KEGG   PATHWAY: xtr04115
Entry
xtr04115                    Pathway                                
Name
p53 signaling pathway - Xenopus tropicalis (tropical clawed frog)
Description
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
Class
Cellular Processes; Cell growth and death
Pathway map
xtr04115  p53 signaling pathway
xtr04115

Organism
Xenopus tropicalis (tropical clawed frog) [GN:xtr]
Gene
100490767  atm; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
100144952  chek2; serine/threonine-protein kinase Chk2 [KO:K06641] [EC:2.7.11.1]
100495593  atr; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
100038224  chek1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
100485483  gorab; RAB6-interacting golgin isoform X1 [KO:K19748]
394853  mdm2; E3 ubiquitin-protein ligase Mdm2 isoform 1 [KO:K06643] [EC:2.3.2.27]
100216294  mdm4; protein Mdm4 [KO:K10127]
431679  tp53; cellular tumor antigen p53 [KO:K04451]
733947  ppp1r13l; relA-associated inhibitor [KO:K27356]
100038054  cdkn1a; cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
448045  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
548862  ccndx; cyclin Dx [KO:K04503]
100038071  ccnd2; G1/S-specific cyclin-D2 [KO:K10151]
549496  cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
100489734  cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
549082  ccne1; G1/S-specific cyclin-E1 [KO:K06626]
549021  ccne2; G1/S-specific cyclin-E2 [KO:K06626]
493498  cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
100135025  rprm; reprimo, TP53 dependent G2 arrest mediator homolog [KO:K10128]
394726  ccnb1.2; cyclin B1 [KO:K05868]
100101736  ccnb1; G2/mitotic-specific cyclin-B1 [KO:K05868]
100270772  ccnb2; cyclin B2 [KO:K21770]
394448  cyclin B5 [KO:K21770]
394503  cdk1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
448442  gadd45g; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
548905  gadd45a; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
100487013  gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
448634  gtse1; G2 and S phase-expressed protein 1 [KO:K10129]
100492172  znf385a; zinc finger protein 385A isoform X2 [KO:K26543]
100124750  fas; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390]
100488788  pidd1; p53-induced death domain-containing protein 1 isoform X1 [KO:K10130]
448240  tnfrsf10b; tumor necrosis factor receptor superfamily member 10A precursor [KO:K04722]
100495471  casp8; caspase-8 [KO:K04398] [EC:3.4.22.61]
100036674  bid; BH3 interacting domain death agonist [KO:K04726]
394793  bax; apoptosis regulator BAX [KO:K02159]
733962  siva1; apoptosis regulatory protein Siva [KO:K22744]
447991  bcl2l1; BCL2 like 1 [KO:K04570]
100485267  bcl2; apoptosis regulator Bcl-2 [KO:K02161]
779670  tp53i3; quinone oxidoreductase PIG3 [KO:K10133] [EC:1.-.-.-]
549941  ei24; etoposide-induced protein 2.4 homolog [KO:K10134]
548916  perp; p53 apoptosis effector related to PMP-22 isoform 1 [KO:K10136]
549898  zmat3; zinc finger matrin-type protein 3 [KO:K10137]
548553  siah1; E3 ubiquitin-protein ligase SIAH1 [KO:K04506] [EC:2.3.2.27]
493538  cyct; cytochrome c, somatic [KO:K08738]
394490  cycs; cytochrome c, testis-specific [KO:K08738]
100127738  apaf1; apoptotic protease-activating factor 1 [KO:K02084]
100144708  casp9; caspase-9 [KO:K04399] [EC:3.4.22.62]
100151728  casp3.2; caspase-3 [KO:K02187] [EC:3.4.22.56]
100486222  casp3.1; caspase-3 isoform X2 [KO:K02187] [EC:3.4.22.56]
100216030  aifm2; apoptosis-inducing factor 2 [KO:K22745]
100486334  igf1; insulin-like growth factor I [KO:K05459]
100127732  serpine1; plasminogen activator inhibitor 1 [KO:K03982]
100492219  adgrb1; adhesion G protein-coupled receptor B1 isoform X5 [KO:K04596]
394799  cd82; CD82 antigen [KO:K06509]
100170153  thbs1; thrombospondin-1 [KO:K16857]
496735  serpinb5; serpin B5 [KO:K10139]
493565  ddb2; DNA damage-binding protein 2 [KO:K10140]
394645  rrm2.1; ribonucleotide reductase M2, gene 1 [KO:K10808] [EC:1.17.4.1]
493274  rrm2.2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
100144925  rrm2b; ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
100170187  sesn1; sestrin-1 [KO:K10141]
100038137  sesn3; sestrin-3 [KO:K10141]
733499  sesn2; sestrin-2 [KO:K20394]
100144716  pten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
100170546  tsc2; tuberin [KO:K07207]
100496101  steap3; metalloreductase STEAP3 isoform X1 [KO:K10142] [EC:1.16.1.-]
548953  cop1; E3 ubiquitin-protein ligase COP1 [KO:K10143] [EC:2.3.2.27]
496979  rchy1; RING finger and CHY zinc finger domain-containing protein 1 [KO:K10144] [EC:2.3.2.27]
448326  ccng1; cyclin-G1 [KO:K10145]
549201  ccng2; cyclin-G2 [KO:K10146]
100489786  ppm1d; protein phosphatase 1D [KO:K10147] [EC:3.1.3.16]
100496308  tp73; tumor protein p73 isoform X1 [KO:K10148]
Reference
PMID:16557269
  Authors
Levine AJ, Hu W, Feng Z.
