KEGG   PATHWAY: salp04115
Entry
salp04115                   Pathway                                
Name
p53 signaling pathway - Salvelinus sp. IW2-2015 (Arctic char)
Description
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
Class
Cellular Processes; Cell growth and death
Pathway map
salp04115  p53 signaling pathway
salp04115

Organism
Salvelinus sp. IW2-2015 (Arctic char) [GN:salp]
Gene
111949419  [KO:K10151]
111950059  [KO:K10141]
111950385  [KO:K10134]
111950504  [KO:K04451]
111950565  [KO:K06625]
111950739  [KO:K10147] [EC:3.1.3.16]
111951371  [KO:K10151]
111951443  [KO:K05459]
111951467  [KO:K06625]
111951781  [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
111951914  [KO:K02087] [EC:2.7.11.22 2.7.11.23]
111952088  [KO:K04390]
111952420  [KO:K04503]
111952772  [KO:K04506] [EC:2.3.2.27]
111953038  cd82; CD82 antigen [KO:K06509]
111953098  [KO:K10151]
111953485  [KO:K02161]
111953534  steap3; metalloreductase STEAP3 isoform X1 [KO:K10142] [EC:1.16.1.-]
111954325  [KO:K10141]
111954357  [KO:K10808] [EC:1.17.4.1]
111954968  [KO:K04451]
111955311  [KO:K02091] [EC:2.7.11.22]
111955442  [KO:K08738]
111955450  [KO:K04596]
111955569  [KO:K02084]
111955811  [KO:K02091] [EC:2.7.11.22]
111956075  [KO:K20394]
111956369  [KO:K10138]
111956730  cop1; E3 ubiquitin-protein ligase RFWD2 isoform X1 [KO:K10143] [EC:2.3.2.27]
111956905  [KO:K04398] [EC:3.4.22.61]
111957166  [KO:K04398] [EC:3.4.22.61]
111957285  [KO:K04402]
111957399  [KO:K04402]
111957639  [KO:K06641] [EC:2.7.11.1]
111957708  [KO:K10146]
111958098  [KO:K10144] [EC:2.3.2.27]
111958113  atm; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
111959114  [KO:K06626]
111959935  [KO:K04398] [EC:3.4.22.61]
111960314  [KO:K04451]
111960797  [KO:K10147] [EC:3.1.3.16]
111961105  [KO:K04402]
111961639  [KO:K05868]
111961653  [KO:K04402]
111961715  [KO:K04722]
111962614  [KO:K04726]
111962629  [KO:K10151]
111963231  [KO:K22744]
111963563  tp53i3; quinone oxidoreductase PIG3 isoform X1 [KO:K10133] [EC:1.-.-.-]
111963641  [KO:K04402]
111963642  [KO:K04402]
111963941  [KO:K04722]
111963995  [KO:K05868]
111964616  [KO:K04596]
111965048  [KO:K06626]
111965495  [KO:K02206] [EC:2.7.11.22]
111965632  [KO:K02089] [EC:2.7.11.22]
111965703  [KO:K10141]
111966353  [KO:K10148]
111966425  [KO:K04570]
111966826  [KO:K26543]
111967168  [KO:K10141]
111967172  [KO:K06625]
111967296  [KO:K02187] [EC:3.4.22.56]
111967778  [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
111968032  [KO:K10136]
111968762  [KO:K16857]
111968782  [KO:K22744]
111969046  [KO:K04570]
111969233  [KO:K02159]
111969265  [KO:K06626]
111969292  [KO:K04503]
111969305  [KO:K05868]
111969379  [KO:K21770]
111969874  [KO:K04570]
111970015  mdm4; protein Mdm4 isoform X1 [KO:K10127]
111970058  [KO:K10152]
111970063  [KO:K06625]
111970188  [KO:K02089] [EC:2.7.11.22]
111970190  [KO:K02089] [EC:2.7.11.22]
111970205  cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
111970595  [KO:K26543]
111971140  [KO:K08738]
111971187  [KO:K10138]
111971481  [KO:K10137]
111971873  [KO:K02159]
111972175  gtse1; G2 and S phase-expressed protein 1 [KO:K10129]
111972372  [KO:K04402]
111972586  rrm2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
111972691  [KO:K16857]
111972792  [KO:K02161]
111973951  [KO:K10146]
111974358  [KO:K04722]
111974408  [KO:K04503]
111974443  [KO:K10128]
111974694  [KO:K02187] [EC:3.4.22.56]
111974769  [KO:K04402]
111974802  [KO:K10144] [EC:2.3.2.27]
111974924  [KO:K06641] [EC:2.7.11.1]
111975063  [KO:K02159]
111975101  [KO:K06626]
111975361  zmat3; zinc finger matrin-type protein 3 isoform X1 [KO:K10137]
111975532  [KO:K08738]
111975582  [KO:K04398] [EC:3.4.22.61]
111975667  [KO:K04402]
111975846  gorab; RAB6-interacting golgin isoform X1 [KO:K19748]
111976109  [KO:K04402]
111976254  [KO:K26543]
111976406  [KO:K04399] [EC:3.4.22.62]
111976415  casp9; caspase-9 [KO:K04399] [EC:3.4.22.62]
111977137  [KO:K10128]
111977217  [KO:K04570]
111977286  [KO:K06509]
111978035  [KO:K10136]
111978075  [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
111978404  [KO:K10142] [EC:1.16.1.-]
111978426  [KO:K02087] [EC:2.7.11.22 2.7.11.23]
111978672  [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
111978817  [KO:K04390]
111978864  [KO:K04402]
111979022  [KO:K10138]
111979249  [KO:K04398] [EC:3.4.22.61]
111979409  [KO:K10143] [EC:2.3.2.27]
111979568  [KO:K04398] [EC:3.4.22.61]
111979635  [KO:K02161]
111980445  [KO:K02159]
111980805  [KO:K02159]
111981062  [KO:K02091] [EC:2.7.11.22]
111981113  [KO:K10141]
111981208  [KO:K02159]
111981701  [KO:K10134]
111982846  [KO:K05459]
112068596  [KO:K04402]
112068696  [KO:K02187] [EC:3.4.22.56]
112069286  [KO:K10141]
112069432  [KO:K08738]
112069670  [KO:K16857]
112069681  [KO:K04506] [EC:2.3.2.27]
112069817  [KO:K10145]
112069851  [KO:K04722]
112070040  [KO:K04503]
112070217  [KO:K10138]
112070227  [KO:K10145]
112070854  [KO:K03982]
112071093  [KO:K10135]
112071199  [KO:K10146]
112071513  [KO:K03982]
112071979  [KO:K10146]
112072446  [KO:K02084]
112073327  [KO:K10151]
112073440  [KO:K10135]
112073542  [KO:K21770]
112074890  ppp1r13l; relA-associated inhibitor [KO:K27356]
112075769  [KO:K06640] [EC:2.7.11.1]
112077473  ddb2; DNA damage-binding protein 2 [KO:K10140]
112078424  [KO:K02159]
112078930  mdm2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
112078987  chek1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
112080561  [KO:K16857]
112080804  aifm2; apoptosis-inducing factor 2 [KO:K22745]
Reference
PMID:16557269
  Authors
Levine AJ, Hu W, Feng Z.
