranvier.
  Journal
Curr Opin Neurobiol 12:476-85 (2002)
DOI:10.1016/S0959-4388(02)00370-7
Reference
PMID:10664064
  Authors
Arroyo EJ, Scherer SS.
  Title
On the molecular architecture of myelinated fibers.
  Journal
Histochem Cell Biol 113:1-18 (2000)
DOI:10.1007/s004180050001
Reference
PMID:14556710
  Authors
Salzer JL.
  Title
Polarized domains of myelinated axons.
  Journal
Neuron 40:297-318 (2003)
DOI:10.1016/S0896-6273(03)00628-7
Reference
PMID:15561584
  Authors
Irie K, Shimizu K, Sakisaka T, Ikeda W, Takai Y.
  Title
Roles and modes of action of nectins in cell-cell adhesion.
  Journal
Semin Cell Dev Biol 15:643-56 (2004)
DOI:10.1016/j.semcdb.2004.09.002
Reference
PMID:15551862
  Authors
Nakanishi H, Takai Y.
  Title
Roles of nectins in cell adhesion, migration and polarization.
  Journal
Biol Chem 385:885-92 (2004)
DOI:10.1515/BC.2004.116
Reference
PMID:15115723
  Authors
Siu MK, Cheng CY.
  Title
Extracellular matrix: recent advances on its role in junction dynamics in the seminiferous epithelium during spermatogenesis.
  Journal
Biol Reprod 71:375-91 (2004)
DOI:10.1095/biolreprod.104.028225
Reference
PMID:15056568
  Authors
Lee NP, Cheng CY.
  Title
Adaptors, junction dynamics, and spermatogenesis.
  Journal
Biol Reprod 71:392-404 (2004)
DOI:10.1095/biolreprod.104.027268
Reference
PMID:15728677
  Authors
Inagaki M, Irie K, Ishizaki H, Tanaka-Okamoto M, Morimoto K, Inoue E, Ohtsuka T, Miyoshi J, Takai Y.
  Title
Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development.
  Journal
Development 132:1525-37 (2005)
DOI:10.1242/dev.01697
Reference
PMID:12500939
  Authors
Marthiens V, Gavard J, Lambert M, Mege RM.
  Title
Cadherin-based cell adhesion in neuromuscular development.
  Journal
Biol Cell 94:315-26 (2002)
DOI:10.1016/S0248-4900(02)00005-9
Reference
PMID:15923648
  Authors
Krauss RS, Cole F, Gaio U, Takaesu G, Zhang W, Kang JS.
  Title
Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact.
  Journal
J Cell Sci 118:2355-62 (2005)
DOI:10.1242/jcs.02397
Related
pathway
rno04520  Adherens junction
rno04530  Tight junction
rno04610  Complement and coagulation cascades
rno04660  T cell receptor signaling pathway
rno04670  Leukocyte transendothelial migration
KO pathway
ko04514   

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