KEGG   PATHWAY: mze04110
Entry
mze04110                    Pathway                                
Name
Cell cycle - Maylandia zebra (zebra mbuna)
Description
Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cyclin-dependent kinases (CDKs) are key regulatory enzymes, each consisting of a catalytic CDK subunit and an activating cyclin subunit. CDKs regulate the cell's progression through the phases of the cell cycle by modulating the activity of key substrates. Downstream targets of CDKs include transcription factor E2F and its regulator Rb. Precise activation and inactivation of CDKs at specific points in the cell cycle are required for orderly cell division. Cyclin-CDK inhibitors (CKIs), such as p16Ink4a, p15Ink4b, p27Kip1, and p21Cip1, are involved in the negative regulation of CDK activities, thus providing a pathway through which the cell cycle is negatively regulated.
 Eukaryotic cells respond to DNA damage by activating signaling pathways that promote cell cycle arrest and DNA repair. In response to DNA damage, the checkpoint kinase ATM phosphorylates and activates Chk2, which in turn directly phosphorylates and activates p53 tumor suppressor protein. p53 and its transcriptional targets play an important role in both G1 and G2 checkpoints. ATR-Chk1-mediated protein degradation of Cdc25A protein phosphatase is also a mechanism conferring intra-S-phase checkpoint activation.
Class
Cellular Processes; Cell growth and death
Pathway map
mze04110  Cell cycle
mze04110

Other DBs
GO: 0000278
Organism
Maylandia zebra (zebra mbuna) [GN:mze]
Gene
101485361  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
101467298  G1/S-specific cyclin-D1 [KO:K04503]
101472403  G1/S-specific cyclin-D2 isoform X1 [KO:K10151]
101479984  G1/S-specific cyclin-D2 [KO:K10151]
101470118  G1/S-specific cyclin-D2 [KO:K10151]
101472513  ccnd3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
101475315  cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
101464773  cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
101478399  cyclin-dependent kinase 4 [KO:K02091] [EC:2.7.11.22]
101480728  rb1; retinoblastoma-associated protein [KO:K06618]
101477214  rbl2; retinoblastoma-like protein 2 isoform X1 [KO:K04681]
101487679  rbl1; retinoblastoma-like protein 1 [KO:K04681]
101477072  retinoblastoma-like protein 2 isoform X1 [KO:K16332]
101475377  abl1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
101478271  hdac2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
101481782  probable histone deacetylase 1-B [KO:K06067] [EC:3.5.1.98]
101473181  probable histone deacetylase 1-B isoform X1 [KO:K06067] [EC:3.5.1.98]
101472732  e2f1; transcription factor E2F1 [KO:K17454]
101474527  e2f2; transcription factor E2F2 isoform X1 [KO:K09389]
101479374  transcription factor E2F3 [KO:K06620]
101464453  e2f3; transcription factor E2F3 [KO:K06620]
101475808  e2f4; transcription factor E2F4 [KO:K04682]
101479954  transcription factor E2F5 [KO:K04682]
101486034  transcription factor E2F5 [KO:K04682]
101486697  tfdp1; transcription factor Dp-1 [KO:K04683]
101487930  gsk3b; glycogen synthase kinase-3 beta isoform X2 [KO:K03083] [EC:2.7.11.26]
101473892  transforming growth factor beta-1 [KO:K13375]
101466107  transforming growth factor beta-2 [KO:K13376]
101469764  tgfb2; transforming growth factor beta-2 isoform X1 [KO:K13376]
101467951  transforming growth factor beta-3 [KO:K13377]
101470853  transforming growth factor beta-3 [KO:K13377]
101470473  mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
101480714  mothers against decapentaplegic homolog 2 isoform X3 [KO:K23605]
101486706  smad3; mothers against decapentaplegic homolog 3 [KO:K23605]
101485832  mothers against decapentaplegic homolog 3 [KO:K23605]
101481185  mothers against decapentaplegic homolog 4 [KO:K04501]
101485614  mothers against decapentaplegic homolog 4 [KO:K04501]
101485383  mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
101467180  mothers against decapentaplegic homolog 4 [KO:K04501]
101464606  transcriptional regulator Myc-2 isoform X1 [KO:K04377]
101479046  transcriptional regulator Myc-A [KO:K04377]
