KEGG   PATHWAY: tfn05020
Entry
tfn05020                    Pathway                                
Name
Prion disease - Trachypithecus francoisi (Francois's langur)
Description
Prion diseases, also termed transmissible spongiform encephalopathies (TSEs), are a group of fatal neurodegenerative diseases that affect humans and a number of other animal species. The etiology of these diseases is thought to be associated with the conversion of a normal protein, PrPC, into an infectious, pathogenic form, PrPSc. The conversion is induced by prion infections (for example, variant Creutzfeldt-Jakob disease (vCJD), iatrogenic CJD, Kuru), mutations (familial CJD, Gerstmann-Straussler-Scheinker syndrome, fatal familial insomnia (FFI)) or unknown factors (sporadic CJD (sCJD)), and is thought to occur after PrPC has reached the plasma membrane or is re-internalized for degradation. The PrPSc form shows greater protease resistance than PrPC and accumulates in affected individuals, often in the form of extracellular plaques. Pathways that may lead to neuronal death comprise oxidative stress, regulated activation of complement, ubiquitin-proteasome and endosomal-lysosomal systems, synaptic alterations and dendritic atrophy, corticosteroid response, and endoplasmic reticulum stress. In addition, the conformational transition could lead to the lost of a beneficial activity of the natively folded protein, PrPC.
Class
Human Diseases; Neurodegenerative disease
Pathway map
tfn05020  Prion disease
tfn05020

Disease
H00061  Prion disease
Organism
Trachypithecus francoisi (Francois's langur) [GN:tfn]
Gene
117062157  [KO:K02128]
117062173  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
117062187  IL1A; interleukin-1 alpha [KO:K04383]
117062188  IL1B; interleukin-1 beta [KO:K04519]
117062240  [KO:K10881]
117062413  [KO:K02270]
117062944  [KO:K00235] [EC:1.3.5.1]
117063629  [KO:K03947]
117063944  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
117063948  [KO:K03957]
117064038  PSMA8; proteasome subunit alpha-type 8 isoform X1 [KO:K02731] [EC:3.4.25.1]
117064141  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial isoform X1 [KO:K03943] [EC:7.1.1.2]
117064172  TUBB6; tubulin beta-6 chain [KO:K07375]
117064180  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
117064660  [KO:K00234] [EC:1.3.5.1]
117064675  SDHA; LOW QUALITY PROTEIN: succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
117064676  [KO:K00234] [EC:1.3.5.1]
117064716  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
117064808  [KO:K07375]
117064943  [KO:K02272]
117065049  C9; complement component C9 [KO:K04000]
117065057  C7; complement component C7 isoform X1 [KO:K03996]
117065060  C6; LOW QUALITY PROTEIN: complement component C6 [KO:K03995]
117065109  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial isoform X1 [KO:K03937]
117065132  [KO:K02272]
117065203  [KO:K03938]
117065206  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
117065429  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
117065757  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
117065800  EGR1; early growth response protein 1 [KO:K09203]
117065867  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
117065879  [KO:K00418]
117066643  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
117066659  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
117067078  PSMD3; LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
117067104  [KO:K02272]
117067118  PSMB3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
117067177  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
117067390  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
117067435  PSMC5; 26S proteasome regulatory subunit 8 isoform X1 [KO:K03066]
117067484  CCL5; C-C motif chemokine 5 [KO:K12499]
117067543  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 isoform X1 [KO:K03036]
117067730  [KO:K02267]
117067872  PSMB6; proteasome subunit beta type-6 isoform X1 [KO:K02738] [EC:3.4.25.1]
117068009  [KO:K03960]
117068386  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
117068501  PRNP; major prion protein [KO:K05634]
117068593  CSNK2A1; casein kinase II subunit alpha isoform X1 [KO:K03097] [EC:2.7.11.1]
117068615  [KO:K02263]
117068693  [KO:K02272]
117069008  TUBB1; tubulin beta-1 chain [KO:K07375]
117069010  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
117069034  PSMA7; proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
117069039  ADRM1; proteasomal ubiquitin receptor ADRM1 isoform X1 [KO:K06691]
117069444  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
117069576  PSMA3; proteasome subunit alpha type-3 [KO:K02727] [EC:3.4.25.1]
117069640  PSMC6; 26S proteasome regulatory subunit 10B isoform X1 [KO:K03064]
117069703  [KO:K03963]
117069794  [KO:K03964]
117069813  PSMA6; proteasome subunit alpha type-6 isoform X1 [KO:K02730] [EC:3.4.25.1]
117069984  PSMB5; proteasome subunit beta type-5 isoform X1 [KO:K02737] [EC:3.4.25.1]
117070036  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
117070318  PSMA4; proteasome subunit alpha type-4 isoform X1 [KO:K02728] [EC:3.4.25.1]
117070355  [KO:K02264]
117070400  [KO:K02127]
117070928  [KO:K02272]
