KEGG   PATHWAY: tfd03460
Entry
tfd03460                    Pathway                                
Name
Fanconi anemia pathway - Tachysurus fulvidraco (yellow catfish)
Description
The Fanconi anemia pathway is required for the efficient repair of damaged DNA, especially interstrand cross-links (ICLs). DNA ICL is directly recognized by FANCM and associated proteins, that recruit the FA core complex. The FA core complex monoubiquitinates FANCD2 and FANCI. The monoubiquitinated FANCD2/FANCI becomes an active form and interacts with a series of DNA repair proteins and facilitates downstream repair pathways. Fanconi anemia is caused by mutations in one of at least 13 FA genes and is characterized by congenital growth abnormalities, bone marrow failure and cancer predisposition.
Class
Genetic Information Processing; Replication and repair
Pathway map
tfd03460  Fanconi anemia pathway
tfd03460

Other DBs
GO: 0043240
Organism
Tachysurus fulvidraco (yellow catfish) [GN:tfd]
Gene
113635178  mus81; crossover junction endonuclease MUS81 [KO:K08991] [EC:3.1.22.-]
113636319  fancl; E3 ubiquitin-protein ligase FANCL [KO:K10606] [EC:2.3.2.27]
113637160  ercc4; DNA repair endonuclease XPF [KO:K10848] [EC:3.1.-.-]
113637163  pms2; mismatch repair endonuclease PMS2 isoform X2 [KO:K10858]
113637552  polk; DNA polymerase kappa [KO:K03511] [EC:2.7.7.7]
113638499  atr; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
113639035  faap100; Fanconi anemia core complex-associated protein 100 [KO:K10993]
113639051  [KO:K10905]
113639192  faap24; Fanconi anemia core complex-associated protein 24 [KO:K10898]
113639736  ercc1; DNA excision repair protein ERCC-1 [KO:K10849]
113640290  palb2; partner and localizer of BRCA2 isoform X1 [KO:K10897]
113640716  her6; hairy-related 6 [KO:K06054]
113641936  ube2t; ubiquitin-conjugating enzyme E2 T [KO:K13960] [EC:2.3.2.23]
113643024  cenps; centromere protein S [KO:K11511]
113643144  fancd2; Fanconi anemia group D2 protein [KO:K10891]
113643232  usp1; ubiquitin carboxyl-terminal hydrolase 1 isoform X1 [KO:K11832] [EC:3.4.19.12]
113643510  rpa1; replication protein A 70 kDa DNA-binding subunit [KO:K07466]
113643762  brip1; Fanconi anemia group J protein isoform X1 [KO:K15362] [EC:5.6.2.3]
113643970  top3a; DNA topoisomerase 3-alpha isoform X1 [KO:K03165] [EC:5.6.2.1]
113644060  wdr48b; WD repeat-containing protein 48 isoform X1 [KO:K15361]
113644653  rpa2; replication protein A 32 kDa subunit isoform X2 [KO:K10739]
113644688  wdr48a; WD repeat-containing protein 48a isoform X1 [KO:K15361]
113644866  telo2; telomere length regulation protein TEL2 homolog isoform X1 [KO:K11137]
113644982  mlh1; DNA mismatch repair protein Mlh1 isoform X1 [KO:K08734]
113648463  eme1; crossover junction endonuclease EME1 [KO:K10882] [EC:3.1.22.-]
113649412  brca2; breast cancer type 2 susceptibility protein isoform X1 [KO:K08775]
113650273  rad51c; DNA repair protein RAD51 homolog 3 [KO:K10870]
113651228  fancm; Fanconi anemia group M protein isoform X2 [KO:K10896]
113651700  rad51; DNA repair protein RAD51 homolog 1 isoform X1 [KO:K04482]
113651932  [KO:K10888]
113652558  blm; Bloom syndrome protein homolog isoform X1 [KO:K10901] [EC:5.6.2.4]
113652758  fan1; fanconi-associated nuclease 1 [KO:K15363] [EC:3.1.21.- 3.1.4.1]
113653296  top3b; DNA topoisomerase 3-beta-1 [KO:K03165] [EC:5.6.2.1]
113653324  fancg; Fanconi anemia group G protein [KO:K10894]
113654504  rev1; DNA repair protein REV1 isoform X3 [KO:K03515] [EC:2.7.7.-]
113654688  [KO:K10739]
113655222  polh; DNA polymerase eta [KO:K03509] [EC:2.7.7.7]
113656092  rmi1; recQ-mediated genome instability protein 1 [KO:K10990]
113656291  fance; Fanconi anemia group E protein [KO:K10892]
113656336  fancc; Fanconi anemia group C protein [KO:K10890]
113656755  poli; DNA polymerase iota isoform X1 [KO:K03510] [EC:2.7.7.7]
113657012  slx4; structure-specific endonuclease subunit SLX4 [KO:K10484]
113657593  slx1b; structure-specific endonuclease subunit SLX1 [KO:K15078] [EC:3.6.1.-]
113658083  her9; hairy-related 9 [KO:K06054]
113658991  rpa3; replication protein A 14 kDa subunit [KO:K10740]
113659242  cenpx; centromere protein X isoform X2 [KO:K15360]
113660018  fancf; Fanconi anemia group F protein [KO:K10893]
113660105  fanci; Fanconi anemia group I protein isoform X2 [KO:K10895]
113660402  rmi2; recQ-mediated genome instability protein 2 [KO:K15365]
113661149  rev3l; DNA polymerase zeta catalytic subunit isoform X2 [KO:K02350] [EC:2.7.7.7]
113662646  [KO:K10605] [EC:2.3.2.27]
113663116  poln; DNA polymerase nu [KO:K16618] [EC:2.7.7.7]
Reference
PMID:18047734
  Authors
Jacquemont C, Taniguchi T
  Title
The Fanconi anemia pathway and ubiquitin.
  Journal
BMC Biochem 8 Suppl 1:S10 (2007)
DOI:10.1186/1471-2091-8-S1-S10
Reference
PMID:19805513
  Authors
Bhagwat N, Olsen AL, Wang AT, Hanada K, Stuckert P, Kanaar R, D'Andrea A, Niedernhofer LJ, McHugh PJ
  Title
XPF-ERCC1 participates in the Fanconi anemia pathway of cross-link repair.
  Journal
Mol Cell Biol 29:6427-37 (2009)
DOI:10.1128/MCB.00086-09
Reference
PMID:21701511
  Authors
Deans AJ, West SC
  Title
DNA interstrand crosslink repair and cancer.
  Journal
Nat Rev Cancer 11:467-80 (2011)
DOI:10.1038/nrc3088
Reference
PMID:20064461
  Authors
Deans AJ, West SC
  Title
FANCM connects the genome instability disorders Bloom's Syndrome and Fanconi Anemia.
  Journal
Mol Cell 36:943-53 (2009)
DOI:10.1016/j.molcel.2009.12.006
Reference
PMID:20039786
  Authors
Muniandy PA, Liu J, Majumdar A, Liu ST, Seidman MM
  Title
DNA interstrand crosslink repair in mammalian cells: step by step.
  Journal
Crit Rev Biochem Mol Biol 45:23-49 (2010)
DOI:10.3109/10409230903501819
Reference
PMID:18518821
  Authors
Ciccia A, McDonald N, West SC
  Title
Structural and functional relationships of the XPF/MUS81 family of proteins.
  Journal
Annu Rev Biochem 77:259-87 (2008)
DOI:10.1146/annurev.biochem.77.070306.102408
Related
pathway
tfd03430  Mismatch repair
tfd03440  Homologous recombination
KO pathway
ko03460   

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