101474120  myc; myc proto-oncogene protein [KO:K04377]
101486678  zbtb17; zinc finger and BTB domain-containing protein 17 [KO:K10500]
101471656  cyclin-dependent kinase 4 inhibitor B [KO:K04685]
112430374  cyclin-dependent kinase 4 inhibitor C-like [KO:K06622]
101484144  cyclin-dependent kinase 4 inhibitor C [KO:K06622]
101475113  cdkn2d; cyclin-dependent kinase 4 inhibitor D [KO:K06623]
101468035  cdkn1b; cyclin-dependent kinase inhibitor 1B [KO:K06624]
101466273  cyclin-dependent kinase inhibitor 1B [KO:K06624]
101468416  cyclin-dependent kinase inhibitor 1 [KO:K09993]
101476359  cyclin-dependent kinase inhibitor 1C [KO:K09993]
101474553  cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
101467117  cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
101482763  ccne1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
101486478  G1/S-specific cyclin-E1 [KO:K06626]
101470307  G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
101479025  cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
101469121  skp1; S-phase kinase-associated protein 1 [KO:K03094]
101485891  cul1; cullin-1 [KO:K03347]
101480103  rbx1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
101475050  skp2; S-phase kinase-associated protein 2 [KO:K03875]
101473222  ccna1; cyclin-A1 [KO:K06627]
101477005  cyclin-A2 [KO:K06627]
101471117  cdc6; cell division control protein 6 homolog [KO:K02213]
101475035  cdt1; DNA replication factor Cdt1 isoform X1 [KO:K10727]
101484023  orc1; origin recognition complex subunit 1 [KO:K02603]
101484007  orc2; origin recognition complex subunit 2 [KO:K02604]
101463574  orc3; origin recognition complex subunit 3 [KO:K02605]
101482176  orc4; origin recognition complex subunit 4 [KO:K02606]
101483173  orc5; origin recognition complex subunit 5 [KO:K02607]
101464772  mcm2; DNA replication licensing factor MCM2 [KO:K02540] [EC:5.6.2.3]
101479493  mcm3; DNA replication licensing factor MCM3 [KO:K02541] [EC:5.6.2.3]
101463880  mcm4; DNA replication licensing factor MCM4 [KO:K02212] [EC:5.6.2.3]
101464355  mcm5; DNA replication licensing factor MCM5 [KO:K02209] [EC:5.6.2.3]
101476670  zygotic DNA replication licensing factor mcm6-B [KO:K02542] [EC:5.6.2.3]
112436452  zygotic DNA replication licensing factor mcm6-B-like [KO:K02542] [EC:5.6.2.3]
101479028  mcm7; DNA replication licensing factor MCM7 isoform X1 [KO:K02210] [EC:5.6.2.3]
101478843  cdc45; cell division control protein 45 homolog [KO:K06628]
101486735  ticrr; treslin [KO:K26117]
101464750  mtbp; mdm2-binding protein [KO:K26116]
101467355  cdc7; cell division cycle 7-related protein kinase isoform X1 [KO:K02214] [EC:2.7.11.1]
101469330  dbf4; protein DBF4 homolog A [KO:K06629]
101483840  uncharacterized protein LOC101483840 isoform X1 [KO:K06629]
101478485  cdk1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
101483226  ccnb1; G2/mitotic-specific cyclin-B1 [KO:K05868]
101472628  G2/mitotic-specific cyclin-B2 isoform X1 [KO:K21770]
101486399  ccnb3; G2/mitotic-specific cyclin-B3 [KO:K21771]
101482927  M-phase inducer phosphatase 1 isoform X1 [KO:K05866] [EC:3.1.3.48]
101473746  14-3-3 protein zeta [KO:K16197]
101471951  14-3-3 protein beta/alpha-A [KO:K16197]
101468055  14-3-3 protein beta/alpha [KO:K16197]
101484489  14-3-3 protein beta/alpha-A [KO:K16197]
101481383  14-3-3 protein zeta/delta [KO:K16197]
101468387  14-3-3 protein epsilon isoform X1 [KO:K06630]
101470309  14-3-3 protein epsilon isoform X1 [KO:K06630]
101481074  14-3-3 protein gamma-1 [KO:K16198]
101483393  14-3-3 protein gamma-B [KO:K16198]
101467664  plk1; serine/threonine-protein kinase PLK1 [KO:K06631] [EC:2.7.11.21]
101474252  wee1; wee1-like protein kinase [KO:K06632] [EC:2.7.11.1]
101475313  wee1-like protein kinase 2 isoform X1 [KO:K06632] [EC:2.7.11.1]
101479538  pkmyt1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase [KO:K06633] [EC:2.7.11.1]
101473484  ccnh; cyclin-H isoform X1 [KO:K06634]
101463697  cdk7; cyclin-dependent kinase 7 [KO:K02202] [EC:2.7.11.22 2.7.11.23]
101469535  anapc1; anaphase-promoting complex subunit 1 [KO:K03348]
101473137  anapc2; anaphase-promoting complex subunit 2 [KO:K03349]