  Title
The P53 pathway: what questions remain to be explored?
  Journal
Cell Death Differ 13:1027-36 (2006)
DOI:10.1038/sj.cdd.4401910
Reference
PMID:15838523
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
PMID:11747320
  Authors
Balint E E, Vousden KH.
  Title
Activation and activities of the p53 tumour suppressor protein.
  Journal
Br J Cancer 85:1813-23 (2001)
DOI:10.1054/bjoc.2001.2128
Reference
PMID:11313928
  Authors
Taylor WR, Stark GR.
  Title
Regulation of the G2/M transition by p53.
  Journal
Oncogene 20:1803-15 (2001)
DOI:10.1038/sj.onc.1204252
Reference
PMID:15116721
  Authors
Hofseth LJ, Hussain SP, Harris CC.
  Title
p53: 25 years after its discovery.
  Journal
Trends Pharmacol Sci 25:177-81 (2004)
DOI:10.1016/j.tips.2004.02.009
Reference
PMID:12505356
  Authors
Pietenpol JA, Stewart ZA.
  Title
Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.
  Journal
Toxicology 181-182:475-81 (2002)
DOI:10.1016/S0300-483X(02)00460-2
Reference
PMID:10714958
  Authors
Tokino T, Nakamura Y.
  Title
The role of p53-target genes in human cancer.
  Journal
Crit Rev Oncol Hematol 33:1-6 (2000)
DOI:10.1016/S1040-8428(99)00051-7
Reference
PMID:16697662
  Authors
Hermeking H, Benzinger A.
  Title
14-3-3 proteins in cell cycle regulation.
  Journal
Semin Cancer Biol 16:183-92 (2006)
DOI:10.1016/j.semcancer.2006.03.002
Reference
PMID:16915296
  Authors
Sherr CJ.
  Title
Divorcing ARF and p53: an unsettled case.
  Journal
Nat Rev Cancer 6:663-73 (2006)
DOI:10.1038/nrc1954
Reference
PMID:17409411
  Authors
Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ.
  Title
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
  Journal
Cancer Res 67:3043-53 (2007)
DOI:10.1158/0008-5472.CAN-06-4149
Reference
PMID:26037915
  Authors
Resnick-Silverman L, Manfredi JJ
  Title
Two Faces of SIVA.
  Journal
Cancer Discov 5:581-3 (2015)
DOI:10.1158/2159-8290.CD-15-0484
Reference
PMID:19584092
  Authors
Resch U, Schichl YM, Winsauer G, Gudi R, Prasad K, de Martin R
  Title
Siva1 is a XIAP-interacting protein that balances NFkappaB and JNK signalling to promote apoptosis.
  Journal
J Cell Sci 122:2651-61 (2009)
DOI:10.1242/jcs.049940
Reference
PMID:19240372
  Authors
Barkinge JL, Gudi R, Sarah H, Chu F, Borthakur A, Prabhakar BS, Prasad KV
  Title
The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis.
  Journal
J Carcinog 8:2 (2009)
DOI:10.4103/1477-3163.45389
Reference
PMID:12135761
  Authors
Ohiro Y, Garkavtsev I, Kobayashi S, Sreekumar KR, Nantz R, Higashikubo BT, Duffy SL, Higashikubo R, Usheva A, Gius D, Kley N, Horikoshi N
  Title
A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF).
  Journal
FEBS Lett 524:163-71 (2002)
DOI:10.1016/S0014-5793(02)03049-1
Reference
PMID:26646590
  Authors
Hu Y, Ge W, Wang X, Sutendra G, Zhao K, Dedeic Z, Slee EA, Baer C, Lu X
  Title
Caspase cleavage of iASPP potentiates its ability to inhibit p53 and NF-kappaB.
  Journal
Oncotarget 6:42478-90 (2015)
DOI:10.18632/oncotarget.6478
Related
pathway
xtr04110  Cell cycle
xtr04210  Apoptosis
xtr04218  Cellular senescence
KO pathway
ko04115   
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