KEGG   ORTHOLOGY: K04430
Entry
K04430                      KO                                     

Name
MAP2K4, MKK4
Definition
mitogen-activated protein kinase kinase 4 [EC:2.7.12.2]
Pathway
ko04010  MAPK signaling pathway
ko04012  ErbB signaling pathway
ko04013  MAPK signaling pathway - fly
ko04361  Axon regeneration
ko04620  Toll-like receptor signaling pathway
ko04664  Fc epsilon RI signaling pathway
ko04668  TNF signaling pathway
ko04912  GnRH signaling pathway
ko04926  Relaxin signaling pathway
ko04935  Growth hormone synthesis, secretion and action
ko05120  Epithelial cell signaling in Helicobacter pylori infection
ko05132  Salmonella infection
ko05135  Yersinia infection
ko05142  Chagas disease
ko05161  Hepatitis B
ko05166  Human T-cell leukemia virus 1 infection
ko05167  Kaposi sarcoma-associated herpesvirus infection
ko05169  Epstein-Barr virus infection
ko05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   04013 MAPK signaling pathway - fly
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   04012 ErbB signaling pathway
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   04668 TNF signaling pathway
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   04664 Fc epsilon RI signaling pathway
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
  09152 Endocrine system
   04912 GnRH signaling pathway
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   04926 Relaxin signaling pathway
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   04935 Growth hormone synthesis, secretion and action
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
  09158 Development and regeneration
   04361 Axon regeneration
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
 09160 Human Diseases
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
  09171 Infectious disease: bacterial
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   05132 Salmonella infection
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   05135 Yersinia infection
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   05161 Hepatitis B
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   05167 Kaposi sarcoma-associated herpesvirus infection
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
   05169 Epstein-Barr virus infection
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
  09174 Infectious disease: parasitic
   05142 Chagas disease
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
Protein kinases [BR:ko01001]
 Serine/threonine kinases: STE group
  STE7 family
   K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4
Other DBs
GO: 0004708
Genes
HSA: 6416(MAP2K4)
PTR: 455065(MAP2K4)
PPS: 100991495(MAP2K4)
GGO: 101143954(MAP2K4) 101154090
PON: 100439299(MAP2K4)
NLE: 100587718(MAP2K4)
MCC: 718155(MAP2K4)
MCF: 102125035(MAP2K4)
CSAB: 103242403(MAP2K4)
RRO: 104672345(MAP2K4)
RBB: 108517313(MAP2K4)
CJC: 100386168(MAP2K4)
SBQ: 101037589(MAP2K4)
MMU: 26398(Map2k4)
MCAL: 110304803(Map2k4)
MPAH: 110331563(Map2k4)
RNO: 287398(Map2k4)
MUN: 110552225(Map2k4)
CGE: 100770977(Map2k4)
NGI: 103752052(Map2k4)
HGL: 101705822(Map2k4)
CCAN: 109693003(Map2k4)
OCU: 100344852(MAP2K4)
TUP: 102493856(MAP2K4)
CFA: 489508(MAP2K4)
VVP: 112924907(MAP2K4)
AML: 100475919(MAP2K4)
UMR: 103660510(MAP2K4)
UAH: 113271224(MAP2K4)
ORO: 101386473(MAP2K4)
ELK: 111161210
FCA: 101086432(MAP2K4)
PTG: 102966812(MAP2K4)
PPAD: 109246076(MAP2K4)
AJU: 106986552(MAP2K4)
BTA: 526469(MAP2K4)
BOM: 102287278(MAP2K4)
BIU: 109573969(MAP2K4)
BBUB: 102395178(MAP2K4)
CHX: 102175799(MAP2K4)
OAS: 101115045(MAP2K4)
SSC: 100520100(MAP2K4)
CFR: 102513578(MAP2K4)
