KEGG   ORTHOLOGY: K13305
Entry
K13305                      KO                                     

Name
NEDD4L
Definition
E3 ubiquitin-protein ligase NEDD4-like [EC:2.3.2.26]
Pathway
ko04120  Ubiquitin mediated proteolysis
ko04144  Endocytosis
ko04530  Tight junction
ko04960  Aldosterone-regulated sodium reabsorption
Disease
H00270  Periventricular nodular heterotopia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    K13305  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K13305  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like
  09144 Cellular community - eukaryotes
   04530 Tight junction
    K13305  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like
 09150 Organismal Systems
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    K13305  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K13305  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like
   04121 Ubiquitin system
    K13305  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.26  HECT-type E3 ubiquitin transferase
     K13305  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like
Membrane trafficking [BR:ko04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Ubiquitin E3 ligases
    K13305  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  HECT type E3
   K13305  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like
Genes
HSA: 23327(NEDD4L)
PTR: 455443(NEDD4L)
PPS: 100974611(NEDD4L)
GGO: 101145073(NEDD4L)
PON: 100172429(NEDD4L)
NLE: 100589832(NEDD4L)
MCC: 700282(NEDD4L)
MCF: 101867463(NEDD4L)
CSAB: 103244214(NEDD4L)
RRO: 104671248(NEDD4L)
RBB: 108541057(NEDD4L)
CJC: 100399239(NEDD4L)
SBQ: 101049039(NEDD4L)
MMU: 83814(Nedd4l)
MCAL: 110285033(Nedd4l)
MPAH: 110333139(Nedd4l)
RNO: 291553(Nedd4l)
MUN: 110546616(Nedd4l)
CGE: 100769118(Nedd4l)
NGI: 103751817(Nedd4l)
HGL: 101715398(Nedd4l)
CCAN: 109690907(Nedd4l)
OCU: 100353099(NEDD4L)
TUP: 102485790(NEDD4L)
CFA: 476189(NEDD4L)
VVP: 112919291(NEDD4L)
AML: 100477591(NEDD4L)
UMR: 103676078(NEDD4L)
UAH: 113253456(NEDD4L)
ORO: 101362864(NEDD4L)
ELK: 111154313
FCA: 101088369(NEDD4L)
PTG: 102951074(NEDD4L)
PPAD: 109275670(NEDD4L)
AJU: 106978901(NEDD4L)
BTA: 510003(NEDD4L)
BOM: 102267387(NEDD4L)
BIU: 109577739(NEDD4L)
BBUB: 102416190(NEDD4L)
CHX: 102170194(NEDD4L)
OAS: 101122748(NEDD4L)
SSC: 100512083(NEDD4L)
CFR: 102513659(NEDD4L)
CDK: 105105073(NEDD4L)
BACU: 103005326(NEDD4L)
LVE: 103081012(NEDD4L)
OOR: 101271422(NEDD4L)
DLE: 111180228(NEDD4L)
PCAD: 102995919(NEDD4L)
ECB: 100054395(NEDD4L)
EPZ: 103564048(NEDD4L)
EAI: 106842487(NEDD4L)
MYB: 102251438(NEDD4L)
MYD: 102755374(NEDD4L)
MNA: 107545427(NEDD4L)
HAI: 109381739(NEDD4L)
DRO: 112322904(NEDD4L)
PALE: 102892677(NEDD4L)
RAY: 107502178(NEDD4L)
MJV: 108403097(NEDD4L)
LAV: 100664158(NEDD4L)
TMU: 101342682
MDO: 100022149(NEDD4L)
SHR: 100925489(NEDD4L)
PCW: 110214081(NEDD4L)
OAA: 100079902(NEDD4L)
GGA: 107055431 374119(NEDD4L)
MGP: 104914734(NEDD4L)
CJO: 107325935(NEDD4L)
NMEL: 110389419(NEDD4L)
APLA: 101800777(NEDD4L)
ACYG: 106044905(NEDD4L)
LSR: 110478594(NEDD4L)
SCAN: 103824385(NEDD4L)
GFR: 102045539(NEDD4L)
FAB: 101811620(NEDD4L)
PHI: 102111610(NEDD4L)
PMAJ: 107198649(NEDD4L)
CCAE: 111941142(NEDD4L)
CCW: 104698611(NEDD4L)
ETL: 114070189(NEDD4L)
FPG: 101919791(NEDD4L)
FCH: 102056095(NEDD4L)
CLV: 102098886(NEDD4L)
EGZ: 104125002(NEDD4L)
NNI: 104010832(NEDD4L)
ACUN: 113489530(NEDD4L)
PADL: 103916109(NEDD4L)
AAM: 106487216
ASN: 102377323(NEDD4L)
AMJ: 102562914(NEDD4L)
PSS: 102459538(NEDD4L)
CMY: 102934363(NEDD4L)
CPIC: 101933093(NEDD4L)
ACS: 100557964(nedd4l)
PVT: 110085068(NEDD4L)
PBI: 103067479
PMUR: 107285574(NEDD4L)
TSR: 106553260
PMUA: 114606317
GJA: 107115230(NEDD4L)
XLA: 108718432(nedd4l.L) 399396(nedd4l.S)
XTR: 448382(nedd4l)
NPR: 108804482(NEDD4L)
DRE: 559634(nedd4l)
SRX: 107719078 107739713(nedd4l)
CCAR: 109089132
IPU: 108278875(nedd4l)
PHYP: 113535720
AMEX: 103047886(nedd4l)
EEE: 113584578(nedd4l)
TRU: 101075517(nedd4l)
LCO: 104928497(nedd4l)
NCC: 104948013(nedd4l)
MZE: 101477833(nedd4l)
ONL: 100701479(nedd4l)
OLA: 101170200(nedd4l)
XMA: 102218091(nedd4l)
XCO: 114149514(nedd4l)
PRET: 103473874(nedd4l)
CVG: 107085820(nedd4l)
NFU: 107374698(nedd4l)
KMR: 108230988(nedd4l)
ALIM: 106518179(nedd4l)
AOCE: 111577024(nedd4l)
CSEM: 103390273(nedd4l)
POV: 109626314(nedd4l)
LCF: 108874044
SDU: 111234682(nedd4l)
SLAL: 111664746(nedd4l)
HCQ: 109523631(nedd4l)
BPEC: 110160658(nedd4l)
MALB: 109960668
SASA: 106568483(nedd4l)
OTW: 112259495(nedd4l)
SALP: 111980494(nedd4l)
ELS: 105006395
SFM: 108934530(nedd4l)
PKI: 111852603(nedd4l)
LCM: 102359976(NEDD4L)
CMK: 103184866(nedd4l)
RTP: 109931223(nedd4l)
SHX: MS3_07015
EGL: EGR_10270
 » show all
Reference
  Authors
Chan W, Tian R, Lee YF, Sit ST, Lim L, Manser E
  Title
Down-regulation of active ACK1 is mediated by association with the E3 ubiquitin ligase Nedd4-2.
  Journal
J Biol Chem 284:8185-94 (2009)
DOI:10.1074/jbc.M806877200
Reference
  Authors
Malbert-Colas L, Nicolas G, Galand C, Lecomte MC, Dhermy D
  Title
Identification of new partners of the epithelial sodium channel alpha subunit.
  Journal
C R Biol 326:615-24 (2003)
DOI:10.1016/S1631-0691(03)00154-9
  Sequence
[hsa:23327]
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