117070977  PSMB7; proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
117071124  RYR3; LOW QUALITY PROTEIN: ryanodine receptor 3 [KO:K04963]
117071177  [KO:K02136]
117071184  [KO:K03959]
117071291  [KO:K03960]
117071314  KLC1; kinesin light chain 1 isoform X1 [KO:K10407]
117071315  HSPA5; endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
117071500  [KO:K02273]
117071524  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
117071556  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
117071608  [KO:K02272]
117072292  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
117072298  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
117072332  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
117072476  [KO:K02272]
117072525  [KO:K08738]
117072588  NCF1; neutrophil cytosol factor 1 [KO:K08011]
117072720  [KO:K07374]
117072793  IL6; interleukin-6 isoform X1 [KO:K05405]
117072825  [KO:K08738]
117072944  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
117073003  [KO:K02263]
117073224  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
117073263  PSMA2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
117073294  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
117073439  CAV1; caveolin-1 isoform X1 [KO:K06278]
117073440  CAV2; caveolin-2 isoform X1 [KO:K12958]
117073578  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
117073672  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
117073751  [KO:K07374]
117074342  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236]
117074523  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
117074547  NCF2; neutrophil cytosol factor 2 isoform X1 [KO:K08010]
117074574  HSPA6; LOW QUALITY PROTEIN: heat shock 70 kDa protein 6 [KO:K03283]
117074655  TUBB4A; tubulin beta-4A chain [KO:K07375]
117074672  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X1 [KO:K03029]
117074969  [KO:K00236]
117074996  [KO:K02127]
117075022  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
117075139  [KO:K02187] [EC:3.4.22.56]
117075209  [KO:K03938]
117075323  [KO:K00420]
117075332  GRIN3B; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
117075478  [KO:K07375]
117075517  [KO:K03956]
117075518  [KO:K03956]
117075642  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
117075702  [KO:K02128]
117075723  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 isoform X1 [KO:K03956]
117075732  PSMA5; proteasome subunit alpha type-5 isoform X1 [KO:K02729] [EC:3.4.25.1]
117075856  [KO:K02126]
117075878  [KO:K02126]
117075932  PSMB4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
117076037  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial isoform X1 [KO:K02127]
117076186  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
117076189  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
117076305  ATP5F1D; ATP synthase subunit delta, mitochondrial [KO:K02134]
117076373  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial isoform X1 [KO:K03935] [EC:7.1.1.2]
117076540  RYR2; ryanodine receptor 2 isoform X1 [KO:K04962]
117076644  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 isoform X1 [KO:K11353]
117076663  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1 [KO:K03940] [EC:7.1.1.2]
117076742  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
117076746  [KO:K02271]
117076828  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
117076830  [KO:K03949]
117076850  LAMC1; laminin subunit gamma-1 [KO:K05635]
117077276  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
117077312  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
117077366  [KO:K02272]
117077518  CACNA1F; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
117077670  [KO:K03948]
117077892  [KO:K02272]
117077936  [KO:K05863]
117077947  [KO:K02272]
117078078  [KO:K02270]
117078337  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
117078522  [KO:K02271]
117078537  [KO:K21421] [EC:1.-.-.-]
117078869  [KO:K02268]
117078921  [KO:K08738]
117078953  [KO:K08738]
117079196  [KO:K03959]
117079239  [KO:K04565] [EC:1.15.1.1]
117079278  [KO:K07375]
117079304  [KO:K00413]
117079397  [KO:K00417]
117079542  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
117079868  [KO:K08738]
117079881  NCAM1; neural cell adhesion molecule 1 isoform X1 [KO:K06491]
117079895  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
117079974  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
117080186  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial isoform X1 [KO:K03936] [EC:7.1.1.2]
117080413  PSMC3; 26S proteasome regulatory subunit 6A [KO:K03065]
117080458  [KO:K03061]
117080478  KLC2; kinesin light chain 2 [KO:K10407]
117080612  BAD; bcl2-associated agonist of cell death [KO:K02158]
117080617  STIP1; stress-induced-phosphoprotein 1 isoform X1 [KO:K09553]
117080679  [KO:K02272]
117080718  [KO:K08738]
117080779  [KO:K03062]
117080933  [KO:K00414]
117080942  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X1 [KO:K03941] [EC:7.1.1.2]
117081005  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
117081060  [KO:K02273]
117081344  [KO:K02266]
117081555  PSMA1; proteasome subunit alpha type-1 isoform X1 [KO:K02725] [EC:3.4.25.1]
117081557  [KO:K08738]
117081565  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
