KEGG   PATHWAY: shr04720
Entry
shr04720                    Pathway                                
Name
Long-term potentiation - Sarcophilus harrisii (Tasmanian devil)
Description
Hippocampal long-term potentiation (LTP), a long-lasting increase in synaptic efficacy, is the molecular basis for learning and memory. Tetanic stimulation of afferents in the CA1 region of the hippocampus induces glutamate release and activation of glutamate receptors in dendritic spines. A large increase in [Ca2+]i resulting from influx through NMDA receptors leads to constitutive activation of CaM kinase II (CaM KII) . Constitutively active CaM kinase II phosphorylates AMPA receptors, resulting in potentiation of the ionic conductance of AMPA receptors. Early-phase LTP (E-LTP) expression is due, in part, to this phosphorylation of the AMPA receptor. It is hypothesized that postsynaptic Ca2+ increases generated through NMDA receptors activate several signal transduction pathways including the Erk/MAP kinase and cAMP regulatory pathways. The convergence of these pathways at the level of the CREB/CRE transcriptional pathway may increase expression of a family of genes required for late-phase LTP (L-LTP).
Class
Organismal Systems; Nervous system
Pathway map
shr04720  Long-term potentiation
shr04720

Other DBs
GO: 0048169
Organism
Sarcophilus harrisii (Tasmanian devil) [GN:shr]
Gene
100913231  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
100913241  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
100913337  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
100913697  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
100913731  [KO:K04345] [EC:2.7.11.11]
100913901  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
100913975  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
100915116  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
100915297  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X2 [KO:K04348] [EC:3.1.3.16]
100915481  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
100915526  KRAS; GTPase KRas isoform X1 [KO:K07827]
100916183  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
100916233  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
100916996  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X2 [KO:K04960]
100917281  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
100917396  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
100918408  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
100918427  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
100918532  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X7 [KO:K04958]
100918689  PPP3R1; calcineurin subunit B type 1 isoform X2 [KO:K06268]
100919608  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
100920008  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
100920135  RAP1B; ras-related protein Rap-1b [KO:K07836]
100920429  CALM2; calmodulin-2 [KO:K02183]
100920526  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
100920792  CAMK4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
100921187  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
100921270  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
100921899  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
100922193  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
100922600  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X3 [KO:K05208]
100922827  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
100922938  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
100923157  [KO:K04373] [EC:2.7.11.1]
100923450  PPP1R1A; protein phosphatase 1 regulatory subunit 1A isoform X2 [KO:K08050]
100923926  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
100924022  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
100924175  GRIA1; glutamate receptor 1 isoform X1 [KO:K05197]
100925046  CALML4; calmodulin-like protein 4 [KO:K02183]
100925807  RAPGEF3; rap guanine nucleotide exchange factor 3 isoform X1 [KO:K08014]
100926283  CREBBP; CREB-binding protein isoform X2 [KO:K04498] [EC:2.3.1.48]
100926323  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
100926503  [KO:K04850]
100927252  [KO:K07827]
100927884  GRIA2; glutamate receptor 2 isoform X1 [KO:K05198]
100928498  RPS6KA6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
100928986  NRAS; GTPase NRas [KO:K07828]
100929015  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
100929017  CALM1; calmodulin-1 isoform X2 [KO:K02183]
100929168  [KO:K02833]
100929360  [KO:K04345] [EC:2.7.11.11]
100929426  [KO:K07827]
100930570  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
100931566  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X4 [KO:K04373] [EC:2.7.11.1]
100931854  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X2 [KO:K04373] [EC:2.7.11.1]
100934049  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
100934183  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X2 [KO:K04345] [EC:2.7.11.11]
100934311  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
100934330  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100934801  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
100934917  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
100935134  CALM3; calmodulin-3 isoform X1 [KO:K02183]
100935202  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
100935225  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
100935403  RAP1A; ras-related protein Rap-1A isoform X2 [KO:K04353]
105750699  [KO:K02183]
111720153  GRIN2D; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2D [KO:K05212]
116419081  [KO:K02183]
116419913  HRAS; GTPase HRas [KO:K02833]
116422810  RPS6KA1; LOW QUALITY PROTEIN: ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
116423459  [KO:K02183]
116423460  [KO:K02183]
Compound
C00025  L-Glutamate
C00076  Calcium cation
C00165  Diacylglycerol
C00305  Magnesium cation
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
Reference
PMID:15652868
  Authors
Blitzer RD, Iyengar R, Landau EM.
  Title
Postsynaptic signaling networks: cellular cogwheels underlying long-term plasticity.
  Journal
Biol Psychiatry 57:113-9 (2005)
DOI:10.1016/j.biopsych.2004.02.031
Reference
PMID:10652548
  Authors
Soderling TR, Derkach VA.
  Title
Postsynaptic protein phosphorylation and LTP.
  Journal
Trends Neurosci 23:75-80 (2000)
DOI:10.1016/S0166-2236(99)01490-3
Reference
PMID:11378299
  Authors
Poser S, Storm DR.
  Title
Role of Ca2+-stimulated adenylyl cyclases in LTP and memory formation.
  Journal
Int J Dev Neurosci 19:387-94 (2001)
DOI:10.1016/S0736-5748(00)00094-0
Reference
PMID:15803158
  Authors
Xia Z, Storm DR.
  Title
The role of calmodulin as a signal integrator for synaptic plasticity.
  Journal
Nat Rev Neurosci 6:267-76 (2005)
DOI:10.1038/nrn1647
Reference
  Authors
Purves D, Augustine GJ (ed).
  Title
Neuroscience
  Journal
Sunderland, Mass.:Sinauer Associates (2004)
Reference
PMID:14715912
  Authors
Lynch MA.
  Title
Long-term potentiation and memory.
  Journal
Physiol Rev 84:87-136 (2004)
DOI:10.1152/physrev.00014.2003
Reference
PMID:15857686
  Authors
Kelly PT, Mackinnon RL 2nd, Dietz RV, Maher BJ, Wang J.
  Title
Postsynaptic IP3 receptor-mediated Ca2+ release modulates synaptic transmission in hippocampal neurons.
  Journal
Brain Res Mol Brain Res 135:232-48 (2005)
DOI:10.1016/j.molbrainres.2004.12.018
Reference
PMID:9697848
  Authors
Berridge MJ.
  Title
Neuronal calcium signaling.
  Journal
Neuron 21:13-26 (1998)
DOI:10.1016/S0896-6273(00)80510-3
Related
pathway
shr04010  MAPK signaling pathway
shr04020  Calcium signaling pathway
shr04724  Glutamatergic synapse
KO pathway
ko04720   

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