KEGG   ORTHOLOGY: K13998
Entry
K13998                      KO                                     

Name
DHFR-TS
Definition
dihydrofolate reductase / thymidylate synthase [EC:1.5.1.3 2.1.1.45]
Pathway
ko00240  Pyrimidine metabolism
ko00670  One carbon pool by folate
ko00790  Folate biosynthesis
ko01100  Metabolic pathways
ko01240  Biosynthesis of cofactors
Module
M00053  Pyrimidine deoxyribonuleotide biosynthesis, CDP/CTP => dCDP/dCTP,dTDP/dTTP
M00126  Tetrahydrofolate biosynthesis, GTP => THF
M00841  Tetrahydrofolate biosynthesis, mediated by PTPS, GTP => THF
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00240 Pyrimidine metabolism
    K13998  DHFR-TS; dihydrofolate reductase / thymidylate synthase
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    K13998  DHFR-TS; dihydrofolate reductase / thymidylate synthase
   00670 One carbon pool by folate
    K13998  DHFR-TS; dihydrofolate reductase / thymidylate synthase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.3  dihydrofolate reductase
     K13998  DHFR-TS; dihydrofolate reductase / thymidylate synthase
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.45  thymidylate synthase
     K13998  DHFR-TS; dihydrofolate reductase / thymidylate synthase
Other DBs
RN: R00936 R00937 R00939 R00940 R02101 R02235 R02236
GO: 0004146 0004799
Genes
DPTE: 113798991
ATH: AT2G16370(THY-1) AT2G21550 AT4G34570(THY-2)
ALY: 9305209 9316457 9322288
CRB: 17877840 17887860 17891157
CSAT: 104702701 104713608 104716677 104721335 104729758 104747430 104751813 104766934 104792357
EUS: EUTSA_v10000156mg EUTSA_v10022646mg EUTSA_v10024973mg
BRP: 103836808 103858399 103860451 103862355
BNA: 106354095 106393759 106406829 106428737
BOE: 106309714 106328327 106329435
RSZ: 108842569 108861958
THJ: 104807303 104819616 104824813
CIT: 102610005 112495493
CIC: CICLE_v10028191mg
TCC: 18591434 18607742
GRA: 105769038 105772952 105795321
GHI: 107905452 107908795 107927990 107928896 107937003
GAB: 108453978 108474386 108480725
DZI: 111282035 111296923
EGR: 104448780 104453306
GMX: 100786311 100786329 100788658 547833(DHFR-TS)
GSJ: 114374890 114379844 114408452 114414471
PVU: PHAVU_009G022100g PHAVU_011G043000g
VRA: 106755099 106762733 106765682
VAR: 108324425 108331800 108338839
VUN: 114163394 114168580
CCAJ: 109788871 109800919
MTR: MTR_3g117080 MTR_4g070670 MTR_6g015630
CAM: 101489312 101514182
LJA: Lj1g3v3381400.1(Lj1g3v3381400.1) Lj1g3v3381400.2(Lj1g3v3381400.2) Lj3g3v3363560.1(Lj3g3v3363560.1)
ADU: 107460028 107471889 107476648
AIP: 107610060 107623690 107628864
LANG: 109344038 109355467
FVE: 101310472
RCN: 112173264
PPER: 18768793
PMUM: 103335682
PAVI: 110768489
MDM: 103440375 103448418
PXB: 103967122
ZJU: 107403693 107405872
CSV: 101208660
CMO: 103499691
MCHA: 111015400
CMAX: 111484218 111499552
CMOS: 111448895 111451711
CPEP: 111777623 111794868
RCU: 8275764 8285348
JCU: 105630137