117081580  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 isoform X1 [KO:K03039]
117081585  [KO:K02273]
117082093  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial isoform X1 [KO:K09565] [EC:5.2.1.8]
117082220  [KO:K02738] [EC:3.4.25.1]
117082240  [KO:K02128]
117082326  [KO:K03948]
117082443  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
117082510  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
117082599  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
117082738  KIF5B; kinesin-1 heavy chain [KO:K10396]
117082746  VDAC2; voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15040]
117082784  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
117082864  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
117082999  PRKCD; protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
117083004  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
117083033  [KO:K08738]
117083084  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 isoform X1 [KO:K03037]
117083173  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
117083193  CAV3; caveolin-3 [KO:K12959]
117083313  [KO:K02187] [EC:3.4.22.56]
117083450  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
117083458  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
117083761  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
117083769  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform X1 [KO:K03961]
117083822  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
117084122  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
117084391  [KO:K03949]
117084440  [KO:K03960]
117084476  [KO:K02726] [EC:3.4.25.1]
117084498  [KO:K07375]
117084835  [KO:K07374]
117084864  [KO:K02272]
117085362  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
117085388  [KO:K02138]
117085400  [KO:K02265]
117085655  [KO:K02271]
117085754  [KO:K04392]
117085890  SLC25A31; ADP/ATP translocase 4 isoform X1 [KO:K05863]
117085925  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
117086072  [KO:K11351]
117086196  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
117086204  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
117086238  [KO:K07375]
117086624  TUBB2A; tubulin beta-2A chain [KO:K07375]
117086685  [KO:K03283]
117086926  TNF; tumor necrosis factor isoform X1 [KO:K03156]
117086944  CSNK2B; casein kinase II subunit beta isoform X1 [KO:K03115]
117086963  HSPA1A; LOW QUALITY PROTEIN: heat shock 70 kDa protein 1A [KO:K03283]
117086964  HSPA1L; heat shock 70 kDa protein 1-like [KO:K03283]
117086987  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
117087057  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
117087120  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
117087121  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
117087240  KLC4; kinesin light chain 4 [KO:K10407]
117087463  [KO:K02270]
117087492  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
117087515  [KO:K00415]
117087546  [KO:K07374]
117087606  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
117087695  [KO:K03947]
117087707  [KO:K02266]
117087739  [KO:K02728] [EC:3.4.25.1]
117087870  CSNK2A2; casein kinase II subunit alpha' isoform X1 [KO:K03097] [EC:2.7.11.1]
117087884  [KO:K02137]
117087981  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
117088155  [KO:K02263]
117088204  [KO:K08009]
117088263  [KO:K07375]
117088384  TUBB; tubulin beta chain [KO:K07375]
117088583  [KO:K10407]
117088659  [KO:K02272]
117089263  PSMD9; 26S proteasome non-ATPase regulatory subunit 9 [KO:K06693]
117089300  [KO:K02266]
117089559  [KO:K02734] [EC:3.4.25.1]
117089565  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
117089604  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 isoform X1 [KO:K11352]
117089611  [KO:K03945]
117089867  KIF5A; kinesin heavy chain [KO:K10396]
117089884  DDIT3; DNA damage-inducible transcript 3 protein isoform X1 [KO:K04452]
117089896  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
117089918  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
117090028  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial isoform X1 [KO:K02128]
117090172  [KO:K07374]
117090173  TUBA1C; tubulin alpha-1C chain [KO:K07374]
117090175  [KO:K07374]
117090367  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
117090480  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
117090671  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
117090701  [KO:K04850]
117091396  KLC3; kinesin light chain 3 isoform X1 [KO:K10407]
117091505  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
117091541  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
117091738  [KO:K02267]
117091974  C8A; complement component C8 alpha chain [KO:K03997]
117091975  C8B; complement component C8 beta chain [KO:K03998]
117092025  [KO:K00411] [EC:7.1.1.8]
117092158  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
117092233  [KO:K03948]
117092255  [KO:K00411] [EC:7.1.1.8]
117092366  [KO:K02267]
117092474  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
117092481  RYR1; ryanodine receptor 1 [KO:K04961]
117092536  PSMC4; 26S proteasome regulatory subunit 6B [KO:K03063]
117092657  [KO:K00416]