  Title
The P53 pathway: what questions remain to be explored?
  Journal
Cell Death Differ 13:1027-36 (2006)
DOI:10.1038/sj.cdd.4401910
Reference
PMID:15838523
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
PMID:11747320
  Authors
Balint E E, Vousden KH.
  Title
Activation and activities of the p53 tumour suppressor protein.
  Journal
Br J Cancer 85:1813-23 (2001)
DOI:10.1054/bjoc.2001.2128
Reference
PMID:11313928
  Authors
Taylor WR, Stark GR.
  Title
Regulation of the G2/M transition by p53.
  Journal
Oncogene 20:1803-15 (2001)
DOI:10.1038/sj.onc.1204252
Reference
PMID:15116721
  Authors
Hofseth LJ, Hussain SP, Harris CC.
  Title
p53: 25 years after its discovery.
  Journal
Trends Pharmacol Sci 25:177-81 (2004)
DOI:10.1016/j.tips.2004.02.009
Reference
PMID:12505356
  Authors
Pietenpol JA, Stewart ZA.
  Title
Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.
  Journal
Toxicology 181-182:475-81 (2002)
DOI:10.1016/S0300-483X(02)00460-2
Reference
PMID:10714958
  Authors
Tokino T, Nakamura Y.
  Title
The role of p53-target genes in human cancer.
  Journal
Crit Rev Oncol Hematol 33:1-6 (2000)
DOI:10.1016/S1040-8428(99)00051-7
Reference
PMID:16697662
  Authors
Hermeking H, Benzinger A.
  Title
14-3-3 proteins in cell cycle regulation.
  Journal
Semin Cancer Biol 16:183-92 (2006)
DOI:10.1016/j.semcancer.2006.03.002
Reference
PMID:16915296
  Authors
Sherr CJ.
  Title
Divorcing ARF and p53: an unsettled case.
  Journal
Nat Rev Cancer 6:663-73 (2006)
DOI:10.1038/nrc1954
Reference
PMID:17409411
  Authors
Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ.
  Title
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
  Journal
Cancer Res 67:3043-53 (2007)
DOI:10.1158/0008-5472.CAN-06-4149
Reference
PMID:26037915
  Authors
Resnick-Silverman L, Manfredi JJ
  Title
Two Faces of SIVA.
  Journal
Cancer Discov 5:581-3 (2015)
DOI:10.1158/2159-8290.CD-15-0484
Reference
PMID:19584092
  Authors
Resch U, Schichl YM, Winsauer G, Gudi R, Prasad K, de Martin R
  Title
Siva1 is a XIAP-interacting protein that balances NFkappaB and JNK signalling to promote apoptosis.
  Journal
J Cell Sci 122:2651-61 (2009)
DOI:10.1242/jcs.049940
Reference
PMID:19240372
  Authors
Barkinge JL, Gudi R, Sarah H, Chu F, Borthakur A, Prabhakar BS, Prasad KV
  Title
The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis.
  Journal
J Carcinog 8:2 (2009)
DOI:10.4103/1477-3163.45389
Reference
PMID:12135761
  Authors
Ohiro Y, Garkavtsev I, Kobayashi S, Sreekumar KR, Nantz R, Higashikubo BT, Duffy SL, Higashikubo R, Usheva A, Gius D, Kley N, Horikoshi N
  Title
A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF).
  Journal
FEBS Lett 524:163-71 (2002)
DOI:10.1016/S0014-5793(02)03049-1
Reference
PMID:26646590
  Authors
Hu Y, Ge W, Wang X, Sutendra G, Zhao K, Dedeic Z, Slee EA, Baer C, Lu X
  Title
Caspase cleavage of iASPP potentiates its ability to inhibit p53 and NF-kappaB.
  Journal
Oncotarget 6:42478-90 (2015)
DOI:10.18632/oncotarget.6478
Related
pathway
salp04110  Cell cycle
salp04210  Apoptosis
salp04218  Cellular senescence
KO pathway
ko04115   

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