KEGG    Network variation - TCR/BCR signaling
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ENTRYnt06537
NameTCR/BCR signaling
CategoryPathway view; Immune system
Pathwayhsa04660 T cell receptor signaling pathway
hsa04662 B cell receptor signaling pathway
DiseaseH02526 Disorders of adaptive immunity
Display drug-target relation   disease type
N01106    (TCR+CD3+CD4)→(LCK,FYN,ZAP70)→(SLP76+GADS+LAT+VA..→PLCG→IP3→ITPR→Ca2+(cyto)
    IMD17/18/19/25 CD3*
    IMD79 CD4*
    IMD22   LCK*
    IMD48/ADMIO2   ZAP70*
    IMD81     SLP76*
    IMD52     LAT*
    IMD132           ITPR3*↗
N01107    Yersinia YopH⊣LCK
N01108    Yersinia   YopH⊣(SLP76,LAT,VAV)
 
N01696      ICOSLG→ICOS→PI3Kdelta→PIP3→AKT
    CVID1     ICOS*
N00683      (CD80,CD86)→CD28→PI3K→PIP3→AKT⊣GSK3B
    IMD123     CD28*
N00684    MV   (F,H)→CBLB⊣PI3K
   D1
 |		    
N01165    (PDL1,PDL2)→PDCD1→SHP1/2⊣PI3Kdelta
    ADMIO4   PDCD1*
N01579        (CD80,CD86)→CTLA4→PP2A⊣AKT
    SLE/ALPS5/HT       CTLA4*
 
N00487    IGH→(LYN,SYK)→(BTK,BLNK)→PLCG2→IP3→Ca2+→CALM=CN→NFAT
    IMD82   SYK*↗
    AGMX1/IGHD3     BTK*
    AGM4     BLNK*
    APLAID/FCAS3       PLCG2*↗
N00488    (LMP2A+NEDD4)⊣(LYN,SYK)
N00490    HTLV-1       P12=(CALR,CANX)→Ca2+
 
N01695    IGH→(LYN,SYK)→(PIK3AP1,(CD19+CD2..→PI3Kdelta→PIP3→AKT
    IMD82   SYK*↗
    CVID3     CD19*
    CVID7     CR2*
    CVID6     CD81*
    APDS/IMD14       PIK3CD*↗
    ROCHIS       PIK3CD*
    APDS2       PIK3R1*↗
    SHORT/AGM7       PIK3R1*

Disease nameDisease category
IMD17/18/19/25H00091T-B+Severe combined immunodeficiencyPrimary immunodeficiency
H00093Combined immunodeficiencyPrimary immunodeficiency
IMD79H02526Disorders of adaptive immunityImmune system disease
IMD22H00093Combined immunodeficiencyPrimary immunodeficiency
IMD48/ADMIO2H00093Combined immunodeficiencyPrimary immunodeficiency
H02540Infantile-onset multisystem autoimmune diseaseImmune system disease
IMD81H02526Disorders of adaptive immunityImmune system disease
IMD52H02526Disorders of adaptive immunityImmune system disease
IMD132H00093Combined immunodeficiencyPrimary immunodeficiency
YersiniaH00297PlagueBacterial infectious disease
H00298YersiniosisBacterial infectious disease
CVID1H00088Common variable immunodeficiencyImmune system disease
IMD123H02526Disorders of adaptive immunityImmune system disease
MVH00394MeaslesViral infectious disease
ADMIO4H02540Infantile-onset multisystem autoimmune diseaseImmune system disease
SLE/ALPS5/HTH00080Systemic lupus erythematosusImmune system disease
H00108Autoimmune lymphoproliferative syndromesPrimary immunodeficiency
H00081Hashimoto thyroiditisImmune system disease
IMD82H02526Disorders of adaptive immunityImmune system disease
AGMX1/IGHD3H00085AgammaglobulinemiasImmune system disease
H00254Growth hormone deficiencyEndocrine and metabolic disease
AGM4H00085AgammaglobulinemiasImmune system disease
APLAID/FCAS3H01743Autoinflammation and PLCG2-associated antibody deficiency and immune dysregulationImmune system disease
H02159Familial cold autoinflammatory syndromeImmune system disease
EBVH00008Burkitt lymphomaCancer
H00007Hodgkin lymphomaCancer
H00054Nasopharyngeal cancerCancer
HTLV-1H00009Adult T-cell leukemiaCancer
CVID3H00088Common variable immunodeficiencyImmune system disease
CVID7H00088Common variable immunodeficiencyImmune system disease
CVID6H00088Common variable immunodeficiencyImmune system disease
APDS/IMD14H01387Activated PI3K-delta syndromeImmune system disease
H01725Primary immunodeficiency diseaseImmune system disease
ROCHISH02585Roifman-Chitayat syndromeImmune system disease
APDS2H01387Activated PI3K-delta syndromeImmune system disease
SHORT/AGM7H01370SHORT syndromeCongenital malformation
H00085AgammaglobulinemiasImmune system disease


Drug name
D1D12751Serplulimab (USAN/INN)