117092662  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
117092766  [KO:K00236]
117092829  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 isoform X1 [KO:K03938]
117092898  PSMB2; proteasome subunit beta type-2 [KO:K02734] [EC:3.4.25.1]
117093154  C1QB; complement C1q subcomponent subunit B [KO:K03987]
117093155  C1QC; complement C1q subcomponent subunit C isoform X1 [KO:K03988]
117093156  C1QA; complement C1q subcomponent subunit A [KO:K03986]
117093179  [KO:K02272]
117093193  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
117093237  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial isoform X1 [KO:K00235] [EC:1.3.5.1]
117093253  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
117093348  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
117093380  [KO:K08738]
117093644  [KO:K03955]
117093658  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 isoform X1 [KO:K03947]
117093839  [KO:K02272]
117094305  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform X1 [KO:K03954]
117094392  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
117094495  [KO:K07374]
117094598  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
117094614  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial isoform X1 [KO:K03934] [EC:7.1.1.2]
117094831  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
117094833  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
117094952  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
117095022  KIF5C; kinesin heavy chain [KO:K10396]
117095055  [KO:K02137]
117095227  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
117095317  [KO:K02735] [EC:3.4.25.1]
117095320  [KO:K03948]
117095431  [KO:K02272]
117095616  NCAM2; neural cell adhesion molecule 2 isoform X1 [KO:K06491]
117095627  ATP5PF; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
117095682  [KO:K03062]
117095687  SOD1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
117095688  [KO:K00417]
117095701  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
117095725  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
117095749  [KO:K02270]
117095835  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
117095969  NCF4; neutrophil cytosol factor 4 isoform X1 [KO:K08012]
117096062  TUBA8; tubulin alpha-8 chain isoform X1 [KO:K07374]
117096163  [KO:K00419]
117096273  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
117096276  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
117096387  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
117096463  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
117096477  [KO:K02265]
117096627  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
117096655  [KO:K03946]
117096842  [KO:K08738]
117096846  PSMB1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
117096942  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
117097361  [KO:K03949]
117097668  [KO:K05209]
117097828  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
117097957  [KO:K08738]
117098307  [KO:K05862]
117098492  [KO:K08738]
117098498  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
117098684  [KO:K03037]
117098709  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 isoform X1 [KO:K03962]
117098726  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 isoform X1 [KO:K03952]
117098742  C5; complement C5 isoform X1 [KO:K03994]
117098894  GRIN3A; glutamate receptor ionotropic, NMDA 3A isoform X1 [KO:K05213]
117098896  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
117099006  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
117099070  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
117099095  TUBB4B; tubulin beta-4B chain [KO:K07375]
117099100  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
117099134  C8G; complement component C8 gamma chain [KO:K03999]
117099151  NOTCH1; neurogenic locus notch homolog protein 1 [KO:K02599]
117099374  [KO:K07375]
117099609  [KO:K02265]
117099768  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
117099787  [KO:K02128]
18985073  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
18985074  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
18985075  COX2; cytochrome c oxidase subunit II [KO:K02261]
18985076  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
18985077  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
18985078  COX3; cytochrome c oxidase subunit III [KO:K02262]
18985079  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
18985080  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
18985081  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
18985082  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
18985083  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
18985084  CYTB; cytochrome b [KO:K00412]
18985085  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00575  3',5'-Cyclic AMP
C00704  Superoxide
C02140  Corticosterone
Reference
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Expert Rev Mol Med 18:e5 (2016)
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Reference
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Reference
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Almost a century of prion protein(s): From pathology to physiology, and back to pathology.