101466261  cdc27; cell division cycle protein 27 homolog isoform X1 [KO:K03350]
101481954  anapc4; anaphase-promoting complex subunit 4 [KO:K03351]
101487425  anapc5; anaphase-promoting complex subunit 5 isoform X1 [KO:K03352]
101473773  cdc16; cell division cycle protein 16 homolog isoform X1 [KO:K03353]
101477520  anapc7; anaphase-promoting complex subunit 7 [KO:K03354]
101465222  cdc23; cell division cycle protein 23 homolog [KO:K03355]
101470123  anaphase-promoting complex subunit 10 isoform X1 [KO:K03357]
112432202  anaphase-promoting complex subunit 10 isoform X1 [KO:K03357]
101474241  anaphase-promoting complex subunit 11 [KO:K03358]
112429995  anaphase-promoting complex subunit 11 [KO:K03358]
101480892  cdc26; anaphase-promoting complex subunit CDC26 [KO:K03359]
101479686  anaphase-promoting complex subunit 13 [KO:K12456]
112435215  anaphase-promoting complex subunit 13 [KO:K12456]
101484616  anapc15; anaphase-promoting complex subunit 15 [KO:K25228]
101480224  anapc16; anaphase-promoting complex subunit 16 [KO:K25229]
101481704  cdc20; cell division cycle protein 20 homolog [KO:K03363]
101479793  cell division cycle protein 20 homolog B [KO:K03363]
101486479  pttg1; securin [KO:K06635]
101471736  espl1; separin isoform X1 [KO:K02365] [EC:3.4.22.49]
101471615  structural maintenance of chromosomes protein 1B [KO:K06636]
101479638  smc1a; structural maintenance of chromosomes protein 1A [KO:K06636]
101473155  smc3; structural maintenance of chromosomes protein 3 [KO:K06669]
101478831  double-strand-break repair protein rad21 homolog [KO:K06670]
101475623  double-strand-break repair protein rad21 homolog isoform X1 [KO:K06670]
101466708  double-strand-break repair protein rad21 homolog [KO:K06670]
101471047  cohesin subunit SA-2 [KO:K06671]
101485810  cohesin subunit SA-2 [KO:K06671]
101472688  cohesin subunit SA-2 isoform X2 [KO:K06671]
101474275  stag3; cohesin subunit SA-3 isoform X1 [KO:K06671]
101477598  stag1; cohesin subunit SA-1 [KO:K06671]
101477639  transcriptional regulator ATRX isoform X1 [KO:K10779]
101486163  atrx; transcriptional regulator ATRX isoform X1 [KO:K10779]
101484513  ddx11; ATP-dependent DNA helicase DDX11 [KO:K11273] [EC:5.6.2.7]
101470690  nipbl; nipped-B-like protein isoform X1 [KO:K06672]
101478247  nipped-B-like protein [KO:K06672]
101467148  MAU2 chromatid cohesion factor homolog isoform X1 [KO:K11266]
101486710  mau2; MAU2 chromatid cohesion factor homolog [KO:K11266]
101473694  hdac8; histone deacetylase 8 [KO:K11405] [EC:3.5.1.98]
101479606  esco2; N-acetyltransferase ESCO2 isoform X1 [KO:K11268] [EC:2.3.1.-]
101478437  pds5a; sister chromatid cohesion protein PDS5 homolog A isoform X1 [KO:K11267]
101476132  pds5b; sister chromatid cohesion protein PDS5 homolog B [KO:K11267]
101485449  wings apart-like protein homolog isoform X1 [KO:K25163]
101473076  wings apart-like protein homolog [KO:K25163]
101482108  cdca5; sororin [KO:K17390]
101477914  aurora kinase B [KO:K11479] [EC:2.7.11.1]
101476413  sgo1; shugoshin 1 isoform X1 [KO:K11580]
101470047  ppp2ca; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
101479611  ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
101487597  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
101483438  ppp2r1b; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
101474489  ppp2r5d; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
101483131  ppp2r5c; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X4 [KO:K11584]
101473650  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
101479139  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
101480593  ppp2r5e; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
101482445  ppp2r5b; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
101485342  ndc80; kinetochore protein NDC80 homolog [KO:K11547]
101467995  knl1; kinetochore scaffold 1 [KO:K11542]
101482760  ttk; dual specificity protein kinase TTK isoform X1 [KO:K08866] [EC:2.7.12.1]
101470681  mad1l1; mitotic spindle assembly checkpoint protein MAD1 [KO:K06679]
101466811  mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
101487471  mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
