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Entry |
Name |
Definition |
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N00001
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EGF-EGFR-RAS-ERK signaling pathway
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EGF → EGFR → GRB2 → SOS → RAS → RAF → MEK → ERK → CCND1
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N00002
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BCR-ABL fusion kinase to RAS-ERK signaling pathway
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BCR-ABL → GRB2 → SOS → RAS → RAF → MEK → ERK
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N00003
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Mutation-activated KIT to RAS-ERK signaling pathway
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KIT* → GRB2 → SOS → RAS → RAF → MEK → ERK
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N00004
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Duplication or mutation-activated FLT3 to RAS-ERK signaling pathway
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FLT3* → GRB2 → SOS → RAS → RAF → MEK → ERK
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N00005
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Mutation-activated MET to RAS-ERK signaling pathway
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MET* → GRB2 → SOS → RAS → RAF → MEK → ERK → CCND1
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N00006
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Amplified EGFR to RAS-ERK signaling pathway
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EGFR* → GRB2 → SOS → RAS → RAF → MEK → ERK
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N00007
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EML4-ALK fusion kinase to RAS-ERK signaling pathway
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EML4-ALK → RAS → RAF → MEK → ERK → CCND1
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N00008
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RET fusion kinase to RAS-ERK signaling pathway
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RET* → RAS → RAF → MEK → ERK
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N00009
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TRK fusion kinase to RAS-ERK signaling pathway
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TRK* → RAS → RAF → MEK → ERK
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N00010
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Mutation-inactivated PTCH1 to Hedgehog signaling pathway
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PTCH1* ⌿ SMO → (SUFU+KIF7) ⌿ GLI ⇒ (BMP2/4,HHIP,GLI1,PTCH,WNT)
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N00011
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Mutation-activated FGFR3 to RAS-ERK signaling pathway
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FGFR3* → GRB2 → SOS → RAS → RAF → MEK → ERK → MSK1 → MYC
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N00012
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Mutation-activated KRAS/NRAS to ERK signaling pathway
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(KRAS*,NRAS*) → RAF → MEK → ERK → CCND1
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N00013
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Mutation-activated BRAF to ERK signaling pathway
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BRAF* → MEK → ERK
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N00014
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Mutation-activated EGFR to RAS-ERK signaling pathway
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EGFR* → GRB2 → SOS → RAS → RAF → MEK → ERK → CCND1
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N00015
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PDGF-PDGFR-RAS-ERK signaling pathway
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PDGF → PDGFR → GRB2 → SOS → RAS → RAF → MEK → ERK
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N00016
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PDGF-overexpression to RAS-ERK signaling pathway
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PDGF* → PDGFR → GRB2 → SOS → RAS → RAF → MEK → ERK
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N00017
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Mutation-activated SMO to Hedgehog signaling pathway
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SMO* → (SUFU+KIF7) ⌿ GLI ⇒ (BMP2/4,HHIP,GLI1,PTCH,WNT)
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N00018
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Amplified PDGFR to RAS-ERK signaling pathway
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PDGFR* → GRB2 → SOS → RAS → RAF → MEK → ERK
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N00019
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FGF-FGFR-RAS-ERK signaling pathway
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FGF → FGFR → GRB2 → SOS → RAS → RAF → MEK → ERK
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N00020
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Amplified FGFR to RAS-ERK signaling pathway
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FGFR* → GRB2 → SOS → RAS → RAF → MEK → ERK
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N00021
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EGF-ERBB2-RAS-ERK signaling pathway
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EGF → (ERBB2+EGFR) → GRB2 → SOS → RAS → RAF → MEK → ERK
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N00022
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ERBB2-overexpression to RAS-ERK signaling pathway
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EGF → (ERBB2*+EGFR) → GRB2 → SOS → RAS → RAF → MEK → ERK
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N00023
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EGF-EGFR-PLCG-ERK signaling pathway
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EGF → EGFR → PLCG → IP3 → (Ca2+,DAG) → PKC → RAF → MEK → ERK → CCND1
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N00024
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Mutation-activated EGFR to PLCG-ERK signaling pathway
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EGFR* → PLCG → IP3 → (Ca2+,DAG) → PKC → RAF → MEK → ERK → CCND1
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N00025
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EML4-ALK fusion kinase to PLCG-ERK signaling pathway
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EML4-ALK → PLCG → IP3 → (Ca2+,DAG) → PKC → RAF → MEK → ERK → CCND1
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N00026
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EGF-EGFR-PLCG-CAMK signaling pathway
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EGF → EGFR → PLCG → IP3 → Ca2+ → CALM == CAMK
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N00027
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Amplified EGFR to PLCG-CAMK signaling pathway
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EGFR* → PLCG → IP3 → Ca2+ → CALM == CAMK
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N00028
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PDGF-PDGFR-PLCG-CAMK signaling pathway
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PDGF → PDGFR → PLCG → IP3 → Ca2+ → CALM == CAMK
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N00029
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Amplified PDGFR to PLCG-CAMK signaling pathway
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PDGFR* → PLCG → IP3 → Ca2+ → CALM == CAMK
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N00030
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EGF-EGFR-RAS-PI3K signaling pathway
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EGF → EGFR → GRB2 → SOS → RAS → PI3K → PIP3 → AKT ⊣ BAD
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N00031
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Duplication or mutation-activated FLT3 to RAS-PI3K signaling pathway
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FLT3* → GRB2 → SOS → RAS → PI3K → PIP3 → AKT ⊣ BAD
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N00032
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Mutation-activated KRAS/NRAS to PI3K signaling pathway
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(KRAS*,NRAS*) → PI3K → PIP3 → AKT ⊣ BAD
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N00033
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EGF-EGFR-PI3K signaling pathway
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EGF → EGFR → PI3K → PIP3 → AKT ⊣ BAD
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N00034
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ERBB2-overexpression to PI3K signaling pathway
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EGF → (ERBB2*+EGFR) → PI3K → PIP3 → AKT → MTOR → S6K
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N00035
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Amplified EGFR to PI3K signaling pathway
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EGFR* → PI3K → PIP3 → AKT → MTOR
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N00036
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Mutation-activated EGFR to PI3K signaling pathway
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EGFR* → PI3K → PIP3 → AKT ⊣ BAD
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N00037
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FGF-FGFR-PI3K signaling pathway
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FGF → FGFR → PI3K → PIP3 → AKT → MTOR → S6K
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N00038
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Amplified FGFR to PI3K signaling pathway
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FGFR* → PI3K → PIP3 → AKT → MTOR
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N00039
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PDGF-PDGFR-PI3K signaling pathway
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PDGF → PDGFR → PI3K → PIP3 → AKT → MTOR → S6K
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N00040
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Amplified PDGFR to PI3K signaling pathway
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PDGFR* → PI3K → PIP3 → AKT → MTOR
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