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Molecular mechanisms of neurodegeneration mediated by dysfunctional subcellular organelles in transmissible spongiform encephalopathies.
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Reference
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Reference
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Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD.
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Reference
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Reference
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Reference
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Reference
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Understanding the neurospecificity of Prion protein signaling.
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Front Biosci (Landmark Ed) 16:169-86 (2011)
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Reference
PMID:23479001
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  Title
Prion protein and its role in signal transduction.
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Cell Mol Biol Lett 18:209-30 (2013)
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Reference
PMID:28507517
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  Title
The Role of Unfolded Protein Response and Mitogen-Activated Protein Kinase Signaling in Neurodegenerative Diseases with Special Focus on Prion Diseases.
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Front Aging Neurosci 9:120 (2017)
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Reference
PMID:15528202
  Authors
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  Title
Pathological prion protein exposure switches on neuronal mitogen-activated protein kinase pathway resulting in microglia recruitment.
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J Biol Chem 280:1529-34 (2005)
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Reference
PMID:15640354
  Authors
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  Title
Notch-1 activation and dendritic atrophy in prion disease.
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Proc Natl Acad Sci U S A 102:886-91 (2005)
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Reference
PMID:20205843
  Authors
Dearmond SJ, Bajsarowicz K
  Title
PrPSc accumulation in neuronal plasma membranes links Notch-1 activation to dendritic degeneration in prion diseases.
  Journal
Mol Neurodegener 5:6 (2010)
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Reference
PMID:29998397
  Authors
Hirsch TZ, Martin-Lanneree S, Reine F, Hernandez-Rapp J, Herzog L, Dron M, Privat N, Passet B, Halliez S, Villa-Diaz A, Lacroux C, Klein V, Haik S, Andreoletti O, Torres JM, Vilotte JL, Beringue V, Mouillet-Richard S
  Title
Epigenetic Control of the Notch and Eph Signaling Pathways by the Prion Protein: Implications for Prion Diseases.
  Journal
Mol Neurobiol 56:2159-2173 (2019)
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Reference
PMID:28714865
  Authors
Aguzzi A, Zhu C
  Title
Microglia in prion diseases.
  Journal
J Clin Invest 127:3230-3239 (2017)
DOI:10.1172/JCI90605
Reference
PMID:15342004
  Authors
Mabbott NA
  Title
The complement system in prion diseases.
  Journal
Curr Opin Immunol 16:587-93 (2004)
DOI:10.1016/j.coi.2004.07.002
Reference
PMID:15611724
  Authors
Mallucci G, Collinge J
  Title
Rational targeting for prion therapeutics.
  Journal
Nat Rev Neurosci 6:23-34 (2005)
DOI:10.1038/nrn1584
Related
pathway
tfn00190  Oxidative phosphorylation
tfn03050  Proteasome
tfn04020  Calcium signaling pathway
tfn04140  Autophagy - animal
tfn04141  Protein processing in endoplasmic reticulum
tfn04142  Lysosome
tfn04144  Endocytosis
tfn04210  Apoptosis
tfn04330  Notch signaling pathway
tfn04610  Complement and coagulation cascades
tfn04668  TNF signaling pathway
KO pathway
ko05020   

DBGET integrated database retrieval system