101484853  mad2l2; mitotic spindle assembly checkpoint protein MAD2B [KO:K13728]
101474622  bub1b; mitotic checkpoint serine/threonine-protein kinase BUB1 beta [KO:K06637] [EC:2.7.11.1]
101471408  bub3; mitotic checkpoint protein BUB3 [KO:K02180]
101475470  mitotic checkpoint serine/threonine-protein kinase BUB1 isoform X1 [KO:K02178] [EC:2.7.11.1]
101475492  trip13; pachytene checkpoint protein 2 homolog [KO:K22399]
101464247  mad2l1bp; MAD2L1-binding protein [KO:K26093]
101485033  fizzy-related protein homolog [KO:K03364]
101486463  fizzy-related protein homolog [KO:K03364]
101466637  fizzy-related protein homolog isoform X1 [KO:K03364]
101475624  fbxo5; F-box only protein 5 [KO:K10292]
101465928  cdc14a; dual specificity protein phosphatase CDC14A isoform X1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
101482502  dual specificity protein phosphatase CDC14A isoform X3 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
112431659  dual specificity protein phosphatase CDC14AB-like isoform X1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
112433423  dual specificity protein phosphatase CDC14AB-like [KO:K06639] [EC:3.1.3.16 3.1.3.48]
105940431  dual specificity protein phosphatase CDC14AB-like [KO:K06639] [EC:3.1.3.16 3.1.3.48]
101470221  LOW QUALITY PROTEIN: dual specificity protein phosphatase CDC14AB [KO:K06639] [EC:3.1.3.16 3.1.3.48]
101484551  dual specificity protein phosphatase CDC14AB-like isoform X1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
101467023  CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
101478121  ep300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
101468013  histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
101476833  crebbp; CREB-binding protein [KO:K04498] [EC:2.3.1.48]
101484851  prkdc; DNA-dependent protein kinase catalytic subunit [KO:K06642] [EC:2.7.11.1]
101475692  atr; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
101485570  atm; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
112435930  serine-protein kinase ATM-like [KO:K04728] [EC:2.7.11.1]
101466094  mdm2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
101480650  cellular tumor antigen p53 [KO:K04451]
112432676  serine/arginine repetitive matrix protein 1-like isoform X1 [KO:K04451]
101486438  gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
101471114  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
101471410  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
101471344  growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
101463564  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
101463858  growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
101479184  growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
101486094  gadd45g; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
101470608  growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
101482883  pcna; proliferating cell nuclear antigen [KO:K04802]
101487018  chek1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
101485707  chek2; serine/threonine-protein kinase Chk2 [KO:K06641] [EC:2.7.11.1]
Reference
PMID:7908906
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  Title
D-type cyclin-binding regions of proliferating cell nuclear antigen.
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J Biol Chem 269:11030-6 (1994)
Reference
PMID:8242749
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Welch PJ, Wang JY
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A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle.
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Cell 75:779-90 (1993)
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Reference
PMID:16936746
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Rb family proteins as modulators of gene expression and new aspects regarding the interaction with chromatin remodeling enzymes.
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Oncogene 25:5263-7 (2006)
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Reference
PMID:15838516
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Cobrinik D
  Title
Pocket proteins and cell cycle control.