CDK: 105095916(MAP2K4)
BACU: 103012105(MAP2K4)
LVE: 103091203(MAP2K4)
OOR: 101270607(MAP2K4)
DLE: 111186018(MAP2K4)
PCAD: 102993818(MAP2K4)
ECB: 100073094(MAP2K4)
EPZ: 103567795
EAI: 106845730(MAP2K4)
MYB: 102244251(MAP2K4)
MYD: 102769098(MAP2K4)
MNA: 107544551(MAP2K4)
HAI: 109389137(MAP2K4)
DRO: 112308830(MAP2K4)
PALE: 102894945(MAP2K4)
RAY: 107517401(MAP2K4)
MJV: 108397589(MAP2K4)
LAV: 100655007(MAP2K4)
TMU: 101349700
MDO: 100019828(MAP2K4)
SHR: 100931587(MAP2K4)
PCW: 110193880(MAP2K4)
OAA: 100091407(MAP2K4)
GGA: 417312(MAP2K4)
MGP: 100544828(MAP2K4)
CJO: 107322213(MAP2K4)
NMEL: 110407172(MAP2K4)
APLA: 101805315(MAP2K4)
ACYG: 106047193(MAP2K4)
TGU: 100219801(MAP2K4)
SCAN: 103823926(MAP2K4)
GFR: 102037348(MAP2K4)
FAB: 101822010(MAP2K4)
PHI: 102102585(MAP2K4)
PMAJ: 107212510(MAP2K4)
CCAE: 111937201(MAP2K4)
CCW: 104695676(MAP2K4)
ETL: 114067595(MAP2K4)
FPG: 101918161(MAP2K4)
FCH: 102047307(MAP2K4)
CLV: 102085780(MAP2K4)
EGZ: 104133811(MAP2K4)
NNI: 104014564(MAP2K4)
ACUN: 113486906(MAP2K4)
PADL: 103925347(MAP2K4)
AAM: 106496868(MAP2K4)
ASN: 102379245(MAP2K4)
AMJ: 102577347(MAP2K4)
PSS: 102452927(MAP2K4)
CMY: 102929430
CPIC: 101939128(MAP2K4)
ACS: 100556629(map2k4)
PVT: 110075065(MAP2K4)
PBI: 103061657(MAP2K4)
PMUR: 107282461(MAP2K4)
PMUA: 114590704(MAP2K4)
GJA: 107123125(MAP2K4)
XLA: 399471(map2k4.L) 431908(map2k4.S)
XTR: 100135013(map2k4)
NPR: 108801499(MAP2K4)
DRE: 403052(map2k4a) 568951(map2k4b)
SANH: 107654000(map2k4) 107695698
IPU: 108272999(map2k4) 108274195
AMEX: 103042940 103045018(map2k4)
TRU: 101064151 101078980(map2k4)
LCO: 104919484 104933979(map2k4)
NCC: 104946717(map2k4) 104947390
ONL: 100707267(map2k4) 100711257
OLA: 101161098 101174917(map2k4)
XMA: 102225231 102232155(map2k4)
XCO: 114151734 114159409(map2k4)
PRET: 103469437 103481917(map2k4)
CVG: 107091771(map2k4) 107096251
NFU: 107397308(map2k4) 107397353
CSEM: 103382416(map2k4) 103392559
LCF: 108873371(map2k4) 108890897
LCM: 102352547(MAP2K4)
CMK: 103175698(map2k4)
RTP: 109935414(map2k4)
BFO: 118429574
CIN: 778672(mapkk4)
APLC: 110976118
SKO: 100329105
DME: Dmel_CG9738(Mkk4)
DER: 6552519
DSE: 6607241
DSI: Dsimw501_GD20857(Dsim_GD20857)
DAN: 6499128
DSR: 110187954
DPE: 6588025
DMN: 108155865
DWI: 6650986
DAZ: 108621241
DNV: 108659014
DHE: 111604816
DVI: 6633159
MDE: 101894864
LCQ: 111674490
AAG: 5580276
AME: 410575
BIM: 100747905
BTER: 100652087
CCAL: 108625314
OBB: 114875157
SOC: 105196567
AEC: 105148189
ACEP: 105627432
PBAR: 105430971
VEM: 105565617
HST: 105185937
DQU: 106743213
CFO: 105249095
LHU: 105671428
PGC: 109859606
OBO: 105283883
PCF: 106783911
NVI: 100119456
CSOL: 105361947
MDL: 103568930
TCA: 662917
DPA: 109538313
ATD: 109608868
NVL: 108569750
BMOR: 101735877
BMAN: 114253376
PMAC: 106718060
PRAP: 110993585
HAW: 110376193
TNL: 113492155
PXY: 105391083
API: 100161114
DNX: 107170671
AGS: 114125925
RMD: 113548440
BTAB: 109032567
CLEC: 106665045
ZNE: 110836450
FCD: 110859794
PVM: 113821072
PTEP: 107440235
CEL: CELE_F42G10.2(mkk-4) CELE_VZC374L.1(sek-6) CELE_ZC449.3(sek-3)
CBR: CBG01940(Cbr-mkk-4) CBG14588
TSP: Tsp_00085
PCAN: 112559469
CRG: 105345787
MYI: 110442146
OBI: 106873711
SHX: MS3_10235
EGL: EGR_05607
NVE: 5520533
EPA: 110238540
AMIL: 114958622
PDAM: 113680422
SPIS: 111321601
DGT: 114519309
HMG: 100200909
 » show all
Reference
PMID:7716521
  Authors
Lin A, Minden A, Martinetto H, Claret FX, Lange-Carter C, Mercurio F, Johnson GL, Karin M
  Title
Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2.
  Journal
Science 268:286-90 (1995)
DOI:10.1126/science.7716521
  Sequence
[hsa:6416]
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