HBR: 110645146 110648723 110651614 110658623
MESC: 110606532 110613044 110626513
POP: 7454375 7456362 7470002 7477628
PEU: 105134685 105142240 105142730
JRE: 108983433 108986993 108991352
QSU: 111986005 112011045
VVI: 100255872 100267529
SLY: 101267455
SPEN: 107008381
SOT: 102593228
CANN: 107840424
NTA: 107792811 107794251
NSY: 104226167 104246758
NTO: 104105538
NAU: 109223692 109229673
INI: 109161459 109165210
SIND: 105159256
OEU: 111388204 111401309 111410074
HAN: 110900389 110929462
LSV: 111908602 111918249
CCAV: 112500613 112516607
DCR: 108193031 108227144
BVG: 104904324
SOE: 110803064
CQI: 110698439 110702982 110705118 110724197
NNU: 104595633
PSOM: 113285996 113307581 113323259
OSA: 4350527 9271078
DOSA: Os11t0484400-01(Os11g0484400) Os12t0446900-01(Os12g0446900)
OBR: 102699594 102706896
BDI: 100832991
ATS: 109782258(LOC109782258)
SBI: 8068714
ZMA: 100286018(umc1821) 103644908 103653497 541707(DRTS)
SITA: 101772369 101778216
PDA: 103701887 103704597
EGU: 105046541 105048636
MUS: 103975558
DCT: 110095917 110107974
PEQ: 110030414
AOF: 109830591
ATR: 18437260
SMO: SELMODRAFT_233517 SELMODRAFT_404548
PPP: 112291384
CRE: CHLREDRAFT_139742
VCN: VOLCADRAFT_66296
MNG: MNEG_15931
CSL: COCSUDRAFT_37014
CVR: CHLNCDRAFT_30873
APRO: F751_2439
OLU: OSTLU_49676
OTA: OT_ostta01g05920
BPG: Bathy03g03500
MIS: MICPUN_58650(DHFR-TS)
MPP: MICPUCDRAFT_56456(DHFR-TS)
CME: CYME_CMS462C
GSL: Gasu_03410
CCP: CHC_T00010030001
ACAN: ACA1_057010 ACA1_199730
PFA: PF3D7_0417200
PFD: PFDG_04158
PYO: PY17X_0719300
PCB: PCHAS_072830(PC000873.02.0)
PBE: PBANKA_0719300
PKN: PKH_052130
PVX: PVX_089950
PCY: PCYB_053150
TAN: TA08775
TPV: TP04_0504
TOT: TOT_040000412
BEQ: BEWA_008170
BBO: BBOV_II000780(18.m06049)
BMIC: BMR1_02g03680
CPV: cgd4_4460
CHO: Chro.40506
TGO: TGME49_249180
TET: TTHERM_00312120
PTM: GSPATT00019973001
PTI: PHATRDRAFT_1690
FCY: FRACYDRAFT_157897
TPS: THAPS_13647(TMS1)
AAF: AURANDRAFT_38942
PIF: PITG_06749
PSOJ: PHYSODRAFT_555231
SPAR: SPRG_06761
EHX: EMIHUDRAFT_451981
GTT: GUITHDRAFT_69716
TBR: Tb927.7.5480
TBG: TbgDal_VII6360
TCR: 509153.90
LMA: LMJF_06_0860(DHFR-TS)
LIF: LINJ_06_0890(DHFR-TS)
LDO: LDBPK_060890
LMI: LMXM_06_0860
LBZ: LBRM_06_0830
LPAN: LPMP_060820(DHFR-TS)
NGR: NAEGRDRAFT_76251
 » show all
Reference
PMID:8374616
  Authors
Lazar G, Zhang H, Goodman HM
  Title
The origin of the bifunctional dihydrofolate reductase-thymidylate synthase isogenes of Arabidopsis thaliana.
  Journal
Plant J 3:657-68 (1993)
DOI:10.1111/j.1365-313X.1993.00657.x
  Sequence
Reference
PMID:8628226
  Authors
Schlichtherle IM, Roos DS, Van Houten JL
  Title
Cloning and molecular analysis of the bifunctional dihydrofolate reductase-thymidylate synthase gene in the ciliated protozoan Paramecium tetraurelia.
  Journal
Mol Gen Genet 250:665-73 (1996)
DOI:10.1007/BF02172977
LinkDB

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