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Oncogene 24:2796-809 (2005)
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Reference
PMID:17568790
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Boutros R, Lobjois V, Ducommun B
  Title
CDC25 phosphatases in cancer cells: key players? Good targets?
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Nat Rev Cancer 7:495-507 (2007)
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Reference
PMID:9832503
  Authors
Diehl JA, Cheng M, Roussel MF, Sherr CJ
  Title
Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization.
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Genes Dev 12:3499-511 (1998)
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Reference
PMID:19020303
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Klein EA, Assoian RK
  Title
Transcriptional regulation of the cyclin D1 gene at a glance.
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J Cell Sci 121:3853-7 (2008)
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Reference
PMID:10385618
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Sherr CJ, Roberts JM
  Title
CDK inhibitors: positive and negative regulators of G1-phase progression.
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Genes Dev 13:1501-12 (1999)
DOI:10.1101/gad.13.12.1501
Reference
PMID:12809600
  Authors
Shi Y, Massague J.
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Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
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Cell 113:685-700 (2003)
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Reference
PMID:12925736
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Kamura T, Hara T, Kotoshiba S, Yada M, Ishida N, Imaki H, Hatakeyama S, Nakayama K, Nakayama KI
  Title
Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation.
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Proc Natl Acad Sci U S A 100:10231-6 (2003)
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Reference
PMID:16212951
  Authors
Bond M, Sala-Newby GB, Wu YJ, Newby AC
  Title
Biphasic effect of p21Cip1 on smooth muscle cell proliferation: role of PI 3-kinase and Skp2-mediated degradation.
  Journal
Cardiovasc Res 69:198-206 (2006)
DOI:10.1016/j.cardiores.2005.08.020
Reference
PMID:15838523
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
PMID:11099028
  Authors
Vogelstein B, Lane D, Levine AJ
  Title
Surfing the p53 network.
  Journal
Nature 408:307-10 (2000)
DOI:10.1038/35042675
Reference
PMID:7973727
  Authors
Smith ML, Chen IT, Zhan Q, Bae I, Chen CY, Gilmer TM, Kastan MB, O'Connor PM, Fornace AJ Jr
  Title
Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen.
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Science 266:1376-80 (1994)
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Reference
PMID:9889196
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Petersen BO, Lukas J, Sorensen CS, Bartek J, Helin K
  Title
Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization.
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EMBO J 18:396-410 (1999)
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Reference
PMID:17018296
  Authors
Sheu YJ, Stillman B
  Title
Cdc7-Dbf4 phosphorylates MCM proteins via a docking site-mediated mechanism to promote S phase progression.
  Journal
Mol Cell 24:101-13 (2006)
DOI:10.1016/j.molcel.2006.07.033
Reference
PMID:9029154
  Authors
Martinez AM, Afshar M, Martin F, Cavadore JC, Labbe JC, Doree M
  Title
Dual phosphorylation of the T-loop in cdk7: its role in controlling cyclin H binding and CAK activity.
  Journal
EMBO J 16:343-54 (1997)
DOI:10.1093/emboj/16.2.343
Reference
PMID:15876871
  Authors
Lolli G, Johnson LN
  Title
CAK-Cyclin-dependent Activating Kinase: a key kinase in cell cycle control and a target for drugs?
  Journal
Cell Cycle 4:572-7 (2005)
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Reference
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The spindle-assembly checkpoint in space and time.
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Nat Rev Mol Cell Biol 8:379-93 (2007)
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PMID:12573239
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Chromosome cohesion and separation: from men and molecules.
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Curr Biol 13:R104-14 (2003)
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PMID:15568976
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Stegmeier F, Amon A
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Closing mitosis: the functions of the Cdc14 phosphatase and its regulation.
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Annu Rev Genet 38:203-32 (2004)
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PMID:9618481
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Moustakas A, Kardassis D
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Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members.
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Proc Natl Acad Sci U S A 95:6733-8 (1998)
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PMID:26650195
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Controlling the response to DNA damage by the APC/C-Cdh1.
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Cell Mol Life Sci 73:949-60 (2016)
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PMID:20935501
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Cell Cycle 9:3904-12 (2010)
DOI:10.4161/cc.9.19.13585
Related
pathway
mze03030  DNA replication
mze04010  MAPK signaling pathway
mze04120  Ubiquitin mediated proteolysis
mze04210  Apoptosis
KO pathway
ko04110   
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